Patient perception of the benefit of a BRAF inhibitor in metastatic melanoma: quality-of-life analyses of the BREAK-3 study comparing dabrafenib with dacarbazine.
Identifieur interne : 001992 ( Ncbi/Curation ); précédent : 001991; suivant : 001993Patient perception of the benefit of a BRAF inhibitor in metastatic melanoma: quality-of-life analyses of the BREAK-3 study comparing dabrafenib with dacarbazine.
Auteurs : J-J Grob [France] ; M M Amonkar [États-Unis] ; S. Martin-Algarra [Espagne] ; L V Demidov [Russie] ; V. Goodman [États-Unis] ; K. Grotzinger [États-Unis] ; P. Haney [États-Unis] ; E. K Mpgen [Allemagne] ; B. Karaszewska [Pologne] ; C. Mauch [Allemagne] ; W H Miller [Canada] ; M. Millward [Australie] ; B. Mirakhur [États-Unis] ; P. Rutkowski [Pologne] ; V. Chiarion-Sileni [Italie] ; S. Swann [États-Unis] ; A. Hauschild [Allemagne]Source :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Mélanome.
- traitement médicamenteux : Mélanome.
- usage thérapeutique : Antinéoplasiques, Dacarbazine, Imidazoles, Oximes.
- Humains, Métastase tumorale, Qualité de vie.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antineoplastic Agents, Dacarbazine, Imidazoles, Oximes.
- drug therapy : Melanoma.
- pathology : Melanoma.
- Humans, Neoplasm Metastasis, Quality of Life.
Abstract
In a randomized phase III study (BREAK-3), dabrafenib showed prolonged progression-free survival (PFS) (median 5.1 versus 2.7 months; hazard ratio = 0.30; 95% confidence interval 0.18-0.53; P < 0.0001) compared with dacarbazine (DTIC) in patients with BRAF V600E metastatic melanoma. Assessing how these results are transformed into a real health benefit for patients is crucial.
DOI: 10.1093/annonc/mdu154
PubMed: 24769640
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Links to Exploration step
pubmed:24769640Le document en format XML
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<term>Oximes</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mélanome</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Melanoma</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Melanoma</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Mélanome</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques</term>
<term>Dacarbazine</term>
<term>Imidazoles</term>
<term>Oximes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Neoplasm Metastasis</term>
<term>Quality of Life</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Métastase tumorale</term>
<term>Qualité de vie</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">In a randomized phase III study (BREAK-3), dabrafenib showed prolonged progression-free survival (PFS) (median 5.1 versus 2.7 months; hazard ratio = 0.30; 95% confidence interval 0.18-0.53; P < 0.0001) compared with dacarbazine (DTIC) in patients with BRAF V600E metastatic melanoma. Assessing how these results are transformed into a real health benefit for patients is crucial.</div>
</front>
</TEI>
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