Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis
Identifieur interne : 001090 ( Ncbi/Curation ); précédent : 001089; suivant : 001091Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis
Auteurs : Philippe Corcia [France] ; Clovis Tauber [France] ; Johnnie Vercoullie [France] ; Nicolas Arlicot [France] ; Caroline Prunier [France] ; Julien Praline [France] ; Guillaume Nicolas [France] ; Yann Venel [France] ; Caroline Hommet [France] ; Jean-Louis Baulieu [France] ; Jean-Philippe Cottier [France] ; Catherine Roussel [France] ; Mickael Kassiou [Australie] ; Denis Guilloteau [France] ; Maria-Joao Ribeiro [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
There is growing evidence of activated microglia and inflammatory processes in the cerebral cortex in amyotrophic lateral sclerosis (ALS). Activated microglia is characterized by increased expression of the 18 kDa translocator protein (TSPO) in the brain and may be a useful biomarker of inflammation. In this study, we evaluated neuroinflammation in ALS patients using a radioligand of TSPO, 18F-DPA-714. Ten patients with probable or definite ALS (all right-handed, without dementia, and untreated by riluzole or other medication that might bias the binding on the TSPO), were enrolled prospectively and eight healthy controls matched for age underwent a PET study. Comparison of the distribution volume ratios between both groups were performed using a Mann-Whitney’s test. Significant increase of distribution of volume ratios values corresponding to microglial activation was found in the ALS sample in primary motor, supplementary motor and temporal cortex (
Url:
DOI: 10.1371/journal.pone.0052941
PubMed: 23300829
PubMed Central: 3534121
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PMC:3534121Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis</title>
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<author><name sortKey="Vercoullie, Johnnie" sort="Vercoullie, Johnnie" uniqKey="Vercoullie J" first="Johnnie" last="Vercoullie">Johnnie Vercoullie</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Université François Rabelais de Tours, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université François Rabelais de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université François-Rabelais de Tours</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Inserm U 930, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U 930, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arlicot, Nicolas" sort="Arlicot, Nicolas" uniqKey="Arlicot N" first="Nicolas" last="Arlicot">Nicolas Arlicot</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Université François Rabelais de Tours, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université François Rabelais de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université François-Rabelais de Tours</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Inserm U 930, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U 930, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Nuclear Medicine Department, CHRU Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Nuclear Medicine Department, CHRU Tours</wicri:regionArea>
<wicri:noRegion>CHRU Tours</wicri:noRegion>
<wicri:noRegion>CHRU Tours</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Prunier, Caroline" sort="Prunier, Caroline" uniqKey="Prunier C" first="Caroline" last="Prunier">Caroline Prunier</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Nuclear Medicine Department, CHRU Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Nuclear Medicine Department, CHRU Tours</wicri:regionArea>
<wicri:noRegion>CHRU Tours</wicri:noRegion>
<wicri:noRegion>CHRU Tours</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Praline, Julien" sort="Praline, Julien" uniqKey="Praline J" first="Julien" last="Praline">Julien Praline</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>ALS Center, Department of Neurology, CHRU Bretonneau, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ALS Center, Department of Neurology, CHRU Bretonneau, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nicolas, Guillaume" sort="Nicolas, Guillaume" uniqKey="Nicolas G" first="Guillaume" last="Nicolas">Guillaume Nicolas</name>
<affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>ALS Center, Department of Neurology, CHRU Angers, Angers, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ALS Center, Department of Neurology, CHRU Angers, Angers</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Angers</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Venel, Yann" sort="Venel, Yann" uniqKey="Venel Y" first="Yann" last="Venel">Yann Venel</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Nuclear Medicine Department, CHRU Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Nuclear Medicine Department, CHRU Tours</wicri:regionArea>
<wicri:noRegion>CHRU Tours</wicri:noRegion>
<wicri:noRegion>CHRU Tours</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hommet, Caroline" sort="Hommet, Caroline" uniqKey="Hommet C" first="Caroline" last="Hommet">Caroline Hommet</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Université François Rabelais de Tours, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université François Rabelais de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université François-Rabelais de Tours</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Inserm U 930, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U 930, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baulieu, Jean Louis" sort="Baulieu, Jean Louis" uniqKey="Baulieu J" first="Jean-Louis" last="Baulieu">Jean-Louis Baulieu</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Université François Rabelais de Tours, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université François Rabelais de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université François-Rabelais de Tours</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Inserm U 930, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U 930, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Nuclear Medicine Department, CHRU Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Nuclear Medicine Department, CHRU Tours</wicri:regionArea>
<wicri:noRegion>CHRU Tours</wicri:noRegion>
<wicri:noRegion>CHRU Tours</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cottier, Jean Philippe" sort="Cottier, Jean Philippe" uniqKey="Cottier J" first="Jean-Philippe" last="Cottier">Jean-Philippe Cottier</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Université François Rabelais de Tours, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université François Rabelais de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université François-Rabelais de Tours</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Inserm U 930, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U 930, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roussel, Catherine" sort="Roussel, Catherine" uniqKey="Roussel C" first="Catherine" last="Roussel">Catherine Roussel</name>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>CIC-IT 806 Ultrasons et Radiopharmaceutiques, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIC-IT 806 Ultrasons et Radiopharmaceutiques, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kassiou, Mickael" sort="Kassiou, Mickael" uniqKey="Kassiou M" first="Mickael" last="Kassiou">Mickael Kassiou</name>
<affiliation wicri:level="4"><nlm:aff id="aff7"><addr-line>School of Chemistry, University of Sydney, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Chemistry, University of Sydney, New South Wales</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Brain and Mind Research Institute, Sydney, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Brain and Mind Research Institute, Sydney, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Discipline of Med Rad Sci, Univ Sydney, New South, Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Discipline of Med Rad Sci, Univ Sydney, New South, Wales</wicri:regionArea>
<wicri:noRegion>Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guilloteau, Denis" sort="Guilloteau, Denis" uniqKey="Guilloteau D" first="Denis" last="Guilloteau">Denis Guilloteau</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Université François Rabelais de Tours, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université François Rabelais de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université François-Rabelais de Tours</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Inserm U 930, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U 930, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Nuclear Medicine Department, CHRU Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Nuclear Medicine Department, CHRU Tours</wicri:regionArea>
<wicri:noRegion>CHRU Tours</wicri:noRegion>
<wicri:noRegion>CHRU Tours</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>CIC-IT 806 Ultrasons et Radiopharmaceutiques, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIC-IT 806 Ultrasons et Radiopharmaceutiques, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ribeiro, Maria Joao" sort="Ribeiro, Maria Joao" uniqKey="Ribeiro M" first="Maria-Joao" last="Ribeiro">Maria-Joao Ribeiro</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Université François Rabelais de Tours, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université François Rabelais de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
<settlement type="city">Tours</settlement>
</placeName>
<orgName type="university">Université François-Rabelais de Tours</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Inserm U 930, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U 930, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Nuclear Medicine Department, CHRU Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Nuclear Medicine Department, CHRU Tours</wicri:regionArea>
<wicri:noRegion>CHRU Tours</wicri:noRegion>
<wicri:noRegion>CHRU Tours</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>CIC-IT 806 Ultrasons et Radiopharmaceutiques, Tours, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CIC-IT 806 Ultrasons et Radiopharmaceutiques, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>There is growing evidence of activated microglia and inflammatory processes in the cerebral cortex in amyotrophic lateral sclerosis (ALS). Activated microglia is characterized by increased expression of the 18 kDa translocator protein (TSPO) in the brain and may be a useful biomarker of inflammation. In this study, we evaluated neuroinflammation in ALS patients using a radioligand of TSPO, <sup>18</sup>
F-DPA-714. Ten patients with probable or definite ALS (all right-handed, without dementia, and untreated by riluzole or other medication that might bias the binding on the TSPO), were enrolled prospectively and eight healthy controls matched for age underwent a PET study. Comparison of the distribution volume ratios between both groups were performed using a Mann-Whitney’s test. Significant increase of distribution of volume ratios values corresponding to microglial activation was found in the ALS sample in primary motor, supplementary motor and temporal cortex (<italic>p</italic>
= 0.009, <italic>p</italic>
= 0.001 and <italic>p</italic>
= 0.004, respectively). These results suggested that the cortical uptake of <sup>18</sup>
F-DPA-714 was increased in ALS patients during the “time of diagnosis” phase of the disease. This finding might improve our understanding of the pathophysiology of ALS and might be a surrogate marker of efficacy of treatment on microglial activation.</p>
</div>
</front>
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