Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis
Identifieur interne : 003808 ( Ncbi/Curation ); précédent : 003807; suivant : 003809Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis
Auteurs : Emilie Dalloneau [France] ; Nadine Baroukh [France] ; Konstantinos Mavridis [Grèce] ; Agnès Maillet [France] ; Fabien Gueugnon [France] ; Yves Courty [France] ; Agnès Petit [France] ; Thomas Kryza [Australie] ; Maguy Del Rio [France] ; Serge Guyetant [France] ; Diana Carolina Cadena Castaneda [France] ; Christine Dhommée [France] ; Christophe Arnoult [France] ; Andreas Scorilas [Grèce] ; Valérie Gouilleux-Gruart [France] ; Nathalie Heuzé-Vourc'H [France]Source :
- Oncotarget [ 1949-2553 ] ; 2016.
Abstract
Lung cancer is the leading cause of cancer-related death worldwide. Although the recommended tumor, node and metastasis (TNM) classification and stage determination are important to select therapeutic options for patients with non-small cell lung carcinoma (NSCLC), additional molecular markers are required to indicate the prognosis, in particular within a specific stage, and help with the management of patients.
Because neonatal Fc receptor (FcRn) has recently been involved in colon cancer immunosurveillance, we measured its expression in non-cancerous and NSCLC lung tissues and evaluated its prognostic value in overall survival for patient with NSCLC. FcRn expression was determined at both mRNA and protein levels on cancerous and adjacent non-cancerous tissues from 80 NSCLC patients. In NSCLC, FcRn was mainly found in resident and tumor infiltrating immune cells. The corresponding mRNA and protein were significantly less abundant in lung tumor than non-cancerous tissue. Moreover, analysis of our cohort and datasets from the public data bases show that
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DOI: 10.18632/oncotarget.10074
PubMed: 27384673
PubMed Central: 5342352
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non-small cell lung cancer tissue is associated with a poor prognosis</title><author><name sortKey="Dalloneau, Emilie" sort="Dalloneau, Emilie" uniqKey="Dalloneau E" first="Emilie" last="Dalloneau">Emilie Dalloneau</name><affiliation wicri:level="3"><nlm:aff id="A1"> Université François Rabelais, UMR 1100, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université François Rabelais, UMR 1100, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Baroukh, Nadine" sort="Baroukh, Nadine" uniqKey="Baroukh N" first="Nadine" last="Baroukh">Nadine Baroukh</name><affiliation wicri:level="3"><nlm:aff id="A3"> Université François Rabelais de Tours, CNRS, GICC UMR 7292, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université François Rabelais de Tours, CNRS, GICC UMR 7292, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Mavridis, Konstantinos" sort="Mavridis, Konstantinos" uniqKey="Mavridis K" first="Konstantinos" last="Mavridis">Konstantinos Mavridis</name><affiliation wicri:level="3"><nlm:aff id="A4"> Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Maillet, Agnes" sort="Maillet, Agnes" uniqKey="Maillet A" first="Agnès" last="Maillet">Agnès Maillet</name><affiliation wicri:level="3"><nlm:aff id="A1"> Université François Rabelais, UMR 1100, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université François Rabelais, UMR 1100, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Gueugnon, Fabien" sort="Gueugnon, Fabien" uniqKey="Gueugnon F" first="Fabien" last="Gueugnon">Fabien Gueugnon</name><affiliation wicri:level="3"><nlm:aff id="A1"> Université François Rabelais, UMR 1100, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université François Rabelais, UMR 1100, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Courty, Yves" sort="Courty, Yves" uniqKey="Courty Y" first="Yves" last="Courty">Yves Courty</name><affiliation wicri:level="3"><nlm:aff id="A1"> Université François Rabelais, UMR 1100, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université François Rabelais, UMR 1100, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Petit, Agnes" sort="Petit, Agnes" uniqKey="Petit A" first="Agnès" last="Petit">Agnès Petit</name><affiliation wicri:level="3"><nlm:aff id="A1"> Université François Rabelais, UMR 1100, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université François Rabelais, UMR 1100, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Kryza, Thomas" sort="Kryza, Thomas" uniqKey="Kryza T" first="Thomas" last="Kryza">Thomas Kryza</name><affiliation wicri:level="1"><nlm:aff id="A5"> Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Del Rio, Maguy" sort="Del Rio, Maguy" uniqKey="Del Rio M" first="Maguy" last="Del Rio">Maguy Del Rio</name><affiliation wicri:level="3"><nlm:aff id="A6"> IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Guyetant, Serge" sort="Guyetant, Serge" uniqKey="Guyetant S" first="Serge" last="Guyetant">Serge Guyetant</name><affiliation wicri:level="3"><nlm:aff id="A1"> Université François Rabelais, UMR 1100, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université François Rabelais, UMR 1100, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Castaneda, Diana Carolina Cadena" sort="Castaneda, Diana Carolina Cadena" uniqKey="Castaneda D" first="Diana Carolina Cadena" last="Castaneda">Diana Carolina Cadena Castaneda</name><affiliation wicri:level="3"><nlm:aff id="A3"> Université François Rabelais de Tours, CNRS, GICC UMR 7292, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université François Rabelais de Tours, CNRS, GICC UMR 7292, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Dhommee, Christine" sort="Dhommee, Christine" uniqKey="Dhommee C" first="Christine" last="Dhommée">Christine Dhommée</name><affiliation wicri:level="3"><nlm:aff id="A3"> Université François Rabelais de Tours, CNRS, GICC UMR 7292, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université François Rabelais de Tours, CNRS, GICC UMR 7292, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Arnoult, Christophe" sort="Arnoult, Christophe" uniqKey="Arnoult C" first="Christophe" last="Arnoult">Christophe Arnoult</name><affiliation wicri:level="3"><nlm:aff id="A3"> Université François Rabelais de Tours, CNRS, GICC UMR 7292, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université François Rabelais de Tours, CNRS, GICC UMR 7292, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Scorilas, Andreas" sort="Scorilas, Andreas" uniqKey="Scorilas A" first="Andreas" last="Scorilas">Andreas Scorilas</name><affiliation wicri:level="3"><nlm:aff id="A4"> Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Gouilleux Gruart, Valerie" sort="Gouilleux Gruart, Valerie" uniqKey="Gouilleux Gruart V" first="Valérie" last="Gouilleux-Gruart">Valérie Gouilleux-Gruart</name><affiliation wicri:level="3"><nlm:aff id="A3"> Université François Rabelais de Tours, CNRS, GICC UMR 7292, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université François Rabelais de Tours, CNRS, GICC UMR 7292, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A7"> CHRU de TOURS, Laboratoire d'Immunologie, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CHRU de TOURS, Laboratoire d'Immunologie, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Heuze Vourc H, Nathalie" sort="Heuze Vourc H, Nathalie" uniqKey="Heuze Vourc H N" first="Nathalie" last="Heuzé-Vourc'H">Nathalie Heuzé-Vourc'H</name><affiliation wicri:level="3"><nlm:aff id="A1"> Université François Rabelais, UMR 1100, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université François Rabelais, UMR 1100, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="eISSN">1949-2553</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lung cancer is the leading cause of cancer-related death worldwide. Although the recommended tumor, node and metastasis (TNM) classification and stage determination are important to select therapeutic options for patients with non-small cell lung carcinoma (NSCLC), additional molecular markers are required to indicate the prognosis, in particular within a specific stage, and help with the management of patients.</p><p>Because neonatal Fc receptor (FcRn) has recently been involved in colon cancer immunosurveillance, we measured its expression in non-cancerous and NSCLC lung tissues and evaluated its prognostic value in overall survival for patient with NSCLC. FcRn expression was determined at both mRNA and protein levels on cancerous and adjacent non-cancerous tissues from 80 NSCLC patients. In NSCLC, FcRn was mainly found in resident and tumor infiltrating immune cells. The corresponding mRNA and protein were significantly less abundant in lung tumor than non-cancerous tissue. Moreover, analysis of our cohort and datasets from the public data bases show that <italic>FCGRT</italic> mRNA down-regulation is a robust and independent, unfavorable predictive factor of NSCLC patient survival. We conclude that <italic>FCGRT</italic> mRNA expression may be a useful additional marker for immunoscoring, reflecting tumor immune system, and help in the decision-making process for NSCLC patients.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Domagala Kulawik, J" uniqKey="Domagala Kulawik J">J Domagala-Kulawik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alifano, M" uniqKey="Alifano M">M Alifano</name></author><author><name sortKey="Mansuet Lupo, A" uniqKey="Mansuet Lupo A">A Mansuet-Lupo</name></author><author><name sortKey="Lococo, F" uniqKey="Lococo F">F Lococo</name></author><author><name sortKey="Roche, N" uniqKey="Roche N">N Roche</name></author><author><name sortKey="Bobbio, A" uniqKey="Bobbio A">A Bobbio</name></author><author><name sortKey="Canny, E" uniqKey="Canny E">E Canny</name></author><author><name sortKey="Schussler, O" uniqKey="Schussler O">O 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