AustralieFrV1, Ncbi, Curation, bibRecord, 002193

Oligodendroglial Maturation Is Dependent on Intracellular Protein Shuttling

Identifieur interne : 002193 ( Ncbi/Curation ); précédent : 002192; suivant : 002194

Oligodendroglial Maturation Is Dependent on Intracellular Protein Shuttling

Auteurs : Peter Göttle [Allemagne] ; Jennifer K. Sabo [Australie] ; André Heinen [Allemagne] ; Gene Venables [Australie] ; Klintsy Torres [Allemagne] ; Nevena Tzekova [Allemagne] ; Carlos M. Parras [France] ; David Kremer [Allemagne] ; Hans-Peter Hartung [Allemagne] ; Holly S. Cate [Australie] ; Patrick Küry [Allemagne]

Source :

The Journal of Neuroscience [ 0270-6474 ] ; 2015.

RBID : PMC:4300332

Descripteurs français

English descriptors

KwdEn :
- Active Transport, Cell Nucleus, Animals, Basic Helix-Loop-Helix Transcription Factors (metabolism), Cell Differentiation (physiology), Cell Nucleus (metabolism), Cells, Cultured, Cerebellar Cortex (metabolism), Cyclin-Dependent Kinase 2 (metabolism), Cyclin-Dependent Kinase Inhibitor p57 (metabolism), Humans, Lim Kinases (metabolism), Mice, Multiple Sclerosis (metabolism), Myelin Sheath (metabolism), Oligodendroglia (cytology), Oligodendroglia (metabolism), Protein Transport (physiology), Rats, Rats, Wistar, Repressor Proteins (metabolism).
MESH :
- chemical , metabolism : Basic Helix-Loop-Helix Transcription Factors, Cyclin-Dependent Kinase 2, Cyclin-Dependent Kinase Inhibitor p57, Lim Kinases, Repressor Proteins.
- cytology : Oligodendroglia.
- metabolism : Cell Nucleus, Cerebellar Cortex, Multiple Sclerosis, Myelin Sheath, Oligodendroglia.
- physiology : Cell Differentiation, Protein Transport.
- Active Transport, Cell Nucleus, Animals, Cells, Cultured, Humans, Mice, Rats, Rats, Wistar.

Abstract

Multiple sclerosis is an autoimmune disease of the CNS resulting in degeneration of myelin sheaths and loss of oligodendrocytes, which means that protection and electrical insulation of axons and rapid signal propagation are impaired, leading to axonal damage and permanent disabilities. Partial replacement of lost oligodendrocytes and remyelination can occur as a result of activation and recruitment of resident oligodendroglial precursor cells. However, the overall remyelination capacity remains inefficient because precursor cells often fail to generate new oligodendrocytes. Increasing evidence points to the existence of several molecular inhibitors that act on these cells and interfere with their cellular maturation. The p57kip2 gene encodes one such potent inhibitor of oligodendroglial differentiation and this study sheds light on the underlying mode of action. We found that subcellular distribution of the p57kip2 protein changed during differentiation of rat, mouse, and human oligodendroglial cells both in vivo and in vitro. Nuclear export of p57kip2 was correlated with promoted myelin expression, higher morphological phenotypes, and enhanced myelination in vitro. In contrast, nuclear accumulation of p57kip2 resulted in blocked oligodendroglial differentiation. Experimental evidence suggests that the inhibitory role of p57kip2 depends on specific interactions with binding proteins such as LIMK-1, CDK2, Mash1, and Hes5 either by controlling their site of action or their activity. Because functional restoration in demyelinating diseases critically depends on the successful generation of oligodendroglial cells, a therapeutic need that is currently unmet, the regulatory mechanism described here might be of particular interest for identifying suitable drug targets and devising novel therapeutic approaches.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300332

DOI: 10.1523/JNEUROSCI.1423-14.2015
PubMed: 25609610
PubMed Central: 4300332

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001995
to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :001853
to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000E27
to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003112
to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :003016
to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003016
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002193

Links to Exploration step

PMC:4300332

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oligodendroglial Maturation Is Dependent on Intracellular Protein Shuttling</title>
<author><name sortKey="Gottle, Peter" sort="Gottle, Peter" uniqKey="Gottle P" first="Peter" last="Göttle">Peter Göttle</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sabo, Jennifer K" sort="Sabo, Jennifer K" uniqKey="Sabo J" first="Jennifer K." last="Sabo">Jennifer K. Sabo</name>
<affiliation wicri:level="4"><nlm:aff wicri:cut=", and" id="aff2">Department of Anatomy and Neuroscience, University of Melbourne, Parkville, 3010 Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Anatomy and Neuroscience, University of Melbourne, Parkville, 3010 Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heinen, Andre" sort="Heinen, Andre" uniqKey="Heinen A" first="André" last="Heinen">André Heinen</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Venables, Gene" sort="Venables, Gene" uniqKey="Venables G" first="Gene" last="Venables">Gene Venables</name>
<affiliation wicri:level="4"><nlm:aff wicri:cut=", and" id="aff2">Department of Anatomy and Neuroscience, University of Melbourne, Parkville, 3010 Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Anatomy and Neuroscience, University of Melbourne, Parkville, 3010 Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Torres, Klintsy" sort="Torres, Klintsy" uniqKey="Torres K" first="Klintsy" last="Torres">Klintsy Torres</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tzekova, Nevena" sort="Tzekova, Nevena" uniqKey="Tzekova N" first="Nevena" last="Tzekova">Nevena Tzekova</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Parras, Carlos M" sort="Parras, Carlos M" uniqKey="Parras C" first="Carlos M." last="Parras">Carlos M. Parras</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, Inserm U1127, 75013 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, Inserm U1127, 75013 Paris</wicri:regionArea>
<wicri:noRegion>75013 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kremer, David" sort="Kremer, David" uniqKey="Kremer D" first="David" last="Kremer">David Kremer</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hartung, Hans Peter" sort="Hartung, Hans Peter" uniqKey="Hartung H" first="Hans-Peter" last="Hartung">Hans-Peter Hartung</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cate, Holly S" sort="Cate, Holly S" uniqKey="Cate H" first="Holly S." last="Cate">Holly S. Cate</name>
<affiliation wicri:level="4"><nlm:aff wicri:cut=", and" id="aff2">Department of Anatomy and Neuroscience, University of Melbourne, Parkville, 3010 Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Anatomy and Neuroscience, University of Melbourne, Parkville, 3010 Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kury, Patrick" sort="Kury, Patrick" uniqKey="Kury P" first="Patrick" last="Küry">Patrick Küry</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25609610</idno>
<idno type="pmc">4300332</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300332</idno>
<idno type="RBID">PMC:4300332</idno>
<idno type="doi">10.1523/JNEUROSCI.1423-14.2015</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">001995</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001995</idno>
<idno type="wicri:Area/Pmc/Curation">001853</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001853</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000E27</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E27</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">003112</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003112</idno>
<idno type="wicri:Area/PubMed/Curation">003016</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003016</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003016</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003016</idno>
<idno type="wicri:Area/Ncbi/Merge">002193</idno>
<idno type="wicri:Area/Ncbi/Curation">002193</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Oligodendroglial Maturation Is Dependent on Intracellular Protein Shuttling</title>
<author><name sortKey="Gottle, Peter" sort="Gottle, Peter" uniqKey="Gottle P" first="Peter" last="Göttle">Peter Göttle</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sabo, Jennifer K" sort="Sabo, Jennifer K" uniqKey="Sabo J" first="Jennifer K." last="Sabo">Jennifer K. Sabo</name>
<affiliation wicri:level="4"><nlm:aff wicri:cut=", and" id="aff2">Department of Anatomy and Neuroscience, University of Melbourne, Parkville, 3010 Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Anatomy and Neuroscience, University of Melbourne, Parkville, 3010 Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heinen, Andre" sort="Heinen, Andre" uniqKey="Heinen A" first="André" last="Heinen">André Heinen</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Venables, Gene" sort="Venables, Gene" uniqKey="Venables G" first="Gene" last="Venables">Gene Venables</name>
<affiliation wicri:level="4"><nlm:aff wicri:cut=", and" id="aff2">Department of Anatomy and Neuroscience, University of Melbourne, Parkville, 3010 Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Anatomy and Neuroscience, University of Melbourne, Parkville, 3010 Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Torres, Klintsy" sort="Torres, Klintsy" uniqKey="Torres K" first="Klintsy" last="Torres">Klintsy Torres</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tzekova, Nevena" sort="Tzekova, Nevena" uniqKey="Tzekova N" first="Nevena" last="Tzekova">Nevena Tzekova</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Parras, Carlos M" sort="Parras, Carlos M" uniqKey="Parras C" first="Carlos M." last="Parras">Carlos M. Parras</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, Inserm U1127, 75013 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, Inserm U1127, 75013 Paris</wicri:regionArea>
<wicri:noRegion>75013 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kremer, David" sort="Kremer, David" uniqKey="Kremer D" first="David" last="Kremer">David Kremer</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hartung, Hans Peter" sort="Hartung, Hans Peter" uniqKey="Hartung H" first="Hans-Peter" last="Hartung">Hans-Peter Hartung</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cate, Holly S" sort="Cate, Holly S" uniqKey="Cate H" first="Holly S." last="Cate">Holly S. Cate</name>
<affiliation wicri:level="4"><nlm:aff wicri:cut=", and" id="aff2">Department of Anatomy and Neuroscience, University of Melbourne, Parkville, 3010 Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Anatomy and Neuroscience, University of Melbourne, Parkville, 3010 Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kury, Patrick" sort="Kury, Patrick" uniqKey="Kury P" first="Patrick" last="Küry">Patrick Küry</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Neuroscience</title>
<idno type="ISSN">0270-6474</idno>
<idno type="eISSN">1529-2401</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Active Transport, Cell Nucleus</term>
<term>Animals</term>
<term>Basic Helix-Loop-Helix Transcription Factors (metabolism)</term>
<term>Cell Differentiation (physiology)</term>
<term>Cell Nucleus (metabolism)</term>
<term>Cells, Cultured</term>
<term>Cerebellar Cortex (metabolism)</term>
<term>Cyclin-Dependent Kinase 2 (metabolism)</term>
<term>Cyclin-Dependent Kinase Inhibitor p57 (metabolism)</term>
<term>Humans</term>
<term>Lim Kinases (metabolism)</term>
<term>Mice</term>
<term>Multiple Sclerosis (metabolism)</term>
<term>Myelin Sheath (metabolism)</term>
<term>Oligodendroglia (cytology)</term>
<term>Oligodendroglia (metabolism)</term>
<term>Protein Transport (physiology)</term>
<term>Rats</term>
<term>Rats, Wistar</term>
<term>Repressor Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Cortex cérébelleux (métabolisme)</term>
<term>Différenciation cellulaire (physiologie)</term>
<term>Facteurs de transcription à motif basique hélice-boucle-hélice (métabolisme)</term>
<term>Gaine de myéline (métabolisme)</term>
<term>Humains</term>
<term>Inhibiteur p57 de kinase cycline-dépendante (métabolisme)</term>
<term>Kinase-2 cycline-dépendante (métabolisme)</term>
<term>Lim Kinases (métabolisme)</term>
<term>Noyau de la cellule (métabolisme)</term>
<term>Oligodendroglie (cytologie)</term>
<term>Oligodendroglie (métabolisme)</term>
<term>Protéines de répression (métabolisme)</term>
<term>Rat Wistar</term>
<term>Rats</term>
<term>Sclérose en plaques (métabolisme)</term>
<term>Souris</term>
<term>Transport de protéines (physiologie)</term>
<term>Transport nucléaire actif</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Basic Helix-Loop-Helix Transcription Factors</term>
<term>Cyclin-Dependent Kinase 2</term>
<term>Cyclin-Dependent Kinase Inhibitor p57</term>
<term>Lim Kinases</term>
<term>Repressor Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Oligodendroglie</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Oligodendroglia</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Nucleus</term>
<term>Cerebellar Cortex</term>
<term>Multiple Sclerosis</term>
<term>Myelin Sheath</term>
<term>Oligodendroglia</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cortex cérébelleux</term>
<term>Facteurs de transcription à motif basique hélice-boucle-hélice</term>
<term>Gaine de myéline</term>
<term>Inhibiteur p57 de kinase cycline-dépendante</term>
<term>Kinase-2 cycline-dépendante</term>
<term>Lim Kinases</term>
<term>Noyau de la cellule</term>
<term>Oligodendroglie</term>
<term>Protéines de répression</term>
<term>Sclérose en plaques</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Différenciation cellulaire</term>
<term>Transport de protéines</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Differentiation</term>
<term>Protein Transport</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Active Transport, Cell Nucleus</term>
<term>Animals</term>
<term>Cells, Cultured</term>
<term>Humans</term>
<term>Mice</term>
<term>Rats</term>
<term>Rats, Wistar</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Humains</term>
<term>Rat Wistar</term>
<term>Rats</term>
<term>Souris</term>
<term>Transport nucléaire actif</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Multiple sclerosis is an autoimmune disease of the CNS resulting in degeneration of myelin sheaths and loss of oligodendrocytes, which means that protection and electrical insulation of axons and rapid signal propagation are impaired, leading to axonal damage and permanent disabilities. Partial replacement of lost oligodendrocytes and remyelination can occur as a result of activation and recruitment of resident oligodendroglial precursor cells. However, the overall remyelination capacity remains inefficient because precursor cells often fail to generate new oligodendrocytes. Increasing evidence points to the existence of several molecular inhibitors that act on these cells and interfere with their cellular maturation. The <italic>p57kip2</italic>
 gene encodes one such potent inhibitor of oligodendroglial differentiation and this study sheds light on the underlying mode of action. We found that subcellular distribution of the p57kip2 protein changed during differentiation of rat, mouse, and human oligodendroglial cells both <italic>in vivo</italic>
 and <italic>in vitro</italic>
. Nuclear export of p57kip2 was correlated with promoted myelin expression, higher morphological phenotypes, and enhanced myelination <italic>in vitro</italic>
. In contrast, nuclear accumulation of p57kip2 resulted in blocked oligodendroglial differentiation. Experimental evidence suggests that the inhibitory role of p57kip2 depends on specific interactions with binding proteins such as LIMK-1, CDK2, Mash1, and Hes5 either by controlling their site of action or their activity. Because functional restoration in demyelinating diseases critically depends on the successful generation of oligodendroglial cells, a therapeutic need that is currently unmet, the regulatory mechanism described here might be of particular interest for identifying suitable drug targets and devising novel therapeutic approaches.</p>
</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Ncbi/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002193 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 002193 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Ncbi
   |étape=   Curation
   |type=    RBID
   |clé=     PMC:4300332
   |texte=   Oligodendroglial Maturation Is Dependent on Intracellular Protein Shuttling
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i   -Sk "pubmed:25609610" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Oligodendroglial Maturation Is Dependent on Intracellular Protein Shuttling

Oligodendroglial Maturation Is Dependent on Intracellular Protein Shuttling

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki