Consensus guidelines for the detection of immunogenic cell death
Identifieur interne : 002533 ( Ncbi/Curation ); précédent : 002532; suivant : 002534Consensus guidelines for the detection of immunogenic cell death
Auteurs : Oliver Kepp [France] ; Laura Senovilla [France] ; Ilio Vitale [Italie] ; Erika Vacchelli [France] ; Sandy Adjemian [France, Brésil] ; Patrizia Agostinis [Belgique] ; Lionel Apetoh [France] ; Fernando Aranda [France] ; Vincenzo Barnaba [Italie] ; Norma Bloy [France] ; Laura Bracci [Italie] ; Karine Breckpot [Belgique] ; David Brough [Royaume-Uni] ; Aitziber Buqué [France] ; Maria G. Castro [États-Unis] ; Mara Cirone [Italie] ; Maria I. Colombo [Argentine] ; Isabelle Cremer [France] ; Sandra Demaria [États-Unis] ; Luciana Dini [Italie] ; Aristides G. Eliopoulos [Grèce] ; Alberto Faggioni [Italie] ; Silvia C. Formenti [États-Unis] ; Jitka Fu Ková [République tchèque] ; Lucia Gabriele [Italie] ; Udo S. Gaipl [Allemagne] ; Jérôme Galon [France] ; Abhishek Garg [Belgique] ; François Ghiringhelli [France] ; Nathalia A. Giese [Allemagne] ; Zong Sheng Guo [États-Unis] ; Akseli Hemminki [Finlande] ; Martin Herrmann [Allemagne] ; James W. Hodge [États-Unis] ; Stefan Holdenrieder [Allemagne] ; Jamie Honeychurch [Royaume-Uni] ; Hong-Min Hu [République populaire de Chine, États-Unis] ; Xing Huang [France] ; Tim M. Illidge [Royaume-Uni] ; Koji Kono [Singapour] ; Mladen Korbelik [Canada] ; Dmitri V. Krysko [Belgique] ; Sherene Loi [Australie] ; Pedro R. Lowenstein [États-Unis] ; Enrico Lugli [Italie] ; Yuting Ma [France] ; Frank Madeo [Autriche] ; Angelo A. Manfredi [Italie] ; Isabelle Martins [France] ; Domenico Mavilio [Italie] ; Laurie Menger [France, Royaume-Uni] ; Nicol Merendino [Italie] ; Michael Michaud [France] ; Gregoire Mignot [France] ; Karen L. Mossman [Canada] ; Gabriele Multhoff [Allemagne] ; Rudolf Oehler [Autriche] ; Fabio Palombo [Italie] ; Theocharis Panaretakis [Suède] ; Jonathan Pol [France] ; Enrico Proietti [Italie] ; Jean-Ehrland Ricci [France] ; Chiara Riganti [Italie] ; Patrizia Rovere-Querini [Italie] ; Anna Rubartelli [Italie] ; Antonella Sistigu [Italie] ; Mark J. Smyth [Australie] ; Juergen Sonnemann [Allemagne] ; Radek Spisek [République tchèque] ; John Stagg [Canada] ; Abdul Qader Sukkurwala [France, Pakistan] ; Eric Tartour [France] ; Andrew Thorburn [États-Unis] ; Stephen H. Thorne [États-Unis] ; Peter Vandenabeele [Belgique] ; Francesca Velotti [Italie] ; Samuel T. Workenhe [Canada] ; Haining Yang [États-Unis] ; Wei-Xing Zong [États-Unis] ; Laurence Zitvogel [France] ; Guido Kroemer [France] ; Lorenzo Galluzzi [France]Source :
- Oncoimmunology [ 2162-4011 ] ; 2014.
Abstract
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm of the immune system, which we named “immunogenic cell death” (ICD). ICD is preceded or accompanied by the emission of a series of immunostimulatory damage-associated molecular patterns (DAMPs) in a precise spatiotemporal configuration. Several anticancer agents that have been successfully employed in the clinic for decades, including various chemotherapeutics and radiotherapy, can elicit ICD. Moreover, defects in the components that underlie the capacity of the immune system to perceive cell death as immunogenic negatively influence disease outcome among cancer patients treated with ICD inducers. Thus, ICD has profound clinical and therapeutic implications. Unfortunately, the gold-standard approach to detect ICD relies on vaccination experiments involving immunocompetent murine models and syngeneic cancer cells, an approach that is incompatible with large screening campaigns. Here, we outline strategies conceived to detect surrogate markers of ICD
Url:
DOI: 10.4161/21624011.2014.955691
PubMed: 25941621
PubMed Central: 4292729
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; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
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</nlm:aff>
<country xml:lang="fr">Belgique</country>
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</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<country xml:lang="fr">France</country>
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<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
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</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Castro, Maria G" sort="Castro, Maria G" uniqKey="Castro M" first="Maria G." last="Castro">Maria G. Castro</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Cirone, Mara" sort="Cirone, Mara" uniqKey="Cirone M" first="Mara" last="Cirone">Mara Cirone</name>
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; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Colombo, Maria I" sort="Colombo, Maria I" uniqKey="Colombo M" first="Maria I." last="Colombo">Maria I. Colombo</name>
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</nlm:aff>
<country xml:lang="fr">Argentine</country>
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</affiliation>
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<author><name sortKey="Cremer, Isabelle" sort="Cremer, Isabelle" uniqKey="Cremer I" first="Isabelle" last="Cremer">Isabelle Cremer</name>
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; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0020"><institution>Université Pierre et Marie Curie/Paris VI</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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</nlm:aff>
<country xml:lang="fr">France</country>
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</affiliation>
</author>
<author><name sortKey="Demaria, Sandra" sort="Demaria, Sandra" uniqKey="Demaria S" first="Sandra" last="Demaria">Sandra Demaria</name>
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; New York, NY<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dini, Luciana" sort="Dini, Luciana" uniqKey="Dini L" first="Luciana" last="Dini">Luciana Dini</name>
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; Lecce,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eliopoulos, Aristides G" sort="Eliopoulos, Aristides G" uniqKey="Eliopoulos A" first="Aristides G." last="Eliopoulos">Aristides G. Eliopoulos</name>
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</nlm:aff>
<country xml:lang="fr">Grèce</country>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0025"><institution>Institute of Molecular Biology and Biotechnology; Foundation of Research and Technology - Hellas</institution>
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</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Faggioni, Alberto" sort="Faggioni, Alberto" uniqKey="Faggioni A" first="Alberto" last="Faggioni">Alberto Faggioni</name>
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<author><name sortKey="Formenti, Silvia C" sort="Formenti, Silvia C" uniqKey="Formenti S" first="Silvia C." last="Formenti">Silvia C. Formenti</name>
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; New York, NY<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Fu Kova, Jitka" sort="Fu Kova, Jitka" uniqKey="Fu Kova J" first="Jitka" last="Fu Ková">Jitka Fu Ková</name>
<affiliation wicri:level="1"><nlm:aff id="af0027"><institution>Department of Immunology; 2<sup>nd</sup>
Faculty of Medicine and University Hospital Motol, Charles University</institution>
; Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0028"><institution>Sotio</institution>
; Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gabriele, Lucia" sort="Gabriele, Lucia" uniqKey="Gabriele L" first="Lucia" last="Gabriele">Lucia Gabriele</name>
<affiliation wicri:level="1"><nlm:aff id="af0014"><institution>Department of Hematology; Oncology and Molecular Medicine; Istituto Superiore di Sanità (ISS)</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gaipl, Udo S" sort="Gaipl, Udo S" uniqKey="Gaipl U" first="Udo S." last="Gaipl">Udo S. Gaipl</name>
<affiliation wicri:level="1"><nlm:aff id="af0029"><institution>Department of Radiation Oncology; University Hospital Erlangen; University of Erlangen-Nürnberg</institution>
; Erlangen,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Galon, Jerome" sort="Galon, Jerome" uniqKey="Galon J" first="Jérôme" last="Galon">Jérôme Galon</name>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0020"><institution>Université Pierre et Marie Curie/Paris VI</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0030"><institution>Université Paris Descartes/Paris V; Sorbonne Paris Cité</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0031"><institution>Laboratory of Integrative Cancer Immunology; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Garg, Abhishek" sort="Garg, Abhishek" uniqKey="Garg A" first="Abhishek" last="Garg">Abhishek Garg</name>
<affiliation wicri:level="1"><nlm:aff id="af0008"><institution>Cell Death Research and Therapy (CDRT) Laboratory; Department of Cellular and Molecular Medicine; University of Leuven</institution>
; Leuven,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ghiringhelli, Francois" sort="Ghiringhelli, Francois" uniqKey="Ghiringhelli F" first="François" last="Ghiringhelli">François Ghiringhelli</name>
<affiliation wicri:level="1"><nlm:aff id="af0009"><institution>INSERM; UMR866</institution>
; Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0010"><institution>Centre Georges François Leclerc</institution>
; Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0011"><institution>Université de Bourgogne</institution>
; Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giese, Nathalia A" sort="Giese, Nathalia A" uniqKey="Giese N" first="Nathalia A." last="Giese">Nathalia A. Giese</name>
<affiliation wicri:level="1"><nlm:aff id="af0032"><institution>European Pancreas Center; Department of Surgery; University Hospital Heidelberg</institution>
; Heidelberg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guo, Zong Sheng" sort="Guo, Zong Sheng" uniqKey="Guo Z" first="Zong Sheng" last="Guo">Zong Sheng Guo</name>
<affiliation wicri:level="1"><nlm:aff id="af0033"><institution>Department of Surgery; University of Pittsburgh</institution>
; Pittsburgh, PA<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hemminki, Akseli" sort="Hemminki, Akseli" uniqKey="Hemminki A" first="Akseli" last="Hemminki">Akseli Hemminki</name>
<affiliation wicri:level="1"><nlm:aff id="af0034"><institution>Cancer Gene Therapy Group; Transplantation laboratory; Haartman Institute; University of Helsinki</institution>
; Helsinki,<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Herrmann, Martin" sort="Herrmann, Martin" uniqKey="Herrmann M" first="Martin" last="Herrmann">Martin Herrmann</name>
<affiliation wicri:level="1"><nlm:aff id="af0035"><institution>Department of Internal Medicine 3; University of Erlangen-Nuremberg</institution>
; Erlangen,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hodge, James W" sort="Hodge, James W" uniqKey="Hodge J" first="James W." last="Hodge">James W. Hodge</name>
<affiliation wicri:level="1"><nlm:aff id="af0036"><institution>Laboratory of Tumor Immunology and Biology; Center for Cancer Research; National Cancer Institute (NCI), National Institutes of Health (NIH)</institution>
; Bethesda, MD<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Holdenrieder, Stefan" sort="Holdenrieder, Stefan" uniqKey="Holdenrieder S" first="Stefan" last="Holdenrieder">Stefan Holdenrieder</name>
<affiliation wicri:level="1"><nlm:aff id="af0037"><institution>Institute of Clinical Chemistry and Clinical Pharmacology; University Hospital Bonn</institution>
; Bonn,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Honeychurch, Jamie" sort="Honeychurch, Jamie" uniqKey="Honeychurch J" first="Jamie" last="Honeychurch">Jamie Honeychurch</name>
<affiliation wicri:level="1"><nlm:aff id="af0038"><institution>Faculty of Medical and Human Sciences, Institute of Cancer Studies; Manchester Academic Health Sciences Center; University of Manchester</institution>
; Manchester,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hu, Hong Min" sort="Hu, Hong Min" uniqKey="Hu H" first="Hong-Min" last="Hu">Hong-Min Hu</name>
<affiliation wicri:level="1"><nlm:aff id="af0039"><institution>Cancer Research and Biotherapy Center; Second Affiliated Hospital of Southeast University</institution>
; Nanjing,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0040"><institution>Laboratory of Cancer Immunobiology; Earle A. Chiles Research Institute; Providence Portland Medical Center</institution>
; Portland, OR<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huang, Xing" sort="Huang, Xing" uniqKey="Huang X" first="Xing" last="Huang">Xing Huang</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0003"><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Illidge, Tim M" sort="Illidge, Tim M" uniqKey="Illidge T" first="Tim M." last="Illidge">Tim M. Illidge</name>
<affiliation wicri:level="1"><nlm:aff id="af0038"><institution>Faculty of Medical and Human Sciences, Institute of Cancer Studies; Manchester Academic Health Sciences Center; University of Manchester</institution>
; Manchester,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kono, Koji" sort="Kono, Koji" uniqKey="Kono K" first="Koji" last="Kono">Koji Kono</name>
<affiliation wicri:level="1"><nlm:aff id="af0041"><institution>Department of Surgery; National University of Singapore</institution>
; Singapore,<country>Singapore</country>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0042"><institution>Cancer Science Institute of Singapore; National University of Singapore</institution>
; Singapore,<country>Singapore</country>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Korbelik, Mladen" sort="Korbelik, Mladen" uniqKey="Korbelik M" first="Mladen" last="Korbelik">Mladen Korbelik</name>
<affiliation wicri:level="1"><nlm:aff id="af0043"><institution>British Columbia Cancer Agency</institution>
; Vancouver,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krysko, Dmitri V" sort="Krysko, Dmitri V" uniqKey="Krysko D" first="Dmitri V." last="Krysko">Dmitri V. Krysko</name>
<affiliation wicri:level="1"><nlm:aff id="af0044"><institution>VIB Inflammation Research Center</institution>
; Ghent,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0045"><institution>Department of Biomedical Molecular Biology; Ghent University</institution>
; Ghent,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name>
<affiliation wicri:level="1"><nlm:aff id="af0046"><institution>Division of Cancer Medicine and Division of Research; Peter MacCallum Cancer Center; East Melbourne</institution>
; Victoria,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lowenstein, Pedro R" sort="Lowenstein, Pedro R" uniqKey="Lowenstein P" first="Pedro R." last="Lowenstein">Pedro R. Lowenstein</name>
<affiliation wicri:level="1"><nlm:aff id="af0017"><institution>Department of Neurosurgery and Cell and Developmental Biology; University of Michigan School of Medicine</institution>
; Ann Arbor, MI<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lugli, Enrico" sort="Lugli, Enrico" uniqKey="Lugli E" first="Enrico" last="Lugli">Enrico Lugli</name>
<affiliation wicri:level="1"><nlm:aff id="af0047"><institution>Unit of Clinical and Experimental Immunology; Humanitas Clinical and Research Center</institution>
; Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0048"><institution>Department of Medical Biotechnologies and Translational Medicine, University of Milan</institution>
; Rozzano,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ma, Yuting" sort="Ma, Yuting" uniqKey="Ma Y" first="Yuting" last="Ma">Yuting Ma</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Madeo, Frank" sort="Madeo, Frank" uniqKey="Madeo F" first="Frank" last="Madeo">Frank Madeo</name>
<affiliation wicri:level="1"><nlm:aff id="af0049"><institution>Institute of Molecular Biosciences; University of Graz</institution>
; Graz,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Manfredi, Angelo A" sort="Manfredi, Angelo A" uniqKey="Manfredi A" first="Angelo A." last="Manfredi">Angelo A. Manfredi</name>
<affiliation wicri:level="1"><nlm:aff id="af0050"><institution>University Vita-Salute San Raffaele</institution>
; Milano,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0051"><institution>San Raffaele Scientific Institute</institution>
; Milano,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Martins, Isabelle" sort="Martins, Isabelle" uniqKey="Martins I" first="Isabelle" last="Martins">Isabelle Martins</name>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0052"><institution>INSERM, U1030</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0053"><institution>Faculté de Médecine; Université Paris-Sud/Paris XI</institution>
; Kremlin-Bicêtre,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mavilio, Domenico" sort="Mavilio, Domenico" uniqKey="Mavilio D" first="Domenico" last="Mavilio">Domenico Mavilio</name>
<affiliation wicri:level="1"><nlm:aff id="af0047"><institution>Unit of Clinical and Experimental Immunology; Humanitas Clinical and Research Center</institution>
; Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0048"><institution>Department of Medical Biotechnologies and Translational Medicine, University of Milan</institution>
; Rozzano,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Menger, Laurie" sort="Menger, Laurie" uniqKey="Menger L" first="Laurie" last="Menger">Laurie Menger</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0054"><institution>Cancer Immunology Unit, Research Department of Haematology; University College London (UCL) Cancer Institute</institution>
; London,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Merendino, Nicol" sort="Merendino, Nicol" uniqKey="Merendino N" first="Nicol" last="Merendino">Nicol Merendino</name>
<affiliation wicri:level="1"><nlm:aff id="af0055"><institution>Department of Ecological and Biological Sciences (DEB), Tuscia University</institution>
; Viterbo,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Michaud, Michael" sort="Michaud, Michael" uniqKey="Michaud M" first="Michael" last="Michaud">Michael Michaud</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mignot, Gregoire" sort="Mignot, Gregoire" uniqKey="Mignot G" first="Gregoire" last="Mignot">Gregoire Mignot</name>
<affiliation wicri:level="1"><nlm:aff id="af0056"><institution>Cellular and Molecular Immunology and Endocrinology</institution>
, Oniris; Nantes,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mossman, Karen L" sort="Mossman, Karen L" uniqKey="Mossman K" first="Karen L." last="Mossman">Karen L. Mossman</name>
<affiliation wicri:level="1"><nlm:aff id="af0057"><institution>Department of Pathology and Molecular Medicine; McMaster Immunology Research Center</institution>
; Hamilton,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0058"><institution>Institute for Infectious Disease Research; McMaster University</institution>
; Hamilton,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Multhoff, Gabriele" sort="Multhoff, Gabriele" uniqKey="Multhoff G" first="Gabriele" last="Multhoff">Gabriele Multhoff</name>
<affiliation wicri:level="1"><nlm:aff id="af0059"><institution>Department of Radiation Oncology; Klinikum rechts der Isar; Technical University of Munich</institution>
; Munich,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oehler, Rudolf" sort="Oehler, Rudolf" uniqKey="Oehler R" first="Rudolf" last="Oehler">Rudolf Oehler</name>
<affiliation wicri:level="1"><nlm:aff id="af0060"><institution>Comprehensive Cancer Center; Medical University of Vienna</institution>
; Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Palombo, Fabio" sort="Palombo, Fabio" uniqKey="Palombo F" first="Fabio" last="Palombo">Fabio Palombo</name>
<affiliation wicri:level="1"><nlm:aff id="af0012"><institution>Departement of Internal Medicine and Medical Sciences; University of Rome La Sapienza</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0013"><institution>Istituto Pasteur; Fondazione Cenci Bolognetti</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Panaretakis, Theocharis" sort="Panaretakis, Theocharis" uniqKey="Panaretakis T" first="Theocharis" last="Panaretakis">Theocharis Panaretakis</name>
<affiliation wicri:level="1"><nlm:aff id="af0061"><institution>Department of Oncology-Pathology; Karolinska Institute</institution>
; Stockholm,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pol, Jonathan" sort="Pol, Jonathan" uniqKey="Pol J" first="Jonathan" last="Pol">Jonathan Pol</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Proietti, Enrico" sort="Proietti, Enrico" uniqKey="Proietti E" first="Enrico" last="Proietti">Enrico Proietti</name>
<affiliation wicri:level="1"><nlm:aff id="af0014"><institution>Department of Hematology; Oncology and Molecular Medicine; Istituto Superiore di Sanità (ISS)</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ricci, Jean Ehrland" sort="Ricci, Jean Ehrland" uniqKey="Ricci J" first="Jean-Ehrland" last="Ricci">Jean-Ehrland Ricci</name>
<affiliation wicri:level="1"><nlm:aff id="af0062"><institution>INSERM; U1065</institution>
; Nice,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0063"><institution>Equipe “Contrôle Métabolique des Morts Cellulaires,” Center Méditerranéen de Médecine Moléculaire (C3M)</institution>
; Nice,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0064"><institution>Faculté de Médecine; Université de Nice Sophia Antipolis</institution>
; Nice,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0065"><institution>Centre Hospitalier Universitaire de Nice</institution>
; Nice,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Riganti, Chiara" sort="Riganti, Chiara" uniqKey="Riganti C" first="Chiara" last="Riganti">Chiara Riganti</name>
<affiliation wicri:level="1"><nlm:aff id="af0066"><institution>Department of Oncology and Subalpine Center for Research and Experimental Medicine (CeRMS); University of Turin</institution>
; Turin,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rovere Querini, Patrizia" sort="Rovere Querini, Patrizia" uniqKey="Rovere Querini P" first="Patrizia" last="Rovere-Querini">Patrizia Rovere-Querini</name>
<affiliation wicri:level="1"><nlm:aff id="af0050"><institution>University Vita-Salute San Raffaele</institution>
; Milano,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0051"><institution>San Raffaele Scientific Institute</institution>
; Milano,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rubartelli, Anna" sort="Rubartelli, Anna" uniqKey="Rubartelli A" first="Anna" last="Rubartelli">Anna Rubartelli</name>
<affiliation wicri:level="1"><nlm:aff id="af0067"><institution>Cell Biology Unit; Azienda Ospedaliera Universitaria San Martino</institution>
;<institution>Istituto Nazionale per la Ricerca sul Cancro</institution>
; Genova,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sistigu, Antonella" sort="Sistigu, Antonella" uniqKey="Sistigu A" first="Antonella" last="Sistigu">Antonella Sistigu</name>
<affiliation wicri:level="1"><nlm:aff id="af0005"><institution>Regina Elena National Cancer Institute</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J." last="Smyth">Mark J. Smyth</name>
<affiliation wicri:level="1"><nlm:aff id="af0068"><institution>Immunology in Cancer and Infection Laboratory; QIMR Berghofer Medical Research Institute</institution>
; Herston,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0069"><institution>School of Medicine, University of Queensland</institution>
; Herston,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sonnemann, Juergen" sort="Sonnemann, Juergen" uniqKey="Sonnemann J" first="Juergen" last="Sonnemann">Juergen Sonnemann</name>
<affiliation wicri:level="1"><nlm:aff id="af0070"><institution>Department of Pediatric Haematology and Oncology; Jena University Hospital, Children's Clinic</institution>
; Jena,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Spisek, Radek" sort="Spisek, Radek" uniqKey="Spisek R" first="Radek" last="Spisek">Radek Spisek</name>
<affiliation wicri:level="1"><nlm:aff id="af0027"><institution>Department of Immunology; 2<sup>nd</sup>
Faculty of Medicine and University Hospital Motol, Charles University</institution>
; Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0028"><institution>Sotio</institution>
; Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stagg, John" sort="Stagg, John" uniqKey="Stagg J" first="John" last="Stagg">John Stagg</name>
<affiliation wicri:level="1"><nlm:aff id="af0071"><institution>Centre de Recherche du Center Hospitalier de l’Université de Montréal; Faculté de Pharmacie, Université de Montréal</institution>
; Montréal,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sukkurwala, Abdul Qader" sort="Sukkurwala, Abdul Qader" uniqKey="Sukkurwala A" first="Abdul Qader" last="Sukkurwala">Abdul Qader Sukkurwala</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0072"><institution>Department of Pathology, Dow International Medical College; Dow University of Health Sciences</institution>
; Karachi,<country>Pakistan</country>
</nlm:aff>
<country xml:lang="fr">Pakistan</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tartour, Eric" sort="Tartour, Eric" uniqKey="Tartour E" first="Eric" last="Tartour">Eric Tartour</name>
<affiliation wicri:level="1"><nlm:aff id="af0073"><institution>INSERM; U970</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0074"><institution>Pôle de Biologie; Hôpital Européen Georges Pompidou; AP-HP</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thorburn, Andrew" sort="Thorburn, Andrew" uniqKey="Thorburn A" first="Andrew" last="Thorburn">Andrew Thorburn</name>
<affiliation wicri:level="1"><nlm:aff id="af0075"><institution>Department of Pharmacology; University of Colorado School of Medicine</institution>
; Aurora, CO<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thorne, Stephen H" sort="Thorne, Stephen H" uniqKey="Thorne S" first="Stephen H." last="Thorne">Stephen H. Thorne</name>
<affiliation wicri:level="1"><nlm:aff id="af0033"><institution>Department of Surgery; University of Pittsburgh</institution>
; Pittsburgh, PA<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vandenabeele, Peter" sort="Vandenabeele, Peter" uniqKey="Vandenabeele P" first="Peter" last="Vandenabeele">Peter Vandenabeele</name>
<affiliation wicri:level="1"><nlm:aff id="af0044"><institution>VIB Inflammation Research Center</institution>
; Ghent,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0045"><institution>Department of Biomedical Molecular Biology; Ghent University</institution>
; Ghent,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0076"><institution>Methusalem Program; Ghent University</institution>
; Ghent,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Velotti, Francesca" sort="Velotti, Francesca" uniqKey="Velotti F" first="Francesca" last="Velotti">Francesca Velotti</name>
<affiliation wicri:level="1"><nlm:aff id="af0055"><institution>Department of Ecological and Biological Sciences (DEB), Tuscia University</institution>
; Viterbo,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Workenhe, Samuel T" sort="Workenhe, Samuel T" uniqKey="Workenhe S" first="Samuel T." last="Workenhe">Samuel T. Workenhe</name>
<affiliation wicri:level="1"><nlm:aff id="af0057"><institution>Department of Pathology and Molecular Medicine; McMaster Immunology Research Center</institution>
; Hamilton,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0058"><institution>Institute for Infectious Disease Research; McMaster University</institution>
; Hamilton,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yang, Haining" sort="Yang, Haining" uniqKey="Yang H" first="Haining" last="Yang">Haining Yang</name>
<affiliation wicri:level="1"><nlm:aff id="af0077"><institution>University of Hawaii Cancer Center</institution>
; Honolulu, HI<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zong, Wei Xing" sort="Zong, Wei Xing" uniqKey="Zong W" first="Wei-Xing" last="Zong">Wei-Xing Zong</name>
<affiliation wicri:level="1"><nlm:aff id="af0078"><institution>Department of Molecular Genetics and Microbiology; Stony Brook University</institution>
; Stony Brook, NY<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name>
<affiliation wicri:level="1"><nlm:aff id="af0004"><institution>INSERM; U1015</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0079"><institution>Centre d’Investigation Clinique Biothérapie 507 (CICBT507); Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0003"><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0030"><institution>Université Paris Descartes/Paris V; Sorbonne Paris Cité</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0074"><institution>Pôle de Biologie; Hôpital Européen Georges Pompidou; AP-HP</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0030"><institution>Université Paris Descartes/Paris V; Sorbonne Paris Cité</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25941621</idno>
<idno type="pmc">4292729</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292729</idno>
<idno type="RBID">PMC:4292729</idno>
<idno type="doi">10.4161/21624011.2014.955691</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000395</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000395</idno>
<idno type="wicri:Area/Pmc/Curation">000395</idno>
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<idno type="wicri:Area/Pmc/Checkpoint">001684</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001684</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">003207</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003207</idno>
<idno type="wicri:Area/PubMed/Curation">003097</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003097</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003097</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003097</idno>
<idno type="wicri:Area/Ncbi/Merge">002533</idno>
<idno type="wicri:Area/Ncbi/Curation">002533</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Consensus guidelines for the detection of immunogenic cell death</title>
<author><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0003"><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Senovilla, Laura" sort="Senovilla, Laura" uniqKey="Senovilla L" first="Laura" last="Senovilla">Laura Senovilla</name>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0003"><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0004"><institution>INSERM; U1015</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vitale, Ilio" sort="Vitale, Ilio" uniqKey="Vitale I" first="Ilio" last="Vitale">Ilio Vitale</name>
<affiliation wicri:level="1"><nlm:aff id="af0005"><institution>Regina Elena National Cancer Institute</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vacchelli, Erika" sort="Vacchelli, Erika" uniqKey="Vacchelli E" first="Erika" last="Vacchelli">Erika Vacchelli</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Adjemian, Sandy" sort="Adjemian, Sandy" uniqKey="Adjemian S" first="Sandy" last="Adjemian">Sandy Adjemian</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0007"><institution>Molecular Cell Biology Laboratory; Department of Immunology; Institute of Biomedical Sciences; University of São Paulo</institution>
; São Paulo,<country>Brazil</country>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Agostinis, Patrizia" sort="Agostinis, Patrizia" uniqKey="Agostinis P" first="Patrizia" last="Agostinis">Patrizia Agostinis</name>
<affiliation wicri:level="1"><nlm:aff id="af0008"><institution>Cell Death Research and Therapy (CDRT) Laboratory; Department of Cellular and Molecular Medicine; University of Leuven</institution>
; Leuven,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Apetoh, Lionel" sort="Apetoh, Lionel" uniqKey="Apetoh L" first="Lionel" last="Apetoh">Lionel Apetoh</name>
<affiliation wicri:level="1"><nlm:aff id="af0009"><institution>INSERM; UMR866</institution>
; Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0010"><institution>Centre Georges François Leclerc</institution>
; Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0011"><institution>Université de Bourgogne</institution>
; Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aranda, Fernando" sort="Aranda, Fernando" uniqKey="Aranda F" first="Fernando" last="Aranda">Fernando Aranda</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barnaba, Vincenzo" sort="Barnaba, Vincenzo" uniqKey="Barnaba V" first="Vincenzo" last="Barnaba">Vincenzo Barnaba</name>
<affiliation wicri:level="1"><nlm:aff id="af0012"><institution>Departement of Internal Medicine and Medical Sciences; University of Rome La Sapienza</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0013"><institution>Istituto Pasteur; Fondazione Cenci Bolognetti</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bloy, Norma" sort="Bloy, Norma" uniqKey="Bloy N" first="Norma" last="Bloy">Norma Bloy</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bracci, Laura" sort="Bracci, Laura" uniqKey="Bracci L" first="Laura" last="Bracci">Laura Bracci</name>
<affiliation wicri:level="1"><nlm:aff id="af0014"><institution>Department of Hematology; Oncology and Molecular Medicine; Istituto Superiore di Sanità (ISS)</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Breckpot, Karine" sort="Breckpot, Karine" uniqKey="Breckpot K" first="Karine" last="Breckpot">Karine Breckpot</name>
<affiliation wicri:level="1"><nlm:aff id="af0015"><institution>Laboratory of Molecular and Cellular Therapy (LMCT); Department of Biomedical Sciences Medical School of the Free University of Brussels (VUB)</institution>
; Jette,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brough, David" sort="Brough, David" uniqKey="Brough D" first="David" last="Brough">David Brough</name>
<affiliation wicri:level="1"><nlm:aff id="af0016"><institution>Faculty of Life Sciences; University of Manchester</institution>
; Manchester,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buque, Aitziber" sort="Buque, Aitziber" uniqKey="Buque A" first="Aitziber" last="Buqué">Aitziber Buqué</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Castro, Maria G" sort="Castro, Maria G" uniqKey="Castro M" first="Maria G." last="Castro">Maria G. Castro</name>
<affiliation wicri:level="1"><nlm:aff id="af0017"><institution>Department of Neurosurgery and Cell and Developmental Biology; University of Michigan School of Medicine</institution>
; Ann Arbor, MI<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cirone, Mara" sort="Cirone, Mara" uniqKey="Cirone M" first="Mara" last="Cirone">Mara Cirone</name>
<affiliation wicri:level="1"><nlm:aff id="af0018"><institution>Department of Experimental Medicine; University of Rome La Sapienza</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Colombo, Maria I" sort="Colombo, Maria I" uniqKey="Colombo M" first="Maria I." last="Colombo">Maria I. Colombo</name>
<affiliation wicri:level="1"><nlm:aff id="af0019"><institution>Laboratorio de Biología Celular y Molecular; Instituto de Histología y Embriología (IHEM); Facultad de Ciencias Médicas; Universidad Nacional de Cuyo; CONICET</institution>
; Mendoza,<country>Argentina</country>
</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cremer, Isabelle" sort="Cremer, Isabelle" uniqKey="Cremer I" first="Isabelle" last="Cremer">Isabelle Cremer</name>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0020"><institution>Université Pierre et Marie Curie/Paris VI</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0021"><institution>Equipe 13; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Demaria, Sandra" sort="Demaria, Sandra" uniqKey="Demaria S" first="Sandra" last="Demaria">Sandra Demaria</name>
<affiliation wicri:level="1"><nlm:aff id="af0022"><institution>Department of Pathology; New York University School of Medicine</institution>
; New York, NY<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dini, Luciana" sort="Dini, Luciana" uniqKey="Dini L" first="Luciana" last="Dini">Luciana Dini</name>
<affiliation wicri:level="1"><nlm:aff id="af0023"><institution>Department of Biological and Environmental Science and Technology (DiSTeBA); University of Salento</institution>
; Lecce,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eliopoulos, Aristides G" sort="Eliopoulos, Aristides G" uniqKey="Eliopoulos A" first="Aristides G." last="Eliopoulos">Aristides G. Eliopoulos</name>
<affiliation wicri:level="1"><nlm:aff id="af0024"><institution>Molecular and Cellular Biology Laboratory; Division of Basic Sciences; University of Crete Medical School</institution>
; Heraklion,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0025"><institution>Institute of Molecular Biology and Biotechnology; Foundation of Research and Technology - Hellas</institution>
; Heraklion,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Faggioni, Alberto" sort="Faggioni, Alberto" uniqKey="Faggioni A" first="Alberto" last="Faggioni">Alberto Faggioni</name>
<affiliation wicri:level="1"><nlm:aff id="af0018"><institution>Department of Experimental Medicine; University of Rome La Sapienza</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Formenti, Silvia C" sort="Formenti, Silvia C" uniqKey="Formenti S" first="Silvia C." last="Formenti">Silvia C. Formenti</name>
<affiliation wicri:level="1"><nlm:aff id="af0026"><institution>Department of Radiation Oncology; NewYork University School of Medicine and Langone Medical Center</institution>
; New York, NY<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fu Kova, Jitka" sort="Fu Kova, Jitka" uniqKey="Fu Kova J" first="Jitka" last="Fu Ková">Jitka Fu Ková</name>
<affiliation wicri:level="1"><nlm:aff id="af0027"><institution>Department of Immunology; 2<sup>nd</sup>
Faculty of Medicine and University Hospital Motol, Charles University</institution>
; Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0028"><institution>Sotio</institution>
; Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gabriele, Lucia" sort="Gabriele, Lucia" uniqKey="Gabriele L" first="Lucia" last="Gabriele">Lucia Gabriele</name>
<affiliation wicri:level="1"><nlm:aff id="af0014"><institution>Department of Hematology; Oncology and Molecular Medicine; Istituto Superiore di Sanità (ISS)</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gaipl, Udo S" sort="Gaipl, Udo S" uniqKey="Gaipl U" first="Udo S." last="Gaipl">Udo S. Gaipl</name>
<affiliation wicri:level="1"><nlm:aff id="af0029"><institution>Department of Radiation Oncology; University Hospital Erlangen; University of Erlangen-Nürnberg</institution>
; Erlangen,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Galon, Jerome" sort="Galon, Jerome" uniqKey="Galon J" first="Jérôme" last="Galon">Jérôme Galon</name>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0020"><institution>Université Pierre et Marie Curie/Paris VI</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0030"><institution>Université Paris Descartes/Paris V; Sorbonne Paris Cité</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0031"><institution>Laboratory of Integrative Cancer Immunology; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Garg, Abhishek" sort="Garg, Abhishek" uniqKey="Garg A" first="Abhishek" last="Garg">Abhishek Garg</name>
<affiliation wicri:level="1"><nlm:aff id="af0008"><institution>Cell Death Research and Therapy (CDRT) Laboratory; Department of Cellular and Molecular Medicine; University of Leuven</institution>
; Leuven,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ghiringhelli, Francois" sort="Ghiringhelli, Francois" uniqKey="Ghiringhelli F" first="François" last="Ghiringhelli">François Ghiringhelli</name>
<affiliation wicri:level="1"><nlm:aff id="af0009"><institution>INSERM; UMR866</institution>
; Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0010"><institution>Centre Georges François Leclerc</institution>
; Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0011"><institution>Université de Bourgogne</institution>
; Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giese, Nathalia A" sort="Giese, Nathalia A" uniqKey="Giese N" first="Nathalia A." last="Giese">Nathalia A. Giese</name>
<affiliation wicri:level="1"><nlm:aff id="af0032"><institution>European Pancreas Center; Department of Surgery; University Hospital Heidelberg</institution>
; Heidelberg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guo, Zong Sheng" sort="Guo, Zong Sheng" uniqKey="Guo Z" first="Zong Sheng" last="Guo">Zong Sheng Guo</name>
<affiliation wicri:level="1"><nlm:aff id="af0033"><institution>Department of Surgery; University of Pittsburgh</institution>
; Pittsburgh, PA<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hemminki, Akseli" sort="Hemminki, Akseli" uniqKey="Hemminki A" first="Akseli" last="Hemminki">Akseli Hemminki</name>
<affiliation wicri:level="1"><nlm:aff id="af0034"><institution>Cancer Gene Therapy Group; Transplantation laboratory; Haartman Institute; University of Helsinki</institution>
; Helsinki,<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Herrmann, Martin" sort="Herrmann, Martin" uniqKey="Herrmann M" first="Martin" last="Herrmann">Martin Herrmann</name>
<affiliation wicri:level="1"><nlm:aff id="af0035"><institution>Department of Internal Medicine 3; University of Erlangen-Nuremberg</institution>
; Erlangen,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hodge, James W" sort="Hodge, James W" uniqKey="Hodge J" first="James W." last="Hodge">James W. Hodge</name>
<affiliation wicri:level="1"><nlm:aff id="af0036"><institution>Laboratory of Tumor Immunology and Biology; Center for Cancer Research; National Cancer Institute (NCI), National Institutes of Health (NIH)</institution>
; Bethesda, MD<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Holdenrieder, Stefan" sort="Holdenrieder, Stefan" uniqKey="Holdenrieder S" first="Stefan" last="Holdenrieder">Stefan Holdenrieder</name>
<affiliation wicri:level="1"><nlm:aff id="af0037"><institution>Institute of Clinical Chemistry and Clinical Pharmacology; University Hospital Bonn</institution>
; Bonn,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Honeychurch, Jamie" sort="Honeychurch, Jamie" uniqKey="Honeychurch J" first="Jamie" last="Honeychurch">Jamie Honeychurch</name>
<affiliation wicri:level="1"><nlm:aff id="af0038"><institution>Faculty of Medical and Human Sciences, Institute of Cancer Studies; Manchester Academic Health Sciences Center; University of Manchester</institution>
; Manchester,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hu, Hong Min" sort="Hu, Hong Min" uniqKey="Hu H" first="Hong-Min" last="Hu">Hong-Min Hu</name>
<affiliation wicri:level="1"><nlm:aff id="af0039"><institution>Cancer Research and Biotherapy Center; Second Affiliated Hospital of Southeast University</institution>
; Nanjing,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0040"><institution>Laboratory of Cancer Immunobiology; Earle A. Chiles Research Institute; Providence Portland Medical Center</institution>
; Portland, OR<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huang, Xing" sort="Huang, Xing" uniqKey="Huang X" first="Xing" last="Huang">Xing Huang</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0003"><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Illidge, Tim M" sort="Illidge, Tim M" uniqKey="Illidge T" first="Tim M." last="Illidge">Tim M. Illidge</name>
<affiliation wicri:level="1"><nlm:aff id="af0038"><institution>Faculty of Medical and Human Sciences, Institute of Cancer Studies; Manchester Academic Health Sciences Center; University of Manchester</institution>
; Manchester,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kono, Koji" sort="Kono, Koji" uniqKey="Kono K" first="Koji" last="Kono">Koji Kono</name>
<affiliation wicri:level="1"><nlm:aff id="af0041"><institution>Department of Surgery; National University of Singapore</institution>
; Singapore,<country>Singapore</country>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0042"><institution>Cancer Science Institute of Singapore; National University of Singapore</institution>
; Singapore,<country>Singapore</country>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Korbelik, Mladen" sort="Korbelik, Mladen" uniqKey="Korbelik M" first="Mladen" last="Korbelik">Mladen Korbelik</name>
<affiliation wicri:level="1"><nlm:aff id="af0043"><institution>British Columbia Cancer Agency</institution>
; Vancouver,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krysko, Dmitri V" sort="Krysko, Dmitri V" uniqKey="Krysko D" first="Dmitri V." last="Krysko">Dmitri V. Krysko</name>
<affiliation wicri:level="1"><nlm:aff id="af0044"><institution>VIB Inflammation Research Center</institution>
; Ghent,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0045"><institution>Department of Biomedical Molecular Biology; Ghent University</institution>
; Ghent,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name>
<affiliation wicri:level="1"><nlm:aff id="af0046"><institution>Division of Cancer Medicine and Division of Research; Peter MacCallum Cancer Center; East Melbourne</institution>
; Victoria,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lowenstein, Pedro R" sort="Lowenstein, Pedro R" uniqKey="Lowenstein P" first="Pedro R." last="Lowenstein">Pedro R. Lowenstein</name>
<affiliation wicri:level="1"><nlm:aff id="af0017"><institution>Department of Neurosurgery and Cell and Developmental Biology; University of Michigan School of Medicine</institution>
; Ann Arbor, MI<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lugli, Enrico" sort="Lugli, Enrico" uniqKey="Lugli E" first="Enrico" last="Lugli">Enrico Lugli</name>
<affiliation wicri:level="1"><nlm:aff id="af0047"><institution>Unit of Clinical and Experimental Immunology; Humanitas Clinical and Research Center</institution>
; Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0048"><institution>Department of Medical Biotechnologies and Translational Medicine, University of Milan</institution>
; Rozzano,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ma, Yuting" sort="Ma, Yuting" uniqKey="Ma Y" first="Yuting" last="Ma">Yuting Ma</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Madeo, Frank" sort="Madeo, Frank" uniqKey="Madeo F" first="Frank" last="Madeo">Frank Madeo</name>
<affiliation wicri:level="1"><nlm:aff id="af0049"><institution>Institute of Molecular Biosciences; University of Graz</institution>
; Graz,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Manfredi, Angelo A" sort="Manfredi, Angelo A" uniqKey="Manfredi A" first="Angelo A." last="Manfredi">Angelo A. Manfredi</name>
<affiliation wicri:level="1"><nlm:aff id="af0050"><institution>University Vita-Salute San Raffaele</institution>
; Milano,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0051"><institution>San Raffaele Scientific Institute</institution>
; Milano,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Martins, Isabelle" sort="Martins, Isabelle" uniqKey="Martins I" first="Isabelle" last="Martins">Isabelle Martins</name>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0052"><institution>INSERM, U1030</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0053"><institution>Faculté de Médecine; Université Paris-Sud/Paris XI</institution>
; Kremlin-Bicêtre,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mavilio, Domenico" sort="Mavilio, Domenico" uniqKey="Mavilio D" first="Domenico" last="Mavilio">Domenico Mavilio</name>
<affiliation wicri:level="1"><nlm:aff id="af0047"><institution>Unit of Clinical and Experimental Immunology; Humanitas Clinical and Research Center</institution>
; Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0048"><institution>Department of Medical Biotechnologies and Translational Medicine, University of Milan</institution>
; Rozzano,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Menger, Laurie" sort="Menger, Laurie" uniqKey="Menger L" first="Laurie" last="Menger">Laurie Menger</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0054"><institution>Cancer Immunology Unit, Research Department of Haematology; University College London (UCL) Cancer Institute</institution>
; London,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Merendino, Nicol" sort="Merendino, Nicol" uniqKey="Merendino N" first="Nicol" last="Merendino">Nicol Merendino</name>
<affiliation wicri:level="1"><nlm:aff id="af0055"><institution>Department of Ecological and Biological Sciences (DEB), Tuscia University</institution>
; Viterbo,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Michaud, Michael" sort="Michaud, Michael" uniqKey="Michaud M" first="Michael" last="Michaud">Michael Michaud</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mignot, Gregoire" sort="Mignot, Gregoire" uniqKey="Mignot G" first="Gregoire" last="Mignot">Gregoire Mignot</name>
<affiliation wicri:level="1"><nlm:aff id="af0056"><institution>Cellular and Molecular Immunology and Endocrinology</institution>
, Oniris; Nantes,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mossman, Karen L" sort="Mossman, Karen L" uniqKey="Mossman K" first="Karen L." last="Mossman">Karen L. Mossman</name>
<affiliation wicri:level="1"><nlm:aff id="af0057"><institution>Department of Pathology and Molecular Medicine; McMaster Immunology Research Center</institution>
; Hamilton,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0058"><institution>Institute for Infectious Disease Research; McMaster University</institution>
; Hamilton,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Multhoff, Gabriele" sort="Multhoff, Gabriele" uniqKey="Multhoff G" first="Gabriele" last="Multhoff">Gabriele Multhoff</name>
<affiliation wicri:level="1"><nlm:aff id="af0059"><institution>Department of Radiation Oncology; Klinikum rechts der Isar; Technical University of Munich</institution>
; Munich,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oehler, Rudolf" sort="Oehler, Rudolf" uniqKey="Oehler R" first="Rudolf" last="Oehler">Rudolf Oehler</name>
<affiliation wicri:level="1"><nlm:aff id="af0060"><institution>Comprehensive Cancer Center; Medical University of Vienna</institution>
; Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Palombo, Fabio" sort="Palombo, Fabio" uniqKey="Palombo F" first="Fabio" last="Palombo">Fabio Palombo</name>
<affiliation wicri:level="1"><nlm:aff id="af0012"><institution>Departement of Internal Medicine and Medical Sciences; University of Rome La Sapienza</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0013"><institution>Istituto Pasteur; Fondazione Cenci Bolognetti</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Panaretakis, Theocharis" sort="Panaretakis, Theocharis" uniqKey="Panaretakis T" first="Theocharis" last="Panaretakis">Theocharis Panaretakis</name>
<affiliation wicri:level="1"><nlm:aff id="af0061"><institution>Department of Oncology-Pathology; Karolinska Institute</institution>
; Stockholm,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pol, Jonathan" sort="Pol, Jonathan" uniqKey="Pol J" first="Jonathan" last="Pol">Jonathan Pol</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Proietti, Enrico" sort="Proietti, Enrico" uniqKey="Proietti E" first="Enrico" last="Proietti">Enrico Proietti</name>
<affiliation wicri:level="1"><nlm:aff id="af0014"><institution>Department of Hematology; Oncology and Molecular Medicine; Istituto Superiore di Sanità (ISS)</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ricci, Jean Ehrland" sort="Ricci, Jean Ehrland" uniqKey="Ricci J" first="Jean-Ehrland" last="Ricci">Jean-Ehrland Ricci</name>
<affiliation wicri:level="1"><nlm:aff id="af0062"><institution>INSERM; U1065</institution>
; Nice,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0063"><institution>Equipe “Contrôle Métabolique des Morts Cellulaires,” Center Méditerranéen de Médecine Moléculaire (C3M)</institution>
; Nice,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0064"><institution>Faculté de Médecine; Université de Nice Sophia Antipolis</institution>
; Nice,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0065"><institution>Centre Hospitalier Universitaire de Nice</institution>
; Nice,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Riganti, Chiara" sort="Riganti, Chiara" uniqKey="Riganti C" first="Chiara" last="Riganti">Chiara Riganti</name>
<affiliation wicri:level="1"><nlm:aff id="af0066"><institution>Department of Oncology and Subalpine Center for Research and Experimental Medicine (CeRMS); University of Turin</institution>
; Turin,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rovere Querini, Patrizia" sort="Rovere Querini, Patrizia" uniqKey="Rovere Querini P" first="Patrizia" last="Rovere-Querini">Patrizia Rovere-Querini</name>
<affiliation wicri:level="1"><nlm:aff id="af0050"><institution>University Vita-Salute San Raffaele</institution>
; Milano,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0051"><institution>San Raffaele Scientific Institute</institution>
; Milano,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rubartelli, Anna" sort="Rubartelli, Anna" uniqKey="Rubartelli A" first="Anna" last="Rubartelli">Anna Rubartelli</name>
<affiliation wicri:level="1"><nlm:aff id="af0067"><institution>Cell Biology Unit; Azienda Ospedaliera Universitaria San Martino</institution>
;<institution>Istituto Nazionale per la Ricerca sul Cancro</institution>
; Genova,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sistigu, Antonella" sort="Sistigu, Antonella" uniqKey="Sistigu A" first="Antonella" last="Sistigu">Antonella Sistigu</name>
<affiliation wicri:level="1"><nlm:aff id="af0005"><institution>Regina Elena National Cancer Institute</institution>
; Rome,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J." last="Smyth">Mark J. Smyth</name>
<affiliation wicri:level="1"><nlm:aff id="af0068"><institution>Immunology in Cancer and Infection Laboratory; QIMR Berghofer Medical Research Institute</institution>
; Herston,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0069"><institution>School of Medicine, University of Queensland</institution>
; Herston,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sonnemann, Juergen" sort="Sonnemann, Juergen" uniqKey="Sonnemann J" first="Juergen" last="Sonnemann">Juergen Sonnemann</name>
<affiliation wicri:level="1"><nlm:aff id="af0070"><institution>Department of Pediatric Haematology and Oncology; Jena University Hospital, Children's Clinic</institution>
; Jena,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Spisek, Radek" sort="Spisek, Radek" uniqKey="Spisek R" first="Radek" last="Spisek">Radek Spisek</name>
<affiliation wicri:level="1"><nlm:aff id="af0027"><institution>Department of Immunology; 2<sup>nd</sup>
Faculty of Medicine and University Hospital Motol, Charles University</institution>
; Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0028"><institution>Sotio</institution>
; Prague,<country>Czech Republic</country>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stagg, John" sort="Stagg, John" uniqKey="Stagg J" first="John" last="Stagg">John Stagg</name>
<affiliation wicri:level="1"><nlm:aff id="af0071"><institution>Centre de Recherche du Center Hospitalier de l’Université de Montréal; Faculté de Pharmacie, Université de Montréal</institution>
; Montréal,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sukkurwala, Abdul Qader" sort="Sukkurwala, Abdul Qader" uniqKey="Sukkurwala A" first="Abdul Qader" last="Sukkurwala">Abdul Qader Sukkurwala</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0072"><institution>Department of Pathology, Dow International Medical College; Dow University of Health Sciences</institution>
; Karachi,<country>Pakistan</country>
</nlm:aff>
<country xml:lang="fr">Pakistan</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tartour, Eric" sort="Tartour, Eric" uniqKey="Tartour E" first="Eric" last="Tartour">Eric Tartour</name>
<affiliation wicri:level="1"><nlm:aff id="af0073"><institution>INSERM; U970</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0074"><institution>Pôle de Biologie; Hôpital Européen Georges Pompidou; AP-HP</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thorburn, Andrew" sort="Thorburn, Andrew" uniqKey="Thorburn A" first="Andrew" last="Thorburn">Andrew Thorburn</name>
<affiliation wicri:level="1"><nlm:aff id="af0075"><institution>Department of Pharmacology; University of Colorado School of Medicine</institution>
; Aurora, CO<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thorne, Stephen H" sort="Thorne, Stephen H" uniqKey="Thorne S" first="Stephen H." last="Thorne">Stephen H. Thorne</name>
<affiliation wicri:level="1"><nlm:aff id="af0033"><institution>Department of Surgery; University of Pittsburgh</institution>
; Pittsburgh, PA<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vandenabeele, Peter" sort="Vandenabeele, Peter" uniqKey="Vandenabeele P" first="Peter" last="Vandenabeele">Peter Vandenabeele</name>
<affiliation wicri:level="1"><nlm:aff id="af0044"><institution>VIB Inflammation Research Center</institution>
; Ghent,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0045"><institution>Department of Biomedical Molecular Biology; Ghent University</institution>
; Ghent,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0076"><institution>Methusalem Program; Ghent University</institution>
; Ghent,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Velotti, Francesca" sort="Velotti, Francesca" uniqKey="Velotti F" first="Francesca" last="Velotti">Francesca Velotti</name>
<affiliation wicri:level="1"><nlm:aff id="af0055"><institution>Department of Ecological and Biological Sciences (DEB), Tuscia University</institution>
; Viterbo,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Workenhe, Samuel T" sort="Workenhe, Samuel T" uniqKey="Workenhe S" first="Samuel T." last="Workenhe">Samuel T. Workenhe</name>
<affiliation wicri:level="1"><nlm:aff id="af0057"><institution>Department of Pathology and Molecular Medicine; McMaster Immunology Research Center</institution>
; Hamilton,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0058"><institution>Institute for Infectious Disease Research; McMaster University</institution>
; Hamilton,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yang, Haining" sort="Yang, Haining" uniqKey="Yang H" first="Haining" last="Yang">Haining Yang</name>
<affiliation wicri:level="1"><nlm:aff id="af0077"><institution>University of Hawaii Cancer Center</institution>
; Honolulu, HI<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zong, Wei Xing" sort="Zong, Wei Xing" uniqKey="Zong W" first="Wei-Xing" last="Zong">Wei-Xing Zong</name>
<affiliation wicri:level="1"><nlm:aff id="af0078"><institution>Department of Molecular Genetics and Microbiology; Stony Brook University</institution>
; Stony Brook, NY<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name>
<affiliation wicri:level="1"><nlm:aff id="af0004"><institution>INSERM; U1015</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0079"><institution>Centre d’Investigation Clinique Biothérapie 507 (CICBT507); Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0003"><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0030"><institution>Université Paris Descartes/Paris V; Sorbonne Paris Cité</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0074"><institution>Pôle de Biologie; Hôpital Européen Georges Pompidou; AP-HP</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>INSERM; U1138</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0030"><institution>Université Paris Descartes/Paris V; Sorbonne Paris Cité</institution>
; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Oncoimmunology</title>
<idno type="ISSN">2162-4011</idno>
<idno type="eISSN">2162-402X</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm of the immune system, which we named “immunogenic cell death” (ICD). ICD is preceded or accompanied by the emission of a series of immunostimulatory damage-associated molecular patterns (DAMPs) in a precise spatiotemporal configuration. Several anticancer agents that have been successfully employed in the clinic for decades, including various chemotherapeutics and radiotherapy, can elicit ICD. Moreover, defects in the components that underlie the capacity of the immune system to perceive cell death as immunogenic negatively influence disease outcome among cancer patients treated with ICD inducers. Thus, ICD has profound clinical and therapeutic implications. Unfortunately, the gold-standard approach to detect ICD relies on vaccination experiments involving immunocompetent murine models and syngeneic cancer cells, an approach that is incompatible with large screening campaigns. Here, we outline strategies conceived to detect surrogate markers of ICD <italic>in vitro</italic>
and to screen large chemical libraries for putative ICD inducers, based on a high-content, high-throughput platform that we recently developed. Such a platform allows for the detection of multiple DAMPs, like cell surface-exposed calreticulin, extracellular ATP and high mobility group box 1 (HMGB1), and/or the processes that underlie their emission, such as endoplasmic reticulum stress, autophagy and necrotic plasma membrane permeabilization. We surmise that this technology will facilitate the development of next-generation anticancer regimens, which kill malignant cells and simultaneously convert them into a cancer-specific therapeutic vaccine. </p>
</div>
</front>
</TEI>
</record>
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