The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease
Identifieur interne : 001F14 ( Ncbi/Curation ); précédent : 001F13; suivant : 001F15The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease
Auteurs : Yi-Ping Fu [États-Unis] ; Indu Kohaar [États-Unis] ; Lee E. Moore [États-Unis] ; Petra Lenz [États-Unis] ; Jonine D. Figueroa [États-Unis] ; Wei Tang [États-Unis] ; Patricia Porter-Gill [États-Unis] ; Nilanjan Chatterjee [États-Unis] ; Alexandra Scott-Johnson [États-Unis] ; Montserrat Garcia-Closas [Royaume-Uni] ; Brian Muchmore [États-Unis] ; Dalsu Baris [États-Unis] ; Ashley Paquin [États-Unis] ; Kris Ylaya [États-Unis] ; Molly Schwenn [États-Unis] ; Andrea B. Apolo [États-Unis] ; Margaret R. Karagas [États-Unis] ; Mcanthony Tarway [États-Unis] ; Alison Johnson [États-Unis] ; Adam Mumy [États-Unis] ; Alan Schned [États-Unis] ; Liliana Guedez [États-Unis] ; Michael A. Jones [États-Unis] ; Masatoshi Kida [États-Unis] ; Gm Monawar Hosain [États-Unis] ; Nuria Malats [Espagne] ; Manolis Kogevinas [Espagne, Grèce] ; Adonina Tardon [Espagne] ; Consol Serra [Espagne] ; Alfredo Carrato [Espagne] ; Reina Garcia-Closas [Espagne] ; Josep Lloreta [Espagne] ; Xifeng Wu [États-Unis] ; Mark Purdue [États-Unis] ; Gerald L. Andriole [États-Unis] ; Robert L. Grubb [États-Unis] ; Amanda Black [États-Unis] ; Maria T. Landi [États-Unis] ; Neil E. Caporaso [États-Unis] ; Paolo Vineis [Royaume-Uni, Italie] ; Afshan Siddiq [Royaume-Uni] ; H. Bas Bueno-De-Mesquita [Pays-Bas, Royaume-Uni, Malaisie] ; Dimitrios Trichopoulos [États-Unis, Grèce] ; Börje Ljungberg [Suède] ; Gianluca Severi [Italie, Australie] ; Elisabete Weiderpass [Norvège, Suède, Finlande] ; Vittorio Krogh [Italie] ; Miren Dorronsoro [Espagne] ; Ruth C. Travis [Royaume-Uni] ; Anne Tj Nneland [Danemark] ; Paul Brennan [France] ; Jenny Chang-Claude [Allemagne] ; Elio Riboli [Royaume-Uni] ; Jennifer Prescott [États-Unis] ; Constance Chen [États-Unis] ; Immaculata De Vivo [États-Unis] ; Edward Govannucci [États-Unis] ; David Hunter [États-Unis] ; Peter Kraft [États-Unis] ; Sara Lindstrom [États-Unis] ; Susan M. Gapstur [États-Unis] ; Eric J. Jacobs [États-Unis] ; W. Ryan Diver [États-Unis] ; Demetrius Albanes [États-Unis] ; Stephanie J. Weinstein [États-Unis] ; Jarmo Virtamo [Finlande] ; Charles Kooperberg [États-Unis] ; Chancellor Hohensee [États-Unis] ; Rebecca J. Rodabough [États-Unis] ; Victoria K. Cortessis [États-Unis] ; David V. Conti [États-Unis] ; Manuela Gago-Dominguez [Espagne] ; Mariana C. Stern [États-Unis] ; Malcolm C. Pike [États-Unis] ; David Van Den Berg [États-Unis] ; Jian-Min Yuan [États-Unis] ; Christopher A. Haiman [États-Unis] ; Olivier Cussenot [France] ; Geraldine Cancel-Tassin [France] ; Morgan Roupret [France] ; Eva Comperat [France] ; Stefano Porru [Italie] ; Angela Carta [Italie] ; Sofia Pavanello [Italie] ; Cecilia Arici [Italie] ; Giuseppe Mastrangelo [Italie] ; H. Barton Grossman [États-Unis] ; Zhaoming Wang [États-Unis] ; Xiang Deng [États-Unis] ; Charles C. Chung [États-Unis] ; Amy Hutchinson [États-Unis] ; Laurie Burdette [États-Unis] ; William Wheeler [États-Unis] ; Joseph Fraumeni [États-Unis] ; Stephen J. Chanock [États-Unis] ; Stephen M. Hewitt [États-Unis] ; Debra T. Silverman [États-Unis] ; Nathaniel Rothman [États-Unis] ; Ludmila Prokunina-Olsson [États-Unis]Source :
- Cancer research [ 0008-5472 ] ; 2014.
Descripteurs français
- KwdFr :
- Cellules HeLa, Chromosomes humains de la paire 19 (génétique), Cycline E (génétique), Cycline E (métabolisme), Expression des gènes, Fréquence d'allèle, Haplotypes, Humains, Polymorphisme de nucléotide simple, Protéines oncogènes (génétique), Protéines oncogènes (métabolisme), Tumeurs de la vessie urinaire (anatomopathologie), Tumeurs de la vessie urinaire (génétique), Vessie urinaire (anatomopathologie), Vessie urinaire (métabolisme), Étude d'association pangénomique, Études cas-témoins.
- MESH :
- anatomopathologie : Tumeurs de la vessie urinaire, Vessie urinaire.
- génétique : Chromosomes humains de la paire 19, Cycline E, Protéines oncogènes, Tumeurs de la vessie urinaire.
- métabolisme : Cycline E, Protéines oncogènes, Vessie urinaire.
- Cellules HeLa, Expression des gènes, Fréquence d'allèle, Haplotypes, Humains, Polymorphisme de nucléotide simple, Étude d'association pangénomique, Études cas-témoins.
English descriptors
- KwdEn :
- Case-Control Studies, Chromosomes, Human, Pair 19 (genetics), Cyclin E (genetics), Cyclin E (metabolism), Gene Expression, Gene Frequency, Genome-Wide Association Study, Haplotypes, HeLa Cells, Humans, Oncogene Proteins (genetics), Oncogene Proteins (metabolism), Polymorphism, Single Nucleotide, Urinary Bladder (metabolism), Urinary Bladder (pathology), Urinary Bladder Neoplasms (genetics), Urinary Bladder Neoplasms (pathology).
- MESH :
- chemical , genetics : Cyclin E, Oncogene Proteins.
- genetics : Chromosomes, Human, Pair 19, Urinary Bladder Neoplasms.
- chemical , metabolism : Cyclin E, Oncogene Proteins, Urinary Bladder.
- pathology : Urinary Bladder, Urinary Bladder Neoplasms.
- Case-Control Studies, Gene Expression, Gene Frequency, Genome-Wide Association Study, Haplotypes, HeLa Cells, Humans, Polymorphism, Single Nucleotide.
Abstract
A genome-wide association study (GWAS) of bladder cancer identified a genetic marker rs8102137 within the 19q12 region as a novel susceptibility variant. This marker is located upstream of the
Url:
DOI: 10.1158/0008-5472.CAN-14-1531
PubMed: 25320178
PubMed Central: 4203382
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PMC:4203382Le document en format XML
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<author><name sortKey="Karagas, Margaret R" sort="Karagas, Margaret R" uniqKey="Karagas M" first="Margaret R." last="Karagas">Margaret R. Karagas</name>
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<author><name sortKey="Tarway, Mcanthony" sort="Tarway, Mcanthony" uniqKey="Tarway M" first="Mcanthony" last="Tarway">Mcanthony Tarway</name>
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<author><name sortKey="Mumy, Adam" sort="Mumy, Adam" uniqKey="Mumy A" first="Adam" last="Mumy">Adam Mumy</name>
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<author><name sortKey="Jones, Michael A" sort="Jones, Michael A" uniqKey="Jones M" first="Michael A." last="Jones">Michael A. Jones</name>
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<author><name sortKey="Kida, Masatoshi" sort="Kida, Masatoshi" uniqKey="Kida M" first="Masatoshi" last="Kida">Masatoshi Kida</name>
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<author><name sortKey="Monawar Hosain, Gm" sort="Monawar Hosain, Gm" uniqKey="Monawar Hosain G" first="Gm" last="Monawar Hosain">Gm Monawar Hosain</name>
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<author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Nuria" last="Malats">Nuria Malats</name>
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<affiliation wicri:level="3"><nlm:aff id="A17">National School of Public Health, Athens, Greece</nlm:aff>
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<author><name sortKey="Tardon, Adonina" sort="Tardon, Adonina" uniqKey="Tardon A" first="Adonina" last="Tardon">Adonina Tardon</name>
<affiliation wicri:level="3"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A19">Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo</wicri:regionArea>
<wicri:noRegion>Oviedo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Serra, Consol" sort="Serra, Consol" uniqKey="Serra C" first="Consol" last="Serra">Consol Serra</name>
<affiliation wicri:level="3"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A20">Universitat Pompeu Fabra, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Universitat Pompeu Fabra, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
<settlement type="city">Barcelone</settlement>
</placeName>
<orgName type="university">Université Pompeu Fabra</orgName>
</affiliation>
</author>
<author><name sortKey="Carrato, Alfredo" sort="Carrato, Alfredo" uniqKey="Carrato A" first="Alfredo" last="Carrato">Alfredo Carrato</name>
<affiliation wicri:level="3"><nlm:aff id="A21">Ramón y Cajal Hospital, Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Ramón y Cajal Hospital, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Garcia Closas, Reina" sort="Garcia Closas, Reina" uniqKey="Garcia Closas R" first="Reina" last="Garcia-Closas">Reina Garcia-Closas</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Unidad de Investigación, Hospital Universitario de Canarias, La Laguna, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Unidad de Investigación, Hospital Universitario de Canarias, La Laguna</wicri:regionArea>
<wicri:noRegion>La Laguna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lloreta, Josep" sort="Lloreta, Josep" uniqKey="Lloreta J" first="Josep" last="Lloreta">Josep Lloreta</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Hospital del Mar-IMIM, Univesitat Pompeu Fabra, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital del Mar-IMIM, Univesitat Pompeu Fabra, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wu, Xifeng" sort="Wu, Xifeng" uniqKey="Wu X" first="Xifeng" last="Wu">Xifeng Wu</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Purdue, Mark" sort="Purdue, Mark" uniqKey="Purdue M" first="Mark" last="Purdue">Mark Purdue</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Andriole, Gerald L" sort="Andriole, Gerald L" uniqKey="Andriole G" first="Gerald L." last="Andriole">Gerald L. Andriole</name>
<affiliation wicri:level="4"><nlm:aff id="A25">Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Grubb, Robert L" sort="Grubb, Robert L" uniqKey="Grubb R" first="Robert L." last="Grubb">Robert L. Grubb</name>
<affiliation wicri:level="4"><nlm:aff id="A25">Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Landi, Maria T" sort="Landi, Maria T" uniqKey="Landi M" first="Maria T." last="Landi">Maria T. Landi</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E." last="Caporaso">Neil E. Caporaso</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name>
<affiliation wicri:level="3"><nlm:aff id="A26">School of Public Health, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A27">Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Human Genetics Foundation (HuGeF), Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Siddiq, Afshan" sort="Siddiq, Afshan" uniqKey="Siddiq A" first="Afshan" last="Siddiq">Afshan Siddiq</name>
<affiliation wicri:level="3"><nlm:aff id="A26">School of Public Health, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name>
<affiliation wicri:level="1"><nlm:aff id="A29">National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A30">Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A67">Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A68">Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</nlm:aff>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea>
<wicri:noRegion>Kuala Lumpur</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name>
<affiliation wicri:level="2"><nlm:aff id="A31">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A32">Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Bureau of Epidemiologic Research, Academy of Athens, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A33">Hellenic Health Foundation, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ljungberg, Borje" sort="Ljungberg, Borje" uniqKey="Ljungberg B" first="Börje" last="Ljungberg">Börje Ljungberg</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå</wicri:regionArea>
<wicri:noRegion>Umeå</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="3"><nlm:aff id="A27">Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Human Genetics Foundation (HuGeF), Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A35">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A36">Centre for Epidemiology and Biostatistics, University of Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, University of Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name>
<affiliation wicri:level="1"><nlm:aff id="A37">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø</wicri:regionArea>
<wicri:noRegion>Tromsø</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A38">Department of Research, Cancer Registry of Norway, Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Research, Cancer Registry of Norway, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A39">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A40">Samfundet Folkhälsan, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Samfundet Folkhälsan, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name>
<affiliation wicri:level="1"><nlm:aff id="A41">Fondazione IRCCS Istituto Nazionale dei Tumori - Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Istituto Nazionale dei Tumori - Milano</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name>
<affiliation wicri:level="1"><nlm:aff id="A42">Public Health Division of Gipuzkoa, Basque Regional Health Department and Ciberesp-Biodonostia, San Sebastian, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Public Health Division of Gipuzkoa, Basque Regional Health Department and Ciberesp-Biodonostia, San Sebastian</wicri:regionArea>
<wicri:noRegion>San Sebastian</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name>
<affiliation wicri:level="4"><nlm:aff id="A43">Cancer Epidemiology Unit, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Epidemiology Unit, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name>
<affiliation wicri:level="3"><nlm:aff id="A44">Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Danish Cancer Society Research Center, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name>
<affiliation wicri:level="3"><nlm:aff id="A45">International Agency for Research on Cancer, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation wicri:level="3"><nlm:aff id="A46">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name>
<affiliation wicri:level="3"><nlm:aff id="A26">School of Public Health, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prescott, Jennifer" sort="Prescott, Jennifer" uniqKey="Prescott J" first="Jennifer" last="Prescott">Jennifer Prescott</name>
<affiliation wicri:level="2"><nlm:aff id="A47">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name>
<affiliation wicri:level="2"><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Vivo, Immaculata" sort="De Vivo, Immaculata" uniqKey="De Vivo I" first="Immaculata" last="De Vivo">Immaculata De Vivo</name>
<affiliation wicri:level="2"><nlm:aff id="A47">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Govannucci, Edward" sort="Govannucci, Edward" uniqKey="Govannucci E" first="Edward" last="Govannucci">Edward Govannucci</name>
<affiliation wicri:level="2"><nlm:aff id="A49">Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hunter, David" sort="Hunter, David" uniqKey="Hunter D" first="David" last="Hunter">David Hunter</name>
<affiliation wicri:level="2"><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation wicri:level="2"><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name>
<affiliation wicri:level="2"><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name>
<affiliation wicri:level="2"><nlm:aff id="A50">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J." last="Jacobs">Eric J. Jacobs</name>
<affiliation wicri:level="2"><nlm:aff id="A50">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name>
<affiliation wicri:level="2"><nlm:aff id="A50">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J." last="Weinstein">Stephanie J. Weinstein</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name>
<affiliation wicri:level="1"><nlm:aff id="A51">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name>
<affiliation wicri:level="2"><nlm:aff id="A52">Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hohensee, Chancellor" sort="Hohensee, Chancellor" uniqKey="Hohensee C" first="Chancellor" last="Hohensee">Chancellor Hohensee</name>
<affiliation wicri:level="2"><nlm:aff id="A52">Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rodabough, Rebecca J" sort="Rodabough, Rebecca J" uniqKey="Rodabough R" first="Rebecca J." last="Rodabough">Rebecca J. Rodabough</name>
<affiliation wicri:level="2"><nlm:aff id="A52">Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cortessis, Victoria K" sort="Cortessis, Victoria K" uniqKey="Cortessis V" first="Victoria K." last="Cortessis">Victoria K. Cortessis</name>
<affiliation wicri:level="4"><nlm:aff id="A53">Department of Obstetrics & Gynecology, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Obstetrics & Gynecology, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. Conti</name>
<affiliation wicri:level="4"><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Gago Dominguez, Manuela" sort="Gago Dominguez, Manuela" uniqKey="Gago Dominguez M" first="Manuela" last="Gago-Dominguez">Manuela Gago-Dominguez</name>
<affiliation wicri:level="1"><nlm:aff id="A55">Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela</wicri:regionArea>
<wicri:noRegion>Santiago de Compostela</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stern, Mariana C" sort="Stern, Mariana C" uniqKey="Stern M" first="Mariana C." last="Stern">Mariana C. Stern</name>
<affiliation wicri:level="4"><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Pike, Malcolm C" sort="Pike, Malcolm C" uniqKey="Pike M" first="Malcolm C." last="Pike">Malcolm C. Pike</name>
<affiliation wicri:level="2"><nlm:aff id="A56">Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Den Berg, David" sort="Van Den Berg, David" uniqKey="Van Den Berg D" first="David" last="Van Den Berg">David Van Den Berg</name>
<affiliation wicri:level="4"><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name>
<affiliation wicri:level="2"><nlm:aff id="A57">University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="4"><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Cussenot, Olivier" sort="Cussenot, Olivier" uniqKey="Cussenot O" first="Olivier" last="Cussenot">Olivier Cussenot</name>
<affiliation wicri:level="3"><nlm:aff id="A58">AP-HP, Hopital Tenon, GHU-Est, Department of Urology, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HP, Hopital Tenon, GHU-Est, Department of Urology, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Recherche sur les Pathologies Prostatiques, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cancel Tassin, Geraldine" sort="Cancel Tassin, Geraldine" uniqKey="Cancel Tassin G" first="Geraldine" last="Cancel-Tassin">Geraldine Cancel-Tassin</name>
<affiliation wicri:level="3"><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Recherche sur les Pathologies Prostatiques, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roupret, Morgan" sort="Roupret, Morgan" uniqKey="Roupret M" first="Morgan" last="Roupret">Morgan Roupret</name>
<affiliation wicri:level="3"><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Recherche sur les Pathologies Prostatiques, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A61">AP-HP, Hopital Pitie-Salpetriere, GHU-Est, Departments of Urology and Pathology, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HP, Hopital Pitie-Salpetriere, GHU-Est, Departments of Urology and Pathology, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Comperat, Eva" sort="Comperat, Eva" uniqKey="Comperat E" first="Eva" last="Comperat">Eva Comperat</name>
<affiliation wicri:level="3"><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Recherche sur les Pathologies Prostatiques, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A61">AP-HP, Hopital Pitie-Salpetriere, GHU-Est, Departments of Urology and Pathology, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HP, Hopital Pitie-Salpetriere, GHU-Est, Departments of Urology and Pathology, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Porru, Stefano" sort="Porru, Stefano" uniqKey="Porru S" first="Stefano" last="Porru">Stefano Porru</name>
<affiliation wicri:level="1"><nlm:aff id="A62">Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia</wicri:regionArea>
<wicri:noRegion>Brescia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carta, Angela" sort="Carta, Angela" uniqKey="Carta A" first="Angela" last="Carta">Angela Carta</name>
<affiliation wicri:level="1"><nlm:aff id="A62">Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia</wicri:regionArea>
<wicri:noRegion>Brescia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pavanello, Sofia" sort="Pavanello, Sofia" uniqKey="Pavanello S" first="Sofia" last="Pavanello">Sofia Pavanello</name>
<affiliation wicri:level="1"><nlm:aff id="A63">Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua</wicri:regionArea>
<wicri:noRegion>Padua</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Arici, Cecilia" sort="Arici, Cecilia" uniqKey="Arici C" first="Cecilia" last="Arici">Cecilia Arici</name>
<affiliation wicri:level="1"><nlm:aff id="A62">Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia</wicri:regionArea>
<wicri:noRegion>Brescia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mastrangelo, Giuseppe" sort="Mastrangelo, Giuseppe" uniqKey="Mastrangelo G" first="Giuseppe" last="Mastrangelo">Giuseppe Mastrangelo</name>
<affiliation wicri:level="1"><nlm:aff id="A63">Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua</wicri:regionArea>
<wicri:noRegion>Padua</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grossman, H Barton" sort="Grossman, H Barton" uniqKey="Grossman H" first="H. Barton" last="Grossman">H. Barton Grossman</name>
<affiliation wicri:level="2"><nlm:aff id="A64">Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name>
<affiliation wicri:level="2"><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deng, Xiang" sort="Deng, Xiang" uniqKey="Deng X" first="Xiang" last="Deng">Xiang Deng</name>
<affiliation wicri:level="2"><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chung, Charles C" sort="Chung, Charles C" uniqKey="Chung C" first="Charles C." last="Chung">Charles C. Chung</name>
<affiliation wicri:level="2"><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hutchinson, Amy" sort="Hutchinson, Amy" uniqKey="Hutchinson A" first="Amy" last="Hutchinson">Amy Hutchinson</name>
<affiliation wicri:level="2"><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease</title>
<author><name sortKey="Fu, Yi Ping" sort="Fu, Yi Ping" uniqKey="Fu Y" first="Yi-Ping" last="Fu">Yi-Ping Fu</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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</placeName>
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</author>
<author><name sortKey="Kohaar, Indu" sort="Kohaar, Indu" uniqKey="Kohaar I" first="Indu" last="Kohaar">Indu Kohaar</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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<author><name sortKey="Moore, Lee E" sort="Moore, Lee E" uniqKey="Moore L" first="Lee E." last="Moore">Lee E. Moore</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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</placeName>
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<author><name sortKey="Lenz, Petra" sort="Lenz, Petra" uniqKey="Lenz P" first="Petra" last="Lenz">Petra Lenz</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clinical Research Directorate/Clinical Monitoring Research Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea>
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<author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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<author><name sortKey="Tang, Wei" sort="Tang, Wei" uniqKey="Tang W" first="Wei" last="Tang">Wei Tang</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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</placeName>
</affiliation>
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<author><name sortKey="Porter Gill, Patricia" sort="Porter Gill, Patricia" uniqKey="Porter Gill P" first="Patricia" last="Porter-Gill">Patricia Porter-Gill</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Scott Johnson, Alexandra" sort="Scott Johnson, Alexandra" uniqKey="Scott Johnson A" first="Alexandra" last="Scott-Johnson">Alexandra Scott-Johnson</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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<author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Epidemiology, Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
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</affiliation>
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<author><name sortKey="Muchmore, Brian" sort="Muchmore, Brian" uniqKey="Muchmore B" first="Brian" last="Muchmore">Brian Muchmore</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Baris, Dalsu" sort="Baris, Dalsu" uniqKey="Baris D" first="Dalsu" last="Baris">Dalsu Baris</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Paquin, Ashley" sort="Paquin, Ashley" uniqKey="Paquin A" first="Ashley" last="Paquin">Ashley Paquin</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Ylaya, Kris" sort="Ylaya, Kris" uniqKey="Ylaya K" first="Kris" last="Ylaya">Kris Ylaya</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Pathology, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Schwenn, Molly" sort="Schwenn, Molly" uniqKey="Schwenn M" first="Molly" last="Schwenn">Molly Schwenn</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Maine Cancer Registry, Augusta, Maine</wicri:regionArea>
<placeName><region type="state">Maine (État)</region>
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</affiliation>
</author>
<author><name sortKey="Apolo, Andrea B" sort="Apolo, Andrea B" uniqKey="Apolo A" first="Andrea B." last="Apolo">Andrea B. Apolo</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genitourinary Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Karagas, Margaret R" sort="Karagas, Margaret R" uniqKey="Karagas M" first="Margaret R." last="Karagas">Margaret R. Karagas</name>
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<wicri:regionArea>Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire</wicri:regionArea>
<placeName><region type="state">New Hampshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tarway, Mcanthony" sort="Tarway, Mcanthony" uniqKey="Tarway M" first="Mcanthony" last="Tarway">Mcanthony Tarway</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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<author><name sortKey="Johnson, Alison" sort="Johnson, Alison" uniqKey="Johnson A" first="Alison" last="Johnson">Alison Johnson</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vermont Cancer Registry, Burlington, Vermont</wicri:regionArea>
<placeName><region type="state">Vermont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mumy, Adam" sort="Mumy, Adam" uniqKey="Mumy A" first="Adam" last="Mumy">Adam Mumy</name>
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<country xml:lang="fr">États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Schned, Alan" sort="Schned, Alan" uniqKey="Schned A" first="Alan" last="Schned">Alan Schned</name>
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<wicri:regionArea>Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire</wicri:regionArea>
<placeName><region type="state">New Hampshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guedez, Liliana" sort="Guedez, Liliana" uniqKey="Guedez L" first="Liliana" last="Guedez">Liliana Guedez</name>
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<wicri:regionArea>Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Jones, Michael A" sort="Jones, Michael A" uniqKey="Jones M" first="Michael A." last="Jones">Michael A. Jones</name>
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<wicri:regionArea>Department of Pathology and Laboratory Medicine, Maine Medical Center, Portland, Maine</wicri:regionArea>
<placeName><region type="state">Maine (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kida, Masatoshi" sort="Kida, Masatoshi" uniqKey="Kida M" first="Masatoshi" last="Kida">Masatoshi Kida</name>
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<wicri:regionArea>Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Monawar Hosain, Gm" sort="Monawar Hosain, Gm" uniqKey="Monawar Hosain G" first="Gm" last="Monawar Hosain">Gm Monawar Hosain</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>New Hampshire State Cancer Registry, Concord, New Hampshire</wicri:regionArea>
<placeName><region type="state">New Hampshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Nuria" last="Malats">Nuria Malats</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish National Cancer Research Centre, Madrid</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name>
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<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A16">Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain</nlm:aff>
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<wicri:regionArea>Hospital del Mar Medical Research Institute (IMIM), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A17">National School of Public Health, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>National School of Public Health, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
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</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
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</placeName>
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<author><name sortKey="Tardon, Adonina" sort="Tardon, Adonina" uniqKey="Tardon A" first="Adonina" last="Tardon">Adonina Tardon</name>
<affiliation wicri:level="3"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A19">Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo</wicri:regionArea>
<wicri:noRegion>Oviedo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Serra, Consol" sort="Serra, Consol" uniqKey="Serra C" first="Consol" last="Serra">Consol Serra</name>
<affiliation wicri:level="3"><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A20">Universitat Pompeu Fabra, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Universitat Pompeu Fabra, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
<settlement type="city">Barcelone</settlement>
</placeName>
<orgName type="university">Université Pompeu Fabra</orgName>
</affiliation>
</author>
<author><name sortKey="Carrato, Alfredo" sort="Carrato, Alfredo" uniqKey="Carrato A" first="Alfredo" last="Carrato">Alfredo Carrato</name>
<affiliation wicri:level="3"><nlm:aff id="A21">Ramón y Cajal Hospital, Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Ramón y Cajal Hospital, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Garcia Closas, Reina" sort="Garcia Closas, Reina" uniqKey="Garcia Closas R" first="Reina" last="Garcia-Closas">Reina Garcia-Closas</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Unidad de Investigación, Hospital Universitario de Canarias, La Laguna, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Unidad de Investigación, Hospital Universitario de Canarias, La Laguna</wicri:regionArea>
<wicri:noRegion>La Laguna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lloreta, Josep" sort="Lloreta, Josep" uniqKey="Lloreta J" first="Josep" last="Lloreta">Josep Lloreta</name>
<affiliation wicri:level="3"><nlm:aff id="A23">Hospital del Mar-IMIM, Univesitat Pompeu Fabra, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital del Mar-IMIM, Univesitat Pompeu Fabra, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wu, Xifeng" sort="Wu, Xifeng" uniqKey="Wu X" first="Xifeng" last="Wu">Xifeng Wu</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Purdue, Mark" sort="Purdue, Mark" uniqKey="Purdue M" first="Mark" last="Purdue">Mark Purdue</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Andriole, Gerald L" sort="Andriole, Gerald L" uniqKey="Andriole G" first="Gerald L." last="Andriole">Gerald L. Andriole</name>
<affiliation wicri:level="4"><nlm:aff id="A25">Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Grubb, Robert L" sort="Grubb, Robert L" uniqKey="Grubb R" first="Robert L." last="Grubb">Robert L. Grubb</name>
<affiliation wicri:level="4"><nlm:aff id="A25">Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Landi, Maria T" sort="Landi, Maria T" uniqKey="Landi M" first="Maria T." last="Landi">Maria T. Landi</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E." last="Caporaso">Neil E. Caporaso</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name>
<affiliation wicri:level="3"><nlm:aff id="A26">School of Public Health, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A27">Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Human Genetics Foundation (HuGeF), Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Siddiq, Afshan" sort="Siddiq, Afshan" uniqKey="Siddiq A" first="Afshan" last="Siddiq">Afshan Siddiq</name>
<affiliation wicri:level="3"><nlm:aff id="A26">School of Public Health, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name>
<affiliation wicri:level="1"><nlm:aff id="A29">National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A30">Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A67">Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A68">Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</nlm:aff>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea>
<wicri:noRegion>Kuala Lumpur</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name>
<affiliation wicri:level="2"><nlm:aff id="A31">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A32">Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Bureau of Epidemiologic Research, Academy of Athens, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A33">Hellenic Health Foundation, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ljungberg, Borje" sort="Ljungberg, Borje" uniqKey="Ljungberg B" first="Börje" last="Ljungberg">Börje Ljungberg</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå</wicri:regionArea>
<wicri:noRegion>Umeå</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="3"><nlm:aff id="A27">Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Human Genetics Foundation (HuGeF), Torino</wicri:regionArea>
<placeName><settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A35">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A36">Centre for Epidemiology and Biostatistics, University of Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, University of Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name>
<affiliation wicri:level="1"><nlm:aff id="A37">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø</wicri:regionArea>
<wicri:noRegion>Tromsø</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A38">Department of Research, Cancer Registry of Norway, Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Research, Cancer Registry of Norway, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A39">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A40">Samfundet Folkhälsan, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Samfundet Folkhälsan, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name>
<affiliation wicri:level="1"><nlm:aff id="A41">Fondazione IRCCS Istituto Nazionale dei Tumori - Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Istituto Nazionale dei Tumori - Milano</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name>
<affiliation wicri:level="1"><nlm:aff id="A42">Public Health Division of Gipuzkoa, Basque Regional Health Department and Ciberesp-Biodonostia, San Sebastian, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Public Health Division of Gipuzkoa, Basque Regional Health Department and Ciberesp-Biodonostia, San Sebastian</wicri:regionArea>
<wicri:noRegion>San Sebastian</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name>
<affiliation wicri:level="4"><nlm:aff id="A43">Cancer Epidemiology Unit, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Epidemiology Unit, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name>
<affiliation wicri:level="3"><nlm:aff id="A44">Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Danish Cancer Society Research Center, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name>
<affiliation wicri:level="3"><nlm:aff id="A45">International Agency for Research on Cancer, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation wicri:level="3"><nlm:aff id="A46">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name>
<affiliation wicri:level="3"><nlm:aff id="A26">School of Public Health, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Public Health, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prescott, Jennifer" sort="Prescott, Jennifer" uniqKey="Prescott J" first="Jennifer" last="Prescott">Jennifer Prescott</name>
<affiliation wicri:level="2"><nlm:aff id="A47">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name>
<affiliation wicri:level="2"><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Vivo, Immaculata" sort="De Vivo, Immaculata" uniqKey="De Vivo I" first="Immaculata" last="De Vivo">Immaculata De Vivo</name>
<affiliation wicri:level="2"><nlm:aff id="A47">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Govannucci, Edward" sort="Govannucci, Edward" uniqKey="Govannucci E" first="Edward" last="Govannucci">Edward Govannucci</name>
<affiliation wicri:level="2"><nlm:aff id="A49">Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hunter, David" sort="Hunter, David" uniqKey="Hunter D" first="David" last="Hunter">David Hunter</name>
<affiliation wicri:level="2"><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation wicri:level="2"><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name>
<affiliation wicri:level="2"><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name>
<affiliation wicri:level="2"><nlm:aff id="A50">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J." last="Jacobs">Eric J. Jacobs</name>
<affiliation wicri:level="2"><nlm:aff id="A50">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name>
<affiliation wicri:level="2"><nlm:aff id="A50">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J." last="Weinstein">Stephanie J. Weinstein</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name>
<affiliation wicri:level="1"><nlm:aff id="A51">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name>
<affiliation wicri:level="2"><nlm:aff id="A52">Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hohensee, Chancellor" sort="Hohensee, Chancellor" uniqKey="Hohensee C" first="Chancellor" last="Hohensee">Chancellor Hohensee</name>
<affiliation wicri:level="2"><nlm:aff id="A52">Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rodabough, Rebecca J" sort="Rodabough, Rebecca J" uniqKey="Rodabough R" first="Rebecca J." last="Rodabough">Rebecca J. Rodabough</name>
<affiliation wicri:level="2"><nlm:aff id="A52">Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cortessis, Victoria K" sort="Cortessis, Victoria K" uniqKey="Cortessis V" first="Victoria K." last="Cortessis">Victoria K. Cortessis</name>
<affiliation wicri:level="4"><nlm:aff id="A53">Department of Obstetrics & Gynecology, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Obstetrics & Gynecology, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. Conti</name>
<affiliation wicri:level="4"><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Gago Dominguez, Manuela" sort="Gago Dominguez, Manuela" uniqKey="Gago Dominguez M" first="Manuela" last="Gago-Dominguez">Manuela Gago-Dominguez</name>
<affiliation wicri:level="1"><nlm:aff id="A55">Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela</wicri:regionArea>
<wicri:noRegion>Santiago de Compostela</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stern, Mariana C" sort="Stern, Mariana C" uniqKey="Stern M" first="Mariana C." last="Stern">Mariana C. Stern</name>
<affiliation wicri:level="4"><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Pike, Malcolm C" sort="Pike, Malcolm C" uniqKey="Pike M" first="Malcolm C." last="Pike">Malcolm C. Pike</name>
<affiliation wicri:level="2"><nlm:aff id="A56">Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Den Berg, David" sort="Van Den Berg, David" uniqKey="Van Den Berg D" first="David" last="Van Den Berg">David Van Den Berg</name>
<affiliation wicri:level="4"><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name>
<affiliation wicri:level="2"><nlm:aff id="A57">University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="4"><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Cussenot, Olivier" sort="Cussenot, Olivier" uniqKey="Cussenot O" first="Olivier" last="Cussenot">Olivier Cussenot</name>
<affiliation wicri:level="3"><nlm:aff id="A58">AP-HP, Hopital Tenon, GHU-Est, Department of Urology, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HP, Hopital Tenon, GHU-Est, Department of Urology, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Recherche sur les Pathologies Prostatiques, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cancel Tassin, Geraldine" sort="Cancel Tassin, Geraldine" uniqKey="Cancel Tassin G" first="Geraldine" last="Cancel-Tassin">Geraldine Cancel-Tassin</name>
<affiliation wicri:level="3"><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Recherche sur les Pathologies Prostatiques, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roupret, Morgan" sort="Roupret, Morgan" uniqKey="Roupret M" first="Morgan" last="Roupret">Morgan Roupret</name>
<affiliation wicri:level="3"><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Recherche sur les Pathologies Prostatiques, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A61">AP-HP, Hopital Pitie-Salpetriere, GHU-Est, Departments of Urology and Pathology, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HP, Hopital Pitie-Salpetriere, GHU-Est, Departments of Urology and Pathology, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Comperat, Eva" sort="Comperat, Eva" uniqKey="Comperat E" first="Eva" last="Comperat">Eva Comperat</name>
<affiliation wicri:level="3"><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Recherche sur les Pathologies Prostatiques, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A61">AP-HP, Hopital Pitie-Salpetriere, GHU-Est, Departments of Urology and Pathology, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>AP-HP, Hopital Pitie-Salpetriere, GHU-Est, Departments of Urology and Pathology, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Porru, Stefano" sort="Porru, Stefano" uniqKey="Porru S" first="Stefano" last="Porru">Stefano Porru</name>
<affiliation wicri:level="1"><nlm:aff id="A62">Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia</wicri:regionArea>
<wicri:noRegion>Brescia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carta, Angela" sort="Carta, Angela" uniqKey="Carta A" first="Angela" last="Carta">Angela Carta</name>
<affiliation wicri:level="1"><nlm:aff id="A62">Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia</wicri:regionArea>
<wicri:noRegion>Brescia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pavanello, Sofia" sort="Pavanello, Sofia" uniqKey="Pavanello S" first="Sofia" last="Pavanello">Sofia Pavanello</name>
<affiliation wicri:level="1"><nlm:aff id="A63">Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua</wicri:regionArea>
<wicri:noRegion>Padua</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Arici, Cecilia" sort="Arici, Cecilia" uniqKey="Arici C" first="Cecilia" last="Arici">Cecilia Arici</name>
<affiliation wicri:level="1"><nlm:aff id="A62">Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia</wicri:regionArea>
<wicri:noRegion>Brescia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mastrangelo, Giuseppe" sort="Mastrangelo, Giuseppe" uniqKey="Mastrangelo G" first="Giuseppe" last="Mastrangelo">Giuseppe Mastrangelo</name>
<affiliation wicri:level="1"><nlm:aff id="A63">Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua</wicri:regionArea>
<wicri:noRegion>Padua</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grossman, H Barton" sort="Grossman, H Barton" uniqKey="Grossman H" first="H. Barton" last="Grossman">H. Barton Grossman</name>
<affiliation wicri:level="2"><nlm:aff id="A64">Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name>
<affiliation wicri:level="2"><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deng, Xiang" sort="Deng, Xiang" uniqKey="Deng X" first="Xiang" last="Deng">Xiang Deng</name>
<affiliation wicri:level="2"><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chung, Charles C" sort="Chung, Charles C" uniqKey="Chung C" first="Charles C." last="Chung">Charles C. Chung</name>
<affiliation wicri:level="2"><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hutchinson, Amy" sort="Hutchinson, Amy" uniqKey="Hutchinson A" first="Amy" last="Hutchinson">Amy Hutchinson</name>
<affiliation wicri:level="2"><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Burdette, Laurie" sort="Burdette, Laurie" uniqKey="Burdette L" first="Laurie" last="Burdette">Laurie Burdette</name>
<affiliation wicri:level="2"><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wheeler, William" sort="Wheeler, William" uniqKey="Wheeler W" first="William" last="Wheeler">William Wheeler</name>
<affiliation wicri:level="2"><nlm:aff id="A66">Information Management Services, Rockville, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Information Management Services, Rockville, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fraumeni, Joseph" sort="Fraumeni, Joseph" uniqKey="Fraumeni J" first="Joseph" last="Fraumeni">Joseph Fraumeni</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hewitt, Stephen M" sort="Hewitt, Stephen M" uniqKey="Hewitt S" first="Stephen M." last="Hewitt">Stephen M. Hewitt</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Laboratory of Pathology, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Pathology, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Silverman, Debra T" sort="Silverman, Debra T" uniqKey="Silverman D" first="Debra T." last="Silverman">Debra T. Silverman</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prokunina Olsson, Ludmila" sort="Prokunina Olsson, Ludmila" uniqKey="Prokunina Olsson L" first="Ludmila" last="Prokunina-Olsson">Ludmila Prokunina-Olsson</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Cancer research</title>
<idno type="ISSN">0008-5472</idno>
<idno type="eISSN">1538-7445</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case-Control Studies</term>
<term>Chromosomes, Human, Pair 19 (genetics)</term>
<term>Cyclin E (genetics)</term>
<term>Cyclin E (metabolism)</term>
<term>Gene Expression</term>
<term>Gene Frequency</term>
<term>Genome-Wide Association Study</term>
<term>Haplotypes</term>
<term>HeLa Cells</term>
<term>Humans</term>
<term>Oncogene Proteins (genetics)</term>
<term>Oncogene Proteins (metabolism)</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Urinary Bladder (metabolism)</term>
<term>Urinary Bladder (pathology)</term>
<term>Urinary Bladder Neoplasms (genetics)</term>
<term>Urinary Bladder Neoplasms (pathology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Cellules HeLa</term>
<term>Chromosomes humains de la paire 19 (génétique)</term>
<term>Cycline E (génétique)</term>
<term>Cycline E (métabolisme)</term>
<term>Expression des gènes</term>
<term>Fréquence d'allèle</term>
<term>Haplotypes</term>
<term>Humains</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Protéines oncogènes (génétique)</term>
<term>Protéines oncogènes (métabolisme)</term>
<term>Tumeurs de la vessie urinaire (anatomopathologie)</term>
<term>Tumeurs de la vessie urinaire (génétique)</term>
<term>Vessie urinaire (anatomopathologie)</term>
<term>Vessie urinaire (métabolisme)</term>
<term>Étude d'association pangénomique</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cyclin E</term>
<term>Oncogene Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs de la vessie urinaire</term>
<term>Vessie urinaire</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human, Pair 19</term>
<term>Urinary Bladder Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chromosomes humains de la paire 19</term>
<term>Cycline E</term>
<term>Protéines oncogènes</term>
<term>Tumeurs de la vessie urinaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclin E</term>
<term>Oncogene Proteins</term>
<term>Urinary Bladder</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cycline E</term>
<term>Protéines oncogènes</term>
<term>Vessie urinaire</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Urinary Bladder</term>
<term>Urinary Bladder Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term>
<term>Gene Expression</term>
<term>Gene Frequency</term>
<term>Genome-Wide Association Study</term>
<term>Haplotypes</term>
<term>HeLa Cells</term>
<term>Humans</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Cellules HeLa</term>
<term>Expression des gènes</term>
<term>Fréquence d'allèle</term>
<term>Haplotypes</term>
<term>Humains</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Étude d'association pangénomique</term>
<term>Études cas-témoins</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en"><p id="P1">A genome-wide association study (GWAS) of bladder cancer identified a genetic marker rs8102137 within the 19q12 region as a novel susceptibility variant. This marker is located upstream of the <italic>CCNE1</italic>
gene, which encodes cyclin E, a cell cycle protein. We performed genetic fine mapping analysis of the <italic>CCNE1</italic>
region using data from two bladder cancer GWAS (5,942 cases and 10,857 controls). We found that the original GWAS marker rs8102137 represents a group of 47 linked SNPs (with r<sup>2</sup>
≥0.7) associated with increased bladder cancer risk. From this group we selected a functional promoter variant rs7257330, which showed strong allele-specific binding of nuclear proteins in several cell lines. In both GWAS, rs7257330 was associated only with aggressive bladder cancer, with a combined per-allele odds ratio (OR) =1.18 (95%CI=1.09-1.27, p=4.67×10<sup>−5</sup>
vs. OR =1.01 (95%CI=0.93-1.10, p=0.79) for non-aggressive disease, with p=0.0015 for case-only analysis. Cyclin E protein expression analyzed in 265 bladder tumors was increased in aggressive tumors (p=0.013) and, independently, with each rs7257330-A risk allele (p<sub>trend</sub>
=0.024). Over-expression of recombinant cyclin E in cell lines caused significant acceleration of cell cycle. In conclusion, we defined the 19q12 signal as the first GWAS signal specific for aggressive bladder cancer. Molecular mechanisms of this genetic association may be related to cyclin E over-expression and alteration of cell cycle in carriers of <italic>CCNE1</italic>
risk variants. In combination with established bladder cancer risk factors and other somatic and germline genetic markers, the <italic>CCNE1</italic>
variants could be useful for inclusion into bladder cancer risk prediction models.</p>
</div>
</front>
</TEI>
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