Caspases Connect Cell-Death Signaling to Organismal Homeostasis.
Identifieur interne : 003145 ( Ncbi/Curation ); précédent : 003144; suivant : 003146Caspases Connect Cell-Death Signaling to Organismal Homeostasis.
Auteurs : Lorenzo Galluzzi [France] ; Alejandro L Pez-Soto [Espagne] ; Sharad Kumar [Australie] ; Guido Kroemer [Suède]Source :
- Immunity [ 1097-4180 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Caspases.
- Animaux, Homéostasie, Humains, Mort cellulaire, Transduction du signal.
English descriptors
- KwdEn :
- MESH :
- chemical , physiology : Caspases.
- Animals, Cell Death, Homeostasis, Humans, Signal Transduction.
Abstract
Some forms of regulated cell death, such as apoptosis, are precipitated by the activation of cysteine proteases of the caspase family, including caspase 8, 9, and 3. Other caspases, such as caspase 1 and 4, are well known for their pro-inflammatory functions but regulate cell death in a limited number of pathophysiological settings. Accumulating evidence suggests that the most conserved function of mammalian caspases is not to control cell death sensu stricto, but to regulate inflammatory and immune reactions to dying cells and infectious challenges. Here, we review the molecular and cellular mechanisms though which mammalian caspases connect cell-death signaling to the maintenance of organismal homeostasis.
DOI: 10.1016/j.immuni.2016.01.020
PubMed: 26885855
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Electronic address: kroemer@orange.fr.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France; INSERM, U1138, 75006 Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France; Université Pierre et Marie Curie/Paris VI, 75006 Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; Department of Women's and Children's Health, Karolinska University Hospital, 17176 Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author></analytic><series><title level="j">Immunity</title><idno type="eISSN">1097-4180</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Caspases (physiology)</term><term>Cell Death</term><term>Homeostasis</term><term>Humans</term><term>Signal Transduction</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Caspases (physiologie)</term><term>Homéostasie</term><term>Humains</term><term>Mort cellulaire</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Caspases</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Caspases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Death</term><term>Homeostasis</term><term>Humans</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Homéostasie</term><term>Humains</term><term>Mort cellulaire</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Some forms of regulated cell death, such as apoptosis, are precipitated by the activation of cysteine proteases of the caspase family, including caspase 8, 9, and 3. Other caspases, such as caspase 1 and 4, are well known for their pro-inflammatory functions but regulate cell death in a limited number of pathophysiological settings. Accumulating evidence suggests that the most conserved function of mammalian caspases is not to control cell death sensu stricto, but to regulate inflammatory and immune reactions to dying cells and infectious challenges. Here, we review the molecular and cellular mechanisms though which mammalian caspases connect cell-death signaling to the maintenance of organismal homeostasis.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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