Correlation between severe infection and breast cancer metastases in the EORTC 10994/BIG 1-00 trial: Investigating innate immunity as a tumour suppressor in breast cancer.
Identifieur interne : 004095 ( Ncbi/Checkpoint ); précédent : 004094; suivant : 004096Correlation between severe infection and breast cancer metastases in the EORTC 10994/BIG 1-00 trial: Investigating innate immunity as a tumour suppressor in breast cancer.
Auteurs : Nathan Touati [Belgique] ; Konstantinos Tryfonidis [Belgique] ; Franco Caramia [Australie] ; Hervé Bonnefoi [France] ; David Cameron [Royaume-Uni] ; Leen Slaets [Belgique] ; Belinda S. Parker [Australie] ; Sherene Loi [Australie]Source :
- European journal of cancer (Oxford, England : 1990) [ 1879-0852 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Agents de maintien de la densité osseuse (usage thérapeutique), Analyse de régression, Dénosumab (usage thérapeutique), Facteur-7 de régulation d'interféron (immunologie), Facteur-7 de régulation d'interféron (métabolisme), Femelle, Humains, Immunité innée (physiologie), Incidence, Infection (immunologie), Métastase tumorale (immunologie), Neutropénie fébrile (immunologie), Sujet âgé, Traitement médicamenteux adjuvant, Tumeurs du sein (anatomopathologie), Tumeurs du sein (immunologie), Tumeurs du sein (métabolisme), Tumeurs du sein (traitement médicamenteux), Tumeurs osseuses (secondaire), Tumeurs osseuses (épidémiologie), Études de suivi.
- MESH :
- anatomopathologie : Tumeurs du sein.
- immunologie : Facteur-7 de régulation d'interféron, Infection, Métastase tumorale, Neutropénie fébrile, Tumeurs du sein.
- métabolisme : Facteur-7 de régulation d'interféron, Tumeurs du sein.
- physiologie : Immunité innée.
- secondaire : Tumeurs osseuses.
- traitement médicamenteux : Tumeurs du sein.
- usage thérapeutique : Agents de maintien de la densité osseuse, Dénosumab.
- épidémiologie : Tumeurs osseuses.
- Adulte, Adulte d'âge moyen, Analyse de régression, Femelle, Humains, Incidence, Sujet âgé, Traitement médicamenteux adjuvant, Études de suivi.
English descriptors
- KwdEn :
- Adult, Aged, Bone Density Conservation Agents (therapeutic use), Bone Neoplasms (epidemiology), Bone Neoplasms (secondary), Breast Neoplasms (drug therapy), Breast Neoplasms (immunology), Breast Neoplasms (metabolism), Breast Neoplasms (pathology), Chemotherapy, Adjuvant, Denosumab (therapeutic use), Febrile Neutropenia (immunology), Female, Follow-Up Studies, Humans, Immunity, Innate (physiology), Incidence, Infection (immunology), Interferon Regulatory Factor-7 (immunology), Interferon Regulatory Factor-7 (metabolism), Middle Aged, Neoplasm Metastasis (immunology), Regression Analysis.
- MESH :
- chemical , immunology : Interferon Regulatory Factor-7.
- chemical , metabolism : Interferon Regulatory Factor-7.
- chemical , therapeutic use : Bone Density Conservation Agents, Denosumab.
- drug therapy : Breast Neoplasms.
- epidemiology : Bone Neoplasms.
- immunology : Breast Neoplasms, Febrile Neutropenia, Infection, Neoplasm Metastasis.
- metabolism : Breast Neoplasms.
- pathology : Breast Neoplasms.
- physiology : Immunity, Innate.
- secondary : Bone Neoplasms.
- Adult, Aged, Chemotherapy, Adjuvant, Female, Follow-Up Studies, Humans, Incidence, Middle Aged, Regression Analysis.
Abstract
Breast cancer cells which express an innate immune signature regulated by interferon regulatory factor 7 (IRF7) have reduced metastatic potential. Infections can induce interferon signalling and may activate an anti-tumour immune response. We investigated whether 'severe infection' can be a clinical surrogate of this phenomenon and/or the presence of high levels of the IRF7 signature at diagnosis before neo-adjuvant chemotherapy (NACT) is associated with a reduced distant relapse risk, specifically in bones.
DOI: 10.1016/j.ejca.2016.11.015
PubMed: 28027521
Affiliations:
- Australie, Belgique, France, Royaume-Uni
- Aquitaine, Nouvelle-Aquitaine, Victoria (État), Vienne (Autriche)
- Bordeaux, Melbourne, Vienne (Autriche)
- Université de Melbourne
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001095
- to stream PubMed, to step Curation: 001092
- to stream PubMed, to step Checkpoint: 001092
- to stream Ncbi, to step Merge: 004095
- to stream Ncbi, to step Curation: 004095
Links to Exploration step
pubmed:28027521Le document en format XML
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<term>Neoplasm Metastasis (immunology)</term>
<term>Regression Analysis</term>
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<term>Analyse de régression</term>
<term>Dénosumab (usage thérapeutique)</term>
<term>Facteur-7 de régulation d'interféron (immunologie)</term>
<term>Facteur-7 de régulation d'interféron (métabolisme)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunité innée (physiologie)</term>
<term>Incidence</term>
<term>Infection (immunologie)</term>
<term>Métastase tumorale (immunologie)</term>
<term>Neutropénie fébrile (immunologie)</term>
<term>Sujet âgé</term>
<term>Traitement médicamenteux adjuvant</term>
<term>Tumeurs du sein (anatomopathologie)</term>
<term>Tumeurs du sein (immunologie)</term>
<term>Tumeurs du sein (métabolisme)</term>
<term>Tumeurs du sein (traitement médicamenteux)</term>
<term>Tumeurs osseuses (secondaire)</term>
<term>Tumeurs osseuses (épidémiologie)</term>
<term>Études de suivi</term>
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<term>Denosumab</term>
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</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Bone Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Facteur-7 de régulation d'interféron</term>
<term>Infection</term>
<term>Métastase tumorale</term>
<term>Neutropénie fébrile</term>
<term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Breast Neoplasms</term>
<term>Febrile Neutropenia</term>
<term>Infection</term>
<term>Neoplasm Metastasis</term>
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<term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Immunité innée</term>
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</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents de maintien de la densité osseuse</term>
<term>Dénosumab</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Tumeurs osseuses</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Chemotherapy, Adjuvant</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Incidence</term>
<term>Middle Aged</term>
<term>Regression Analysis</term>
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<term>Adulte d'âge moyen</term>
<term>Analyse de régression</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Sujet âgé</term>
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<front><div type="abstract" xml:lang="en">Breast cancer cells which express an innate immune signature regulated by interferon regulatory factor 7 (IRF7) have reduced metastatic potential. Infections can induce interferon signalling and may activate an anti-tumour immune response. We investigated whether 'severe infection' can be a clinical surrogate of this phenomenon and/or the presence of high levels of the IRF7 signature at diagnosis before neo-adjuvant chemotherapy (NACT) is associated with a reduced distant relapse risk, specifically in bones.</div>
</front>
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<country name="Royaume-Uni"><noRegion><name sortKey="Cameron, David" sort="Cameron, David" uniqKey="Cameron D" first="David" last="Cameron">David Cameron</name>
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