Ponatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trial.
Identifieur interne : 003418 ( Ncbi/Curation ); précédent : 003417; suivant : 003419Ponatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trial.
Auteurs : Jeffrey H. Lipton [Canada] ; Charles Chuah [Singapour] ; Agnès Guerci-Bresler [France] ; Gianantonio Rosti [Italie] ; David Simpson [Nouvelle-Zélande] ; Sarit Assouline [Canada] ; Gabriel Etienne [France] ; Franck E. Nicolini [France] ; Philipp Le Coutre [Allemagne] ; Richard E. Clark [Royaume-Uni] ; Leif Stenke [Suède] ; David Andorsky [États-Unis] ; Vivian Oehler [États-Unis] ; Stephanie Lustgarten [États-Unis] ; Victor M. Rivera [États-Unis] ; Timothy Clackson [États-Unis] ; Frank G. Haluska [États-Unis] ; Michele Baccarani [Italie] ; Jorge E. Cortes [États-Unis] ; François Guilhot [France] ; Andreas Hochhaus [Allemagne] ; Timothy Hughes [Australie] ; Hagop M. Kantarjian [États-Unis] ; Neil P. Shah [États-Unis] ; Moshe Talpaz [États-Unis] ; Michael W. Deininger [États-Unis]Source :
- The Lancet. Oncology [ 1474-5488 ] ; 2016.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Chromosome Philadelphie (), Effets secondaires indésirables des médicaments (), Effets secondaires indésirables des médicaments (anatomopathologie), Estimation de Kaplan-Meier, Femelle, Humains, Imidazoles (administration et posologie), Imidazoles (effets indésirables), Leucémie myéloïde chronique BCR-ABL positive (anatomopathologie), Leucémie myéloïde chronique BCR-ABL positive (génétique), Leucémie myéloïde chronique BCR-ABL positive (traitement médicamenteux), Mâle, Mésylate d'imatinib (administration et posologie), Mésylate d'imatinib (effets indésirables), Protocoles de polychimiothérapie antinéoplasique (administration et posologie), Protocoles de polychimiothérapie antinéoplasique (effets indésirables), Protéines de fusion bcr-abl (génétique), Pyridazines (administration et posologie), Pyridazines (effets indésirables), Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute.
- MESH :
- administration et posologie : Imidazoles, Mésylate d'imatinib, Protocoles de polychimiothérapie antinéoplasique, Pyridazines.
- anatomopathologie : Effets secondaires indésirables des médicaments, Leucémie myéloïde chronique BCR-ABL positive.
- effets indésirables : Imidazoles, Mésylate d'imatinib, Protocoles de polychimiothérapie antinéoplasique, Pyridazines.
- génétique : Leucémie myéloïde chronique BCR-ABL positive, Protéines de fusion bcr-abl.
- traitement médicamenteux : Leucémie myéloïde chronique BCR-ABL positive.
- Adolescent, Adulte, Adulte d'âge moyen, Chromosome Philadelphie, Effets secondaires indésirables des médicaments, Estimation de Kaplan-Meier, Femelle, Humains, Mâle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols (administration & dosage), Antineoplastic Combined Chemotherapy Protocols (adverse effects), Disease-Free Survival, Drug-Related Side Effects and Adverse Reactions (classification), Drug-Related Side Effects and Adverse Reactions (pathology), Female, Fusion Proteins, bcr-abl (genetics), Humans, Imatinib Mesylate (administration & dosage), Imatinib Mesylate (adverse effects), Imidazoles (administration & dosage), Imidazoles (adverse effects), Kaplan-Meier Estimate, Leukemia, Myelogenous, Chronic, BCR-ABL Positive (drug therapy), Leukemia, Myelogenous, Chronic, BCR-ABL Positive (genetics), Leukemia, Myelogenous, Chronic, BCR-ABL Positive (pathology), Male, Middle Aged, Philadelphia Chromosome (drug effects), Pyridazines (administration & dosage), Pyridazines (adverse effects), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Imatinib Mesylate, Imidazoles, Pyridazines.
- chemical , adverse effects : Imatinib Mesylate, Imidazoles, Pyridazines.
- chemical , genetics : Fusion Proteins, bcr-abl.
- administration & dosage : Antineoplastic Combined Chemotherapy Protocols.
- adverse effects : Antineoplastic Combined Chemotherapy Protocols.
- classification : Drug-Related Side Effects and Adverse Reactions.
- drug effects : Philadelphia Chromosome.
- drug therapy : Leukemia, Myelogenous, Chronic, BCR-ABL Positive.
- genetics : Leukemia, Myelogenous, Chronic, BCR-ABL Positive.
- pathology : Drug-Related Side Effects and Adverse Reactions, Leukemia, Myelogenous, Chronic, BCR-ABL Positive.
- Adolescent, Adult, Aged, Aged, 80 and over, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Treatment Outcome.
Abstract
Ponatinib has shown potent activity against chronic myeloid leukaemia that is resistant to available treatment, although it is associated with arterial occlusion. We investigated whether this activity and safety profile would result in superior outcomes compared with imatinib in previously untreated patients with chronic myeloid leukaemia.
DOI: 10.1016/S1470-2045(16)00080-2
PubMed: 27083332
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pubmed:27083332Le document en format XML
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT</wicri:regionArea>
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<author><name sortKey="Guerci Bresler, Agnes" sort="Guerci Bresler, Agnes" uniqKey="Guerci Bresler A" first="Agnès" last="Guerci-Bresler">Agnès Guerci-Bresler</name>
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<author><name sortKey="Rosti, Gianantonio" sort="Rosti, Gianantonio" uniqKey="Rosti G" first="Gianantonio" last="Rosti">Gianantonio Rosti</name>
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<author><name sortKey="Simpson, David" sort="Simpson, David" uniqKey="Simpson D" first="David" last="Simpson">David Simpson</name>
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<wicri:regionArea>Department of Oncology-Pathology, Karolinska Institute and University Hospital, Stockholm</wicri:regionArea>
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<author><name sortKey="Andorsky, David" sort="Andorsky, David" uniqKey="Andorsky D" first="David" last="Andorsky">David Andorsky</name>
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<placeName><region type="state">Colorado</region>
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<author><name sortKey="Rivera, Victor M" sort="Rivera, Victor M" uniqKey="Rivera V" first="Victor M" last="Rivera">Victor M. Rivera</name>
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<author><name sortKey="Clackson, Timothy" sort="Clackson, Timothy" uniqKey="Clackson T" first="Timothy" last="Clackson">Timothy Clackson</name>
<affiliation wicri:level="2"><nlm:affiliation>ARIAD Pharmaceuticals, Inc, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>ARIAD Pharmaceuticals, Inc, Cambridge, MA</wicri:regionArea>
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<author><name sortKey="Haluska, Frank G" sort="Haluska, Frank G" uniqKey="Haluska F" first="Frank G" last="Haluska">Frank G. Haluska</name>
<affiliation wicri:level="2"><nlm:affiliation>ARIAD Pharmaceuticals, Inc, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>ARIAD Pharmaceuticals, Inc, Cambridge, MA</wicri:regionArea>
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<author><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
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<wicri:regionArea>The University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea>
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<author><name sortKey="Guilhot, Francois" sort="Guilhot, Francois" uniqKey="Guilhot F" first="François" last="Guilhot">François Guilhot</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM Clinical Investigation Center 1402, Centre Hospitalier et Universitaire de Poitiers, Poitiers, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM Clinical Investigation Center 1402, Centre Hospitalier et Universitaire de Poitiers, Poitiers</wicri:regionArea>
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<author><name sortKey="Hochhaus, Andreas" sort="Hochhaus, Andreas" uniqKey="Hochhaus A" first="Andreas" last="Hochhaus">Andreas Hochhaus</name>
<affiliation wicri:level="1"><nlm:affiliation>Abteilung für Hämatologie und Onkologie, Universitätsklinikum Jena, Jena, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Abteilung für Hämatologie und Onkologie, Universitätsklinikum Jena, Jena</wicri:regionArea>
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<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
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<author><name sortKey="Hughes, Timothy" sort="Hughes, Timothy" uniqKey="Hughes T" first="Timothy" last="Hughes">Timothy Hughes</name>
<affiliation wicri:level="1"><nlm:affiliation>Haematology Division, Royal Adelaide Hospital, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Haematology Division, Royal Adelaide Hospital, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kantarjian, Hagop M" sort="Kantarjian, Hagop M" uniqKey="Kantarjian H" first="Hagop M" last="Kantarjian">Hagop M. Kantarjian</name>
<affiliation wicri:level="2"><nlm:affiliation>The University of Texas MD Anderson Cancer Center, Houston, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
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</author>
<author><name sortKey="Shah, Neil P" sort="Shah, Neil P" uniqKey="Shah N" first="Neil P" last="Shah">Neil P. Shah</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine (Hematology/Oncology), University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Hematology/Oncology), University of California, San Francisco, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Talpaz, Moshe" sort="Talpaz, Moshe" uniqKey="Talpaz M" first="Moshe" last="Talpaz">Moshe Talpaz</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Hematology/Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
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</author>
<author><name sortKey="Deininger, Michael W" sort="Deininger, Michael W" uniqKey="Deininger M" first="Michael W" last="Deininger">Michael W. Deininger</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT</wicri:regionArea>
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<series><title level="j">The Lancet. Oncology</title>
<idno type="eISSN">1474-5488</idno>
<imprint><date when="2016" type="published">2016</date>
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<front><div type="abstract" xml:lang="en">Ponatinib has shown potent activity against chronic myeloid leukaemia that is resistant to available treatment, although it is associated with arterial occlusion. We investigated whether this activity and safety profile would result in superior outcomes compared with imatinib in previously untreated patients with chronic myeloid leukaemia.</div>
</front>
</TEI>
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