Oral tolerance is inefficient in neonatal mice due to a physiological vitamin A deficiency.
Identifieur interne : 002D15 ( Ncbi/Curation ); précédent : 002D14; suivant : 002D16Oral tolerance is inefficient in neonatal mice due to a physiological vitamin A deficiency.
Auteurs : M. Turfkruyer [France] ; A. Rekima [France] ; P. Macchiaverni [Brésil] ; L. Le Bourhis [France] ; V. Muncan [Pays-Bas] ; G R Van Den Brink [Pays-Bas] ; M K Tulic [France] ; V. Verhasselt [France]Source :
- Mucosal immunology [ 1935-3456 ] ; 2016.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Administration par voie orale, Animaux, Animaux allaités, Animaux nouveau-nés, Antigènes CD (génétique), Antigènes CD (immunologie), Carence en vitamine A (), Carence en vitamine A (immunologie), Carence en vitamine A (physiopathologie), Cellules dendritiques (cytologie), Cellules dendritiques (immunologie), Expression des gènes, Intégrines alpha (génétique), Intégrines alpha (immunologie), Lymphocytes T régulateurs (cytologie), Lymphocytes T régulateurs (immunologie), Lymphocytes auxiliaires Th1 (cytologie), Lymphocytes auxiliaires Th1 (immunologie), Mésentère (cytologie), Mésentère (immunologie), Noeuds lymphatiques (cytologie), Noeuds lymphatiques (immunologie), Ovalbumine (immunologie), Ovalbumine (pharmacologie), Rétinol (administration et posologie), Rétinol (immunologie), Rétinol (métabolisme), Souris, Souris de lignée BALB C, Tolérance immunitaire ().
- MESH :
- administration et posologie : Rétinol.
- cytologie : Cellules dendritiques, Lymphocytes T régulateurs, Lymphocytes auxiliaires Th1, Mésentère, Noeuds lymphatiques.
- génétique : Antigènes CD, Intégrines alpha.
- immunologie : Antigènes CD, Carence en vitamine A, Cellules dendritiques, Intégrines alpha, Lymphocytes T régulateurs, Lymphocytes auxiliaires Th1, Mésentère, Noeuds lymphatiques, Ovalbumine, Rétinol.
- métabolisme : Rétinol.
- pharmacologie : Ovalbumine.
- physiopathologie : Carence en vitamine A.
- Activation des lymphocytes, Administration par voie orale, Animaux, Animaux allaités, Animaux nouveau-nés, Carence en vitamine A, Expression des gènes, Souris, Souris de lignée BALB C, Tolérance immunitaire.
English descriptors
- KwdEn :
- Administration, Oral, Animals, Animals, Newborn, Animals, Suckling, Antigens, CD (genetics), Antigens, CD (immunology), Dendritic Cells (cytology), Dendritic Cells (immunology), Gene Expression, Immune Tolerance (drug effects), Integrin alpha Chains (genetics), Integrin alpha Chains (immunology), Lymph Nodes (cytology), Lymph Nodes (immunology), Lymphocyte Activation, Mesentery (cytology), Mesentery (immunology), Mice, Mice, Inbred BALB C, Ovalbumin (immunology), Ovalbumin (pharmacology), T-Lymphocytes, Regulatory (cytology), T-Lymphocytes, Regulatory (immunology), Th1 Cells (cytology), Th1 Cells (immunology), Vitamin A (administration & dosage), Vitamin A (immunology), Vitamin A (metabolism), Vitamin A Deficiency (immunology), Vitamin A Deficiency (physiopathology), Vitamin A Deficiency (prevention & control).
- MESH :
- chemical , administration & dosage : Vitamin A.
- chemical , genetics : Antigens, CD, Integrin alpha Chains.
- chemical , immunology : Antigens, CD, Integrin alpha Chains, Ovalbumin, Vitamin A.
- cytology : Dendritic Cells, Lymph Nodes, Mesentery, T-Lymphocytes, Regulatory, Th1 Cells.
- drug effects : Immune Tolerance.
- immunology : Dendritic Cells, Lymph Nodes, Mesentery, T-Lymphocytes, Regulatory, Th1 Cells, Vitamin A Deficiency.
- chemical , metabolism : Vitamin A.
- chemical , pharmacology : Ovalbumin.
- physiopathology : Vitamin A Deficiency.
- prevention & control : Vitamin A Deficiency.
- Administration, Oral, Animals, Animals, Newborn, Animals, Suckling, Gene Expression, Lymphocyte Activation, Mice, Mice, Inbred BALB C.
Abstract
Increased risk of allergy during early life indicates deficient immune regulation in this period of life. To date, the cause for inefficient neonatal immune regulation has never been elucidated. We aimed to define the ontogeny of oral tolerance and to identify necessary conditions specific for this stage of life. Ovalbumin (OVA) was administered orally to mice through breast milk and efficiency of systemic tolerance to OVA was assessed in adulthood using a model of allergic airway inflammation. Oral tolerance induction was fully efficient starting third week of life. Inefficiency in neonates was a consequence of abnormal antigen transfer across the gut barrier and retinaldehyde dehydrogenase expression by mesenteric lymph node CD103(+) neonatal dendritic cells, resulting in inefficient T-cell activation. Neonates' serum retinol levels were three times lower than in adult mice, and vitamin A supplementation was sufficient to rescue neonatal defects and allow tolerance induction from birth. The establishment of oral tolerance required the differentiation of Th1 lymphocytes in both vitamin A-supplemented neonates and 3-week-old unsupplemented mice. This knowledge should guide the design of interventions for allergy prevention that are adapted to the neonatal stage of life such as vitamin A supplementation.
DOI: 10.1038/mi.2015.114
PubMed: 26530133
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Rekima</name><affiliation wicri:level="3"><nlm:affiliation>University of Nice Sophia Antipolis, TIM, EA 6302, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Nice Sophia Antipolis, TIM, EA 6302, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Macchiaverni, P" sort="Macchiaverni, P" uniqKey="Macchiaverni P" first="P" last="Macchiaverni">P. 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Turfkruyer</name><affiliation wicri:level="3"><nlm:affiliation>University of Nice Sophia Antipolis, TIM, EA 6302, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Nice Sophia Antipolis, TIM, EA 6302, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Rekima, A" sort="Rekima, A" uniqKey="Rekima A" first="A" last="Rekima">A. Rekima</name><affiliation wicri:level="3"><nlm:affiliation>University of Nice Sophia Antipolis, TIM, EA 6302, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Nice Sophia Antipolis, TIM, EA 6302, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Macchiaverni, P" sort="Macchiaverni, P" uniqKey="Macchiaverni P" first="P" last="Macchiaverni">P. Macchiaverni</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Biomedical Sciences-University of São Paulo, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Institute of Biomedical Sciences-University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Le Bourhis, L" sort="Le Bourhis, L" uniqKey="Le Bourhis L" first="L" last="Le Bourhis">L. Le Bourhis</name><affiliation wicri:level="3"><nlm:affiliation>University of Nice Sophia Antipolis, TIM, EA 6302, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Nice Sophia Antipolis, TIM, EA 6302, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Muncan, V" sort="Muncan, V" uniqKey="Muncan V" first="V" last="Muncan">V. Muncan</name><affiliation wicri:level="3"><nlm:affiliation>Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic medical center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic medical center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Van Den Brink, G R" sort="Van Den Brink, G R" uniqKey="Van Den Brink G" first="G R" last="Van Den Brink">G R Van Den Brink</name><affiliation wicri:level="3"><nlm:affiliation>Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic medical center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic medical center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Tulic, M K" sort="Tulic, M K" uniqKey="Tulic M" first="M K" last="Tulic">M K Tulic</name><affiliation wicri:level="3"><nlm:affiliation>University of Nice Sophia Antipolis, TIM, EA 6302, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Nice Sophia Antipolis, TIM, EA 6302, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Verhasselt, V" sort="Verhasselt, V" uniqKey="Verhasselt V" first="V" last="Verhasselt">V. Verhasselt</name><affiliation wicri:level="3"><nlm:affiliation>University of Nice Sophia Antipolis, TIM, EA 6302, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Nice Sophia Antipolis, TIM, EA 6302, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author></analytic><series><title level="j">Mucosal immunology</title><idno type="eISSN">1935-3456</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Animals, Newborn</term><term>Animals, Suckling</term><term>Antigens, CD (genetics)</term><term>Antigens, CD (immunology)</term><term>Dendritic Cells (cytology)</term><term>Dendritic Cells (immunology)</term><term>Gene Expression</term><term>Immune Tolerance (drug effects)</term><term>Integrin alpha Chains (genetics)</term><term>Integrin alpha Chains (immunology)</term><term>Lymph Nodes (cytology)</term><term>Lymph Nodes (immunology)</term><term>Lymphocyte Activation</term><term>Mesentery (cytology)</term><term>Mesentery (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Ovalbumin (immunology)</term><term>Ovalbumin (pharmacology)</term><term>T-Lymphocytes, Regulatory (cytology)</term><term>T-Lymphocytes, Regulatory (immunology)</term><term>Th1 Cells (cytology)</term><term>Th1 Cells (immunology)</term><term>Vitamin A (administration & dosage)</term><term>Vitamin A (immunology)</term><term>Vitamin A (metabolism)</term><term>Vitamin A Deficiency (immunology)</term><term>Vitamin A Deficiency (physiopathology)</term><term>Vitamin A Deficiency (prevention & control)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term><term>Administration par voie orale</term><term>Animaux</term><term>Animaux allaités</term><term>Animaux nouveau-nés</term><term>Antigènes CD (génétique)</term><term>Antigènes CD (immunologie)</term><term>Carence en vitamine A ()</term><term>Carence en vitamine A (immunologie)</term><term>Carence en vitamine A (physiopathologie)</term><term>Cellules dendritiques (cytologie)</term><term>Cellules dendritiques (immunologie)</term><term>Expression des gènes</term><term>Intégrines alpha (génétique)</term><term>Intégrines alpha (immunologie)</term><term>Lymphocytes T régulateurs (cytologie)</term><term>Lymphocytes T régulateurs (immunologie)</term><term>Lymphocytes auxiliaires Th1 (cytologie)</term><term>Lymphocytes auxiliaires Th1 (immunologie)</term><term>Mésentère (cytologie)</term><term>Mésentère (immunologie)</term><term>Noeuds lymphatiques (cytologie)</term><term>Noeuds lymphatiques (immunologie)</term><term>Ovalbumine (immunologie)</term><term>Ovalbumine (pharmacologie)</term><term>Rétinol (administration et posologie)</term><term>Rétinol (immunologie)</term><term>Rétinol (métabolisme)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Tolérance immunitaire ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Vitamin A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, CD</term><term>Integrin alpha Chains</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, CD</term><term>Integrin alpha Chains</term><term>Ovalbumin</term><term>Vitamin A</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Rétinol</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules dendritiques</term><term>Lymphocytes T régulateurs</term><term>Lymphocytes auxiliaires Th1</term><term>Mésentère</term><term>Noeuds lymphatiques</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Dendritic Cells</term><term>Lymph Nodes</term><term>Mesentery</term><term>T-Lymphocytes, Regulatory</term><term>Th1 Cells</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immune Tolerance</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes CD</term><term>Intégrines alpha</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes CD</term><term>Carence en vitamine A</term><term>Cellules dendritiques</term><term>Intégrines alpha</term><term>Lymphocytes T régulateurs</term><term>Lymphocytes auxiliaires Th1</term><term>Mésentère</term><term>Noeuds lymphatiques</term><term>Ovalbumine</term><term>Rétinol</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Dendritic Cells</term><term>Lymph Nodes</term><term>Mesentery</term><term>T-Lymphocytes, Regulatory</term><term>Th1 Cells</term><term>Vitamin A Deficiency</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Vitamin A</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Rétinol</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Ovalbumine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Ovalbumin</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Carence en vitamine A</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Vitamin A Deficiency</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Vitamin A Deficiency</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Animals, Newborn</term><term>Animals, Suckling</term><term>Gene Expression</term><term>Lymphocyte Activation</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Administration par voie orale</term><term>Animaux</term><term>Animaux allaités</term><term>Animaux nouveau-nés</term><term>Carence en vitamine A</term><term>Expression des gènes</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Tolérance immunitaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Increased risk of allergy during early life indicates deficient immune regulation in this period of life. To date, the cause for inefficient neonatal immune regulation has never been elucidated. We aimed to define the ontogeny of oral tolerance and to identify necessary conditions specific for this stage of life. Ovalbumin (OVA) was administered orally to mice through breast milk and efficiency of systemic tolerance to OVA was assessed in adulthood using a model of allergic airway inflammation. Oral tolerance induction was fully efficient starting third week of life. Inefficiency in neonates was a consequence of abnormal antigen transfer across the gut barrier and retinaldehyde dehydrogenase expression by mesenteric lymph node CD103(+) neonatal dendritic cells, resulting in inefficient T-cell activation. Neonates' serum retinol levels were three times lower than in adult mice, and vitamin A supplementation was sufficient to rescue neonatal defects and allow tolerance induction from birth. The establishment of oral tolerance required the differentiation of Th1 lymphocytes in both vitamin A-supplemented neonates and 3-week-old unsupplemented mice. This knowledge should guide the design of interventions for allergy prevention that are adapted to the neonatal stage of life such as vitamin A supplementation.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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