Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition
Identifieur interne : 004533 ( Ncbi/Checkpoint ); précédent : 004532; suivant : 004534Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition
Auteurs : Florine A. Eggink ; Inge C. Van Gool ; Alexandra Leary [France] ; Pamela M. Pollock [Australie] ; Emma J. Crosbie [Royaume-Uni] ; Linda Mileshkin [Australie] ; Ekaterina S. Jordanova ; Julien Adam [France] ; Luke Freeman-Mills [Royaume-Uni] ; David N. Church [Royaume-Uni] ; Carien L. Creutzberg ; Marco De Bruyn ; Hans W. Nijman ; Tjalling BosseSource :
- Oncoimmunology [ 2162-4011 ] ; 2016.
Abstract
High-risk endometrial cancer (EC) is an aggressive disease for which new therapeutic options are needed. Aims of this study were to validate the enhanced immune response in highly mutated ECs and to explore immune profiles in other EC subgroups. We evaluated immune infiltration in 116 high-risk ECs from the TransPORTEC consortium, previously classified into four molecular subtypes: (i) ultramutated
Url:
DOI: 10.1080/2162402X.2016.1264565
PubMed: 28344870
PubMed Central: 5353925
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immunological profiling of molecularly classified high-risk endometrial cancers identifies <italic>POLE</italic>
-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition</title>
<author><name sortKey="Eggink, Florine A" sort="Eggink, Florine A" uniqKey="Eggink F" first="Florine A." last="Eggink">Florine A. Eggink</name>
<affiliation><nlm:aff id="af0001"><institution>Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen</institution>
, Groningen,<country>the Netherlands</country>
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<wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry>
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<author><name sortKey="Van Gool, Inge C" sort="Van Gool, Inge C" uniqKey="Van Gool I" first="Inge C." last="Van Gool">Inge C. Van Gool</name>
<affiliation><nlm:aff id="af0002"><institution>Department of Pathology, Leiden University Medical Center</institution>
, Leiden,<country>the Netherlands</country>
</nlm:aff>
<wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry>
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<author><name sortKey="Leary, Alexandra" sort="Leary, Alexandra" uniqKey="Leary A" first="Alexandra" last="Leary">Alexandra Leary</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Pollock, Pamela M" sort="Pollock, Pamela M" uniqKey="Pollock P" first="Pamela M." last="Pollock">Pamela M. Pollock</name>
<affiliation wicri:level="1"><nlm:aff id="af0004"><institution>Queensland University of Technology (QUT), Translational Research Institute</institution>
, Brisbane, QLD,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Crosbie, Emma J" sort="Crosbie, Emma J" uniqKey="Crosbie E" first="Emma J." last="Crosbie">Emma J. Crosbie</name>
<affiliation wicri:level="1"><nlm:aff id="af0005"><institution>Institute of Cancer Sciences, University of Manchester, St Marys Hospital</institution>
, Manchester,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mileshkin, Linda" sort="Mileshkin, Linda" uniqKey="Mileshkin L" first="Linda" last="Mileshkin">Linda Mileshkin</name>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Division of Cancer Medicine, Peter MacCallum Cancer Centre</institution>
, East Melbourne, VIC,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jordanova, Ekaterina S" sort="Jordanova, Ekaterina S" uniqKey="Jordanova E" first="Ekaterina S." last="Jordanova">Ekaterina S. Jordanova</name>
<affiliation><nlm:aff id="af0002"><institution>Department of Pathology, Leiden University Medical Center</institution>
, Leiden,<country>the Netherlands</country>
</nlm:aff>
<wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af0007"><institution>Center for Gynecological Oncology Amsterdam, VU Medical Center</institution>
, Amsterdam,<country>the Netherlands</country>
</nlm:aff>
<wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Adam, Julien" sort="Adam, Julien" uniqKey="Adam J" first="Julien" last="Adam">Julien Adam</name>
<affiliation wicri:level="1"><nlm:aff id="af0003"><institution>Department of Medical Oncology, INSERM U981, Gustave Roussy Cancer Center</institution>
, Villejuif,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Freeman Mills, Luke" sort="Freeman Mills, Luke" uniqKey="Freeman Mills L" first="Luke" last="Freeman-Mills">Luke Freeman-Mills</name>
<affiliation wicri:level="1"><nlm:aff id="af0008"><institution>Tumour Genomics and Immunology Group, Oxford Centre for Cancer Gene Research, The Wellcome Trust Centre for Human Genetics, University of Oxford</institution>
, Oxford,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Church, David N" sort="Church, David N" uniqKey="Church D" first="David N." last="Church">David N. Church</name>
<affiliation wicri:level="1"><nlm:aff id="af0008"><institution>Tumour Genomics and Immunology Group, Oxford Centre for Cancer Gene Research, The Wellcome Trust Centre for Human Genetics, University of Oxford</institution>
, Oxford,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af0009"><institution>Oxford Cancer Centre, Churchill Hospital</institution>
, Oxford,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Creutzberg, Carien L" sort="Creutzberg, Carien L" uniqKey="Creutzberg C" first="Carien L." last="Creutzberg">Carien L. Creutzberg</name>
<affiliation><nlm:aff id="af0010"><institution>Department of Clinical Oncology, Leiden University Medical Center</institution>
, Leiden,<country>the Netherlands</country>
</nlm:aff>
<wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="De Bruyn, Marco" sort="De Bruyn, Marco" uniqKey="De Bruyn M" first="Marco" last="De Bruyn">Marco De Bruyn</name>
<affiliation><nlm:aff id="af0001"><institution>Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen</institution>
, Groningen,<country>the Netherlands</country>
</nlm:aff>
<wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nijman, Hans W" sort="Nijman, Hans W" uniqKey="Nijman H" first="Hans W." last="Nijman">Hans W. Nijman</name>
<affiliation><nlm:aff id="af0001"><institution>Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen</institution>
, Groningen,<country>the Netherlands</country>
</nlm:aff>
<wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bosse, Tjalling" sort="Bosse, Tjalling" uniqKey="Bosse T" first="Tjalling" last="Bosse">Tjalling Bosse</name>
<affiliation><nlm:aff id="af0002"><institution>Department of Pathology, Leiden University Medical Center</institution>
, Leiden,<country>the Netherlands</country>
</nlm:aff>
<wicri:noCountry code="nlm country">the Netherlands</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Oncoimmunology</title>
<idno type="ISSN">2162-4011</idno>
<idno type="eISSN">2162-402X</idno>
<imprint><date when="2016">2016</date>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>High-risk endometrial cancer (EC) is an aggressive disease for which new therapeutic options are needed. Aims of this study were to validate the enhanced immune response in highly mutated ECs and to explore immune profiles in other EC subgroups. We evaluated immune infiltration in 116 high-risk ECs from the TransPORTEC consortium, previously classified into four molecular subtypes: (i) ultramutated <italic>POLE</italic>
exonuclease domain-mutant ECs (<italic>POLE</italic>
-mutant); (ii) hypermutated microsatellite unstable (MSI); (iii) p53-mutant; and (iv) no specific molecular profile (NSMP). Within The Cancer Genome Atlas (TCGA) EC cohort, significantly higher numbers of predicted neoantigens were demonstrated in <italic>POLE</italic>
-mutant and MSI tumors compared with NSMP and p53-mutants. This was reflected by enhanced immune expression and infiltration in <italic>POLE</italic>
-mutant and MSI tumors in both the TCGA cohort (mRNA expression) and the TransPORTEC cohort (immunohistochemistry) with high infiltration of CD8<sup>+</sup>
(90% and 69%), PD-1<sup>+</sup>
(73% and 69%) and PD-L1<sup>+</sup>
immune cells (100% and 71%). Notably, a subset of p53-mutant and NSMP cancers was characterized by signs of an antitumor immune response (43% and 31% of tumors with high infiltration of CD8<sup>+</sup>
cells, respectively), despite a low number of predicted neoantigens. In conclusion, the presence of enhanced immune infiltration, particularly high numbers of PD-1 and PD-L1 positive cells, in highly mutated, neoantigen-rich <italic>POLE</italic>
-mutant and MSI endometrial tumors suggests sensitivity to immune checkpoint inhibitors.</p>
</div>
</front>
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</author>
<author><name sortKey="Soria, J C" uniqKey="Soria J">J-C Soria</name>
</author>
<author><name sortKey="Kowanetz, M" uniqKey="Kowanetz M">M Kowanetz</name>
</author>
<author><name sortKey="Fine, Gd" uniqKey="Fine G">GD Fine</name>
</author>
<author><name sortKey="Hamid, O" uniqKey="Hamid O">O Hamid</name>
</author>
<author><name sortKey="Gordon, Ms" uniqKey="Gordon M">MS Gordon</name>
</author>
<author><name sortKey="Sosman, Ja" uniqKey="Sosman J">JA Sosman</name>
</author>
<author><name sortKey="Mcdermott, Df" uniqKey="Mcdermott D">DF McDermott</name>
</author>
<author><name sortKey="Powderly, Jd" uniqKey="Powderly J">JD Powderly</name>
</author>
<author><name sortKey="Gettinger, Sn" uniqKey="Gettinger S">SN Gettinger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hodi, Fs" uniqKey="Hodi F">FS Hodi</name>
</author>
<author><name sortKey="O Day, Sj" uniqKey="O Day S">SJ O'Day</name>
</author>
<author><name sortKey="Mcdermott, Df" uniqKey="Mcdermott D">DF McDermott</name>
</author>
<author><name sortKey="Weber, Rw" uniqKey="Weber R">RW Weber</name>
</author>
<author><name sortKey="Sosman, Ja" uniqKey="Sosman J">JA Sosman</name>
</author>
<author><name sortKey="Haanen, Jb" uniqKey="Haanen J">JB Haanen</name>
</author>
<author><name sortKey="Gonzalez, R" uniqKey="Gonzalez R">R Gonzalez</name>
</author>
<author><name sortKey="Robert, C" uniqKey="Robert C">C Robert</name>
</author>
<author><name sortKey="Schadendorf, D" uniqKey="Schadendorf D">D Schadendorf</name>
</author>
<author><name sortKey="Hassel, Jc" uniqKey="Hassel J">JC Hassel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Le, Dt" uniqKey="Le D">DT Le</name>
</author>
<author><name sortKey="Uram, Jn" uniqKey="Uram J">JN Uram</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Bartlett, Br" uniqKey="Bartlett B">BR Bartlett</name>
</author>
<author><name sortKey="Kemberling, H" uniqKey="Kemberling H">H Kemberling</name>
</author>
<author><name sortKey="Eyring, Ad" uniqKey="Eyring A">AD Eyring</name>
</author>
<author><name sortKey="Skora, Ad" uniqKey="Skora A">AD Skora</name>
</author>
<author><name sortKey="Luber, Bs" uniqKey="Luber B">BS Luber</name>
</author>
<author><name sortKey="Azad, Ns" uniqKey="Azad N">NS Azad</name>
</author>
<author><name sortKey="Laheru, D" uniqKey="Laheru D">D Laheru</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Powles, T" uniqKey="Powles T">T Powles</name>
</author>
<author><name sortKey="Eder, Jp" uniqKey="Eder J">JP Eder</name>
</author>
<author><name sortKey="Fine, Gd" uniqKey="Fine G">GD Fine</name>
</author>
<author><name sortKey="Braiteh, Fs" uniqKey="Braiteh F">FS Braiteh</name>
</author>
<author><name sortKey="Loriot, Y" uniqKey="Loriot Y">Y Loriot</name>
</author>
<author><name sortKey="Cruz, C" uniqKey="Cruz C">C Cruz</name>
</author>
<author><name sortKey="Bellmunt, J" uniqKey="Bellmunt J">J Bellmunt</name>
</author>
<author><name sortKey="Burris, Ha" uniqKey="Burris H">HA Burris</name>
</author>
<author><name sortKey="Petrylak, Dp" uniqKey="Petrylak D">DP Petrylak</name>
</author>
<author><name sortKey="Teng, S" uniqKey="Teng S">S Teng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hamid, O" uniqKey="Hamid O">O Hamid</name>
</author>
<author><name sortKey="Robert, C" uniqKey="Robert C">C Robert</name>
</author>
<author><name sortKey="Daud, A" uniqKey="Daud A">A Daud</name>
</author>
<author><name sortKey="Hodi, Fs" uniqKey="Hodi F">FS Hodi</name>
</author>
<author><name sortKey="Hwu, W J" uniqKey="Hwu W">W-J Hwu</name>
</author>
<author><name sortKey="Kefford, R" uniqKey="Kefford R">R Kefford</name>
</author>
<author><name sortKey="Wolchok, Jd" uniqKey="Wolchok J">JD Wolchok</name>
</author>
<author><name sortKey="Hersey, P" uniqKey="Hersey P">P Hersey</name>
</author>
<author><name sortKey="Joseph, Rw" uniqKey="Joseph R">RW Joseph</name>
</author>
<author><name sortKey="Weber, Js" uniqKey="Weber J">JS Weber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Borghaei, H" uniqKey="Borghaei H">H Borghaei</name>
</author>
<author><name sortKey="Paz Ares, L" uniqKey="Paz Ares L">L Paz-Ares</name>
</author>
<author><name sortKey="Horn, L" uniqKey="Horn L">L Horn</name>
</author>
<author><name sortKey="Spigel, Dr" uniqKey="Spigel D">DR Spigel</name>
</author>
<author><name sortKey="Steins, M" uniqKey="Steins M">M Steins</name>
</author>
<author><name sortKey="Ready, Ne" uniqKey="Ready N">NE Ready</name>
</author>
<author><name sortKey="Chow, Lq" uniqKey="Chow L">LQ Chow</name>
</author>
<author><name sortKey="Vokes, Ee" uniqKey="Vokes E">EE Vokes</name>
</author>
<author><name sortKey="Felip, E" uniqKey="Felip E">E Felip</name>
</author>
<author><name sortKey="Holgado, E" uniqKey="Holgado E">E Holgado</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bouffet, E" uniqKey="Bouffet E">E Bouffet</name>
</author>
<author><name sortKey="Larouche, V" uniqKey="Larouche V">V Larouche</name>
</author>
<author><name sortKey="Campbell, Bb" uniqKey="Campbell B">BB Campbell</name>
</author>
<author><name sortKey="Merico, D" uniqKey="Merico D">D Merico</name>
</author>
<author><name sortKey="De Borja, R" uniqKey="De Borja R">R de Borja</name>
</author>
<author><name sortKey="Aronson, M" uniqKey="Aronson M">M Aronson</name>
</author>
<author><name sortKey="Durno, C" uniqKey="Durno C">C Durno</name>
</author>
<author><name sortKey="Krueger, J" uniqKey="Krueger J">J Krueger</name>
</author>
<author><name sortKey="Cabric, V" uniqKey="Cabric V">V Cabric</name>
</author>
<author><name sortKey="Ramaswamy, V" uniqKey="Ramaswamy V">V Ramaswamy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brown, Sd" uniqKey="Brown S">SD Brown</name>
</author>
<author><name sortKey="Warren, Rl" uniqKey="Warren R">RL Warren</name>
</author>
<author><name sortKey="Gibb, Ea" uniqKey="Gibb E">EA Gibb</name>
</author>
<author><name sortKey="Martin, Sd" uniqKey="Martin S">SD Martin</name>
</author>
<author><name sortKey="Spinelli, Jj" uniqKey="Spinelli J">JJ Spinelli</name>
</author>
<author><name sortKey="Nelson, Bh" uniqKey="Nelson B">BH Nelson</name>
</author>
<author><name sortKey="Holt, Ra" uniqKey="Holt R">RA Holt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rooney, Ms" uniqKey="Rooney M">MS Rooney</name>
</author>
<author><name sortKey="Shukla, Sa" uniqKey="Shukla S">SA Shukla</name>
</author>
<author><name sortKey="Wu, Cj" uniqKey="Wu C">CJ Wu</name>
</author>
<author><name sortKey="Getz, G" uniqKey="Getz G">G Getz</name>
</author>
<author><name sortKey="Hacohen, N" uniqKey="Hacohen N">N Hacohen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giannakis, M" uniqKey="Giannakis M">M Giannakis</name>
</author>
<author><name sortKey="Mu, Xj" uniqKey="Mu X">XJ Mu</name>
</author>
<author><name sortKey="Shukla, Sa" uniqKey="Shukla S">SA Shukla</name>
</author>
<author><name sortKey="Qian, Zr" uniqKey="Qian Z">ZR Qian</name>
</author>
<author><name sortKey="Cohen, O" uniqKey="Cohen O">O Cohen</name>
</author>
<author><name sortKey="Nishihara, R" uniqKey="Nishihara R">R Nishihara</name>
</author>
<author><name sortKey="Bahl, S" uniqKey="Bahl S">S Bahl</name>
</author>
<author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name>
</author>
<author><name sortKey="Amin Mansour, A" uniqKey="Amin Mansour A">A Amin-Mansour</name>
</author>
<author><name sortKey="Yamauchi, M" uniqKey="Yamauchi M">M Yamauchi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pardoll, Dm" uniqKey="Pardoll D">DM Pardoll</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rizvi, Na" uniqKey="Rizvi N">NA Rizvi</name>
</author>
<author><name sortKey="Hellmann, Md" uniqKey="Hellmann M">MD Hellmann</name>
</author>
<author><name sortKey="Snyder, A" uniqKey="Snyder A">A Snyder</name>
</author>
<author><name sortKey="Kvistborg, P" uniqKey="Kvistborg P">P Kvistborg</name>
</author>
<author><name sortKey="Makarov, V" uniqKey="Makarov V">V Makarov</name>
</author>
<author><name sortKey="Havel, Jj" uniqKey="Havel J">JJ Havel</name>
</author>
<author><name sortKey="Lee, W" uniqKey="Lee W">W Lee</name>
</author>
<author><name sortKey="Yuan, J" uniqKey="Yuan J">J Yuan</name>
</author>
<author><name sortKey="Wong, P" uniqKey="Wong P">P Wong</name>
</author>
<author><name sortKey="Ho, Ts" uniqKey="Ho T">TS Ho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Snyder, A" uniqKey="Snyder A">A Snyder</name>
</author>
<author><name sortKey="Makarov, V" uniqKey="Makarov V">V Makarov</name>
</author>
<author><name sortKey="Merghoub, T" uniqKey="Merghoub T">T Merghoub</name>
</author>
<author><name sortKey="Yuan, J" uniqKey="Yuan J">J Yuan</name>
</author>
<author><name sortKey="Zaretsky, Jm" uniqKey="Zaretsky J">JM Zaretsky</name>
</author>
<author><name sortKey="Desrichard, A" uniqKey="Desrichard A">A Desrichard</name>
</author>
<author><name sortKey="Walsh, La" uniqKey="Walsh L">LA Walsh</name>
</author>
<author><name sortKey="Postow, Ma" uniqKey="Postow M">MA Postow</name>
</author>
<author><name sortKey="Wong, P" uniqKey="Wong P">P Wong</name>
</author>
<author><name sortKey="Ho, Ts" uniqKey="Ho T">TS Ho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Ta" uniqKey="Chan T">TA Chan</name>
</author>
<author><name sortKey="Wolchok, Jd" uniqKey="Wolchok J">JD Wolchok</name>
</author>
<author><name sortKey="Snyder, A" uniqKey="Snyder A">A Snyder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zou, W" uniqKey="Zou W">W Zou</name>
</author>
<author><name sortKey="Wolchok, Jd" uniqKey="Wolchok J">JD Wolchok</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tumeh, P" uniqKey="Tumeh P">P Tumeh</name>
</author>
<author><name sortKey="Harview, C" uniqKey="Harview C">C Harview</name>
</author>
<author><name sortKey="Yearley, J" uniqKey="Yearley J">J Yearley</name>
</author>
<author><name sortKey="Al, E" uniqKey="Al E">E Al</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mlecnik, B" uniqKey="Mlecnik B">B Mlecnik</name>
</author>
<author><name sortKey="Bindea, G" uniqKey="Bindea G">G Bindea</name>
</author>
<author><name sortKey="Angell, Hk" uniqKey="Angell H">HK Angell</name>
</author>
<author><name sortKey="Maby, P" uniqKey="Maby P">P Maby</name>
</author>
<author><name sortKey="Angelova, M" uniqKey="Angelova M">M Angelova</name>
</author>
<author><name sortKey="Tougeron, D" uniqKey="Tougeron D">D Tougeron</name>
</author>
<author><name sortKey="Church, Se" uniqKey="Church S">SE Church</name>
</author>
<author><name sortKey="Lafontaine, L" uniqKey="Lafontaine L">L Lafontaine</name>
</author>
<author><name sortKey="Fischer, M" uniqKey="Fischer M">M Fischer</name>
</author>
<author><name sortKey="Fredriksen, T" uniqKey="Fredriksen T">T Fredriksen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Becht, E" uniqKey="Becht E">E Becht</name>
</author>
<author><name sortKey="Giraldo, Na" uniqKey="Giraldo N">NA Giraldo</name>
</author>
<author><name sortKey="Germain, C" uniqKey="Germain C">C Germain</name>
</author>
<author><name sortKey="De Reynies, A" uniqKey="De Reynies A">A de Reyniès</name>
</author>
<author><name sortKey="Laurent Puig, P" uniqKey="Laurent Puig P">P Laurent-Puig</name>
</author>
<author><name sortKey="Zucman Rossi, J" uniqKey="Zucman Rossi J">J Zucman-Rossi</name>
</author>
<author><name sortKey="Dieu Nosjean, M C" uniqKey="Dieu Nosjean M">M-C Dieu-Nosjean</name>
</author>
<author><name sortKey="Sautes Fridman, C" uniqKey="Sautes Fridman C">C Sautès-Fridman</name>
</author>
<author><name sortKey="Fridman, Wh" uniqKey="Fridman W">WH Fridman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kandoth, C" uniqKey="Kandoth C">C Kandoth</name>
</author>
<author><name sortKey="Schultz, N" uniqKey="Schultz N">N Schultz</name>
</author>
<author><name sortKey="Cherniack, Ad" uniqKey="Cherniack A">AD Cherniack</name>
</author>
<author><name sortKey="Akbani, R" uniqKey="Akbani R">R Akbani</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Shen, H" uniqKey="Shen H">H Shen</name>
</author>
<author><name sortKey="Robertson, Ag" uniqKey="Robertson A">AG Robertson</name>
</author>
<author><name sortKey="Pashtan, I" uniqKey="Pashtan I">I Pashtan</name>
</author>
<author><name sortKey="Shen, R" uniqKey="Shen R">R Shen</name>
</author>
<author><name sortKey="Benz, Cc" uniqKey="Benz C">CC Benz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Gool, Ic" uniqKey="Van Gool I">IC van Gool</name>
</author>
<author><name sortKey="Eggink, Fa" uniqKey="Eggink F">FA Eggink</name>
</author>
<author><name sortKey="Freeman Mills, L" uniqKey="Freeman Mills L">L Freeman-Mills</name>
</author>
<author><name sortKey="Stelloo, E" uniqKey="Stelloo E">E Stelloo</name>
</author>
<author><name sortKey="Marchi, E" uniqKey="Marchi E">E Marchi</name>
</author>
<author><name sortKey="De Bruyn, M" uniqKey="De Bruyn M">M de Bruyn</name>
</author>
<author><name sortKey="Palles, C" uniqKey="Palles C">C Palles</name>
</author>
<author><name sortKey="Nout, Ra" uniqKey="Nout R">RA Nout</name>
</author>
<author><name sortKey="De Kroon, Cd" uniqKey="De Kroon C">CD de Kroon</name>
</author>
<author><name sortKey="Osse, Em" uniqKey="Osse E">EM Osse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Howitt, Be" uniqKey="Howitt B">BE Howitt</name>
</author>
<author><name sortKey="Shukla, Sa" uniqKey="Shukla S">SA Shukla</name>
</author>
<author><name sortKey="Sholl, Lm" uniqKey="Sholl L">LM Sholl</name>
</author>
<author><name sortKey="Ritterhouse, Ll" uniqKey="Ritterhouse L">LL Ritterhouse</name>
</author>
<author><name sortKey="Watkins, Jc" uniqKey="Watkins J">JC Watkins</name>
</author>
<author><name sortKey="Rodig, S" uniqKey="Rodig S">S Rodig</name>
</author>
<author><name sortKey="Stover, E" uniqKey="Stover E">E Stover</name>
</author>
<author><name sortKey="Strickland, Kc" uniqKey="Strickland K">KC Strickland</name>
</author>
<author><name sortKey="D Andrea, Ad" uniqKey="D Andrea A">AD D'Andrea</name>
</author>
<author><name sortKey="Wu, Cj" uniqKey="Wu C">CJ Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bellone, S" uniqKey="Bellone S">S Bellone</name>
</author>
<author><name sortKey="Centritto, F" uniqKey="Centritto F">F Centritto</name>
</author>
<author><name sortKey="Black, J" uniqKey="Black J">J Black</name>
</author>
<author><name sortKey="Schwab, C" uniqKey="Schwab C">C Schwab</name>
</author>
<author><name sortKey="English, D" uniqKey="English D">D English</name>
</author>
<author><name sortKey="Cocco, E" uniqKey="Cocco E">E Cocco</name>
</author>
<author><name sortKey="Lopez, S" uniqKey="Lopez S">S Lopez</name>
</author>
<author><name sortKey="Bonazzoli, E" uniqKey="Bonazzoli E">E Bonazzoli</name>
</author>
<author><name sortKey="Predolini, F" uniqKey="Predolini F">F Predolini</name>
</author>
<author><name sortKey="Ferrari, F" uniqKey="Ferrari F">F Ferrari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Gool, Ic" uniqKey="Van Gool I">IC van Gool</name>
</author>
<author><name sortKey="Bosse, T" uniqKey="Bosse T">T Bosse</name>
</author>
<author><name sortKey="Church, Dn" uniqKey="Church D">DN Church</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gros, A" uniqKey="Gros A">A Gros</name>
</author>
<author><name sortKey="Parkhurst, Mr" uniqKey="Parkhurst M">MR Parkhurst</name>
</author>
<author><name sortKey="Tran, E" uniqKey="Tran E">E Tran</name>
</author>
<author><name sortKey="Pasetto, A" uniqKey="Pasetto A">A Pasetto</name>
</author>
<author><name sortKey="Robbins, Pf" uniqKey="Robbins P">PF Robbins</name>
</author>
<author><name sortKey="Ilyas, S" uniqKey="Ilyas S">S Ilyas</name>
</author>
<author><name sortKey="Prickett, Td" uniqKey="Prickett T">TD Prickett</name>
</author>
<author><name sortKey="Gartner, Jj" uniqKey="Gartner J">JJ Gartner</name>
</author>
<author><name sortKey="Crystal, Js" uniqKey="Crystal J">JS Crystal</name>
</author>
<author><name sortKey="Roberts, Im" uniqKey="Roberts I">IM Roberts</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mehnert, Jm" uniqKey="Mehnert J">JM Mehnert</name>
</author>
<author><name sortKey="Panda, A" uniqKey="Panda A">A Panda</name>
</author>
<author><name sortKey="Zhong, H" uniqKey="Zhong H">H Zhong</name>
</author>
<author><name sortKey="Hirshfield, K" uniqKey="Hirshfield K">K Hirshfield</name>
</author>
<author><name sortKey="Damare, S" uniqKey="Damare S">S Damare</name>
</author>
<author><name sortKey="Lane, K" uniqKey="Lane K">K Lane</name>
</author>
<author><name sortKey="Sokol, L" uniqKey="Sokol L">L Sokol</name>
</author>
<author><name sortKey="Stein, Mn" uniqKey="Stein M">MN Stein</name>
</author>
<author><name sortKey="Rodriguez Rodriquez, L" uniqKey="Rodriguez Rodriquez L">L Rodriguez-rodriquez</name>
</author>
<author><name sortKey="Kaufman, Hl" uniqKey="Kaufman H">HL Kaufman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Santin, Ad" uniqKey="Santin A">AD Santin</name>
</author>
<author><name sortKey="Bellone, S" uniqKey="Bellone S">S Bellone</name>
</author>
<author><name sortKey="Buza, N" uniqKey="Buza N">N Buza</name>
</author>
<author><name sortKey="Choi, J" uniqKey="Choi J">J Choi</name>
</author>
<author><name sortKey="Schwartz, Pe" uniqKey="Schwartz P">PE Schwartz</name>
</author>
<author><name sortKey="Schlessinger, J" uniqKey="Schlessinger J">J Schlessinger</name>
</author>
<author><name sortKey="Lifton, Rp" uniqKey="Lifton R">RP Lifton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dong, H" uniqKey="Dong H">H Dong</name>
</author>
<author><name sortKey="Strome, Se" uniqKey="Strome S">SE Strome</name>
</author>
<author><name sortKey="Salomao, Dr" uniqKey="Salomao D">DR Salomao</name>
</author>
<author><name sortKey="Tamura, H" uniqKey="Tamura H">H Tamura</name>
</author>
<author><name sortKey="Hirano, F" uniqKey="Hirano F">F Hirano</name>
</author>
<author><name sortKey="Flies, Db" uniqKey="Flies D">DB Flies</name>
</author>
<author><name sortKey="Roche, Pc" uniqKey="Roche P">PC Roche</name>
</author>
<author><name sortKey="Lu, J" uniqKey="Lu J">J Lu</name>
</author>
<author><name sortKey="Zhu, G" uniqKey="Zhu G">G Zhu</name>
</author>
<author><name sortKey="Tamada, K" uniqKey="Tamada K">K Tamada</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heeren, Am" uniqKey="Heeren A">AM Heeren</name>
</author>
<author><name sortKey="Koster, Bd" uniqKey="Koster B">BD Koster</name>
</author>
<author><name sortKey="Samuels, S" uniqKey="Samuels S">S Samuels</name>
</author>
<author><name sortKey="Ferns, Dm" uniqKey="Ferns D">DM Ferns</name>
</author>
<author><name sortKey="Chondronasiou, D" uniqKey="Chondronasiou D">D Chondronasiou</name>
</author>
<author><name sortKey="Kenter, Gg" uniqKey="Kenter G">GG Kenter</name>
</author>
<author><name sortKey="Jordanova, Es" uniqKey="Jordanova E">ES Jordanova</name>
</author>
<author><name sortKey="De Gruijl, Td" uniqKey="De Gruijl T">TD de Gruijl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schultheis, Am" uniqKey="Schultheis A">AM Schultheis</name>
</author>
<author><name sortKey="Scheel, Ah" uniqKey="Scheel A">AH Scheel</name>
</author>
<author><name sortKey="Ozreti, L" uniqKey="Ozreti L">L Ozretić</name>
</author>
<author><name sortKey="George, J" uniqKey="George J">J George</name>
</author>
<author><name sortKey="Thomas, Rk" uniqKey="Thomas R">RK Thomas</name>
</author>
<author><name sortKey="Hagemann, T" uniqKey="Hagemann T">T Hagemann</name>
</author>
<author><name sortKey="Zander, T" uniqKey="Zander T">T Zander</name>
</author>
<author><name sortKey="Wolf, J" uniqKey="Wolf J">J Wolf</name>
</author>
<author><name sortKey="Buettner, R" uniqKey="Buettner R">R Buettner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Curiel, Tj" uniqKey="Curiel T">TJ Curiel</name>
</author>
<author><name sortKey="Wei, S" uniqKey="Wei S">S Wei</name>
</author>
<author><name sortKey="Dong, H" uniqKey="Dong H">H Dong</name>
</author>
<author><name sortKey="Alvarez, X" uniqKey="Alvarez X">X Alvarez</name>
</author>
<author><name sortKey="Cheng, P" uniqKey="Cheng P">P Cheng</name>
</author>
<author><name sortKey="Mottram, P" uniqKey="Mottram P">P Mottram</name>
</author>
<author><name sortKey="Krzysiek, R" uniqKey="Krzysiek R">R Krzysiek</name>
</author>
<author><name sortKey="Knutson, Kl" uniqKey="Knutson K">KL Knutson</name>
</author>
<author><name sortKey="Daniel, B" uniqKey="Daniel B">B Daniel</name>
</author>
<author><name sortKey="Zimmermann, Mc" uniqKey="Zimmermann M">MC Zimmermann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bakhsh, S" uniqKey="Bakhsh S">S Bakhsh</name>
</author>
<author><name sortKey="Kinloch, M" uniqKey="Kinloch M">M Kinloch</name>
</author>
<author><name sortKey="Hoang, Ln" uniqKey="Hoang L">LN Hoang</name>
</author>
<author><name sortKey="Soslow, Ra" uniqKey="Soslow R">RA Soslow</name>
</author>
<author><name sortKey="Kobel, M" uniqKey="Kobel M">M Köbel</name>
</author>
<author><name sortKey="Lee, Ch" uniqKey="Lee C">CH Lee</name>
</author>
<author><name sortKey="Mcalpine, Jn" uniqKey="Mcalpine J">JN Mcalpine</name>
</author>
<author><name sortKey="Mcconechy, Mk" uniqKey="Mcconechy M">MK Mcconechy</name>
</author>
<author><name sortKey="Gilks, Cb" uniqKey="Gilks C">CB Gilks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mclaughlin, J" uniqKey="Mclaughlin J">J McLaughlin</name>
</author>
<author><name sortKey="Han, G" uniqKey="Han G">G Han</name>
</author>
<author><name sortKey="Schalper, Ka" uniqKey="Schalper K">KA Schalper</name>
</author>
<author><name sortKey="Carvajal Hausdorf, D" uniqKey="Carvajal Hausdorf D">D Carvajal-Hausdorf</name>
</author>
<author><name sortKey="Pelekanou, V" uniqKey="Pelekanou V">V Pelekanou</name>
</author>
<author><name sortKey="Rehman, J" uniqKey="Rehman J">J Rehman</name>
</author>
<author><name sortKey="Velcheti, V" uniqKey="Velcheti V">V Velcheti</name>
</author>
<author><name sortKey="Herbst, R" uniqKey="Herbst R">R Herbst</name>
</author>
<author><name sortKey="Lorusso, P" uniqKey="Lorusso P">P LoRusso</name>
</author>
<author><name sortKey="Rimm, Dl" uniqKey="Rimm D">DL Rimm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dieu Nosjean, Mc" uniqKey="Dieu Nosjean M">MC Dieu-Nosjean</name>
</author>
<author><name sortKey="Giraldo, Na" uniqKey="Giraldo N">NA Giraldo</name>
</author>
<author><name sortKey="Kaplon, H" uniqKey="Kaplon H">H Kaplon</name>
</author>
<author><name sortKey="Germain, C" uniqKey="Germain C">C Germain</name>
</author>
<author><name sortKey="Fridman, Wh" uniqKey="Fridman W">WH Fridman</name>
</author>
<author><name sortKey="Sautes Fridman, C" uniqKey="Sautes Fridman C">C Sautès-Fridman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Germain, C" uniqKey="Germain C">C Germain</name>
</author>
<author><name sortKey="Gnjatic, S" uniqKey="Gnjatic S">S Gnjatic</name>
</author>
<author><name sortKey="Dieu Nosjean, Mc" uniqKey="Dieu Nosjean M">MC Dieu-Nosjean</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kroeger, Dr" uniqKey="Kroeger D">DR Kroeger</name>
</author>
<author><name sortKey="Milne, K" uniqKey="Milne K">K Milne</name>
</author>
<author><name sortKey="Nelson, Bh" uniqKey="Nelson B">BH Nelson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name>
</author>
<author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name>
</author>
<author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name>
</author>
<author><name sortKey="Chan, Dw" uniqKey="Chan D">DW Chan</name>
</author>
<author><name sortKey="Rodland, Kd" uniqKey="Rodland K">KD Rodland</name>
</author>
<author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name>
</author>
<author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name>
</author>
<author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name>
</author>
<author><name sortKey="Payne, Sh" uniqKey="Payne S">SH Payne</name>
</author>
<author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stelloo, E" uniqKey="Stelloo E">E Stelloo</name>
</author>
<author><name sortKey="Versluis, Ma" uniqKey="Versluis M">MA Versluis</name>
</author>
<author><name sortKey="Nijman, Hw" uniqKey="Nijman H">HW Nijman</name>
</author>
<author><name sortKey="De Bruyn, M" uniqKey="De Bruyn M">M de Bruyn</name>
</author>
<author><name sortKey="Plat, A" uniqKey="Plat A">A Plat</name>
</author>
<author><name sortKey="Osse, Em" uniqKey="Osse E">EM Osse</name>
</author>
<author><name sortKey="Van Dijk, Rh" uniqKey="Van Dijk R">RH van Dijk</name>
</author>
<author><name sortKey="Nout, Ra" uniqKey="Nout R">RA Nout</name>
</author>
<author><name sortKey="Creutzberg, Cl" uniqKey="Creutzberg C">CL Creutzberg</name>
</author>
<author><name sortKey="De Bock, Gh" uniqKey="De Bock G">GH de Bock</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taube, Jm" uniqKey="Taube J">JM Taube</name>
</author>
<author><name sortKey="Klein, A" uniqKey="Klein A">A Klein</name>
</author>
<author><name sortKey="Brahmer, Jr" uniqKey="Brahmer J">JR Brahmer</name>
</author>
<author><name sortKey="Xu, H" uniqKey="Xu H">H Xu</name>
</author>
<author><name sortKey="Pan, X" uniqKey="Pan X">X Pan</name>
</author>
<author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name>
</author>
<author><name sortKey="Pardoll, Dm" uniqKey="Pardoll D">DM Pardoll</name>
</author>
<author><name sortKey="Topalian, Sl" uniqKey="Topalian S">SL Topalian</name>
</author>
<author><name sortKey="Anders, Ra" uniqKey="Anders R">RA Anders</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Billingsley, Cc" uniqKey="Billingsley C">CC Billingsley</name>
</author>
<author><name sortKey="Cohn, De" uniqKey="Cohn D">DE Cohn</name>
</author>
<author><name sortKey="Mutch, Dg" uniqKey="Mutch D">DG Mutch</name>
</author>
<author><name sortKey="Hade, Em" uniqKey="Hade E">EM Hade</name>
</author>
<author><name sortKey="Goodfellow, Pj" uniqKey="Goodfellow P">PJ Goodfellow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Church, Dn" uniqKey="Church D">DN Church</name>
</author>
<author><name sortKey="Stelloo, E" uniqKey="Stelloo E">E Stelloo</name>
</author>
<author><name sortKey="Nout, Ra" uniqKey="Nout R">RA Nout</name>
</author>
<author><name sortKey="Valtcheva, N" uniqKey="Valtcheva N">N Valtcheva</name>
</author>
<author><name sortKey="Depreeuw, J" uniqKey="Depreeuw J">J Depreeuw</name>
</author>
<author><name sortKey="Ter Haar, N" uniqKey="Ter Haar N">N ter Haar</name>
</author>
<author><name sortKey="Noske, A" uniqKey="Noske A">A Noske</name>
</author>
<author><name sortKey="Amant, F" uniqKey="Amant F">F Amant</name>
</author>
<author><name sortKey="Tomlinson, Ip" uniqKey="Tomlinson I">IP Tomlinson</name>
</author>
<author><name sortKey="Wild, Pj" uniqKey="Wild P">PJ Wild</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcconechy, Mk" uniqKey="Mcconechy M">MK McConechy</name>
</author>
<author><name sortKey="Talhouk, A" uniqKey="Talhouk A">A Talhouk</name>
</author>
<author><name sortKey="Leung, S" uniqKey="Leung S">S Leung</name>
</author>
<author><name sortKey="Chiu, D" uniqKey="Chiu D">D Chiu</name>
</author>
<author><name sortKey="Yang, W" uniqKey="Yang W">W Yang</name>
</author>
<author><name sortKey="Senz, J" uniqKey="Senz J">J Senz</name>
</author>
<author><name sortKey="Reha Krantz, Lj" uniqKey="Reha Krantz L">LJ Reha-Krantz</name>
</author>
<author><name sortKey="Lee, C H" uniqKey="Lee C">C-H Lee</name>
</author>
<author><name sortKey="Huntsman, Dg" uniqKey="Huntsman D">DG Huntsman</name>
</author>
<author><name sortKey="Gilks, Cb" uniqKey="Gilks C">CB Gilks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stelloo, E" uniqKey="Stelloo E">E Stelloo</name>
</author>
<author><name sortKey="Bosse, T" uniqKey="Bosse T">T Bosse</name>
</author>
<author><name sortKey="Nout, Ra" uniqKey="Nout R">RA Nout</name>
</author>
<author><name sortKey="Mackay, Hj" uniqKey="Mackay H">HJ MacKay</name>
</author>
<author><name sortKey="Church, Dn" uniqKey="Church D">DN Church</name>
</author>
<author><name sortKey="Nijman, Hw" uniqKey="Nijman H">HW Nijman</name>
</author>
<author><name sortKey="Leary, A" uniqKey="Leary A">A Leary</name>
</author>
<author><name sortKey="Edmondson, Rj" uniqKey="Edmondson R">RJ Edmondson</name>
</author>
<author><name sortKey="Powell, Me" uniqKey="Powell M">ME Powell</name>
</author>
<author><name sortKey="Crosbie, Ej" uniqKey="Crosbie E">EJ Crosbie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Church, Dn" uniqKey="Church D">DN Church</name>
</author>
<author><name sortKey="Briggs, Sew" uniqKey="Briggs S">SEW Briggs</name>
</author>
<author><name sortKey="Palles, C" uniqKey="Palles C">C Palles</name>
</author>
<author><name sortKey="Domingo, E" uniqKey="Domingo E">E Domingo</name>
</author>
<author><name sortKey="Kearsey, Sj" uniqKey="Kearsey S">SJ Kearsey</name>
</author>
<author><name sortKey="Grimes, Jm" uniqKey="Grimes J">JM Grimes</name>
</author>
<author><name sortKey="Gorman, M" uniqKey="Gorman M">M Gorman</name>
</author>
<author><name sortKey="Martin, L" uniqKey="Martin L">L Martin</name>
</author>
<author><name sortKey="Howarth, Km" uniqKey="Howarth K">KM Howarth</name>
</author>
<author><name sortKey="Hodgson, S V" uniqKey="Hodgson S">S V Hodgson</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Alexandrov, Lb" uniqKey="Alexandrov L">LB Alexandrov</name>
</author>
<author><name sortKey="Nik Zainal, S" uniqKey="Nik Zainal S">S Nik-Zainal</name>
</author>
<author><name sortKey="Wedge, Dc" uniqKey="Wedge D">DC Wedge</name>
</author>
<author><name sortKey="Aparicio, Sa" uniqKey="Aparicio S">SA Aparicio</name>
</author>
<author><name sortKey="Behjati, S" uniqKey="Behjati S">S Behjati</name>
</author>
<author><name sortKey="Biankin, A V" uniqKey="Biankin A">A V Biankin</name>
</author>
<author><name sortKey="Bignell, Gr" uniqKey="Bignell G">GR Bignell</name>
</author>
<author><name sortKey="Bolli, N" uniqKey="Bolli N">N Bolli</name>
</author>
<author><name sortKey="Borg, A" uniqKey="Borg A">A Borg</name>
</author>
<author><name sortKey="B Rresen Dale, A L" uniqKey="B Rresen Dale A">A-L Børresen-Dale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shinbrot, E" uniqKey="Shinbrot E">E Shinbrot</name>
</author>
<author><name sortKey="Henninger, Ee" uniqKey="Henninger E">EE Henninger</name>
</author>
<author><name sortKey="Weinhold, N" uniqKey="Weinhold N">N Weinhold</name>
</author>
<author><name sortKey="Covington, Kr" uniqKey="Covington K">KR Covington</name>
</author>
<author><name sortKey="Goksenin, Ay" uniqKey="Goksenin A">AY Göksenin</name>
</author>
<author><name sortKey="Schultz, N" uniqKey="Schultz N">N Schultz</name>
</author>
<author><name sortKey="Chao, H" uniqKey="Chao H">H Chao</name>
</author>
<author><name sortKey="Doddapaneni, H" uniqKey="Doddapaneni H">H Doddapaneni</name>
</author>
<author><name sortKey="Muzny, Dm" uniqKey="Muzny D">DM Muzny</name>
</author>
<author><name sortKey="Gibbs, Ra" uniqKey="Gibbs R">RA Gibbs</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Erson Omay, Ez" uniqKey="Erson Omay E">EZ Erson-Omay</name>
</author>
<author><name sortKey="Ca Layan, Ao" uniqKey="Ca Layan A">AO Çağlayan</name>
</author>
<author><name sortKey="Schultz, N" uniqKey="Schultz N">N Schultz</name>
</author>
<author><name sortKey="Weinhold, N" uniqKey="Weinhold N">N Weinhold</name>
</author>
<author><name sortKey="Omay, Sb" uniqKey="Omay S">SB Omay</name>
</author>
<author><name sortKey="Ozduman, K" uniqKey="Ozduman K">K Özduman</name>
</author>
<author><name sortKey="Koksal, Y" uniqKey="Koksal Y">Y Köksal</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Serin Harmanc, A" uniqKey="Serin Harmanc A">A Serin Harmancı</name>
</author>
<author><name sortKey="Clark, V" uniqKey="Clark V">V Clark</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rayner, E" uniqKey="Rayner E">E Rayner</name>
</author>
<author><name sortKey="Van Gool, Ic" uniqKey="Van Gool I">IC van Gool</name>
</author>
<author><name sortKey="Palles, C" uniqKey="Palles C">C Palles</name>
</author>
<author><name sortKey="Kearsey, Se" uniqKey="Kearsey S">SE Kearsey</name>
</author>
<author><name sortKey="Bosse, T" uniqKey="Bosse T">T Bosse</name>
</author>
<author><name sortKey="Tomlinson, I" uniqKey="Tomlinson I">I Tomlinson</name>
</author>
<author><name sortKey="Church, Dn" uniqKey="Church D">DN Church</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Domingo, E" uniqKey="Domingo E">E Domingo</name>
</author>
<author><name sortKey="Freeman Mills, L" uniqKey="Freeman Mills L">L Freeman-Mills</name>
</author>
<author><name sortKey="Rayner, E" uniqKey="Rayner E">E Rayner</name>
</author>
<author><name sortKey="Glaire, M" uniqKey="Glaire M">M Glaire</name>
</author>
<author><name sortKey="Briggs, S" uniqKey="Briggs S">S Briggs</name>
</author>
<author><name sortKey="Vermeulen, L" uniqKey="Vermeulen L">L Vermeulen</name>
</author>
<author><name sortKey="Fessler, E" uniqKey="Fessler E">E Fessler</name>
</author>
<author><name sortKey="Medema, Jp" uniqKey="Medema J">JP Medema</name>
</author>
<author><name sortKey="Boot, A" uniqKey="Boot A">A Boot</name>
</author>
<author><name sortKey="Morreau, H" uniqKey="Morreau H">H Morreau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gargiulo, P" uniqKey="Gargiulo P">P Gargiulo</name>
</author>
<author><name sortKey="Della Pepa, C" uniqKey="Della Pepa C">C Della Pepa</name>
</author>
<author><name sortKey="Berardi, S" uniqKey="Berardi S">S Berardi</name>
</author>
<author><name sortKey="Califano, D" uniqKey="Califano D">D Califano</name>
</author>
<author><name sortKey="Scala, S" uniqKey="Scala S">S Scala</name>
</author>
<author><name sortKey="Buonaguro, L" uniqKey="Buonaguro L">L Buonaguro</name>
</author>
<author><name sortKey="Ciliberto, G" uniqKey="Ciliberto G">G Ciliberto</name>
</author>
<author><name sortKey="Brauchli, P" uniqKey="Brauchli P">P Brauchli</name>
</author>
<author><name sortKey="Pignata, S" uniqKey="Pignata S">S Pignata</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Boer, Sm" uniqKey="De Boer S">SM De Boer</name>
</author>
<author><name sortKey="Powell, Me" uniqKey="Powell M">ME Powell</name>
</author>
<author><name sortKey="Mileshkin, L" uniqKey="Mileshkin L">L Mileshkin</name>
</author>
<author><name sortKey="Katsaros, D" uniqKey="Katsaros D">D Katsaros</name>
</author>
<author><name sortKey="Bessette, P" uniqKey="Bessette P">P Bessette</name>
</author>
<author><name sortKey="Haie Meder, C" uniqKey="Haie Meder C">C Haie-meder</name>
</author>
<author><name sortKey="Ottevanger, Pb" uniqKey="Ottevanger P">PB Ottevanger</name>
</author>
<author><name sortKey="Ledermann, Ja" uniqKey="Ledermann J">JA Ledermann</name>
</author>
<author><name sortKey="Khaw, P" uniqKey="Khaw P">P Khaw</name>
</author>
<author><name sortKey="Colombo, A" uniqKey="Colombo A">A Colombo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Eijk, R" uniqKey="Van Eijk R">R van Eijk</name>
</author>
<author><name sortKey="Stevens, L" uniqKey="Stevens L">L Stevens</name>
</author>
<author><name sortKey="Morreau, H" uniqKey="Morreau H">H Morreau</name>
</author>
<author><name sortKey="Van Wezel, T" uniqKey="Van Wezel T">T van Wezel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Gool, Ic" uniqKey="Van Gool I">IC Van Gool</name>
</author>
<author><name sortKey="Stelloo, E" uniqKey="Stelloo E">E Stelloo</name>
</author>
<author><name sortKey="Nout, Ra" uniqKey="Nout R">RA Nout</name>
</author>
<author><name sortKey="Nijman, Hw" uniqKey="Nijman H">HW Nijman</name>
</author>
<author><name sortKey="Edmondson, Rj" uniqKey="Edmondson R">RJ Edmondson</name>
</author>
<author><name sortKey="Church, Dn" uniqKey="Church D">DN Church</name>
</author>
<author><name sortKey="Mackay, Hj" uniqKey="Mackay H">HJ MacKay</name>
</author>
<author><name sortKey="Leary, A" uniqKey="Leary A">A Leary</name>
</author>
<author><name sortKey="Powell, Me" uniqKey="Powell M">ME Powell</name>
</author>
<author><name sortKey="Mileshkin, L" uniqKey="Mileshkin L">L Mileshkin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Workel, Hh" uniqKey="Workel H">HH Workel</name>
</author>
<author><name sortKey="Komdeur, Fl" uniqKey="Komdeur F">FL Komdeur</name>
</author>
<author><name sortKey="Wouters, Mca" uniqKey="Wouters M">MCA Wouters</name>
</author>
<author><name sortKey="Plat, A" uniqKey="Plat A">A Plat</name>
</author>
<author><name sortKey="Klip, Hg" uniqKey="Klip H">HG Klip</name>
</author>
<author><name sortKey="Eggink, Fa" uniqKey="Eggink F">FA Eggink</name>
</author>
<author><name sortKey="Wisman, Gba" uniqKey="Wisman G">GBA Wisman</name>
</author>
<author><name sortKey="Arts, Hjg" uniqKey="Arts H">HJG Arts</name>
</author>
<author><name sortKey="Oonk, Mhm" uniqKey="Oonk M">MHM Oonk</name>
</author>
<author><name sortKey="Mourits, Mje" uniqKey="Mourits M">MJE Mourits</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jordanova, Es" uniqKey="Jordanova E">ES Jordanova</name>
</author>
<author><name sortKey="Gorter, A" uniqKey="Gorter A">A Gorter</name>
</author>
<author><name sortKey="Ayachi, O" uniqKey="Ayachi O">O Ayachi</name>
</author>
<author><name sortKey="Prins, F" uniqKey="Prins F">F Prins</name>
</author>
<author><name sortKey="Durrant, Lg" uniqKey="Durrant L">LG Durrant</name>
</author>
<author><name sortKey="Kenter, Gg" uniqKey="Kenter G">GG Kenter</name>
</author>
<author><name sortKey="Van Der Burg, Sh" uniqKey="Van Der Burg S">SH van der Burg</name>
</author>
<author><name sortKey="Fleuren, Gj" uniqKey="Fleuren G">GJ Fleuren</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nielsen, M" uniqKey="Nielsen M">M Nielsen</name>
</author>
<author><name sortKey="Lundegaard, C" uniqKey="Lundegaard C">C Lundegaard</name>
</author>
<author><name sortKey="Blicher, T" uniqKey="Blicher T">T Blicher</name>
</author>
<author><name sortKey="Lamberth, K" uniqKey="Lamberth K">K Lamberth</name>
</author>
<author><name sortKey="Harndahl, M" uniqKey="Harndahl M">M Harndahl</name>
</author>
<author><name sortKey="Justesen, S" uniqKey="Justesen S">S Justesen</name>
</author>
<author><name sortKey="R Der, G" uniqKey="R Der G">G Røder</name>
</author>
<author><name sortKey="Peters, B" uniqKey="Peters B">B Peters</name>
</author>
<author><name sortKey="Sette, A" uniqKey="Sette A">A Sette</name>
</author>
<author><name sortKey="Lund, O" uniqKey="Lund O">O Lund</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khalili, Js" uniqKey="Khalili J">JS Khalili</name>
</author>
<author><name sortKey="Hanson, Rw" uniqKey="Hanson R">RW Hanson</name>
</author>
<author><name sortKey="Szallasi, Z" uniqKey="Szallasi Z">Z Szallasi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duan, F" uniqKey="Duan F">F Duan</name>
</author>
<author><name sortKey="Duitama, J" uniqKey="Duitama J">J Duitama</name>
</author>
<author><name sortKey="Al Seesi, S" uniqKey="Al Seesi S">S Al Seesi</name>
</author>
<author><name sortKey="Ayres, Cm" uniqKey="Ayres C">CM Ayres</name>
</author>
<author><name sortKey="Corcelli, Sa" uniqKey="Corcelli S">SA Corcelli</name>
</author>
<author><name sortKey="Pawashe, Ap" uniqKey="Pawashe A">AP Pawashe</name>
</author>
<author><name sortKey="Blanchard, T" uniqKey="Blanchard T">T Blanchard</name>
</author>
<author><name sortKey="Mcmahon, D" uniqKey="Mcmahon D">D McMahon</name>
</author>
<author><name sortKey="Sidney, J" uniqKey="Sidney J">J Sidney</name>
</author>
<author><name sortKey="Sette, A" uniqKey="Sette A">A Sette</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Rooij, N" uniqKey="Van Rooij N">N van Rooij</name>
</author>
<author><name sortKey="Van Buuren, Mm" uniqKey="Van Buuren M">MM van Buuren</name>
</author>
<author><name sortKey="Philips, D" uniqKey="Philips D">D Philips</name>
</author>
<author><name sortKey="Velds, A" uniqKey="Velds A">A Velds</name>
</author>
<author><name sortKey="Toebes, M" uniqKey="Toebes M">M Toebes</name>
</author>
<author><name sortKey="Heemskerk, B" uniqKey="Heemskerk B">B Heemskerk</name>
</author>
<author><name sortKey="Van Dijk, Lja" uniqKey="Van Dijk L">LJA van Dijk</name>
</author>
<author><name sortKey="Behjati, S" uniqKey="Behjati S">S Behjati</name>
</author>
<author><name sortKey="Hilkmann, H" uniqKey="Hilkmann H">H Hilkmann</name>
</author>
<author><name sortKey="El Atmioui, D" uniqKey="El Atmioui D">D El Atmioui</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Royaume-Uni</li>
</country>
</list>
<tree><noCountry><name sortKey="Bosse, Tjalling" sort="Bosse, Tjalling" uniqKey="Bosse T" first="Tjalling" last="Bosse">Tjalling Bosse</name>
<name sortKey="Creutzberg, Carien L" sort="Creutzberg, Carien L" uniqKey="Creutzberg C" first="Carien L." last="Creutzberg">Carien L. Creutzberg</name>
<name sortKey="De Bruyn, Marco" sort="De Bruyn, Marco" uniqKey="De Bruyn M" first="Marco" last="De Bruyn">Marco De Bruyn</name>
<name sortKey="Eggink, Florine A" sort="Eggink, Florine A" uniqKey="Eggink F" first="Florine A." last="Eggink">Florine A. Eggink</name>
<name sortKey="Jordanova, Ekaterina S" sort="Jordanova, Ekaterina S" uniqKey="Jordanova E" first="Ekaterina S." last="Jordanova">Ekaterina S. Jordanova</name>
<name sortKey="Nijman, Hans W" sort="Nijman, Hans W" uniqKey="Nijman H" first="Hans W." last="Nijman">Hans W. Nijman</name>
<name sortKey="Van Gool, Inge C" sort="Van Gool, Inge C" uniqKey="Van Gool I" first="Inge C." last="Van Gool">Inge C. Van Gool</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Leary, Alexandra" sort="Leary, Alexandra" uniqKey="Leary A" first="Alexandra" last="Leary">Alexandra Leary</name>
</noRegion>
<name sortKey="Adam, Julien" sort="Adam, Julien" uniqKey="Adam J" first="Julien" last="Adam">Julien Adam</name>
</country>
<country name="Australie"><noRegion><name sortKey="Pollock, Pamela M" sort="Pollock, Pamela M" uniqKey="Pollock P" first="Pamela M." last="Pollock">Pamela M. Pollock</name>
</noRegion>
<name sortKey="Mileshkin, Linda" sort="Mileshkin, Linda" uniqKey="Mileshkin L" first="Linda" last="Mileshkin">Linda Mileshkin</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Crosbie, Emma J" sort="Crosbie, Emma J" uniqKey="Crosbie E" first="Emma J." last="Crosbie">Emma J. Crosbie</name>
</noRegion>
<name sortKey="Church, David N" sort="Church, David N" uniqKey="Church D" first="David N." last="Church">David N. Church</name>
<name sortKey="Church, David N" sort="Church, David N" uniqKey="Church D" first="David N." last="Church">David N. Church</name>
<name sortKey="Freeman Mills, Luke" sort="Freeman Mills, Luke" uniqKey="Freeman Mills L" first="Luke" last="Freeman-Mills">Luke Freeman-Mills</name>
</country>
</tree>
</affiliations>
</record>
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