Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial.
Identifieur interne : 000631 ( Ncbi/Curation ); précédent : 000630; suivant : 000632Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial.
Auteurs : B E De Galan [Australie] ; S. Zoungas [Australie] ; J. Chalmers [Australie] ; C. Anderson [Australie] ; C. Dufouil [France] ; A. Pillai [Australie] ; M. Cooper [Australie] ; D E Grobbee [Pays-Bas] ; M. Hackett [Australie] ; P. Hamet [Canada] ; S R Heller [Royaume-Uni] ; L. Lisheng [République populaire de Chine] ; S. Macmahon [Australie] ; G. Mancia [Italie] ; B. Neal [Australie] ; C Y Pan [République populaire de Chine] ; A. Patel [Australie] ; N. Poulter [Royaume-Uni] ; F. Travert [France] ; M. Woodward [Australie]Source :
- Diabetologia [ 1432-0428 ] ; 2009.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (épidémiologie), Angiopathies diabétiques (), Angiopathies diabétiques (épidémiologie), Antihypertenseurs (usage thérapeutique), Association de médicaments, Association médicamenteuse, Cognition (), Diabète de type 2 (), Diabète de type 2 (mortalité), Diabète de type 2 (psychologie), Diabète de type 2 (sang), Facteurs de risque, Femelle, Gliclazide (usage thérapeutique), Humains, Hypoglycémiants (usage thérapeutique), Hypoglycémie (épidémiologie), Indapamide (usage thérapeutique), Infarctus du myocarde (épidémiologie), Mâle, Niveau d'instruction, Périndopril (usage thérapeutique), Questionnaire sur l'état mental de Kahn, Sujet âgé, Troubles de la cognition ().
- MESH :
- mortalité : Diabète de type 2.
- psychologie : Diabète de type 2.
- sang : Diabète de type 2.
- usage thérapeutique : Antihypertenseurs, Gliclazide, Hypoglycémiants, Indapamide, Périndopril.
- épidémiologie : Accident vasculaire cérébral, Angiopathies diabétiques, Hypoglycémie, Infarctus du myocarde.
- Angiopathies diabétiques, Association de médicaments, Association médicamenteuse, Cognition, Diabète de type 2, Facteurs de risque, Femelle, Humains, Mâle, Niveau d'instruction, Questionnaire sur l'état mental de Kahn, Sujet âgé, Troubles de la cognition.
English descriptors
- KwdEn :
- Aged, Antihypertensive Agents (therapeutic use), Cognition (drug effects), Cognition Disorders (complications), Diabetes Mellitus, Type 2 (blood), Diabetes Mellitus, Type 2 (complications), Diabetes Mellitus, Type 2 (mortality), Diabetes Mellitus, Type 2 (psychology), Diabetic Angiopathies (epidemiology), Diabetic Angiopathies (prevention & control), Drug Combinations, Drug Therapy, Combination, Educational Status, Female, Gliclazide (therapeutic use), Humans, Hypoglycemia (epidemiology), Hypoglycemic Agents (therapeutic use), Indapamide (therapeutic use), Male, Mental Status Schedule, Myocardial Infarction (epidemiology), Perindopril (therapeutic use), Risk Factors, Stroke (epidemiology).
- MESH :
- chemical , therapeutic use : Antihypertensive Agents, Gliclazide, Hypoglycemic Agents, Indapamide, Perindopril.
- blood : Diabetes Mellitus, Type 2.
- complications : Cognition Disorders, Diabetes Mellitus, Type 2.
- drug effects : Cognition.
- epidemiology : Diabetic Angiopathies, Hypoglycemia, Myocardial Infarction, Stroke.
- mortality : Diabetes Mellitus, Type 2.
- prevention & control : Diabetic Angiopathies.
- psychology : Diabetes Mellitus, Type 2.
- Aged, Drug Combinations, Drug Therapy, Combination, Educational Status, Female, Humans, Male, Mental Status Schedule, Risk Factors.
Abstract
The relationship between cognitive function, cardiovascular disease and premature death is not well established in patients with type 2 diabetes. We assessed the effects of cognitive function in 11,140 patients with type 2 diabetes who participated in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial. Furthermore, we tested whether level of cognitive function altered the beneficial effects of the BP-lowering and glycaemic-control regimens in the trial.
DOI: 10.1007/s00125-009-1484-7
PubMed: 19688336
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pubmed:19688336Le document en format XML
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<country xml:lang="fr">Australie</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial.</title>
<author><name sortKey="De Galan, B E" sort="De Galan, B E" uniqKey="De Galan B" first="B E" last="De Galan">B E De Galan</name>
<affiliation wicri:level="4"><nlm:affiliation>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown, Sydney, NSW, 2050, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
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<author><name sortKey="Zoungas, S" sort="Zoungas, S" uniqKey="Zoungas S" first="S" last="Zoungas">S. Zoungas</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown, Sydney, NSW, 2050</wicri:regionArea>
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<author><name sortKey="Hamet, P" sort="Hamet, P" uniqKey="Hamet P" first="P" last="Hamet">P. Hamet</name>
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<wicri:regionArea>University of Sheffield and Sheffield Teaching Hospitals National Health Service Foundation Trust, Sheffield</wicri:regionArea>
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<author><name sortKey="Lisheng, L" sort="Lisheng, L" uniqKey="Lisheng L" first="L" last="Lisheng">L. Lisheng</name>
<affiliation wicri:level="3"><nlm:affiliation>Chinese Hypertension League Institute, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Chinese Hypertension League Institute, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
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<author><name sortKey="Macmahon, S" sort="Macmahon, S" uniqKey="Macmahon S" first="S" last="Macmahon">S. Macmahon</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown, Sydney, NSW, 2050</wicri:regionArea>
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</author>
<author><name sortKey="Mancia, G" sort="Mancia, G" uniqKey="Mancia G" first="G" last="Mancia">G. Mancia</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Milan-Bicocca and San Gerardo Hospital, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>University of Milan-Bicocca and San Gerardo Hospital, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Neal, B" sort="Neal, B" uniqKey="Neal B" first="B" last="Neal">B. Neal</name>
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<country xml:lang="fr">Australie</country>
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<author><name sortKey="Pan, C Y" sort="Pan, C Y" uniqKey="Pan C" first="C Y" last="Pan">C Y Pan</name>
<affiliation wicri:level="3"><nlm:affiliation>Chinese People's Liberation Army General Hospital, Beijing, China.</nlm:affiliation>
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<wicri:regionArea>Chinese People's Liberation Army General Hospital, Beijing</wicri:regionArea>
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<author><name sortKey="Patel, A" sort="Patel, A" uniqKey="Patel A" first="A" last="Patel">A. Patel</name>
<affiliation wicri:level="4"><nlm:affiliation>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown, Sydney, NSW, 2050, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
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</affiliation>
</author>
<author><name sortKey="Poulter, N" sort="Poulter, N" uniqKey="Poulter N" first="N" last="Poulter">N. Poulter</name>
<affiliation wicri:level="3"><nlm:affiliation>Imperial College and St Mary's Hospital, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Imperial College and St Mary's Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Travert, F" sort="Travert, F" uniqKey="Travert F" first="F" last="Travert">F. Travert</name>
<affiliation wicri:level="3"><nlm:affiliation>UPMC University of Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>UPMC University of Paris, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
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</author>
<author><name sortKey="Woodward, M" sort="Woodward, M" uniqKey="Woodward M" first="M" last="Woodward">M. Woodward</name>
<affiliation wicri:level="4"><nlm:affiliation>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown, Sydney, NSW, 2050, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown, Sydney, NSW, 2050</wicri:regionArea>
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<series><title level="j">Diabetologia</title>
<idno type="eISSN">1432-0428</idno>
<imprint><date when="2009" type="published">2009</date>
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<term>Antihypertensive Agents (therapeutic use)</term>
<term>Cognition (drug effects)</term>
<term>Cognition Disorders (complications)</term>
<term>Diabetes Mellitus, Type 2 (blood)</term>
<term>Diabetes Mellitus, Type 2 (complications)</term>
<term>Diabetes Mellitus, Type 2 (mortality)</term>
<term>Diabetes Mellitus, Type 2 (psychology)</term>
<term>Diabetic Angiopathies (epidemiology)</term>
<term>Diabetic Angiopathies (prevention & control)</term>
<term>Drug Combinations</term>
<term>Drug Therapy, Combination</term>
<term>Educational Status</term>
<term>Female</term>
<term>Gliclazide (therapeutic use)</term>
<term>Humans</term>
<term>Hypoglycemia (epidemiology)</term>
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<term>Indapamide (therapeutic use)</term>
<term>Male</term>
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<term>Myocardial Infarction (epidemiology)</term>
<term>Perindopril (therapeutic use)</term>
<term>Risk Factors</term>
<term>Stroke (epidemiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral (épidémiologie)</term>
<term>Angiopathies diabétiques ()</term>
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<term>Antihypertenseurs (usage thérapeutique)</term>
<term>Association de médicaments</term>
<term>Association médicamenteuse</term>
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<term>Niveau d'instruction</term>
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<term>Questionnaire sur l'état mental de Kahn</term>
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<term>Diabetes Mellitus, Type 2</term>
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</keywords>
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<term>Hypoglycemia</term>
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<term>Stroke</term>
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<term>Drug Combinations</term>
<term>Drug Therapy, Combination</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">The relationship between cognitive function, cardiovascular disease and premature death is not well established in patients with type 2 diabetes. We assessed the effects of cognitive function in 11,140 patients with type 2 diabetes who participated in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial. Furthermore, we tested whether level of cognitive function altered the beneficial effects of the BP-lowering and glycaemic-control regimens in the trial.</div>
</front>
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