Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study.
Identifieur interne : 001425 ( Ncbi/Curation ); précédent : 001424; suivant : 001426Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study.
Auteurs : A. Geloen [Australie] ; K. Chapelier ; A. Cividjian ; E. Dantony ; M. Rabilloud ; C N May ; L. QuintinSource :
- Critical care medicine [ 1530-0293 ] ; 2013.
Descripteurs français
- KwdFr :
- Agonistes des récepteurs alpha-2 adrénergiques (usage thérapeutique), Animaux, Attribution aléatoire, Choc septique (), Choc septique (physiopathologie), Clonidine (usage thérapeutique), Dexmédétomidine (usage thérapeutique), Hypotension artérielle (physiopathologie), Hypotension artérielle (traitement médicamenteux), Hypotension artérielle (étiologie), Lipopolysaccharides, Mâle, Norépinéphrine (usage thérapeutique), Pression artérielle (), Projets pilotes, Rat Sprague-Dawley, Rats, Vasoconstricteurs (usage thérapeutique).
- MESH :
- physiopathologie : Choc septique, Hypotension artérielle.
- traitement médicamenteux : Hypotension artérielle.
- usage thérapeutique : Agonistes des récepteurs alpha-2 adrénergiques, Clonidine, Dexmédétomidine, Norépinéphrine, Vasoconstricteurs.
- étiologie : Hypotension artérielle.
- Animaux, Attribution aléatoire, Choc septique, Lipopolysaccharides, Mâle, Pression artérielle, Projets pilotes, Rat Sprague-Dawley, Rats.
English descriptors
- KwdEn :
- Adrenergic alpha-2 Receptor Agonists (therapeutic use), Animals, Arterial Pressure (drug effects), Clonidine (therapeutic use), Dexmedetomidine (therapeutic use), Hypotension (drug therapy), Hypotension (etiology), Hypotension (physiopathology), Lipopolysaccharides, Male, Norepinephrine (therapeutic use), Pilot Projects, Random Allocation, Rats, Rats, Sprague-Dawley, Shock, Septic (chemically induced), Shock, Septic (complications), Shock, Septic (physiopathology), Vasoconstrictor Agents (therapeutic use).
- MESH :
- chemical , therapeutic use : Adrenergic alpha-2 Receptor Agonists, Clonidine, Dexmedetomidine, Norepinephrine, Vasoconstrictor Agents.
- chemically induced : Shock, Septic.
- complications : Shock, Septic.
- drug effects : Arterial Pressure.
- drug therapy : Hypotension.
- etiology : Hypotension.
- physiopathology : Hypotension, Shock, Septic.
- Animals, Lipopolysaccharides, Male, Pilot Projects, Random Allocation, Rats, Rats, Sprague-Dawley.
Abstract
During septic shock, vasopressors are a cornerstone of therapy. In septic shock, very high doses of vasopressors sometimes have to be used due to vascular desensitization, the mechanisms of which are poorly understood. This study assesses whether α-2 agonists increase pressor responsiveness following lipopolysaccharide administration.
DOI: 10.1097/CCM.0b013e3182986248
PubMed: 23963131
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pubmed:23963131Le document en format XML
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<term>Dexmedetomidine (therapeutic use)</term>
<term>Hypotension (drug therapy)</term>
<term>Hypotension (etiology)</term>
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<term>Norepinephrine</term>
<term>Vasoconstrictor Agents</term>
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<term>Norépinéphrine</term>
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<front><div type="abstract" xml:lang="en">During septic shock, vasopressors are a cornerstone of therapy. In septic shock, very high doses of vasopressors sometimes have to be used due to vascular desensitization, the mechanisms of which are poorly understood. This study assesses whether α-2 agonists increase pressor responsiveness following lipopolysaccharide administration.</div>
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