Autophagy in malignant transformation and cancer progression
Identifieur interne : 002287 ( Ncbi/Curation ); précédent : 002286; suivant : 002288Autophagy in malignant transformation and cancer progression
Auteurs : Lorenzo Galluzzi [France] ; Federico Pietrocola [France] ; José Manuel Bravo-San Pedro [France] ; Ravi K. Amaravadi [États-Unis] ; Eric H. Baehrecke [États-Unis] ; Francesco Cecconi [Danemark, Italie] ; Patrice Codogno [France] ; Jayanta Debnath [États-Unis] ; David A. Gewirtz [États-Unis] ; Vassiliki Karantza [États-Unis] ; Alec Kimmelman [États-Unis] ; Sharad Kumar [Australie] ; Beth Levine [États-Unis] ; Maria Chiara Maiuri [France] ; Seamus J. Martin [Irlande (pays)] ; Josef Penninger [Autriche] ; Mauro Piacentini [Italie] ; David C. Rubinsztein [Royaume-Uni] ; Hans-Uwe Simon [Suisse] ; Anne Simonsen [Norvège] ; Andrew M. Thorburn [États-Unis] ; Guillermo Velasco [Espagne] ; Kevin M. Ryan [Royaume-Uni] ; Guido Kroemer [France]Source :
- The EMBO Journal [ 0261-4189 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Autophagie, Humains, Protéines suppresseurs de tumeurs (immunologie), Protéines suppresseurs de tumeurs (métabolisme), Transformation cellulaire néoplasique (anatomopathologie), Transformation cellulaire néoplasique (immunologie), Transformation cellulaire néoplasique (métabolisme), Tumeurs (), Tumeurs (anatomopathologie), Tumeurs (immunologie), Tumeurs (métabolisme), Échappement de la tumeur à la surveillance immunitaire.
- MESH :
- anatomopathologie : Transformation cellulaire néoplasique, Tumeurs.
- immunologie : Protéines suppresseurs de tumeurs, Transformation cellulaire néoplasique, Tumeurs.
- métabolisme : Protéines suppresseurs de tumeurs, Transformation cellulaire néoplasique, Tumeurs.
- Animaux, Autophagie, Humains, Tumeurs, Échappement de la tumeur à la surveillance immunitaire.
English descriptors
- KwdEn :
- Animals, Autophagy, Cell Transformation, Neoplastic (immunology), Cell Transformation, Neoplastic (metabolism), Cell Transformation, Neoplastic (pathology), Humans, Neoplasms (immunology), Neoplasms (metabolism), Neoplasms (pathology), Neoplasms (therapy), Tumor Escape, Tumor Suppressor Proteins (immunology), Tumor Suppressor Proteins (metabolism).
- MESH :
- chemical , immunology : Tumor Suppressor Proteins.
- immunology : Cell Transformation, Neoplastic, Neoplasms.
- metabolism : Cell Transformation, Neoplastic, Neoplasms, Tumor Suppressor Proteins.
- pathology : Cell Transformation, Neoplastic, Neoplasms.
- therapy : Neoplasms.
- Animals, Autophagy, Humans, Tumor Escape.
Abstract
Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy.
Url:
DOI: 10.15252/embj.201490784
PubMed: 25712477
PubMed Central: 4388596
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PMC:4388596Le document en format XML
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<country xml:lang="fr">France</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Autophagy in malignant transformation and cancer progression</title>
<author><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>INSERM, U1138</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>Gustave Roussy Cancer Campus</institution>
<addr-line>Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Villejuif</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pietrocola, Federico" sort="Pietrocola, Federico" uniqKey="Pietrocola F" first="Federico" last="Pietrocola">Federico Pietrocola</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>INSERM, U1138</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>Gustave Roussy Cancer Campus</institution>
<addr-line>Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bravo San Pedro, Jose Manuel" sort="Bravo San Pedro, Jose Manuel" uniqKey="Bravo San Pedro J" first="José Manuel" last="Bravo-San Pedro">José Manuel Bravo-San Pedro</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>INSERM, U1138</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>Gustave Roussy Cancer Campus</institution>
<addr-line>Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Amaravadi, Ravi K" sort="Amaravadi, Ravi K" uniqKey="Amaravadi R" first="Ravi K" last="Amaravadi">Ravi K. Amaravadi</name>
<affiliation wicri:level="2"><nlm:aff id="au5"><institution>Abramson Cancer Center, University of Pennsylvania</institution>
<addr-line>Philadelphia, PA, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baehrecke, Eric H" sort="Baehrecke, Eric H" uniqKey="Baehrecke E" first="Eric H" last="Baehrecke">Eric H. Baehrecke</name>
<affiliation wicri:level="2"><nlm:aff id="au6"><institution>Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School</institution>
<addr-line>Worcester, MA, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Worcester, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cecconi, Francesco" sort="Cecconi, Francesco" uniqKey="Cecconi F" first="Francesco" last="Cecconi">Francesco Cecconi</name>
<affiliation wicri:level="1"><nlm:aff id="au7"><institution>Cell Stress and Survival Unit, Danish Cancer Society Research Center</institution>
<addr-line>Copenhagen, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au8"><institution>IRCCS Fondazione Santa Lucia and Department of Biology, University of Rome Tor Vergata</institution>
<addr-line>Rome, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Rome</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Codogno, Patrice" sort="Codogno, Patrice" uniqKey="Codogno P" first="Patrice" last="Codogno">Patrice Codogno</name>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au9"><institution>Institut Necker Enfants-Malades (INEM)</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au10"><institution>INSERM, U1151</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au11"><institution>CNRS, UMR8253</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Debnath, Jayanta" sort="Debnath, Jayanta" uniqKey="Debnath J" first="Jayanta" last="Debnath">Jayanta Debnath</name>
<affiliation wicri:level="2"><nlm:aff id="au12"><institution>Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco</institution>
<addr-line>San Francisco, CA, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gewirtz, David A" sort="Gewirtz, David A" uniqKey="Gewirtz D" first="David A" last="Gewirtz">David A. Gewirtz</name>
<affiliation wicri:level="2"><nlm:aff id="au13"><institution>Department of Pharmacology, Toxicology and Medicine, Virginia Commonwealth University</institution>
<addr-line>Richmond, Virginia, VA, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Richmond, Virginia, VA</wicri:regionArea>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Karantza, Vassiliki" sort="Karantza, Vassiliki" uniqKey="Karantza V" first="Vassiliki" last="Karantza">Vassiliki Karantza</name>
<affiliation wicri:level="2"><nlm:aff id="au14"><institution>Merck Research Laboratories</institution>
<addr-line>Rahway, NJ, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rahway, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kimmelman, Alec" sort="Kimmelman, Alec" uniqKey="Kimmelman A" first="Alec" last="Kimmelman">Alec Kimmelman</name>
<affiliation wicri:level="2"><nlm:aff id="au15"><institution>Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute</institution>
<addr-line>Boston, MA, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kumar, Sharad" sort="Kumar, Sharad" uniqKey="Kumar S" first="Sharad" last="Kumar">Sharad Kumar</name>
<affiliation wicri:level="1"><nlm:aff id="au16"><institution>Centre for Cancer Biology, University of South Australia</institution>
<addr-line>Adelaide, SA, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Adelaide, SA</wicri:regionArea>
<wicri:noRegion>SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Levine, Beth" sort="Levine, Beth" uniqKey="Levine B" first="Beth" last="Levine">Beth Levine</name>
<affiliation wicri:level="2"><nlm:aff id="au17"><institution>Center for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center</institution>
<addr-line>Dallas, TX, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dallas, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="au18"><institution>Department of Microbiology, University of Texas Southwestern Medical Center</institution>
<addr-line>Dallas, TX, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dallas, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="au19"><institution>Howard Hughes Medical Institute, University of Texas Southwestern Medical Center</institution>
<addr-line>Dallas, TX, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dallas, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maiuri, Maria Chiara" sort="Maiuri, Maria Chiara" uniqKey="Maiuri M" first="Maria Chiara" last="Maiuri">Maria Chiara Maiuri</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>INSERM, U1138</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>Gustave Roussy Cancer Campus</institution>
<addr-line>Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Martin, Seamus J" sort="Martin, Seamus J" uniqKey="Martin S" first="Seamus J" last="Martin">Seamus J. Martin</name>
<affiliation wicri:level="1"><nlm:aff id="au20"><institution>Department of Genetics, Trinity College, The Smurfit Institute</institution>
<addr-line>Dublin, Ireland</addr-line>
</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Dublin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Penninger, Josef" sort="Penninger, Josef" uniqKey="Penninger J" first="Josef" last="Penninger">Josef Penninger</name>
<affiliation wicri:level="1"><nlm:aff id="au21"><institution>Institute of Molecular Biotechnology of the Austrian Academy of Sciences</institution>
<addr-line>Vienna, Austria</addr-line>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Vienna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Piacentini, Mauro" sort="Piacentini, Mauro" uniqKey="Piacentini M" first="Mauro" last="Piacentini">Mauro Piacentini</name>
<affiliation wicri:level="1"><nlm:aff id="au22"><institution>Department of Biology, University of Rome Tor Vergata</institution>
<addr-line>Rome, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Rome</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au23"><institution>National Institute for Infectious Diseases IRCCS ‘Lazzaro Spallanzani’</institution>
<addr-line>Rome, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Rome</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rubinsztein, David C" sort="Rubinsztein, David C" uniqKey="Rubinsztein D" first="David C" last="Rubinsztein">David C. Rubinsztein</name>
<affiliation wicri:level="1"><nlm:aff id="au24"><institution>Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge</institution>
<addr-line>Cambridge, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cambridge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Simon, Hans Uwe" sort="Simon, Hans Uwe" uniqKey="Simon H" first="Hans-Uwe" last="Simon">Hans-Uwe Simon</name>
<affiliation wicri:level="1"><nlm:aff id="au25"><institution>Institute of Pharmacology, University of Bern</institution>
<addr-line>Bern, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Bern</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Simonsen, Anne" sort="Simonsen, Anne" uniqKey="Simonsen A" first="Anne" last="Simonsen">Anne Simonsen</name>
<affiliation wicri:level="1"><nlm:aff id="au26"><institution>Institute of Basic Medical Sciences, University of Oslo</institution>
<addr-line>Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thorburn, Andrew M" sort="Thorburn, Andrew M" uniqKey="Thorburn A" first="Andrew M" last="Thorburn">Andrew M. Thorburn</name>
<affiliation wicri:level="2"><nlm:aff id="au27"><institution>Department of Pharmacology, University of Colorado School of Medicine</institution>
<addr-line>Aurora, CO, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Aurora, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Velasco, Guillermo" sort="Velasco, Guillermo" uniqKey="Velasco G" first="Guillermo" last="Velasco">Guillermo Velasco</name>
<affiliation wicri:level="1"><nlm:aff id="au28"><institution>Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University of Madrid</institution>
<addr-line>Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Madrid</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au29"><institution>Instituto de Investigaciones Sanitarias San Carlos (IdISSC)</institution>
<addr-line>Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Madrid</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ryan, Kevin M" sort="Ryan, Kevin M" uniqKey="Ryan K" first="Kevin M" last="Ryan">Kevin M. Ryan</name>
<affiliation wicri:level="1"><nlm:aff id="au30"><institution>Cancer Research UK Beatson Institute</institution>
<addr-line>Glasgow, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Glasgow</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>INSERM, U1138</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au31"><institution>Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au32"><institution>Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus</institution>
<addr-line>Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Villejuif</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">The EMBO Journal</title>
<idno type="ISSN">0261-4189</idno>
<idno type="eISSN">1460-2075</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Autophagy</term>
<term>Cell Transformation, Neoplastic (immunology)</term>
<term>Cell Transformation, Neoplastic (metabolism)</term>
<term>Cell Transformation, Neoplastic (pathology)</term>
<term>Humans</term>
<term>Neoplasms (immunology)</term>
<term>Neoplasms (metabolism)</term>
<term>Neoplasms (pathology)</term>
<term>Neoplasms (therapy)</term>
<term>Tumor Escape</term>
<term>Tumor Suppressor Proteins (immunology)</term>
<term>Tumor Suppressor Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Autophagie</term>
<term>Humains</term>
<term>Protéines suppresseurs de tumeurs (immunologie)</term>
<term>Protéines suppresseurs de tumeurs (métabolisme)</term>
<term>Transformation cellulaire néoplasique (anatomopathologie)</term>
<term>Transformation cellulaire néoplasique (immunologie)</term>
<term>Transformation cellulaire néoplasique (métabolisme)</term>
<term>Tumeurs ()</term>
<term>Tumeurs (anatomopathologie)</term>
<term>Tumeurs (immunologie)</term>
<term>Tumeurs (métabolisme)</term>
<term>Échappement de la tumeur à la surveillance immunitaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Tumor Suppressor Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Transformation cellulaire néoplasique</term>
<term>Tumeurs</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Protéines suppresseurs de tumeurs</term>
<term>Transformation cellulaire néoplasique</term>
<term>Tumeurs</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cell Transformation, Neoplastic</term>
<term>Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Transformation, Neoplastic</term>
<term>Neoplasms</term>
<term>Tumor Suppressor Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines suppresseurs de tumeurs</term>
<term>Transformation cellulaire néoplasique</term>
<term>Tumeurs</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cell Transformation, Neoplastic</term>
<term>Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Autophagy</term>
<term>Humans</term>
<term>Tumor Escape</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Autophagie</term>
<term>Humains</term>
<term>Tumeurs</term>
<term>Échappement de la tumeur à la surveillance immunitaire</term>
</keywords>
</textClass>
</profileDesc>
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<front><div type="abstract" xml:lang="en"><p>Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy.</p>
</div>
</front>
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