Diagnostic Microbiologic Methods in the GEMS-1 Case/Control Study
Identifieur interne : 001038 ( Ncbi/Curation ); précédent : 001037; suivant : 001039Diagnostic Microbiologic Methods in the GEMS-1 Case/Control Study
Auteurs : Sandra Panchalingam ; Martin Antonio [Gambie] ; Anowar Hossain [Bangladesh] ; Inacio Mandomando [Mozambique] ; Ben Ochieng ; Joseph Oundo ; T. Ramamurthy [Inde] ; Boubou Tamboura ; Anita K. M. Zaidi [Pakistan] ; William Petri ; Eric Houpt ; Patrick Murray [Géorgie (pays)] ; Valeria Prado ; Roberto Vidal ; Duncan Steele [Suisse] ; Nancy Strockbine [Géorgie (pays)] ; Philippe Sansonetti [France] ; Roger I. Glass [Géorgie (pays)] ; Roy M. Robins-Browne [Australie] ; Marija Tauschek [Australie] ; Ann-Marie Svennerholm [Suède] ; Karen Kotloff ; Myron M. Levine ; James P. NataroSource :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2012.
Abstract
To understand the etiology of moderate-to-severe diarrhea among children in high mortality areas of sub-Saharan Africa and South Asia, we performed a comprehensive case/control study of children aged <5 years at 7 sites. Each site employed an identical case/control study design and each utilized a uniform comprehensive set of microbiological assays to identify the likely bacterial, viral and protozoal etiologies. The selected assays effected a balanced consideration of cost, robustness and performance, and all assays were performed at the study sites. Identification of bacterial pathogens employed streamlined conventional bacteriologic biochemical and serological algorithms. Diarrheagenic
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DOI: 10.1093/cid/cis754
PubMed: 23169941
PubMed Central: 3502308
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diagnostic Microbiologic Methods in the GEMS-1 Case/Control Study</title><author><name sortKey="Panchalingam, Sandra" sort="Panchalingam, Sandra" uniqKey="Panchalingam S" first="Sandra" last="Panchalingam">Sandra Panchalingam</name><affiliation><nlm:aff id="af1"><addr-line>Center for Vaccine Development</addr-line>,<institution>University of Maryland School of Medicine</institution>,<addr-line>Baltimore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Antonio, Martin" sort="Antonio, Martin" uniqKey="Antonio M" first="Martin" last="Antonio">Martin Antonio</name><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Medical Research Council, Fajara</institution>,<country>The Gambia</country></nlm:aff><country xml:lang="fr">Gambie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hossain, Anowar" sort="Hossain, Anowar" uniqKey="Hossain A" first="Anowar" last="Hossain">Anowar Hossain</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>International Center for Diarrhoeal Disease Research</institution>, Dhaka,<country>Bangladesh</country></nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mandomando, Inacio" sort="Mandomando, Inacio" uniqKey="Mandomando I" first="Inacio" last="Mandomando">Inacio Mandomando</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>Centro de Investigacao em Saude</institution>,<addr-line>Manhica, Maputo</addr-line>,<country>Mozambique</country></nlm:aff><country xml:lang="fr">Mozambique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ochieng, Ben" sort="Ochieng, Ben" uniqKey="Ochieng B" first="Ben" last="Ochieng">Ben Ochieng</name><affiliation><nlm:aff id="af5"><institution>Kenya Medical Research Institute/CDC</institution>,<addr-line>Kisumu</addr-line></nlm:aff></affiliation></author><author><name sortKey="Oundo, Joseph" sort="Oundo, Joseph" uniqKey="Oundo J" first="Joseph" last="Oundo">Joseph Oundo</name><affiliation><nlm:aff id="af5"><institution>Kenya Medical Research Institute/CDC</institution>,<addr-line>Kisumu</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ramamurthy, T" sort="Ramamurthy, T" uniqKey="Ramamurthy T" first="T." last="Ramamurthy">T. Ramamurthy</name><affiliation wicri:level="1"><nlm:aff id="af6"><institution>National Institute of Cholera and Enteric Diseases</institution>,<addr-line>Kolkata</addr-line>,<country>India</country></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tamboura, Boubou" sort="Tamboura, Boubou" uniqKey="Tamboura B" first="Boubou" last="Tamboura">Boubou Tamboura</name><affiliation><nlm:aff id="af7"><institution>Center for Vaccine Development–Mali</institution>,<addr-line>Bamako</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zaidi, Anita K M" sort="Zaidi, Anita K M" uniqKey="Zaidi A" first="Anita K. M." last="Zaidi">Anita K. M. Zaidi</name><affiliation wicri:level="1"><nlm:aff id="af8"><institution>The Aga Khan University</institution>,<addr-line>Karachi</addr-line>,<country>Pakistan</country></nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Petri, William" sort="Petri, William" uniqKey="Petri W" first="William" last="Petri">William Petri</name><affiliation><nlm:aff id="af9"><addr-line>Department of Medicine</addr-line>,<institution>University of Virginia School of Medicine</institution>,<addr-line>Charlottesville</addr-line></nlm:aff></affiliation></author><author><name sortKey="Houpt, Eric" sort="Houpt, Eric" uniqKey="Houpt E" first="Eric" last="Houpt">Eric Houpt</name><affiliation><nlm:aff id="af9"><addr-line>Department of Medicine</addr-line>,<institution>University of Virginia School of Medicine</institution>,<addr-line>Charlottesville</addr-line></nlm:aff></affiliation></author><author><name sortKey="Murray, Patrick" sort="Murray, Patrick" uniqKey="Murray P" first="Patrick" last="Murray">Patrick Murray</name><affiliation wicri:level="1"><nlm:aff id="af10"><institution>US Centers for Disease Control and Prevention</institution>,<addr-line>Atlanta, Georgia</addr-line></nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Atlanta</wicri:regionArea></affiliation></author><author><name sortKey="Prado, Valeria" sort="Prado, Valeria" uniqKey="Prado V" first="Valeria" last="Prado">Valeria Prado</name><affiliation><nlm:aff id="af11"><institution>Universidad de Chile</institution>,<addr-line>Santiago</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vidal, Roberto" sort="Vidal, Roberto" uniqKey="Vidal R" first="Roberto" last="Vidal">Roberto Vidal</name><affiliation><nlm:aff id="af11"><institution>Universidad de Chile</institution>,<addr-line>Santiago</addr-line></nlm:aff></affiliation></author><author><name sortKey="Steele, Duncan" sort="Steele, Duncan" uniqKey="Steele D" first="Duncan" last="Steele">Duncan Steele</name><affiliation wicri:level="1"><nlm:aff id="af12"><institution>World Health Organization</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Strockbine, Nancy" sort="Strockbine, Nancy" uniqKey="Strockbine N" first="Nancy" last="Strockbine">Nancy Strockbine</name><affiliation wicri:level="1"><nlm:aff id="af10"><institution>US Centers for Disease Control and Prevention</institution>,<addr-line>Atlanta, Georgia</addr-line></nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Atlanta</wicri:regionArea></affiliation></author><author><name sortKey="Sansonetti, Philippe" sort="Sansonetti, Philippe" uniqKey="Sansonetti P" first="Philippe" last="Sansonetti">Philippe Sansonetti</name><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Institut Pasteur</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Glass, Roger I" sort="Glass, Roger I" uniqKey="Glass R" first="Roger I." last="Glass">Roger I. 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Robins-Browne</name><affiliation wicri:level="1"><nlm:aff id="af14"><institution>University of Melbourne</institution>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tauschek, Marija" sort="Tauschek, Marija" uniqKey="Tauschek M" first="Marija" last="Tauschek">Marija Tauschek</name><affiliation wicri:level="1"><nlm:aff id="af14"><institution>University of Melbourne</institution>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Svennerholm, Ann Marie" sort="Svennerholm, Ann Marie" uniqKey="Svennerholm A" first="Ann-Marie" last="Svennerholm">Ann-Marie Svennerholm</name><affiliation wicri:level="1"><nlm:aff id="af15"><institution>University of Gothenburg</institution>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kotloff, Karen" sort="Kotloff, Karen" uniqKey="Kotloff K" first="Karen" last="Kotloff">Karen Kotloff</name><affiliation><nlm:aff id="af1"><addr-line>Center for Vaccine Development</addr-line>,<institution>University of Maryland School of Medicine</institution>,<addr-line>Baltimore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Levine, Myron M" sort="Levine, Myron M" uniqKey="Levine M" first="Myron M." last="Levine">Myron M. 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Ramamurthy</name><affiliation wicri:level="1"><nlm:aff id="af6"><institution>National Institute of Cholera and Enteric Diseases</institution>,<addr-line>Kolkata</addr-line>,<country>India</country></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tamboura, Boubou" sort="Tamboura, Boubou" uniqKey="Tamboura B" first="Boubou" last="Tamboura">Boubou Tamboura</name><affiliation><nlm:aff id="af7"><institution>Center for Vaccine Development–Mali</institution>,<addr-line>Bamako</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zaidi, Anita K M" sort="Zaidi, Anita K M" uniqKey="Zaidi A" first="Anita K. M." last="Zaidi">Anita K. M. Zaidi</name><affiliation wicri:level="1"><nlm:aff id="af8"><institution>The Aga Khan University</institution>,<addr-line>Karachi</addr-line>,<country>Pakistan</country></nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Petri, William" sort="Petri, William" uniqKey="Petri W" first="William" last="Petri">William Petri</name><affiliation><nlm:aff id="af9"><addr-line>Department of Medicine</addr-line>,<institution>University of Virginia School of Medicine</institution>,<addr-line>Charlottesville</addr-line></nlm:aff></affiliation></author><author><name sortKey="Houpt, Eric" sort="Houpt, Eric" uniqKey="Houpt E" first="Eric" last="Houpt">Eric Houpt</name><affiliation><nlm:aff id="af9"><addr-line>Department of Medicine</addr-line>,<institution>University of Virginia School of Medicine</institution>,<addr-line>Charlottesville</addr-line></nlm:aff></affiliation></author><author><name sortKey="Murray, Patrick" sort="Murray, Patrick" uniqKey="Murray P" first="Patrick" last="Murray">Patrick Murray</name><affiliation wicri:level="1"><nlm:aff id="af10"><institution>US Centers for Disease Control and Prevention</institution>,<addr-line>Atlanta, Georgia</addr-line></nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Atlanta</wicri:regionArea></affiliation></author><author><name sortKey="Prado, Valeria" sort="Prado, Valeria" uniqKey="Prado V" first="Valeria" last="Prado">Valeria Prado</name><affiliation><nlm:aff id="af11"><institution>Universidad de Chile</institution>,<addr-line>Santiago</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vidal, Roberto" sort="Vidal, Roberto" uniqKey="Vidal R" first="Roberto" last="Vidal">Roberto Vidal</name><affiliation><nlm:aff id="af11"><institution>Universidad de Chile</institution>,<addr-line>Santiago</addr-line></nlm:aff></affiliation></author><author><name sortKey="Steele, Duncan" sort="Steele, Duncan" uniqKey="Steele D" first="Duncan" last="Steele">Duncan Steele</name><affiliation wicri:level="1"><nlm:aff id="af12"><institution>World Health Organization</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Strockbine, Nancy" sort="Strockbine, Nancy" uniqKey="Strockbine N" first="Nancy" last="Strockbine">Nancy Strockbine</name><affiliation wicri:level="1"><nlm:aff id="af10"><institution>US Centers for Disease Control and Prevention</institution>,<addr-line>Atlanta, Georgia</addr-line></nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Atlanta</wicri:regionArea></affiliation></author><author><name sortKey="Sansonetti, Philippe" sort="Sansonetti, Philippe" uniqKey="Sansonetti P" first="Philippe" last="Sansonetti">Philippe Sansonetti</name><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Institut Pasteur</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Glass, Roger I" sort="Glass, Roger I" uniqKey="Glass R" first="Roger I." last="Glass">Roger I. Glass</name><affiliation wicri:level="1"><nlm:aff id="af10"><institution>US Centers for Disease Control and Prevention</institution>,<addr-line>Atlanta, Georgia</addr-line></nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Atlanta</wicri:regionArea></affiliation></author><author><name sortKey="Robins Browne, Roy M" sort="Robins Browne, Roy M" uniqKey="Robins Browne R" first="Roy M." last="Robins-Browne">Roy M. Robins-Browne</name><affiliation wicri:level="1"><nlm:aff id="af14"><institution>University of Melbourne</institution>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tauschek, Marija" sort="Tauschek, Marija" uniqKey="Tauschek M" first="Marija" last="Tauschek">Marija Tauschek</name><affiliation wicri:level="1"><nlm:aff id="af14"><institution>University of Melbourne</institution>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Svennerholm, Ann Marie" sort="Svennerholm, Ann Marie" uniqKey="Svennerholm A" first="Ann-Marie" last="Svennerholm">Ann-Marie Svennerholm</name><affiliation wicri:level="1"><nlm:aff id="af15"><institution>University of Gothenburg</institution>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kotloff, Karen" sort="Kotloff, Karen" uniqKey="Kotloff K" first="Karen" last="Kotloff">Karen Kotloff</name><affiliation><nlm:aff id="af1"><addr-line>Center for Vaccine Development</addr-line>,<institution>University of Maryland School of Medicine</institution>,<addr-line>Baltimore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Levine, Myron M" sort="Levine, Myron M" uniqKey="Levine M" first="Myron M." last="Levine">Myron M. Levine</name><affiliation><nlm:aff id="af1"><addr-line>Center for Vaccine Development</addr-line>,<institution>University of Maryland School of Medicine</institution>,<addr-line>Baltimore</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nataro, James P" sort="Nataro, James P" uniqKey="Nataro J" first="James P." last="Nataro">James P. Nataro</name><affiliation><nlm:aff id="af1"><addr-line>Center for Vaccine Development</addr-line>,<institution>University of Maryland School of Medicine</institution>,<addr-line>Baltimore</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af16"><addr-line>Department of Pediatrics</addr-line>,<institution>University of Virginia School of Medicine</institution>,<addr-line>Charlottesville</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>To understand the etiology of moderate-to-severe diarrhea among children in high mortality areas of sub-Saharan Africa and South Asia, we performed a comprehensive case/control study of children aged <5 years at 7 sites. Each site employed an identical case/control study design and each utilized a uniform comprehensive set of microbiological assays to identify the likely bacterial, viral and protozoal etiologies. The selected assays effected a balanced consideration of cost, robustness and performance, and all assays were performed at the study sites. Identification of bacterial pathogens employed streamlined conventional bacteriologic biochemical and serological algorithms. Diarrheagenic <italic>Escherichia coli</italic> were identified by application of a multiplex polymerase chain reaction assay for enterotoxigenic, enteroaggregative, and enteropathogenic <italic>E. coli.</italic> Rotavirus, adenovirus, <italic>Entamoeba histolytica</italic>, <italic>Giardia enterica</italic>, and <italic>Cryptosporidium</italic> species were detected by commercially available enzyme immunoassays on stool samples. Samples positive for adenovirus were further evaluated for adenovirus serotypes 40 and 41. We developed a novel multiplex assay to detect norovirus (types 1 and 2), astrovirus, and sapovirus. The portfolio of diagnostic assays used in the GEMS study can be broadly applied in developing countries seeking robust cost-effective methods for enteric pathogen detection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cary, Sg" uniqKey="Cary S">SG Cary</name></author><author><name sortKey="Blair, Eb" uniqKey="Blair E">EB Blair</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wells, Jg" uniqKey="Wells J">JG Wells</name></author><author><name sortKey="Morris, Gk" uniqKey="Morris G">GK Morris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murray, Pr" uniqKey="Murray P">PR Murray</name></author><author><name sortKey="Baron, Ej" uniqKey="Baron E">EJ Baron</name></author><author><name sortKey="Jorgensen, Jh" uniqKey="Jorgensen J">JH Jorgensen</name></author><author><name sortKey="Pfaller, Ma" uniqKey="Pfaller M">MA Pfaller</name></author><author><name sortKey="Yolken, Rh" uniqKey="Yolken R">RH Yolken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernagozzi, M" uniqKey="Bernagozzi M">M Bernagozzi</name></author><author><name sortKey="Bianucci, F" uniqKey="Bianucci F">F Bianucci</name></author><author><name sortKey="Scerre, E" uniqKey="Scerre E">E Scerre</name></author><author><name sortKey="Sacchetti, R" uniqKey="Sacchetti R">R Sacchetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blaser, Mj" uniqKey="Blaser M">MJ Blaser</name></author><author><name sortKey="Berkowitz, Id" uniqKey="Berkowitz I">ID Berkowitz</name></author><author><name sortKey="Laforce, Fm" uniqKey="Laforce F">FM Laforce</name></author><author><name sortKey="Cravens, J" uniqKey="Cravens J">J Cravens</name></author><author><name sortKey="Reller, Lb" uniqKey="Reller L">LB Reller</name></author><author><name sortKey="Wang, Wl" uniqKey="Wang W">WL 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Scheutz</name></author><author><name sortKey="Rasko, Da" uniqKey="Rasko D">DA Rasko</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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