Rapid Increase in Pertactin-deficient Bordetella pertussis Isolates, Australia
Identifieur interne : 001887 ( Ncbi/Curation ); précédent : 001886; suivant : 001888Rapid Increase in Pertactin-deficient Bordetella pertussis Isolates, Australia
Auteurs : Connie Lam ; Sophie Octavia ; Lawrence Ricafort ; Vitali Sintchenko ; Gwendolyn L. Gilbert ; Nicholas Wood ; Peter Mcintyre ; Helen Marshall ; Nicole Guiso ; Anthony D. Keil ; Andrew Lawrence ; Jenny Robson ; Geoff Hogg ; Ruiting LanSource :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2014.
Abstract
Acellular vaccines against
Url:
DOI: 10.3201/eid2004.131478
PubMed: 24655754
PubMed Central: 3966384
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PMC:3966384Le document en format XML
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Isolates, Australia</title>
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<author><name sortKey="Octavia, Sophie" sort="Octavia, Sophie" uniqKey="Octavia S" first="Sophie" last="Octavia">Sophie Octavia</name>
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<author><name sortKey="Ricafort, Lawrence" sort="Ricafort, Lawrence" uniqKey="Ricafort L" first="Lawrence" last="Ricafort">Lawrence Ricafort</name>
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<author><name sortKey="Sintchenko, Vitali" sort="Sintchenko, Vitali" uniqKey="Sintchenko V" first="Vitali" last="Sintchenko">Vitali Sintchenko</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Rapid Increase in Pertactin-deficient <italic>Bordetella pertussis</italic>
Isolates, Australia</title>
<author><name sortKey="Lam, Connie" sort="Lam, Connie" uniqKey="Lam C" first="Connie" last="Lam">Connie Lam</name>
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<author><name sortKey="Octavia, Sophie" sort="Octavia, Sophie" uniqKey="Octavia S" first="Sophie" last="Octavia">Sophie Octavia</name>
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<author><name sortKey="Ricafort, Lawrence" sort="Ricafort, Lawrence" uniqKey="Ricafort L" first="Lawrence" last="Ricafort">Lawrence Ricafort</name>
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<author><name sortKey="Sintchenko, Vitali" sort="Sintchenko, Vitali" uniqKey="Sintchenko V" first="Vitali" last="Sintchenko">Vitali Sintchenko</name>
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<author><name sortKey="Gilbert, Gwendolyn L" sort="Gilbert, Gwendolyn L" uniqKey="Gilbert G" first="Gwendolyn L." last="Gilbert">Gwendolyn L. Gilbert</name>
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<author><name sortKey="Wood, Nicholas" sort="Wood, Nicholas" uniqKey="Wood N" first="Nicholas" last="Wood">Nicholas Wood</name>
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<author><name sortKey="Mcintyre, Peter" sort="Mcintyre, Peter" uniqKey="Mcintyre P" first="Peter" last="Mcintyre">Peter Mcintyre</name>
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<author><name sortKey="Marshall, Helen" sort="Marshall, Helen" uniqKey="Marshall H" first="Helen" last="Marshall">Helen Marshall</name>
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<author><name sortKey="Guiso, Nicole" sort="Guiso, Nicole" uniqKey="Guiso N" first="Nicole" last="Guiso">Nicole Guiso</name>
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<author><name sortKey="Keil, Anthony D" sort="Keil, Anthony D" uniqKey="Keil A" first="Anthony D." last="Keil">Anthony D. Keil</name>
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<author><name sortKey="Lawrence, Andrew" sort="Lawrence, Andrew" uniqKey="Lawrence A" first="Andrew" last="Lawrence">Andrew Lawrence</name>
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<author><name sortKey="Robson, Jenny" sort="Robson, Jenny" uniqKey="Robson J" first="Jenny" last="Robson">Jenny Robson</name>
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<author><name sortKey="Hogg, Geoff" sort="Hogg, Geoff" uniqKey="Hogg G" first="Geoff" last="Hogg">Geoff Hogg</name>
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<author><name sortKey="Lan, Ruiting" sort="Lan, Ruiting" uniqKey="Lan R" first="Ruiting" last="Lan">Ruiting Lan</name>
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<series><title level="j">Emerging Infectious Diseases</title>
<idno type="ISSN">1080-6040</idno>
<idno type="eISSN">1080-6059</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><p>Acellular vaccines against <italic>Bordetella pertussis</italic>
were introduced in Australia in 1997. By 2000, these vaccines had replaced whole-cell vaccines. During 2008–2012, a large outbreak of pertussis occurred. During this period, 30% (96/320) of <italic>B. pertussis</italic>
isolates did not express the vaccine antigen pertactin (prn). Multiple mechanisms of prn inactivation were documented, including IS<italic>481</italic>
and IS<italic>1002</italic>
disruptions, a variation within a homopolymeric tract, and deletion of the <italic>prn</italic>
gene. The mechanism of lack of expression of prn in 16 (17%) isolates could not be determined at the sequence level. These findings suggest that <italic>B. pertussis</italic>
not expressing prn arose independently multiple times since 2008, rather than by expansion of a single prn-negative clone. All but 1 isolate had <italic>ptxA1</italic>
, <italic>prn2</italic>
, and <italic>ptxP3</italic>
, the alleles representative of currently circulating strains in Australia. This pattern is consistent with continuing evolution of <italic>B. pertussis</italic>
in response to vaccine selection pressure.</p>
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