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White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies⋆

Identifieur interne : 003383 ( Ncbi/Curation ); précédent : 003382; suivant : 003384

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies⋆

Auteurs : Alan J. Burns [Royaume-Uni, Pays-Bas] ; Allan M. Goldstein [États-Unis] ; Donald F. Newgreen [Australie] ; Lincon Stamp [Australie] ; Karl-Herbert Sch Fer [Allemagne] ; Marco Metzger [Allemagne] ; Ryo Hotta [États-Unis] ; Heather M. Young [Australie] ; Peter W. Andrews [Royaume-Uni] ; Nikhil Thapar [Royaume-Uni] ; Jaime Belkind-Gerson [États-Unis] ; Nadege Bondurand [France] ; Joel C. Bornstein [Australie] ; Wood Yee Chan [Hong Kong] ; Kathryn Cheah [Hong Kong] ; Michael D. Gershon [États-Unis] ; Robert O. Heuckeroth [États-Unis] ; Robert M. W. Hofstra [Royaume-Uni, Pays-Bas] ; Lothar Just [Allemagne] ; Raj P. Kapur [États-Unis] ; Sebastian K. King [Australie] ; Conor J. Mccann [Royaume-Uni] ; Nandor Nagy [Hongrie] ; Elly Ngan [Hong Kong] ; Florian Obermayr [Allemagne] ; Vassilis Pachnis [Royaume-Uni] ; Pankaj J. Pasricha [États-Unis] ; Mai Har Sham [Hong Kong] ; Paul Tam [Hong Kong] ; Pieter Vanden Berghe [Belgique]

Source :

Developmental biology [ 0012-1606 ] ; 2016.

RBID : PMC:5026875

Descripteurs français

English descriptors

KwdEn :
- Animals, Cell- and Tissue-Based Therapy (methods), Disease Models, Animal, Enteric Nervous System (pathology), Gastrointestinal Tract (innervation), Gastrointestinal Tract (pathology), Guidelines as Topic, Hirschsprung Disease (pathology), Hirschsprung Disease (therapy), Humans, Intestinal Pseudo-Obstruction (pathology), Intestinal Pseudo-Obstruction (therapy), Neural Stem Cells (transplantation), Stem Cell Transplantation.
MESH :
- innervation : Gastrointestinal Tract.
- methods : Cell- and Tissue-Based Therapy.
- pathology : Enteric Nervous System, Gastrointestinal Tract, Hirschsprung Disease, Intestinal Pseudo-Obstruction.
- therapy : Hirschsprung Disease, Intestinal Pseudo-Obstruction.
- transplantation : Neural Stem Cells.
- Animals, Disease Models, Animal, Guidelines as Topic, Humans, Stem Cell Transplantation.

Abstract

Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts’ views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026875

DOI: 10.1016/j.ydbio.2016.04.001
PubMed: 27059883
PubMed Central: 5026875

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PMC:5026875

Le document en format XML

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<affiliation wicri:level="3"><nlm:aff id="A27">Université Paris-Est, UPEC, F-94000 Créteil, France</nlm:aff>
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<author><name sortKey="Chan, Wood Yee" sort="Chan, Wood Yee" uniqKey="Chan W" first="Wood Yee" last="Chan">Wood Yee Chan</name>
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<author><name sortKey="Heuckeroth, Robert O" sort="Heuckeroth, Robert O" uniqKey="Heuckeroth R" first="Robert O." last="Heuckeroth">Robert O. Heuckeroth</name>
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<affiliation wicri:level="2"><nlm:aff id="A28">Perelman School of Medicine at the University of Pennsylvania, Abramson Research Center, Philadelphia, PA 19104, USA</nlm:aff>
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<author><name sortKey="Kapur, Raj P" sort="Kapur, Raj P" uniqKey="Kapur R" first="Raj P." last="Kapur">Raj P. Kapur</name>
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<author><name sortKey="King, Sebastian K" sort="King, Sebastian K" uniqKey="King S" first="Sebastian K." last="King">Sebastian K. King</name>
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<author><name sortKey="Mccann, Conor J" sort="Mccann, Conor J" uniqKey="Mccann C" first="Conor J." last="Mccann">Conor J. Mccann</name>
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<author><name sortKey="Nagy, Nandor" sort="Nagy, Nandor" uniqKey="Nagy N" first="Nandor" last="Nagy">Nandor Nagy</name>
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<wicri:regionArea>Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest</wicri:regionArea>
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<author><name sortKey="Ngan, Elly" sort="Ngan, Elly" uniqKey="Ngan E" first="Elly" last="Ngan">Elly Ngan</name>
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<country xml:lang="fr">Hong Kong</country>
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<author><name sortKey="Obermayr, Florian" sort="Obermayr, Florian" uniqKey="Obermayr F" first="Florian" last="Obermayr">Florian Obermayr</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pediatric Surgery and Pediatric Urology, University Children’s Hospital Tübingen, D-72076 Tübingen</wicri:regionArea>
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<author><name sortKey="Pachnis, Vassilis" sort="Pachnis, Vassilis" uniqKey="Pachnis V" first="Vassilis" last="Pachnis">Vassilis Pachnis</name>
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<author><name sortKey="Pasricha, Pankaj J" sort="Pasricha, Pankaj J" uniqKey="Pasricha P" first="Pankaj J." last="Pasricha">Pankaj J. Pasricha</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Johns Hopkins Center for Neurogastroenterology, Baltimore, MD, USA</nlm:aff>
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<placeName><region type="state">Maryland</region>
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<author><name sortKey="Sham, Mai Har" sort="Sham, Mai Har" uniqKey="Sham M" first="Mai Har" last="Sham">Mai Har Sham</name>
<affiliation wicri:level="1"><nlm:aff id="A25">Department of Biochemistry, The University of Hong Kong, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Biochemistry, The University of Hong Kong</wicri:regionArea>
<wicri:noRegion>The University of Hong Kong</wicri:noRegion>
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<author><name sortKey="Tam, Paul" sort="Tam, Paul" uniqKey="Tam P" first="Paul" last="Tam">Paul Tam</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Department of Surgery, The University of Hong Kong, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Surgery, The University of Hong Kong</wicri:regionArea>
<wicri:noRegion>The University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Berghe, Pieter Vanden" sort="Berghe, Pieter Vanden" uniqKey="Berghe P" first="Pieter Vanden" last="Berghe">Pieter Vanden Berghe</name>
<affiliation wicri:level="1"><nlm:aff id="A26">Laboratory for Enteric NeuroScience (LENS), TARGID, University of Leuven, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Enteric NeuroScience (LENS), TARGID, University of Leuven</wicri:regionArea>
<wicri:noRegion>University of Leuven</wicri:noRegion>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies<sup><xref ref-type="fn" rid="FN2">⋆</xref>
</sup>
</title>
<author><name sortKey="Burns, Alan J" sort="Burns, Alan J" uniqKey="Burns A" first="Alan J." last="Burns">Alan J. Burns</name>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
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<author><name sortKey="Goldstein, Allan M" sort="Goldstein, Allan M" uniqKey="Goldstein A" first="Allan M." last="Goldstein">Allan M. Goldstein</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Stamp, Lincon" sort="Stamp, Lincon" uniqKey="Stamp L" first="Lincon" last="Stamp">Lincon Stamp</name>
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<country xml:lang="fr">Australie</country>
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</author>
<author><name sortKey="Sch Fer, Karl Herbert" sort="Sch Fer, Karl Herbert" uniqKey="Sch Fer K" first="Karl-Herbert" last="Sch Fer">Karl-Herbert Sch Fer</name>
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<wicri:regionArea>University of Applied Sciences, Kaiserlautern</wicri:regionArea>
<wicri:noRegion>Kaiserlautern</wicri:noRegion>
<wicri:noRegion>Kaiserlautern</wicri:noRegion>
<wicri:noRegion>Kaiserlautern</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:aff id="A7">Clinic of Pediatric Surgery, University Hospital Mannheim, University Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinic of Pediatric Surgery, University Hospital Mannheim, University Heidelberg</wicri:regionArea>
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<wicri:noRegion>University Heidelberg</wicri:noRegion>
<wicri:noRegion>University Heidelberg</wicri:noRegion>
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</author>
<author><name sortKey="Metzger, Marco" sort="Metzger, Marco" uniqKey="Metzger M" first="Marco" last="Metzger">Marco Metzger</name>
<affiliation wicri:level="3"><nlm:aff id="A8">Fraunhofer-Institute Interfacial Engineering and Biotechnology IGB Translational Centre – Würzburg branch and University Hospital Würzburg – Tissue Engineering and Regenerative Medicine (TERM), Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Fraunhofer-Institute Interfacial Engineering and Biotechnology IGB Translational Centre – Würzburg branch and University Hospital Würzburg – Tissue Engineering and Regenerative Medicine (TERM), Würzburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hotta, Ryo" sort="Hotta, Ryo" uniqKey="Hotta R" first="Ryo" last="Hotta">Ryo Hotta</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Young, Heather M" sort="Young, Heather M" uniqKey="Young H" first="Heather M." last="Young">Heather M. Young</name>
<affiliation wicri:level="4"><nlm:aff id="A5">Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Andrews, Peter W" sort="Andrews, Peter W" uniqKey="Andrews P" first="Peter W." last="Andrews">Peter W. Andrews</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Sheffield, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Sheffield</wicri:regionArea>
<wicri:noRegion>Sheffield</wicri:noRegion>
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</author>
<author><name sortKey="Thapar, Nikhil" sort="Thapar, Nikhil" uniqKey="Thapar N" first="Nikhil" last="Thapar">Nikhil Thapar</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Belkind Gerson, Jaime" sort="Belkind Gerson, Jaime" uniqKey="Belkind Gerson J" first="Jaime" last="Belkind-Gerson">Jaime Belkind-Gerson</name>
<affiliation wicri:level="3"><nlm:aff id="A9">Division of Gastroenterology, Hepatology and Nutrition, Massachusetts General Hospital for Children, Harvard Medical School, Boston, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology, Hepatology and Nutrition, Massachusetts General Hospital for Children, Harvard Medical School, Boston</wicri:regionArea>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bondurand, Nadege" sort="Bondurand, Nadege" uniqKey="Bondurand N" first="Nadege" last="Bondurand">Nadege Bondurand</name>
<affiliation wicri:level="3"><nlm:aff id="A10">INSERM U955, 51 Avenue du Maréchal de Lattre de Tassigny, F-94000 Créteil, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U955, 51 Avenue du Maréchal de Lattre de Tassigny, F-94000 Créteil</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A27">Université Paris-Est, UPEC, F-94000 Créteil, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Paris-Est, UPEC, F-94000 Créteil</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bornstein, Joel C" sort="Bornstein, Joel C" uniqKey="Bornstein J" first="Joel C." last="Bornstein">Joel C. Bornstein</name>
<affiliation wicri:level="4"><nlm:aff id="A11">Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Physiology, University of Melbourne, Parkville, Victoria 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chan, Wood Yee" sort="Chan, Wood Yee" uniqKey="Chan W" first="Wood Yee" last="Chan">Wood Yee Chan</name>
<affiliation wicri:level="4"><nlm:aff id="A12">School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong</wicri:regionArea>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author><name sortKey="Cheah, Kathryn" sort="Cheah, Kathryn" uniqKey="Cheah K" first="Kathryn" last="Cheah">Kathryn Cheah</name>
<affiliation wicri:level="1"><nlm:aff id="A13">School of Biomedical Sciences, The University of Hong Kong, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>School of Biomedical Sciences, The University of Hong Kong</wicri:regionArea>
<wicri:noRegion>The University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gershon, Michael D" sort="Gershon, Michael D" uniqKey="Gershon M" first="Michael D." last="Gershon">Michael D. Gershon</name>
<affiliation wicri:level="4"><nlm:aff id="A14">Department of Pathology and Cell Biology, Columbia University, New York 10032, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Cell Biology, Columbia University, New York 10032</wicri:regionArea>
<orgName type="university">Université Columbia</orgName>
<placeName><settlement type="city">New York</settlement>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heuckeroth, Robert O" sort="Heuckeroth, Robert O" uniqKey="Heuckeroth R" first="Robert O." last="Heuckeroth">Robert O. Heuckeroth</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Pediatrics, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A28">Perelman School of Medicine at the University of Pennsylvania, Abramson Research Center, Philadelphia, PA 19104, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Perelman School of Medicine at the University of Pennsylvania, Abramson Research Center, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hofstra, Robert M W" sort="Hofstra, Robert M W" uniqKey="Hofstra R" first="Robert M. W." last="Hofstra">Robert M. W. Hofstra</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A16">Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Just, Lothar" sort="Just, Lothar" uniqKey="Just L" first="Lothar" last="Just">Lothar Just</name>
<affiliation wicri:level="1"><nlm:aff id="A17">Institute of Clinical Anatomy and Cell Analysis, University of Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Clinical Anatomy and Cell Analysis, University of Tübingen</wicri:regionArea>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
<wicri:noRegion>University of Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kapur, Raj P" sort="Kapur, Raj P" uniqKey="Kapur R" first="Raj P." last="Kapur">Raj P. Kapur</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Pathology, University of Washington and Seattle Children’s Hospital, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of Washington and Seattle Children’s Hospital, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="King, Sebastian K" sort="King, Sebastian K" uniqKey="King S" first="Sebastian K." last="King">Sebastian K. King</name>
<affiliation wicri:level="3"><nlm:aff id="A19">Department of Paediatric and Neonatal Surgery, The Royal Children’s Hospital, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Paediatric and Neonatal Surgery, The Royal Children’s Hospital, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mccann, Conor J" sort="Mccann, Conor J" uniqKey="Mccann C" first="Conor J." last="Mccann">Conor J. Mccann</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Stem Cells and Regenerative Medicine, UCL Institute of Child Health, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nagy, Nandor" sort="Nagy, Nandor" uniqKey="Nagy N" first="Nandor" last="Nagy">Nandor Nagy</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, Hungary</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest</wicri:regionArea>
<placeName><settlement type="city">Budapest</settlement>
<region nuts="2">Hongrie centrale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ngan, Elly" sort="Ngan, Elly" uniqKey="Ngan E" first="Elly" last="Ngan">Elly Ngan</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Department of Surgery, The University of Hong Kong, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Surgery, The University of Hong Kong</wicri:regionArea>
<wicri:noRegion>The University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Obermayr, Florian" sort="Obermayr, Florian" uniqKey="Obermayr F" first="Florian" last="Obermayr">Florian Obermayr</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Department of Pediatric Surgery and Pediatric Urology, University Children’s Hospital Tübingen, D-72076 Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pediatric Surgery and Pediatric Urology, University Children’s Hospital Tübingen, D-72076 Tübingen</wicri:regionArea>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>D-72076 Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pachnis, Vassilis" sort="Pachnis, Vassilis" uniqKey="Pachnis V" first="Vassilis" last="Pachnis">Vassilis Pachnis</name>
<affiliation wicri:level="3"><nlm:aff id="A23">The Francis Crick Institute, Mill Hill Laboratory, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Francis Crick Institute, Mill Hill Laboratory, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pasricha, Pankaj J" sort="Pasricha, Pankaj J" uniqKey="Pasricha P" first="Pankaj J." last="Pasricha">Pankaj J. Pasricha</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Johns Hopkins Center for Neurogastroenterology, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Johns Hopkins Center for Neurogastroenterology, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sham, Mai Har" sort="Sham, Mai Har" uniqKey="Sham M" first="Mai Har" last="Sham">Mai Har Sham</name>
<affiliation wicri:level="1"><nlm:aff id="A25">Department of Biochemistry, The University of Hong Kong, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Biochemistry, The University of Hong Kong</wicri:regionArea>
<wicri:noRegion>The University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tam, Paul" sort="Tam, Paul" uniqKey="Tam P" first="Paul" last="Tam">Paul Tam</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Department of Surgery, The University of Hong Kong, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Surgery, The University of Hong Kong</wicri:regionArea>
<wicri:noRegion>The University of Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Berghe, Pieter Vanden" sort="Berghe, Pieter Vanden" uniqKey="Berghe P" first="Pieter Vanden" last="Berghe">Pieter Vanden Berghe</name>
<affiliation wicri:level="1"><nlm:aff id="A26">Laboratory for Enteric NeuroScience (LENS), TARGID, University of Leuven, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Enteric NeuroScience (LENS), TARGID, University of Leuven</wicri:regionArea>
<wicri:noRegion>University of Leuven</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Developmental biology</title>
<idno type="ISSN">0012-1606</idno>
<idno type="eISSN">1095-564X</idno>
<imprint><date when="2016">2016</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cell- and Tissue-Based Therapy (methods)</term>
<term>Disease Models, Animal</term>
<term>Enteric Nervous System (pathology)</term>
<term>Gastrointestinal Tract (innervation)</term>
<term>Gastrointestinal Tract (pathology)</term>
<term>Guidelines as Topic</term>
<term>Hirschsprung Disease (pathology)</term>
<term>Hirschsprung Disease (therapy)</term>
<term>Humans</term>
<term>Intestinal Pseudo-Obstruction (pathology)</term>
<term>Intestinal Pseudo-Obstruction (therapy)</term>
<term>Neural Stem Cells (transplantation)</term>
<term>Stem Cell Transplantation</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules souches neurales (transplantation)</term>
<term>Humains</term>
<term>Maladie de Hirschsprung ()</term>
<term>Maladie de Hirschsprung (anatomopathologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Pseudo-obstruction intestinale ()</term>
<term>Pseudo-obstruction intestinale (anatomopathologie)</term>
<term>Recommandations comme sujet</term>
<term>Système nerveux entérique (anatomopathologie)</term>
<term>Thérapie cellulaire et tissulaire ()</term>
<term>Transplantation de cellules souches</term>
<term>Tube digestif (anatomopathologie)</term>
<term>Tube digestif (innervation)</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladie de Hirschsprung</term>
<term>Pseudo-obstruction intestinale</term>
<term>Système nerveux entérique</term>
<term>Tube digestif</term>
</keywords>
<keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Gastrointestinal Tract</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Cell- and Tissue-Based Therapy</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Enteric Nervous System</term>
<term>Gastrointestinal Tract</term>
<term>Hirschsprung Disease</term>
<term>Intestinal Pseudo-Obstruction</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Hirschsprung Disease</term>
<term>Intestinal Pseudo-Obstruction</term>
</keywords>
<keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Neural Stem Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Guidelines as Topic</term>
<term>Humans</term>
<term>Stem Cell Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="innervation" xml:lang="fr"><term>Animaux</term>
<term>Cellules souches neurales</term>
<term>Humains</term>
<term>Maladie de Hirschsprung</term>
<term>Modèles animaux de maladie humaine</term>
<term>Pseudo-obstruction intestinale</term>
<term>Recommandations comme sujet</term>
<term>Thérapie cellulaire et tissulaire</term>
<term>Transplantation de cellules souches</term>
<term>Tube digestif</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts’ views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.</p>
</div>
</front>
</TEI>
</record>

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White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies⋆

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies⋆

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