Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium
Identifieur interne : 001C53 ( Ncbi/Curation ); précédent : 001C52; suivant : 001C54Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium
Auteurs : C. Bosetti [Italie] ; V. Rosato [Italie] ; D. Li ; D. Silverman ; G. M. Petersen ; P. M. Bracci [États-Unis] ; R. E. Neale [Australie] ; J. Muscat ; K. Anderson [États-Unis] ; S. Gallinger [Canada] ; S. H. Olson [États-Unis] ; A. B. Miller [Canada] ; H. Bas Bueno-De-Mesquita [Pays-Bas, Royaume-Uni] ; G. Scelo [France] ; V. Janout ; I. Holcatova [République tchèque] ; P. Lagiou [États-Unis, Grèce] ; D. Serraino ; E. Lucenteforte [Italie] ; E. Fabianova [Slovaquie] ; P. Ghadirian ; P. A. Baghurst [Australie] ; W. Zatonski [Pologne] ; L. Foretova [République tchèque] ; E. Fontham [États-Unis] ; W. R. Bamlet ; E. A. Holly [États-Unis] ; E. Negri [Italie] ; M. Hassan ; A. Prizment [États-Unis] ; M. Cotterchio [Canada] ; S. Cleary [Canada] ; R. C. Kurtz [États-Unis] ; P. Maisonneuve [Italie] ; D. Trichopoulos [États-Unis] ; J. Polesel ; E. J. Duell [Espagne] ; P. Boffetta [États-Unis] ; C. La Vecchia [Italie]Source :
- Annals of Oncology [ 0923-7534 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Diabète de type 2 (), Diabète de type 2 (anatomopathologie), Diabète de type 2 (traitement médicamenteux), Diabète de type 2 (épidémiologie), Facteurs de risque, Femelle, Humains, Hypoglycémiants (usage thérapeutique), Insuline, Modèles logistiques, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Tabagisme, Tumeurs du pancréas (anatomopathologie), Tumeurs du pancréas (traitement médicamenteux), Tumeurs du pancréas (épidémiologie), Tumeurs du pancréas (étiologie), Études cas-témoins.
- MESH :
- anatomopathologie : Diabète de type 2, Tumeurs du pancréas.
- traitement médicamenteux : Diabète de type 2, Tumeurs du pancréas.
- usage thérapeutique : Hypoglycémiants.
- épidémiologie : Diabète de type 2, Tumeurs du pancréas.
- étiologie : Tumeurs du pancréas.
- Adulte, Adulte d'âge moyen, Diabète de type 2, Facteurs de risque, Femelle, Humains, Insuline, Modèles logistiques, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Tabagisme, Études cas-témoins.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Diabetes Mellitus, Type 2 (complications), Diabetes Mellitus, Type 2 (drug therapy), Diabetes Mellitus, Type 2 (epidemiology), Diabetes Mellitus, Type 2 (pathology), Female, Humans, Hypoglycemic Agents (therapeutic use), Insulin, Logistic Models, Male, Middle Aged, Pancreatic Neoplasms (drug therapy), Pancreatic Neoplasms (epidemiology), Pancreatic Neoplasms (etiology), Pancreatic Neoplasms (pathology), Risk Factors, Smoking.
- MESH :
- chemical , therapeutic use : Hypoglycemic Agents.
- complications : Diabetes Mellitus, Type 2.
- drug therapy : Diabetes Mellitus, Type 2, Pancreatic Neoplasms.
- epidemiology : Diabetes Mellitus, Type 2, Pancreatic Neoplasms.
- etiology : Pancreatic Neoplasms.
- pathology : Diabetes Mellitus, Type 2, Pancreatic Neoplasms.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Humans, Insulin, Logistic Models, Male, Middle Aged, Risk Factors, Smoking.
Abstract
This study confirms a twofold excess risk of pancreatic cancer in diabetics and shows that a 30% excess risk persists more than two decades after diabetes diagnosis, supporting a causal role of diabetes in pancreatic cancer. Oral antidiabetics may decrease pancreatic cancer risk, whereas insulin showed an inconsistent time-related association.
Url:
DOI: 10.1093/annonc/mdu276
PubMed: 25057164
PubMed Central: 4176453
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G. M. Petersen<affiliation><nlm:aff id="mdu276_af4"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Medicine and Medical Genetics</institution>,<addr-line>Mayo Clinic, Rochester</addr-line></nlm:aff><wicri:noCountry code="subfield">Rochester</wicri:noCountry></affiliation><affiliation><nlm:aff id="mdu276_af4"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Medicine and Medical Genetics</institution>,<addr-line>Mayo Clinic, Rochester</addr-line></nlm:aff><wicri:noCountry code="subfield">Rochester</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium</title><author><name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rosato, V" sort="Rosato, V" uniqKey="Rosato V" first="V." last="Rosato">V. Rosato</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, D" sort="Li, D" uniqKey="Li D" first="D." last="Li">D. Li</name><affiliation><nlm:aff id="mdu276_af2"><addr-line>M.D. Anderson Cancer Center</addr-line>,<institution>University of Texas</institution>,<addr-line>Houston</addr-line></nlm:aff></affiliation></author><author><name sortKey="Silverman, D" sort="Silverman, D" uniqKey="Silverman D" first="D." last="Silverman">D. Silverman</name><affiliation><nlm:aff id="mdu276_af3"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda</addr-line></nlm:aff></affiliation></author><author><name sortKey="Petersen, G M" sort="Petersen, G M" uniqKey="Petersen G" first="G. M." last="Petersen">G. M. Petersen</name><affiliation><nlm:aff id="mdu276_af4"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Medicine and Medical Genetics</institution>,<addr-line>Mayo Clinic, Rochester</addr-line></nlm:aff><wicri:noCountry code="subfield">Rochester</wicri:noCountry></affiliation></author><author><name sortKey="Bracci, P M" sort="Bracci, P M" uniqKey="Bracci P" first="P. M." last="Bracci">P. M. Bracci</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af5"><institution>Department of Epidemiology and Biostatistics, University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neale, R E" sort="Neale, R E" uniqKey="Neale R" first="R. E." last="Neale">R. E. Neale</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af6"><institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muscat, J" sort="Muscat, J" uniqKey="Muscat J" first="J." last="Muscat">J. Muscat</name><affiliation><nlm:aff id="mdu276_af7"><addr-line>Department of Public Health Sciences</addr-line>,<institution>Penn State University</institution>,<addr-line>Penn State</addr-line></nlm:aff></affiliation></author><author><name sortKey="Anderson, K" sort="Anderson, K" uniqKey="Anderson K" first="K." last="Anderson">K. Anderson</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af8"><addr-line>Division of Epidemiology and Community Health</addr-line>,<institution>University of Minnesota</institution>,<addr-line>Minneapolis</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S." last="Gallinger">S. Gallinger</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af9"><addr-line>University Health Network, Department of Surgery</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olson, S H" sort="Olson, S H" uniqKey="Olson S" first="S. H." last="Olson">S. H. Olson</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af10"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miller, A B" sort="Miller, A B" uniqKey="Miller A" first="A. B." last="Miller">A. B. Miller</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af11"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bas Bueno De Mesquita, H" sort="Bas Bueno De Mesquita, H" uniqKey="Bas Bueno De Mesquita H" first="H." last="Bas Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation><nlm:aff id="mdu276_af12"><institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="mdu276_af13"><addr-line>Department of Gastroenterology and Hepatology</addr-line>,<institution>University Medical Center Utrecht (UMCU)</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="mdu276_af14"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scelo, G" sort="Scelo, G" uniqKey="Scelo G" first="G." last="Scelo">G. Scelo</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af15"><institution>International Agency for Research on Cancer (IARC)</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Janout, V" sort="Janout, V" uniqKey="Janout V" first="V." last="Janout">V. Janout</name><affiliation><nlm:aff id="mdu276_af16"><addr-line>Department of Preventive Medicine, Faculty of Medicine</addr-line>,<institution>Palacky University</institution>,<addr-line>Olomouc</addr-line></nlm:aff></affiliation></author><author><name sortKey="Holcatova, I" sort="Holcatova, I" uniqKey="Holcatova I" first="I." last="Holcatova">I. Holcatova</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af17"><addr-line>Institute of Hygiene and Epidemiology, 1st Faculty of Medicine</addr-line>,<institution>Charles University in Prague</institution>,<addr-line>Prague</addr-line>,<country>Czech Republic</country></nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lagiou, P" sort="Lagiou, P" uniqKey="Lagiou P" first="P." last="Lagiou">P. Lagiou</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af18"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="mdu276_af19"><addr-line>Department of Hygiene, Epidemiology and Medical Statistics</addr-line>,<institution>School of Medicine, University of Athens</institution>,<addr-line>Athens</addr-line>,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Serraino, D" sort="Serraino, D" uniqKey="Serraino D" first="D." last="Serraino">D. Serraino</name><affiliation><nlm:aff id="mdu276_af20"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>CRO Aviano National Cancer Institute, IRCCS</institution>,<addr-line>Aviano</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lucenteforte, E" sort="Lucenteforte, E" uniqKey="Lucenteforte E" first="E." last="Lucenteforte">E. Lucenteforte</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af21"><addr-line>Department of Preclinical and Clinical Pharmacology Mario Aiazzi Mancini</addr-line>,<institution>Università degli Studi di Firenze</institution>,<addr-line>Florence</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fabianova, E" sort="Fabianova, E" uniqKey="Fabianova E" first="E." last="Fabianova">E. Fabianova</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af22"><institution>Regional Authority of Public Health in Banská Bystrica</institution>,<addr-line>Banská Bystrica</addr-line>,<country>Slovakia</country></nlm:aff><country xml:lang="fr">Slovaquie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ghadirian, P" sort="Ghadirian, P" uniqKey="Ghadirian P" first="P." last="Ghadirian">P. Ghadirian</name></author><author><name sortKey="Baghurst, P A" sort="Baghurst, P A" uniqKey="Baghurst P" first="P. A." last="Baghurst">P. A. Baghurst</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af23"><addr-line>Public Health</addr-line>,<institution>Women's and Children's Hospital</institution>,<addr-line>Adelaide, SA</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zatonski, W" sort="Zatonski, W" uniqKey="Zatonski W" first="W." last="Zatonski">W. Zatonski</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af24"><institution>Cancer Center and Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foretova, L" sort="Foretova, L" uniqKey="Foretova L" first="L." last="Foretova">L. Foretova</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af25"><addr-line>Department of Cancer Epidemiology and Genetics</addr-line>,<institution>Masaryk Memorial Cancer Institute, Institute and MF MU</institution>,<addr-line>Brno</addr-line>,<country>Czech Republic</country></nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fontham, E" sort="Fontham, E" uniqKey="Fontham E" first="E." last="Fontham">E. Fontham</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af26"><institution>Louisiana State University School of Public Health</institution>,<addr-line>New Orleans</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bamlet, W R" sort="Bamlet, W R" uniqKey="Bamlet W" first="W. R." last="Bamlet">W. R. Bamlet</name><affiliation><nlm:aff id="mdu276_af4"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Medicine and Medical Genetics</institution>,<addr-line>Mayo Clinic, Rochester</addr-line></nlm:aff><wicri:noCountry code="subfield">Rochester</wicri:noCountry></affiliation></author><author><name sortKey="Holly, E A" sort="Holly, E A" uniqKey="Holly E" first="E. A." last="Holly">E. A. Holly</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af5"><institution>Department of Epidemiology and Biostatistics, University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hassan, M" sort="Hassan, M" uniqKey="Hassan M" first="M." last="Hassan">M. Hassan</name><affiliation><nlm:aff id="mdu276_af2"><addr-line>M.D. Anderson Cancer Center</addr-line>,<institution>University of Texas</institution>,<addr-line>Houston</addr-line></nlm:aff></affiliation></author><author><name sortKey="Prizment, A" sort="Prizment, A" uniqKey="Prizment A" first="A." last="Prizment">A. Prizment</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af8"><addr-line>Division of Epidemiology and Community Health</addr-line>,<institution>University of Minnesota</institution>,<addr-line>Minneapolis</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af11"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="mdu276_af27"><institution>Cancer Care Ontario</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cleary, S" sort="Cleary, S" uniqKey="Cleary S" first="S." last="Cleary">S. Cleary</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af9"><addr-line>University Health Network, Department of Surgery</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kurtz, R C" sort="Kurtz, R C" uniqKey="Kurtz R" first="R. C." last="Kurtz">R. C. Kurtz</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af28"><addr-line>Department of Medicine</addr-line>,<institution>Memorial Sloan Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af29"><addr-line>Division of Epidemiology and Biostatistics</addr-line>,<institution>European Institute of Oncology</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Trichopoulos, D" sort="Trichopoulos, D" uniqKey="Trichopoulos D" first="D." last="Trichopoulos">D. Trichopoulos</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af18"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name><affiliation><nlm:aff id="mdu276_af20"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>CRO Aviano National Cancer Institute, IRCCS</institution>,<addr-line>Aviano</addr-line></nlm:aff></affiliation></author><author><name sortKey="Duell, E J" sort="Duell, E J" uniqKey="Duell E" first="E. J." last="Duell">E. J. Duell</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af30"><addr-line>Unit of Nutrition, Environment and Cancer</addr-line>,<institution>Catalan Institute of Oncology (ICO-IDIBELL), L'Hospitalet de Llobregat</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af31"><institution>The Tisch Cancer Institute and Institute for Translational Epidemiology</institution>,<institution>Icahn School of Medicine at Mount Sinai</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af32"><addr-line>Department of Clinical Sciences and Community Health</addr-line>,<institution>Università degli Studi di Milano</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25057164</idno><idno type="pmc">4176453</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176453</idno><idno type="RBID">PMC:4176453</idno><idno type="doi">10.1093/annonc/mdu276</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001738</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001738</idno><idno type="wicri:Area/Pmc/Curation">001598</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001598</idno><idno type="wicri:Area/Pmc/Checkpoint">001655</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001655</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">003397</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003397</idno><idno type="wicri:Area/PubMed/Curation">003285</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003285</idno><idno type="wicri:Area/PubMed/Checkpoint">003285</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003285</idno><idno type="wicri:Area/Ncbi/Merge">001C53</idno><idno type="wicri:Area/Ncbi/Curation">001C53</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium</title><author><name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rosato, V" sort="Rosato, V" uniqKey="Rosato V" first="V." last="Rosato">V. Rosato</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, D" sort="Li, D" uniqKey="Li D" first="D." last="Li">D. Li</name><affiliation><nlm:aff id="mdu276_af2"><addr-line>M.D. Anderson Cancer Center</addr-line>,<institution>University of Texas</institution>,<addr-line>Houston</addr-line></nlm:aff></affiliation></author><author><name sortKey="Silverman, D" sort="Silverman, D" uniqKey="Silverman D" first="D." last="Silverman">D. Silverman</name><affiliation><nlm:aff id="mdu276_af3"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>,<institution>National Cancer Institute</institution>,<addr-line>Bethesda</addr-line></nlm:aff></affiliation></author><author><name sortKey="Petersen, G M" sort="Petersen, G M" uniqKey="Petersen G" first="G. M." last="Petersen">G. M. Petersen</name><affiliation><nlm:aff id="mdu276_af4"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Medicine and Medical Genetics</institution>,<addr-line>Mayo Clinic, Rochester</addr-line></nlm:aff><wicri:noCountry code="subfield">Rochester</wicri:noCountry></affiliation></author><author><name sortKey="Bracci, P M" sort="Bracci, P M" uniqKey="Bracci P" first="P. M." last="Bracci">P. M. Bracci</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af5"><institution>Department of Epidemiology and Biostatistics, University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neale, R E" sort="Neale, R E" uniqKey="Neale R" first="R. E." last="Neale">R. E. Neale</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af6"><institution>Queensland Institute of Medical Research</institution>,<addr-line>Brisbane</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muscat, J" sort="Muscat, J" uniqKey="Muscat J" first="J." last="Muscat">J. Muscat</name><affiliation><nlm:aff id="mdu276_af7"><addr-line>Department of Public Health Sciences</addr-line>,<institution>Penn State University</institution>,<addr-line>Penn State</addr-line></nlm:aff></affiliation></author><author><name sortKey="Anderson, K" sort="Anderson, K" uniqKey="Anderson K" first="K." last="Anderson">K. Anderson</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af8"><addr-line>Division of Epidemiology and Community Health</addr-line>,<institution>University of Minnesota</institution>,<addr-line>Minneapolis</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S." last="Gallinger">S. Gallinger</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af9"><addr-line>University Health Network, Department of Surgery</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Olson, S H" sort="Olson, S H" uniqKey="Olson S" first="S. H." last="Olson">S. H. Olson</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af10"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Memorial Sloan Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Miller, A B" sort="Miller, A B" uniqKey="Miller A" first="A. B." last="Miller">A. B. Miller</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af11"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bas Bueno De Mesquita, H" sort="Bas Bueno De Mesquita, H" uniqKey="Bas Bueno De Mesquita H" first="H." last="Bas Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation><nlm:aff id="mdu276_af12"><institution>National Institute for Public Health and the Environment (RIVM)</institution>,<addr-line>Bilthoven</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="mdu276_af13"><addr-line>Department of Gastroenterology and Hepatology</addr-line>,<institution>University Medical Center Utrecht (UMCU)</institution>,<addr-line>Utrecht</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="mdu276_af14"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>School of Public Health, Imperial College London</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scelo, G" sort="Scelo, G" uniqKey="Scelo G" first="G." last="Scelo">G. Scelo</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af15"><institution>International Agency for Research on Cancer (IARC)</institution>,<addr-line>Lyon</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Janout, V" sort="Janout, V" uniqKey="Janout V" first="V." last="Janout">V. Janout</name><affiliation><nlm:aff id="mdu276_af16"><addr-line>Department of Preventive Medicine, Faculty of Medicine</addr-line>,<institution>Palacky University</institution>,<addr-line>Olomouc</addr-line></nlm:aff></affiliation></author><author><name sortKey="Holcatova, I" sort="Holcatova, I" uniqKey="Holcatova I" first="I." last="Holcatova">I. Holcatova</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af17"><addr-line>Institute of Hygiene and Epidemiology, 1st Faculty of Medicine</addr-line>,<institution>Charles University in Prague</institution>,<addr-line>Prague</addr-line>,<country>Czech Republic</country></nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lagiou, P" sort="Lagiou, P" uniqKey="Lagiou P" first="P." last="Lagiou">P. Lagiou</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af18"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="mdu276_af19"><addr-line>Department of Hygiene, Epidemiology and Medical Statistics</addr-line>,<institution>School of Medicine, University of Athens</institution>,<addr-line>Athens</addr-line>,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Serraino, D" sort="Serraino, D" uniqKey="Serraino D" first="D." last="Serraino">D. Serraino</name><affiliation><nlm:aff id="mdu276_af20"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>CRO Aviano National Cancer Institute, IRCCS</institution>,<addr-line>Aviano</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lucenteforte, E" sort="Lucenteforte, E" uniqKey="Lucenteforte E" first="E." last="Lucenteforte">E. Lucenteforte</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af21"><addr-line>Department of Preclinical and Clinical Pharmacology Mario Aiazzi Mancini</addr-line>,<institution>Università degli Studi di Firenze</institution>,<addr-line>Florence</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fabianova, E" sort="Fabianova, E" uniqKey="Fabianova E" first="E." last="Fabianova">E. Fabianova</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af22"><institution>Regional Authority of Public Health in Banská Bystrica</institution>,<addr-line>Banská Bystrica</addr-line>,<country>Slovakia</country></nlm:aff><country xml:lang="fr">Slovaquie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ghadirian, P" sort="Ghadirian, P" uniqKey="Ghadirian P" first="P." last="Ghadirian">P. Ghadirian</name></author><author><name sortKey="Baghurst, P A" sort="Baghurst, P A" uniqKey="Baghurst P" first="P. A." last="Baghurst">P. A. Baghurst</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af23"><addr-line>Public Health</addr-line>,<institution>Women's and Children's Hospital</institution>,<addr-line>Adelaide, SA</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zatonski, W" sort="Zatonski, W" uniqKey="Zatonski W" first="W." last="Zatonski">W. Zatonski</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af24"><institution>Cancer Center and Institute of Oncology</institution>,<addr-line>Warsaw</addr-line>,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foretova, L" sort="Foretova, L" uniqKey="Foretova L" first="L." last="Foretova">L. Foretova</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af25"><addr-line>Department of Cancer Epidemiology and Genetics</addr-line>,<institution>Masaryk Memorial Cancer Institute, Institute and MF MU</institution>,<addr-line>Brno</addr-line>,<country>Czech Republic</country></nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fontham, E" sort="Fontham, E" uniqKey="Fontham E" first="E." last="Fontham">E. Fontham</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af26"><institution>Louisiana State University School of Public Health</institution>,<addr-line>New Orleans</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bamlet, W R" sort="Bamlet, W R" uniqKey="Bamlet W" first="W. R." last="Bamlet">W. R. Bamlet</name><affiliation><nlm:aff id="mdu276_af4"><addr-line>Department of Health Sciences Research</addr-line>,<institution>Medicine and Medical Genetics</institution>,<addr-line>Mayo Clinic, Rochester</addr-line></nlm:aff><wicri:noCountry code="subfield">Rochester</wicri:noCountry></affiliation></author><author><name sortKey="Holly, E A" sort="Holly, E A" uniqKey="Holly E" first="E. A." last="Holly">E. A. Holly</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af5"><institution>Department of Epidemiology and Biostatistics, University of California San Francisco</institution>,<addr-line>San Francisco</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af1"><addr-line>Department of Epidemiology</addr-line>,<institution>IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hassan, M" sort="Hassan, M" uniqKey="Hassan M" first="M." last="Hassan">M. Hassan</name><affiliation><nlm:aff id="mdu276_af2"><addr-line>M.D. Anderson Cancer Center</addr-line>,<institution>University of Texas</institution>,<addr-line>Houston</addr-line></nlm:aff></affiliation></author><author><name sortKey="Prizment, A" sort="Prizment, A" uniqKey="Prizment A" first="A." last="Prizment">A. Prizment</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af8"><addr-line>Division of Epidemiology and Community Health</addr-line>,<institution>University of Minnesota</institution>,<addr-line>Minneapolis</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af11"><addr-line>Dalla Lana School of Public Health</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="mdu276_af27"><institution>Cancer Care Ontario</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cleary, S" sort="Cleary, S" uniqKey="Cleary S" first="S." last="Cleary">S. Cleary</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af9"><addr-line>University Health Network, Department of Surgery</addr-line>,<institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kurtz, R C" sort="Kurtz, R C" uniqKey="Kurtz R" first="R. C." last="Kurtz">R. C. Kurtz</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af28"><addr-line>Department of Medicine</addr-line>,<institution>Memorial Sloan Kettering Cancer Center</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af29"><addr-line>Division of Epidemiology and Biostatistics</addr-line>,<institution>European Institute of Oncology</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Trichopoulos, D" sort="Trichopoulos, D" uniqKey="Trichopoulos D" first="D." last="Trichopoulos">D. Trichopoulos</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af18"><addr-line>Department of Epidemiology</addr-line>,<institution>Harvard School of Public Health</institution>,<addr-line>Boston</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name><affiliation><nlm:aff id="mdu276_af20"><addr-line>Unit of Epidemiology and Biostatistics</addr-line>,<institution>CRO Aviano National Cancer Institute, IRCCS</institution>,<addr-line>Aviano</addr-line></nlm:aff></affiliation></author><author><name sortKey="Duell, E J" sort="Duell, E J" uniqKey="Duell E" first="E. J." last="Duell">E. J. Duell</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af30"><addr-line>Unit of Nutrition, Environment and Cancer</addr-line>,<institution>Catalan Institute of Oncology (ICO-IDIBELL), L'Hospitalet de Llobregat</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af31"><institution>The Tisch Cancer Institute and Institute for Translational Epidemiology</institution>,<institution>Icahn School of Medicine at Mount Sinai</institution>,<addr-line>New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name><affiliation wicri:level="1"><nlm:aff id="mdu276_af32"><addr-line>Department of Clinical Sciences and Community Health</addr-line>,<institution>Università degli Studi di Milano</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Annals of Oncology</title><idno type="ISSN">0923-7534</idno><idno type="eISSN">1569-8041</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Diabetes Mellitus, Type 2 (complications)</term><term>Diabetes Mellitus, Type 2 (drug therapy)</term><term>Diabetes Mellitus, Type 2 (epidemiology)</term><term>Diabetes Mellitus, Type 2 (pathology)</term><term>Female</term><term>Humans</term><term>Hypoglycemic Agents (therapeutic use)</term><term>Insulin</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Pancreatic Neoplasms (drug therapy)</term><term>Pancreatic Neoplasms (epidemiology)</term><term>Pancreatic Neoplasms (etiology)</term><term>Pancreatic Neoplasms (pathology)</term><term>Risk Factors</term><term>Smoking</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Diabète de type 2 ()</term><term>Diabète de type 2 (anatomopathologie)</term><term>Diabète de type 2 (traitement médicamenteux)</term><term>Diabète de type 2 (épidémiologie)</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Hypoglycémiants (usage thérapeutique)</term><term>Insuline</term><term>Modèles logistiques</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tabagisme</term><term>Tumeurs du pancréas (anatomopathologie)</term><term>Tumeurs du pancréas (traitement médicamenteux)</term><term>Tumeurs du pancréas (épidémiologie)</term><term>Tumeurs du pancréas (étiologie)</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hypoglycemic Agents</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Diabète de type 2</term><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Diabetes Mellitus, Type 2</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Diabetes Mellitus, Type 2</term><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Diabetes Mellitus, Type 2</term><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Diabetes Mellitus, Type 2</term><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Diabète de type 2</term><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Hypoglycémiants</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Diabète de type 2</term><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Insulin</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term><term>Smoking</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Diabète de type 2</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Insuline</term><term>Modèles logistiques</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tabagisme</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This study confirms a twofold excess risk of pancreatic cancer in diabetics and shows that a 30% excess risk persists more than two decades after diabetes diagnosis, supporting a causal role of diabetes in pancreatic cancer. Oral antidiabetics may decrease pancreatic cancer risk, whereas insulin showed an inconsistent time-related association.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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