Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons
Identifieur interne : 004455 ( Ncbi/Curation ); précédent : 004454; suivant : 004456Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons
Auteurs : Raquel Martín-Ibá Ez [Espagne] ; M Nica Pardo [Espagne] ; Albert Giralt [Espagne] ; Andrés Miguez [Espagne] ; Inés Guardia [Espagne] ; Lucile Marion-Poll [France] ; Cristina Herranz [Espagne] ; Miriam Esgleas [Espagne] ; Gerardo Garcia-Díaz Barriga [Espagne] ; Michael J. Edel [Espagne] ; Carlos Vicario-Abej N [Espagne] ; Jordi Alberch [Espagne] ; Jean-Antoine Girault [France] ; Susan Chan [Espagne] ; Philippe Kastner [France] ; Josep M. Canals [Espagne]Source :
- Development (Cambridge, England) [ 0950-1991 ] ; 2017.
Descripteurs français
- KwdFr :
- Activité motrice, Animaux, Animaux nouveau-nés, Cellules souches neurales (cytologie), Cellules souches neurales (métabolisme), Corps strié (cytologie), Cycline E (métabolisme), Facteurs de transcription (métabolisme), Globus pallidus (cytologie), Mort cellulaire, Neurogenèse, Neurones (cytologie), Neurones (métabolisme), Numération cellulaire, Phase G1, Phase S, Phénotype, Points de contrôle du cycle cellulaire, Prolifération cellulaire, Protéines de liaison à l'ADN (métabolisme), Souris knockout.
- MESH :
- cytologie : Cellules souches neurales, Corps strié, Globus pallidus, Neurones.
- métabolisme : Cellules souches neurales, Cycline E, Facteurs de transcription, Neurones, Protéines de liaison à l'ADN.
- Activité motrice, Animaux, Animaux nouveau-nés, Mort cellulaire, Neurogenèse, Numération cellulaire, Phase G1, Phase S, Phénotype, Points de contrôle du cycle cellulaire, Prolifération cellulaire, Souris knockout.
English descriptors
- KwdEn :
- Animals, Animals, Newborn, Cell Count, Cell Cycle Checkpoints, Cell Death, Cell Proliferation, Corpus Striatum (cytology), Cyclin E (metabolism), DNA-Binding Proteins (metabolism), G1 Phase, Globus Pallidus (cytology), Mice, Knockout, Motor Activity, Neural Stem Cells (cytology), Neural Stem Cells (metabolism), Neurogenesis, Neurons (cytology), Neurons (metabolism), Phenotype, S Phase, Transcription Factors (metabolism).
- MESH :
- chemical , metabolism : Cyclin E, DNA-Binding Proteins, Transcription Factors.
- cytology : Corpus Striatum, Globus Pallidus, Neural Stem Cells, Neurons.
- metabolism : Neural Stem Cells, Neurons.
- Animals, Animals, Newborn, Cell Count, Cell Cycle Checkpoints, Cell Death, Cell Proliferation, G1 Phase, Mice, Knockout, Motor Activity, Neurogenesis, Phenotype, S Phase.
Abstract
Here, we unravel the mechanism of action of the Ikaros family zinc finger protein Helios (He) during the development of striatal medium spiny neurons (MSNs). He regulates the second wave of striatal neurogenesis involved in the generation of striatopallidal neurons, which express dopamine 2 receptor and enkephalin. To exert this effect, He is expressed in neural progenitor cells (NPCs) keeping them in the G1/G0 phase of the cell cycle. Thus, a lack of He results in an increase of S-phase entry and S-phase length of NPCs, which in turn impairs striatal neurogenesis and produces an accumulation of the number of cycling NPCs in the germinal zone (GZ), which end up dying at postnatal stages. Therefore,
Url:
DOI: 10.1242/dev.138248
PubMed: 28289129
PubMed Central: 5399659
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Michael J. Edel<affiliation><nlm:aff id="af9"><institution>Victor Chang Cardiac Research Institute</institution>,<addr-line>Sydney, New South Wales</addr-line>,<country>2010 Australia</country></nlm:aff><wicri:noCountry code="nlm country">2010 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="af10"><institution>School of Medicine and Pharmacology, Anatomy, Physiology and Human Biology, CCTRM, University of Western Australia</institution>,<addr-line>Western Australia</addr-line>,<country>6009 Australia</country></nlm:aff><wicri:noCountry code="nlm country">6009 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="af10"><institution>School of Medicine and Pharmacology, Anatomy, Physiology and Human Biology, CCTRM, University of Western Australia</institution>,<addr-line>Western Australia</addr-line>,<country>6009 Australia</country></nlm:aff><wicri:noCountry code="nlm country">6009 Australia</wicri:noCountry></affiliation>Le document en format XML
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Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giralt, Albert" sort="Giralt, Albert" uniqKey="Giralt A" first="Albert" last="Giralt">Albert Giralt</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Pathophysiology of Neurodegenerative Diseases Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miguez, Andres" sort="Miguez, Andres" uniqKey="Miguez A" first="Andrés" last="Miguez">Andrés Miguez</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cells and Regenerative Medicine Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guardia, Ines" sort="Guardia, Ines" uniqKey="Guardia I" first="Inés" last="Guardia">Inés Guardia</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cells and Regenerative Medicine Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marion Poll, Lucile" sort="Marion Poll, Lucile" uniqKey="Marion Poll L" first="Lucile" last="Marion-Poll">Lucile Marion-Poll</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Inserm UMR-S839; Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités; Institut du Fer à Moulin</institution>,<addr-line>75005 Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Herranz, Cristina" sort="Herranz, Cristina" uniqKey="Herranz C" first="Cristina" last="Herranz">Cristina Herranz</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cells and Regenerative Medicine Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><institution>Research and Development Unit, Production and Validation Center of Advanced Therapies (Creatio)</institution>,<addr-line>Faculty of Medicine and Health Sciences</addr-line>,<institution>University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Esgleas, Miriam" sort="Esgleas, Miriam" uniqKey="Esgleas M" first="Miriam" last="Esgleas">Miriam Esgleas</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cells and Regenerative Medicine Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Diaz Barriga, Gerardo" sort="Garcia Diaz Barriga, Gerardo" uniqKey="Garcia Diaz Barriga G" first="Gerardo" last="Garcia-Díaz Barriga">Gerardo Garcia-Díaz Barriga</name><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Pathophysiology of Neurodegenerative Diseases Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Edel, Michael J" sort="Edel, Michael J" uniqKey="Edel M" first="Michael J." last="Edel">Michael J. Edel</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Control of Pluripotency Laboratory, Department of Biomedical Sciences, Faculty of Medicine and Health Science</addr-line>,<institution>University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af9"><institution>Victor Chang Cardiac Research Institute</institution>,<addr-line>Sydney, New South Wales</addr-line>,<country>2010 Australia</country></nlm:aff><wicri:noCountry code="nlm country">2010 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="af10"><institution>School of Medicine and Pharmacology, Anatomy, Physiology and Human Biology, CCTRM, University of Western Australia</institution>,<addr-line>Western Australia</addr-line>,<country>6009 Australia</country></nlm:aff><wicri:noCountry code="nlm country">6009 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Vicario Abej N, Carlos" sort="Vicario Abej N, Carlos" uniqKey="Vicario Abej N C" first="Carlos" last="Vicario-Abej N">Carlos Vicario-Abej N</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Departamento de Neurobiología Molecular</addr-line>,<institution>Celular y del Desarrollo, Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC)</institution>,<addr-line>28002 Madrid</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Alberch, Jordi" sort="Alberch, Jordi" uniqKey="Alberch J" first="Jordi" last="Alberch">Jordi Alberch</name><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Girault, Jean Antoine" sort="Girault, Jean Antoine" uniqKey="Girault J" first="Jean-Antoine" last="Girault">Jean-Antoine Girault</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Inserm UMR-S839; Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités; Institut du Fer à Moulin</institution>,<addr-line>75005 Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Susan" sort="Chan, Susan" uniqKey="Chan S" first="Susan" last="Chan">Susan Chan</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cells and Regenerative Medicine Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kastner, Philippe" sort="Kastner, Philippe" uniqKey="Kastner P" first="Philippe" last="Kastner">Philippe Kastner</name><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Department of Functional Genomics and Cancer</addr-line>,<institution>Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Inserm U964, Centre National de la Recherche Scientifique (CNRS) UMR 7104</institution>,<addr-line>67400 Illkirch-Graffenstaden</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><addr-line>Faculté de Médecine</addr-line>,<institution>Université de Strasbourg</institution>,<addr-line>67081 Strasbourg</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Canals, Josep M" sort="Canals, Josep M" uniqKey="Canals J" first="Josep M." last="Canals">Josep M. Canals</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cells and Regenerative Medicine Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><institution>Research and Development Unit, Production and Validation Center of Advanced Therapies (Creatio)</institution>,<addr-line>Faculty of Medicine and Health Sciences</addr-line>,<institution>University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28289129</idno><idno type="pmc">5399659</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399659</idno><idno type="RBID">PMC:5399659</idno><idno type="doi">10.1242/dev.138248</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002401</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002401</idno><idno type="wicri:Area/Pmc/Curation">002251</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002251</idno><idno type="wicri:Area/Pmc/Checkpoint">000270</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000270</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000D80</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D80</idno><idno type="wicri:Area/PubMed/Curation">000D77</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D77</idno><idno type="wicri:Area/PubMed/Checkpoint">000D77</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D77</idno><idno type="wicri:Area/Ncbi/Merge">004455</idno><idno type="wicri:Area/Ncbi/Curation">004455</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons</title><author><name sortKey="Martin Iba Ez, Raquel" sort="Martin Iba Ez, Raquel" uniqKey="Martin Iba Ez R" first="Raquel" last="Martín-Ibá Ez">Raquel Martín-Ibá Ez</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cells and Regenerative Medicine Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><institution>Research and Development Unit, Production and Validation Center of Advanced Therapies (Creatio)</institution>,<addr-line>Faculty of Medicine and Health Sciences</addr-line>,<institution>University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pardo, M Nica" sort="Pardo, M Nica" uniqKey="Pardo M" first="M Nica" last="Pardo">M Nica Pardo</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cells and Regenerative Medicine Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giralt, Albert" sort="Giralt, Albert" uniqKey="Giralt A" first="Albert" last="Giralt">Albert Giralt</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Pathophysiology of Neurodegenerative Diseases Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miguez, Andres" sort="Miguez, Andres" uniqKey="Miguez A" first="Andrés" last="Miguez">Andrés Miguez</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cells and Regenerative Medicine Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guardia, Ines" sort="Guardia, Ines" uniqKey="Guardia I" first="Inés" last="Guardia">Inés Guardia</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cells and Regenerative Medicine Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marion Poll, Lucile" sort="Marion Poll, Lucile" uniqKey="Marion Poll L" first="Lucile" last="Marion-Poll">Lucile Marion-Poll</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Inserm UMR-S839; Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités; Institut du Fer à Moulin</institution>,<addr-line>75005 Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Herranz, Cristina" sort="Herranz, Cristina" uniqKey="Herranz C" first="Cristina" last="Herranz">Cristina Herranz</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cells and Regenerative Medicine Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><institution>Research and Development Unit, Production and Validation Center of Advanced Therapies (Creatio)</institution>,<addr-line>Faculty of Medicine and Health Sciences</addr-line>,<institution>University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Esgleas, Miriam" sort="Esgleas, Miriam" uniqKey="Esgleas M" first="Miriam" last="Esgleas">Miriam Esgleas</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cells and Regenerative Medicine Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Diaz Barriga, Gerardo" sort="Garcia Diaz Barriga, Gerardo" uniqKey="Garcia Diaz Barriga G" first="Gerardo" last="Garcia-Díaz Barriga">Gerardo Garcia-Díaz Barriga</name><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Pathophysiology of Neurodegenerative Diseases Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Edel, Michael J" sort="Edel, Michael J" uniqKey="Edel M" first="Michael J." last="Edel">Michael J. Edel</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Control of Pluripotency Laboratory, Department of Biomedical Sciences, Faculty of Medicine and Health Science</addr-line>,<institution>University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af9"><institution>Victor Chang Cardiac Research Institute</institution>,<addr-line>Sydney, New South Wales</addr-line>,<country>2010 Australia</country></nlm:aff><wicri:noCountry code="nlm country">2010 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="af10"><institution>School of Medicine and Pharmacology, Anatomy, Physiology and Human Biology, CCTRM, University of Western Australia</institution>,<addr-line>Western Australia</addr-line>,<country>6009 Australia</country></nlm:aff><wicri:noCountry code="nlm country">6009 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Vicario Abej N, Carlos" sort="Vicario Abej N, Carlos" uniqKey="Vicario Abej N C" first="Carlos" last="Vicario-Abej N">Carlos Vicario-Abej N</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Departamento de Neurobiología Molecular</addr-line>,<institution>Celular y del Desarrollo, Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC)</institution>,<addr-line>28002 Madrid</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Alberch, Jordi" sort="Alberch, Jordi" uniqKey="Alberch J" first="Jordi" last="Alberch">Jordi Alberch</name><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Girault, Jean Antoine" sort="Girault, Jean Antoine" uniqKey="Girault J" first="Jean-Antoine" last="Girault">Jean-Antoine Girault</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Inserm UMR-S839; Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités; Institut du Fer à Moulin</institution>,<addr-line>75005 Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Susan" sort="Chan, Susan" uniqKey="Chan S" first="Susan" last="Chan">Susan Chan</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cells and Regenerative Medicine Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kastner, Philippe" sort="Kastner, Philippe" uniqKey="Kastner P" first="Philippe" last="Kastner">Philippe Kastner</name><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Department of Functional Genomics and Cancer</addr-line>,<institution>Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Inserm U964, Centre National de la Recherche Scientifique (CNRS) UMR 7104</institution>,<addr-line>67400 Illkirch-Graffenstaden</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><addr-line>Faculté de Médecine</addr-line>,<institution>Université de Strasbourg</institution>,<addr-line>67081 Strasbourg</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Canals, Josep M" sort="Canals, Josep M" uniqKey="Canals J" first="Josep M." last="Canals">Josep M. Canals</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cells and Regenerative Medicine Laboratory</addr-line>,<institution>Production and Validation Center of Advanced Therapies (Creatio), Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Neuroscience Institute, University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>August Pi i Sunyer Biomedical Research Institute (IDIBAPS)</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Networked Biomedical Research Centre for Neurodegenerative Disorders (CIBERNED)</institution>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><institution>Research and Development Unit, Production and Validation Center of Advanced Therapies (Creatio)</institution>,<addr-line>Faculty of Medicine and Health Sciences</addr-line>,<institution>University of Barcelona</institution>,<addr-line>08036 Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Development (Cambridge, England)</title><idno type="ISSN">0950-1991</idno><idno type="eISSN">1477-9129</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Cell Count</term><term>Cell Cycle Checkpoints</term><term>Cell Death</term><term>Cell Proliferation</term><term>Corpus Striatum (cytology)</term><term>Cyclin E (metabolism)</term><term>DNA-Binding Proteins (metabolism)</term><term>G1 Phase</term><term>Globus Pallidus (cytology)</term><term>Mice, Knockout</term><term>Motor Activity</term><term>Neural Stem Cells (cytology)</term><term>Neural Stem Cells (metabolism)</term><term>Neurogenesis</term><term>Neurons (cytology)</term><term>Neurons (metabolism)</term><term>Phenotype</term><term>S Phase</term><term>Transcription Factors (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activité motrice</term><term>Animaux</term><term>Animaux nouveau-nés</term><term>Cellules souches neurales (cytologie)</term><term>Cellules souches neurales (métabolisme)</term><term>Corps strié (cytologie)</term><term>Cycline E (métabolisme)</term><term>Facteurs de transcription (métabolisme)</term><term>Globus pallidus (cytologie)</term><term>Mort cellulaire</term><term>Neurogenèse</term><term>Neurones (cytologie)</term><term>Neurones (métabolisme)</term><term>Numération cellulaire</term><term>Phase G1</term><term>Phase S</term><term>Phénotype</term><term>Points de contrôle du cycle cellulaire</term><term>Prolifération cellulaire</term><term>Protéines de liaison à l'ADN (métabolisme)</term><term>Souris knockout</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclin E</term><term>DNA-Binding Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules souches neurales</term><term>Corps strié</term><term>Globus pallidus</term><term>Neurones</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Corpus Striatum</term><term>Globus Pallidus</term><term>Neural Stem Cells</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neural Stem Cells</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules souches neurales</term><term>Cycline E</term><term>Facteurs de transcription</term><term>Neurones</term><term>Protéines de liaison à l'ADN</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Cell Count</term><term>Cell Cycle Checkpoints</term><term>Cell Death</term><term>Cell Proliferation</term><term>G1 Phase</term><term>Mice, Knockout</term><term>Motor Activity</term><term>Neurogenesis</term><term>Phenotype</term><term>S Phase</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activité motrice</term><term>Animaux</term><term>Animaux nouveau-nés</term><term>Mort cellulaire</term><term>Neurogenèse</term><term>Numération cellulaire</term><term>Phase G1</term><term>Phase S</term><term>Phénotype</term><term>Points de contrôle du cycle cellulaire</term><term>Prolifération cellulaire</term><term>Souris knockout</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Here, we unravel the mechanism of action of the Ikaros family zinc finger protein Helios (He) during the development of striatal medium spiny neurons (MSNs). He regulates the second wave of striatal neurogenesis involved in the generation of striatopallidal neurons, which express dopamine 2 receptor and enkephalin. To exert this effect, He is expressed in neural progenitor cells (NPCs) keeping them in the G<sub>1</sub>/G<sub>0</sub> phase of the cell cycle. Thus, a lack of He results in an increase of S-phase entry and S-phase length of NPCs, which in turn impairs striatal neurogenesis and produces an accumulation of the number of cycling NPCs in the germinal zone (GZ), which end up dying at postnatal stages. Therefore, <italic>He<sup>−/−</sup></italic> mice show a reduction in the number of dorso-medial striatal MSNs in the adult that produces deficits in motor skills acquisition. In addition, overexpression of <italic>He</italic> in NPCs induces misexpression of DARPP-32 when transplanted in mouse striatum. These findings demonstrate that He is involved in the correct development of a subset of striatopallidal MSNs and reveal new cellular mechanisms for neuronal development.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Agoston, D V" uniqKey="Agoston D">D. V. Agoston</name></author><author><name sortKey="Szemes, M" uniqKey="Szemes M">M. Szemes</name></author><author><name sortKey="Dobi, A" uniqKey="Dobi A">A. Dobi</name></author><author><name sortKey="Palkovits, M" uniqKey="Palkovits M">M. Palkovits</name></author><author><name sortKey="Georgopoulos, K" uniqKey="Georgopoulos K">K. Georgopoulos</name></author><author><name sortKey="Gyorgy, A" uniqKey="Gyorgy A">A. Gyorgy</name></author><author><name sortKey="Ring, M A" uniqKey="Ring M">M. A. Ring</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alsio, J M" uniqKey="Alsio J">J. M. 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