Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial.
Identifieur interne : 004230 ( Ncbi/Curation ); précédent : 004229; suivant : 004231Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial.
Auteurs : Zoltan Szakacs [Hongrie] ; Yves Dauvilliers [France] ; Vladimir Mikhaylov [Russie] ; Irina Poverennova [Russie] ; Sergei Krylov ; Slavko Jankovic [Serbie] ; Karel Sonka [République tchèque] ; Philippe Lehert [Australie] ; Isabelle Lecomte [France] ; Jeanne-Marie Lecomte [France] ; Jean-Charles Schwartz [France]Source :
- The Lancet. Neurology [ 1474-4465 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Antihistaminiques des récepteurs H3 (usage thérapeutique), Bases de données bibliographiques (), Cataplexie (traitement médicamenteux), Cataplexie (étiologie), Femelle, Humains, Indice de gravité médicale, Jeune adulte, Mâle, Méthode en double aveugle, Narcolepsie (), Pipéridines (usage thérapeutique), Résultat thérapeutique, Sujet âgé, Études de suivi, Études rétrospectives.
- MESH :
- traitement médicamenteux : Cataplexie.
- usage thérapeutique : Antihistaminiques des récepteurs H3, Pipéridines.
- étiologie : Cataplexie.
- Adolescent, Adulte, Adulte d'âge moyen, Bases de données bibliographiques, Femelle, Humains, Indice de gravité médicale, Jeune adulte, Mâle, Méthode en double aveugle, Narcolepsie, Résultat thérapeutique, Sujet âgé, Études de suivi, Études rétrospectives.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Cataplexy (drug therapy), Cataplexy (etiology), Databases, Bibliographic (statistics & numerical data), Double-Blind Method, Female, Follow-Up Studies, Histamine H3 Antagonists (therapeutic use), Humans, Male, Middle Aged, Narcolepsy (complications), Piperidines (therapeutic use), Retrospective Studies, Severity of Illness Index, Treatment Outcome, Young Adult.
- MESH :
- chemical , therapeutic use : Histamine H3 Antagonists, Piperidines.
- complications : Narcolepsy.
- drug therapy : Cataplexy.
- etiology : Cataplexy.
- statistics & numerical data : Databases, Bibliographic.
- Adolescent, Adult, Aged, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Severity of Illness Index, Treatment Outcome, Young Adult.
Abstract
Histaminergic neurons are crucial to maintain wakefulness, but their role in cataplexy is unknown. We assessed the safety and efficacy of pitolisant, a histamine H3 receptor inverse agonist, for treatment of cataplexy in patients with narcolepsy.
DOI: 10.1016/S1474-4422(16)30333-7
PubMed: 28129985
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Sergei Krylov<affiliation><nlm:affiliation>Clinical Psychiatric Hospital no 1, Simferopol, Crimea.</nlm:affiliation>
<wicri:noCountry code="subField">Crimea</wicri:noCountry>
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<front><div type="abstract" xml:lang="en">Histaminergic neurons are crucial to maintain wakefulness, but their role in cataplexy is unknown. We assessed the safety and efficacy of pitolisant, a histamine H3 receptor inverse agonist, for treatment of cataplexy in patients with narcolepsy.</div>
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