Metabolic orchestration of T lineage differentiation and function.
Identifieur interne : 004E43 ( Ncbi/Checkpoint ); précédent : 004E42; suivant : 004E44Metabolic orchestration of T lineage differentiation and function.
Auteurs : Carmen S. Yong [France] ; Daouda Abba Moussa [France] ; Gaspard Cretenet [France] ; Sandrina Kinet [France] ; Valérie Dardalhon [France] ; Naomi Taylor [France]Source :
- FEBS letters [ 1873-3468 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- cytologie : Lymphocytes T.
- génétique : Métabolome.
- métabolisme : Lymphocytes T.
- Animaux, Différenciation cellulaire, Humains, Lignage cellulaire, Transduction du signal, Épigenèse génétique.
English descriptors
- KwdEn :
- MESH :
- cytology : T-Lymphocytes.
- genetics : Metabolome.
- metabolism : T-Lymphocytes.
- Animals, Cell Differentiation, Cell Lineage, Epigenesis, Genetic, Humans, Signal Transduction.
Abstract
T cells are stimulated by the engagement of antigen, cytokine, pathogen, and hormone receptors. While research performed over many years has focused on deciphering the molecular components of these pathways, recent data underscore the importance of the metabolic environment in conditioning responses to receptor engagement. The ability of T cells to undergo a massive proliferation and cytokine secretion in response to receptor signals requires alterations to their bioenergetic homeostasis, allowing them to meet new energetic and biosynthetic demands. The metabolic reprogramming of activated T cells is regulated not only by changes in intracellular nutrient uptake and utilization but also by nutrient and oxygen concentrations in the extracellular environment. Notably, the extracellular environment can be profoundly altered by pathological conditions such as infections and tumors, thereby perturbing the metabolism and function of antigen-specific T lymphocytes. This review highlights the interplay between diverse metabolic networks and the transcriptional/epigenetic states that condition T-cell differentiation, comparing the metabolic features of T lymphocytes with other immune cells. We further address recent discoveries in the metabolic pathways that govern T-cell function in physiological and pathological conditions.
DOI: 10.1002/1873-3468.12849
PubMed: 28901530
Affiliations:
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Yong</name><affiliation wicri:level="3"><nlm:affiliation>IGMM, CNRS, Univ. Montpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IGMM, CNRS, Univ. Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Abba Moussa, Daouda" sort="Abba Moussa, Daouda" uniqKey="Abba Moussa D" first="Daouda" last="Abba Moussa">Daouda Abba Moussa</name><affiliation wicri:level="3"><nlm:affiliation>IGMM, CNRS, Univ. Montpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IGMM, CNRS, Univ. 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Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Taylor, Naomi" sort="Taylor, Naomi" uniqKey="Taylor N" first="Naomi" last="Taylor">Naomi Taylor</name><affiliation wicri:level="3"><nlm:affiliation>IGMM, CNRS, Univ. Montpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IGMM, CNRS, Univ. Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author></analytic><series><title level="j">FEBS letters</title><idno type="eISSN">1873-3468</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Differentiation</term><term>Cell Lineage</term><term>Epigenesis, Genetic</term><term>Humans</term><term>Metabolome (genetics)</term><term>Signal Transduction</term><term>T-Lymphocytes (cytology)</term><term>T-Lymphocytes (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Différenciation cellulaire</term><term>Humains</term><term>Lignage cellulaire</term><term>Lymphocytes T (cytologie)</term><term>Lymphocytes T (métabolisme)</term><term>Métabolome (génétique)</term><term>Transduction du signal</term><term>Épigenèse génétique</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Metabolome</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Métabolome</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphocytes T</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Differentiation</term><term>Cell Lineage</term><term>Epigenesis, Genetic</term><term>Humans</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Différenciation cellulaire</term><term>Humains</term><term>Lignage cellulaire</term><term>Transduction du signal</term><term>Épigenèse génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">T cells are stimulated by the engagement of antigen, cytokine, pathogen, and hormone receptors. While research performed over many years has focused on deciphering the molecular components of these pathways, recent data underscore the importance of the metabolic environment in conditioning responses to receptor engagement. The ability of T cells to undergo a massive proliferation and cytokine secretion in response to receptor signals requires alterations to their bioenergetic homeostasis, allowing them to meet new energetic and biosynthetic demands. The metabolic reprogramming of activated T cells is regulated not only by changes in intracellular nutrient uptake and utilization but also by nutrient and oxygen concentrations in the extracellular environment. Notably, the extracellular environment can be profoundly altered by pathological conditions such as infections and tumors, thereby perturbing the metabolism and function of antigen-specific T lymphocytes. This review highlights the interplay between diverse metabolic networks and the transcriptional/epigenetic states that condition T-cell differentiation, comparing the metabolic features of T lymphocytes with other immune cells. We further address recent discoveries in the metabolic pathways that govern T-cell function in physiological and pathological conditions.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li></region><settlement><li>Montpellier</li></settlement></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Yong, Carmen S" sort="Yong, Carmen S" uniqKey="Yong C" first="Carmen S" last="Yong">Carmen S. Yong</name></region><name sortKey="Abba Moussa, Daouda" sort="Abba Moussa, Daouda" uniqKey="Abba Moussa D" first="Daouda" last="Abba Moussa">Daouda Abba Moussa</name><name sortKey="Cretenet, Gaspard" sort="Cretenet, Gaspard" uniqKey="Cretenet G" first="Gaspard" last="Cretenet">Gaspard Cretenet</name><name sortKey="Dardalhon, Valerie" sort="Dardalhon, Valerie" uniqKey="Dardalhon V" first="Valérie" last="Dardalhon">Valérie Dardalhon</name><name sortKey="Kinet, Sandrina" sort="Kinet, Sandrina" uniqKey="Kinet S" first="Sandrina" last="Kinet">Sandrina Kinet</name><name sortKey="Taylor, Naomi" sort="Taylor, Naomi" uniqKey="Taylor N" first="Naomi" last="Taylor">Naomi Taylor</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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