Plasmodium vivax Reticulocyte Binding Proteins Are Key Targets of Naturally Acquired Immunity in Young Papua New Guinean Children
Identifieur interne : 003C19 ( Ncbi/Checkpoint ); précédent : 003C18; suivant : 003C20Plasmodium vivax Reticulocyte Binding Proteins Are Key Targets of Naturally Acquired Immunity in Young Papua New Guinean Children
Auteurs : Camila T. França [Australie] ; Wen-Qiang He [Australie] ; Jakub Gruszczyk [Australie] ; Nicholas T. Y. Lim [Australie] ; Enmoore Lin [Papouasie-Nouvelle-Guinée] ; Benson Kiniboro [Papouasie-Nouvelle-Guinée] ; Peter M. Siba [Papouasie-Nouvelle-Guinée] ; Wai-Hong Tham [Australie] ; Ivo Mueller [Australie, France, Espagne]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2016.
Abstract
Major gaps in our understanding of
We assessed the binding specificity of five members of the PvRBP family (PvRBP1a, PvRBP1b, PvRBP2a, PvRBP2b, PvRBP2-P2 and a non-binding fragment of PvRBP2c) to normocytes or reticulocytes. PvRBP2b was identified as the only reticulocyte-specific binder (P<0.001), whereas the others preferentially bound to normocytes (PvRBP1a/b P≤0.034), or showed comparable binding to both (PvRBP2a/2-P2, P = 0.38). Furthermore, we measured levels of total and IgG subclasses 1, 2, 3 and 4 to the six PvRBPs in a cohort of young Papua New Guinean children, and assessed their relationship with prospective risk of
These results demonstrate a diversity of erythrocyte-binding phenotypes of PvRBPs, indicating binding to both reticulocyte-specific and normocyte-specific ligands. Our findings provide further insights into the naturally acquired immunity to
Url:
DOI: 10.1371/journal.pntd.0005014
PubMed: 27677183
PubMed Central: 5038947
Affiliations:
- Australie, Espagne, France, Papouasie-Nouvelle-Guinée
- Catalogne, Victoria (État), Île-de-France
- Barcelone, Melbourne, Paris
- Université de Melbourne
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PMC:5038947Le document en format XML
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Reticulocyte Binding Proteins Are Key Targets of Naturally Acquired Immunity in Young Papua New Guinean Children</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Plasmodium vivax</italic>
Reticulocyte Binding Proteins Are Key Targets of Naturally Acquired Immunity in Young Papua New Guinean Children</title>
<author><name sortKey="Franca, Camila T" sort="Franca, Camila T" uniqKey="Franca C" first="Camila T." last="França">Camila T. França</name>
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<author><name sortKey="He, Wen Qiang" sort="He, Wen Qiang" uniqKey="He W" first="Wen-Qiang" last="He">Wen-Qiang He</name>
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<author><name sortKey="Gruszczyk, Jakub" sort="Gruszczyk, Jakub" uniqKey="Gruszczyk J" first="Jakub" last="Gruszczyk">Jakub Gruszczyk</name>
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<author><name sortKey="Lim, Nicholas T Y" sort="Lim, Nicholas T Y" uniqKey="Lim N" first="Nicholas T. Y." last="Lim">Nicholas T. Y. Lim</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Infection and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
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<author><name sortKey="Lin, Enmoore" sort="Lin, Enmoore" uniqKey="Lin E" first="Enmoore" last="Lin">Enmoore Lin</name>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Madang, Papua New Guinea</addr-line>
</nlm:aff>
<country xml:lang="fr">Papouasie-Nouvelle-Guinée</country>
<wicri:regionArea>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Madang</wicri:regionArea>
<wicri:noRegion>Madang</wicri:noRegion>
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<author><name sortKey="Kiniboro, Benson" sort="Kiniboro, Benson" uniqKey="Kiniboro B" first="Benson" last="Kiniboro">Benson Kiniboro</name>
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</nlm:aff>
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<wicri:regionArea>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Madang</wicri:regionArea>
<wicri:noRegion>Madang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Siba, Peter M" sort="Siba, Peter M" uniqKey="Siba P" first="Peter M." last="Siba">Peter M. Siba</name>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Madang, Papua New Guinea</addr-line>
</nlm:aff>
<country xml:lang="fr">Papouasie-Nouvelle-Guinée</country>
<wicri:regionArea>Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Madang</wicri:regionArea>
<wicri:noRegion>Madang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tham, Wai Hong" sort="Tham, Wai Hong" uniqKey="Tham W" first="Wai-Hong" last="Tham">Wai-Hong Tham</name>
<affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Department of Medical Biology, University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medical Biology, University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
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</nlm:aff>
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<author><name sortKey="Mueller, Ivo" sort="Mueller, Ivo" uniqKey="Mueller I" first="Ivo" last="Mueller">Ivo Mueller</name>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Department of Medical Biology, University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
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<settlement type="city">Melbourne</settlement>
</placeName>
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</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Malaria Parasites and Hosts Unit, Department of Parasites and Insect Vectors, Pasteur Institute, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Malaria Parasites and Hosts Unit, Department of Parasites and Insect Vectors, Pasteur Institute, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Barcelona Institute of Global Health (ISGLOBAL), Barcelona, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Barcelona Institute of Global Health (ISGLOBAL), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
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<series><title level="j">PLoS Neglected Tropical Diseases</title>
<idno type="ISSN">1935-2727</idno>
<idno type="eISSN">1935-2735</idno>
<imprint><date when="2016">2016</date>
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<front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title>
<p>Major gaps in our understanding of <italic>Plasmodium vivax</italic>
biology and the acquisition of immunity to this parasite hinder vaccine development. <italic>P</italic>
. <italic>vivax</italic>
merozoites exclusively invade reticulocytes, making parasite proteins that mediate reticulocyte binding and/or invasion potential key vaccine or drug targets. While protein interactions that mediate invasion are still poorly understood, the <italic>P</italic>
. <italic>vivax</italic>
Reticulocyte-Binding Protein family (PvRBP) is thought to be involved in <italic>P</italic>
. <italic>vivax</italic>
restricted host-cell selectivity.</p>
</sec>
<sec id="sec002"><title>Methodology/Principal findings</title>
<p>We assessed the binding specificity of five members of the PvRBP family (PvRBP1a, PvRBP1b, PvRBP2a, PvRBP2b, PvRBP2-P2 and a non-binding fragment of PvRBP2c) to normocytes or reticulocytes. PvRBP2b was identified as the only reticulocyte-specific binder (P<0.001), whereas the others preferentially bound to normocytes (PvRBP1a/b P≤0.034), or showed comparable binding to both (PvRBP2a/2-P2, P = 0.38). Furthermore, we measured levels of total and IgG subclasses 1, 2, 3 and 4 to the six PvRBPs in a cohort of young Papua New Guinean children, and assessed their relationship with prospective risk of <italic>P</italic>
. <italic>vivax</italic>
malaria. Children had substantial, highly correlated (rho = 0.49–0.82, P<0.001) antibody levels to all six PvRBPs, with dominant IgG1 and IgG3 subclasses. Both total IgG (Incidence Rate Ratio [IRR] 0.63–0.73, P = 0.008–0.041) and IgG1 (IRR 0.56–0.69, P = 0.001–0.035) to PvRBP2b and PvRBP1a were strongly associated with reduced risk of vivax-malaria, independently of age and exposure.</p>
</sec>
<sec id="sec003"><title>Conclusion/Significance</title>
<p>These results demonstrate a diversity of erythrocyte-binding phenotypes of PvRBPs, indicating binding to both reticulocyte-specific and normocyte-specific ligands. Our findings provide further insights into the naturally acquired immunity to <italic>P</italic>
. <italic>vivax</italic>
and highlight the importance of PvRBP proteins as targets of naturally acquired humoral immunity. In-depth studies of the role of PvRBPs in <italic>P</italic>
. <italic>vivax</italic>
invasion and functional validation of the role of anti-PvRBP antibodies in clinical immunity against <italic>P</italic>
. <italic>vivax</italic>
are now required to confirm the potential of the reticulocyte-binding PvRBP2b and PvRBP1a as vaccine candidate antigens.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mueller, I" uniqKey="Mueller I">I Mueller</name>
</author>
<author><name sortKey="Galinski, Mr" uniqKey="Galinski M">MR Galinski</name>
</author>
<author><name sortKey="Baird, Jk" uniqKey="Baird J">JK Baird</name>
</author>
<author><name sortKey="Carlton, Jm" uniqKey="Carlton J">JM Carlton</name>
</author>
<author><name sortKey="Kochar, Dk" uniqKey="Kochar D">DK Kochar</name>
</author>
<author><name sortKey="Alonso, Pl" uniqKey="Alonso P">PL Alonso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cowman, Af" uniqKey="Cowman A">AF Cowman</name>
</author>
<author><name sortKey="Berry, D" uniqKey="Berry D">D Berry</name>
</author>
<author><name sortKey="Baum, J" uniqKey="Baum J">J Baum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tham, Wh" uniqKey="Tham W">WH Tham</name>
</author>
<author><name sortKey="Healer, J" uniqKey="Healer J">J Healer</name>
</author>
<author><name sortKey="Cowman, Af" uniqKey="Cowman A">AF Cowman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Neote, K" uniqKey="Neote K">K Neote</name>
</author>
<author><name sortKey="Mak, Jy" uniqKey="Mak J">JY Mak</name>
</author>
<author><name sortKey="Kolakowski, Lf" uniqKey="Kolakowski L">LF Kolakowski</name>
</author>
<author><name sortKey="Schall, Tj" uniqKey="Schall T">TJ Schall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hester, J" uniqKey="Hester J">J Hester</name>
</author>
<author><name sortKey="Chan, Er" uniqKey="Chan E">ER Chan</name>
</author>
<author><name sortKey="Menard, D" uniqKey="Menard D">D Menard</name>
</author>
<author><name sortKey="Mercereau Puijalon, O" uniqKey="Mercereau Puijalon O">O Mercereau-Puijalon</name>
</author>
<author><name sortKey="Barnwell, J" uniqKey="Barnwell J">J Barnwell</name>
</author>
<author><name sortKey="Zimmerman, Pa" uniqKey="Zimmerman P">PA Zimmerman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menard, D" uniqKey="Menard D">D Menard</name>
</author>
<author><name sortKey="Barnadas, C" uniqKey="Barnadas C">C Barnadas</name>
</author>
<author><name sortKey="Bouchier, C" uniqKey="Bouchier C">C Bouchier</name>
</author>
<author><name sortKey="Henry Halldin, C" uniqKey="Henry Halldin C">C Henry-Halldin</name>
</author>
<author><name sortKey="Gray, Lr" uniqKey="Gray L">LR Gray</name>
</author>
<author><name sortKey="Ratsimbasoa, A" uniqKey="Ratsimbasoa A">A Ratsimbasoa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Woldearegai, Tg" uniqKey="Woldearegai T">TG Woldearegai</name>
</author>
<author><name sortKey="Kremsner, Pg" uniqKey="Kremsner P">PG Kremsner</name>
</author>
<author><name sortKey="Kun, Jf" uniqKey="Kun J">JF Kun</name>
</author>
<author><name sortKey="Mordmuller, B" uniqKey="Mordmuller B">B Mordmuller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galinski, Mr" uniqKey="Galinski M">MR Galinski</name>
</author>
<author><name sortKey="Medina, Cc" uniqKey="Medina C">CC Medina</name>
</author>
<author><name sortKey="Ingravallo, P" uniqKey="Ingravallo P">P Ingravallo</name>
</author>
<author><name sortKey="Barnwell, Jw" uniqKey="Barnwell J">JW Barnwell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carlton, Jm" uniqKey="Carlton J">JM Carlton</name>
</author>
<author><name sortKey="Adams, Jh" uniqKey="Adams J">JH Adams</name>
</author>
<author><name sortKey="Silva, Jc" uniqKey="Silva J">JC Silva</name>
</author>
<author><name sortKey="Bidwell, Sl" uniqKey="Bidwell S">SL Bidwell</name>
</author>
<author><name sortKey="Lorenzi, H" uniqKey="Lorenzi H">H Lorenzi</name>
</author>
<author><name sortKey="Caler, E" uniqKey="Caler E">E Caler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gruszczyk, J" uniqKey="Gruszczyk J">J Gruszczyk</name>
</author>
<author><name sortKey="Lim, Nt" uniqKey="Lim N">NT Lim</name>
</author>
<author><name sortKey="Arnott, A" uniqKey="Arnott A">A Arnott</name>
</author>
<author><name sortKey="He, Wq" uniqKey="He W">WQ He</name>
</author>
<author><name sortKey="Nguitragool, W" uniqKey="Nguitragool W">W Nguitragool</name>
</author>
<author><name sortKey="Roobsoong, W" uniqKey="Roobsoong W">W Roobsoong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hietanen, J" uniqKey="Hietanen J">J Hietanen</name>
</author>
<author><name sortKey="Chim Ong, A" uniqKey="Chim Ong A">A Chim-Ong</name>
</author>
<author><name sortKey="Chiramanewong, T" uniqKey="Chiramanewong T">T Chiramanewong</name>
</author>
<author><name sortKey="Gruszczyk, J" uniqKey="Gruszczyk J">J Gruszczyk</name>
</author>
<author><name sortKey="Roobsoong, W" uniqKey="Roobsoong W">W Roobsoong</name>
</author>
<author><name sortKey="Tham, Wh" uniqKey="Tham W">WH Tham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kosaisavee, V" uniqKey="Kosaisavee V">V Kosaisavee</name>
</author>
<author><name sortKey="Lek Uthai, U" uniqKey="Lek Uthai U">U Lek-Uthai</name>
</author>
<author><name sortKey="Suwanarusk, R" uniqKey="Suwanarusk R">R Suwanarusk</name>
</author>
<author><name sortKey="Gruner, Ac" uniqKey="Gruner A">AC Gruner</name>
</author>
<author><name sortKey="Russell, B" uniqKey="Russell B">B Russell</name>
</author>
<author><name sortKey="Nosten, F" uniqKey="Nosten F">F Nosten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rayner, Jc" uniqKey="Rayner J">JC Rayner</name>
</author>
<author><name sortKey="Tran, Tm" uniqKey="Tran T">TM Tran</name>
</author>
<author><name sortKey="Corredor, V" uniqKey="Corredor V">V Corredor</name>
</author>
<author><name sortKey="Huber, Cs" uniqKey="Huber C">CS Huber</name>
</author>
<author><name sortKey="Barnwell, Jw" uniqKey="Barnwell J">JW Barnwell</name>
</author>
<author><name sortKey="Galinski, Mr" uniqKey="Galinski M">MR Galinski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mueller, I" uniqKey="Mueller I">I Mueller</name>
</author>
<author><name sortKey="Shakri, Ar" uniqKey="Shakri A">AR Shakri</name>
</author>
<author><name sortKey="Chitnis, Ce" uniqKey="Chitnis C">CE Chitnis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cutts, Jc" uniqKey="Cutts J">JC Cutts</name>
</author>
<author><name sortKey="Powell, R" uniqKey="Powell R">R Powell</name>
</author>
<author><name sortKey="Agius, Pa" uniqKey="Agius P">PA Agius</name>
</author>
<author><name sortKey="Beeson, Jg" uniqKey="Beeson J">JG Beeson</name>
</author>
<author><name sortKey="Simpson, Ja" uniqKey="Simpson J">JA Simpson</name>
</author>
<author><name sortKey="Fowkes, Fj" uniqKey="Fowkes F">FJ Fowkes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Han, Jh" uniqKey="Han J">JH Han</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name>
</author>
<author><name sortKey="Lee, Sk" uniqKey="Lee S">SK Lee</name>
</author>
<author><name sortKey="Nyunt, Mh" uniqKey="Nyunt M">MH Nyunt</name>
</author>
<author><name sortKey="Na, S" uniqKey="Na S">S Na</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rojas Caraballo, J" uniqKey="Rojas Caraballo J">J Rojas Caraballo</name>
</author>
<author><name sortKey="Delgado, G" uniqKey="Delgado G">G Delgado</name>
</author>
<author><name sortKey="Rodriguez, R" uniqKey="Rodriguez R">R Rodriguez</name>
</author>
<author><name sortKey="Patarroyo, Ma" uniqKey="Patarroyo M">MA Patarroyo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tran, Tm" uniqKey="Tran T">TM Tran</name>
</author>
<author><name sortKey="Oliveira Ferreira, J" uniqKey="Oliveira Ferreira J">J Oliveira-Ferreira</name>
</author>
<author><name sortKey="Moreno, A" uniqKey="Moreno A">A Moreno</name>
</author>
<author><name sortKey="Santos, F" uniqKey="Santos F">F Santos</name>
</author>
<author><name sortKey="Yazdani, Ss" uniqKey="Yazdani S">SS Yazdani</name>
</author>
<author><name sortKey="Chitnis, Ce" uniqKey="Chitnis C">CE Chitnis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, E" uniqKey="Lin E">E Lin</name>
</author>
<author><name sortKey="Kiniboro, B" uniqKey="Kiniboro B">B Kiniboro</name>
</author>
<author><name sortKey="Gray, L" uniqKey="Gray L">L Gray</name>
</author>
<author><name sortKey="Dobbie, S" uniqKey="Dobbie S">S Dobbie</name>
</author>
<author><name sortKey="Robinson, L" uniqKey="Robinson L">L Robinson</name>
</author>
<author><name sortKey="Laumaea, A" uniqKey="Laumaea A">A Laumaea</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koepfli, C" uniqKey="Koepfli C">C Koepfli</name>
</author>
<author><name sortKey="Colborn, Kl" uniqKey="Colborn K">KL Colborn</name>
</author>
<author><name sortKey="Kiniboro, B" uniqKey="Kiniboro B">B Kiniboro</name>
</author>
<author><name sortKey="Lin, E" uniqKey="Lin E">E Lin</name>
</author>
<author><name sortKey="Speed, Tp" uniqKey="Speed T">TP Speed</name>
</author>
<author><name sortKey="Siba, Pm" uniqKey="Siba P">PM Siba</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kellar, Kl" uniqKey="Kellar K">KL Kellar</name>
</author>
<author><name sortKey="Kalwar, Rr" uniqKey="Kalwar R">RR Kalwar</name>
</author>
<author><name sortKey="Dubois, Ka" uniqKey="Dubois K">KA Dubois</name>
</author>
<author><name sortKey="Crouse, D" uniqKey="Crouse D">D Crouse</name>
</author>
<author><name sortKey="Chafin, Wd" uniqKey="Chafin W">WD Chafin</name>
</author>
<author><name sortKey="Kane, Be" uniqKey="Kane B">BE Kane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Franca, Ct" uniqKey="Franca C">CT Franca</name>
</author>
<author><name sortKey="Hostetler, Jb" uniqKey="Hostetler J">JB Hostetler</name>
</author>
<author><name sortKey="Sharma, S" uniqKey="Sharma S">S Sharma</name>
</author>
<author><name sortKey="White, Mt" uniqKey="White M">MT White</name>
</author>
<author><name sortKey="Lin, E" uniqKey="Lin E">E Lin</name>
</author>
<author><name sortKey="Kiniboro, B" uniqKey="Kiniboro B">B Kiniboro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Piriou, E" uniqKey="Piriou E">E Piriou</name>
</author>
<author><name sortKey="Kimmel, R" uniqKey="Kimmel R">R Kimmel</name>
</author>
<author><name sortKey="Chelimo, K" uniqKey="Chelimo K">K Chelimo</name>
</author>
<author><name sortKey="Middeldorp, Jm" uniqKey="Middeldorp J">JM Middeldorp</name>
</author>
<author><name sortKey="Odada, Ps" uniqKey="Odada P">PS Odada</name>
</author>
<author><name sortKey="Ploutz Snyder, R" uniqKey="Ploutz Snyder R">R Ploutz-Snyder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giraldo, J" uniqKey="Giraldo J">J Giraldo</name>
</author>
<author><name sortKey="Vivas, Nm" uniqKey="Vivas N">NM Vivas</name>
</author>
<author><name sortKey="Vila, E" uniqKey="Vila E">E Vila</name>
</author>
<author><name sortKey="Badia, A" uniqKey="Badia A">A Badia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stanisic, Di" uniqKey="Stanisic D">DI Stanisic</name>
</author>
<author><name sortKey="Javati, S" uniqKey="Javati S">S Javati</name>
</author>
<author><name sortKey="Kiniboro, B" uniqKey="Kiniboro B">B Kiniboro</name>
</author>
<author><name sortKey="Lin, E" uniqKey="Lin E">E Lin</name>
</author>
<author><name sortKey="Jiang, J" uniqKey="Jiang J">J Jiang</name>
</author>
<author><name sortKey="Singh, B" uniqKey="Singh B">B Singh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Draper, Sj" uniqKey="Draper S">SJ Draper</name>
</author>
<author><name sortKey="Angov, E" uniqKey="Angov E">E Angov</name>
</author>
<author><name sortKey="Horii, T" uniqKey="Horii T">T Horii</name>
</author>
<author><name sortKey="Miller, Lh" uniqKey="Miller L">LH Miller</name>
</author>
<author><name sortKey="Srinivasan, P" uniqKey="Srinivasan P">P Srinivasan</name>
</author>
<author><name sortKey="Theisen, M" uniqKey="Theisen M">M Theisen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Longley, Rj" uniqKey="Longley R">RJ Longley</name>
</author>
<author><name sortKey="Sattabongkot, J" uniqKey="Sattabongkot J">J Sattabongkot</name>
</author>
<author><name sortKey="Mueller, I" uniqKey="Mueller I">I Mueller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Noland, Gs" uniqKey="Noland G">GS Noland</name>
</author>
<author><name sortKey="Jansen, P" uniqKey="Jansen P">P Jansen</name>
</author>
<author><name sortKey="Vulule, Jm" uniqKey="Vulule J">JM Vulule</name>
</author>
<author><name sortKey="Park, Gs" uniqKey="Park G">GS Park</name>
</author>
<author><name sortKey="Ondigo, Bn" uniqKey="Ondigo B">BN Ondigo</name>
</author>
<author><name sortKey="Kazura, Jw" uniqKey="Kazura J">JW Kazura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tongren, Je" uniqKey="Tongren J">JE Tongren</name>
</author>
<author><name sortKey="Drakeley, Cj" uniqKey="Drakeley C">CJ Drakeley</name>
</author>
<author><name sortKey="Mcdonald, Sl" uniqKey="Mcdonald S">SL McDonald</name>
</author>
<author><name sortKey="Reyburn, Hg" uniqKey="Reyburn H">HG Reyburn</name>
</author>
<author><name sortKey="Manjurano, A" uniqKey="Manjurano A">A Manjurano</name>
</author>
<author><name sortKey="Nkya, Wm" uniqKey="Nkya W">WM Nkya</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vidarsson, G" uniqKey="Vidarsson G">G Vidarsson</name>
</author>
<author><name sortKey="Dekkers, G" uniqKey="Dekkers G">G Dekkers</name>
</author>
<author><name sortKey="Rispens, T" uniqKey="Rispens T">T Rispens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Osier, Fh" uniqKey="Osier F">FH Osier</name>
</author>
<author><name sortKey="Feng, G" uniqKey="Feng G">G Feng</name>
</author>
<author><name sortKey="Boyle, Mj" uniqKey="Boyle M">MJ Boyle</name>
</author>
<author><name sortKey="Langer, C" uniqKey="Langer C">C Langer</name>
</author>
<author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name>
</author>
<author><name sortKey="Richards, Js" uniqKey="Richards J">JS Richards</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeyrek, Fy" uniqKey="Zeyrek F">FY Zeyrek</name>
</author>
<author><name sortKey="Babaoglu, A" uniqKey="Babaoglu A">A Babaoglu</name>
</author>
<author><name sortKey="Demirel, S" uniqKey="Demirel S">S Demirel</name>
</author>
<author><name sortKey="Erdogan, Dd" uniqKey="Erdogan D">DD Erdogan</name>
</author>
<author><name sortKey="Ak, M" uniqKey="Ak M">M Ak</name>
</author>
<author><name sortKey="Korkmaz, M" uniqKey="Korkmaz M">M Korkmaz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Woodberry, T" uniqKey="Woodberry T">T Woodberry</name>
</author>
<author><name sortKey="Minigo, G" uniqKey="Minigo G">G Minigo</name>
</author>
<author><name sortKey="Piera, Ka" uniqKey="Piera K">KA Piera</name>
</author>
<author><name sortKey="Hanley, Jc" uniqKey="Hanley J">JC Hanley</name>
</author>
<author><name sortKey="De Silva, Hd" uniqKey="De Silva H">HD de Silva</name>
</author>
<author><name sortKey="Salwati, E" uniqKey="Salwati E">E Salwati</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yildiz Zeyrek, F" uniqKey="Yildiz Zeyrek F">F Yildiz Zeyrek</name>
</author>
<author><name sortKey="Palacpac, N" uniqKey="Palacpac N">N Palacpac</name>
</author>
<author><name sortKey="Yuksel, F" uniqKey="Yuksel F">F Yuksel</name>
</author>
<author><name sortKey="Yagi, M" uniqKey="Yagi M">M Yagi</name>
</author>
<author><name sortKey="Honjo, K" uniqKey="Honjo K">K Honjo</name>
</author>
<author><name sortKey="Fujita, Y" uniqKey="Fujita Y">Y Fujita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stanisic, Di" uniqKey="Stanisic D">DI Stanisic</name>
</author>
<author><name sortKey="Fowkes, Fj" uniqKey="Fowkes F">FJ Fowkes</name>
</author>
<author><name sortKey="Koinari, M" uniqKey="Koinari M">M Koinari</name>
</author>
<author><name sortKey="Javati, S" uniqKey="Javati S">S Javati</name>
</author>
<author><name sortKey="Lin, E" uniqKey="Lin E">E Lin</name>
</author>
<author><name sortKey="Kiniboro, B" uniqKey="Kiniboro B">B Kiniboro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Richards, Js" uniqKey="Richards J">JS Richards</name>
</author>
<author><name sortKey="Stanisic, Di" uniqKey="Stanisic D">DI Stanisic</name>
</author>
<author><name sortKey="Fowkes, Fj" uniqKey="Fowkes F">FJ Fowkes</name>
</author>
<author><name sortKey="Tavul, L" uniqKey="Tavul L">L Tavul</name>
</author>
<author><name sortKey="Dabod, E" uniqKey="Dabod E">E Dabod</name>
</author>
<author><name sortKey="Thompson, Jk" uniqKey="Thompson J">JK Thompson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reiling, L" uniqKey="Reiling L">L Reiling</name>
</author>
<author><name sortKey="Richards, Js" uniqKey="Richards J">JS Richards</name>
</author>
<author><name sortKey="Fowkes, Fj" uniqKey="Fowkes F">FJ Fowkes</name>
</author>
<author><name sortKey="Barry, Ae" uniqKey="Barry A">AE Barry</name>
</author>
<author><name sortKey="Triglia, T" uniqKey="Triglia T">T Triglia</name>
</author>
<author><name sortKey="Chokejindachai, W" uniqKey="Chokejindachai W">W Chokejindachai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aucan, C" uniqKey="Aucan C">C Aucan</name>
</author>
<author><name sortKey="Traore, Y" uniqKey="Traore Y">Y Traore</name>
</author>
<author><name sortKey="Tall, F" uniqKey="Tall F">F Tall</name>
</author>
<author><name sortKey="Nacro, B" uniqKey="Nacro B">B Nacro</name>
</author>
<author><name sortKey="Traore Leroux, T" uniqKey="Traore Leroux T">T Traore-Leroux</name>
</author>
<author><name sortKey="Fumoux, F" uniqKey="Fumoux F">F Fumoux</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ahmed, Ismail H" uniqKey="Ahmed I">Ismail H Ahmed</name>
</author>
<author><name sortKey="Tijani, Mk" uniqKey="Tijani M">MK Tijani</name>
</author>
<author><name sortKey="Langer, C" uniqKey="Langer C">C Langer</name>
</author>
<author><name sortKey="Reiling, L" uniqKey="Reiling L">L Reiling</name>
</author>
<author><name sortKey="White, Mt" uniqKey="White M">MT White</name>
</author>
<author><name sortKey="Beeson, Jg" uniqKey="Beeson J">JG Beeson</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Tham, Wh" uniqKey="Tham W">WH Tham</name>
</author>
<author><name sortKey="Lim, Nt" uniqKey="Lim N">NT Lim</name>
</author>
<author><name sortKey="Weiss, Ge" uniqKey="Weiss G">GE Weiss</name>
</author>
<author><name sortKey="Lopaticki, S" uniqKey="Lopaticki S">S Lopaticki</name>
</author>
<author><name sortKey="Ansell, Br" uniqKey="Ansell B">BR Ansell</name>
</author>
<author><name sortKey="Bird, M" uniqKey="Bird M">M Bird</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tham, Wh" uniqKey="Tham W">WH Tham</name>
</author>
<author><name sortKey="Wilson, Dw" uniqKey="Wilson D">DW Wilson</name>
</author>
<author><name sortKey="Lopaticki, S" uniqKey="Lopaticki S">S Lopaticki</name>
</author>
<author><name sortKey="Schmidt, Cq" uniqKey="Schmidt C">CQ Schmidt</name>
</author>
<author><name sortKey="Tetteh Quarcoo, Pb" uniqKey="Tetteh Quarcoo P">PB Tetteh-Quarcoo</name>
</author>
<author><name sortKey="Barlow, Pn" uniqKey="Barlow P">PN Barlow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Crosnier, C" uniqKey="Crosnier C">C Crosnier</name>
</author>
<author><name sortKey="Bustamante, Ly" uniqKey="Bustamante L">LY Bustamante</name>
</author>
<author><name sortKey="Bartholdson, Sj" uniqKey="Bartholdson S">SJ Bartholdson</name>
</author>
<author><name sortKey="Bei, Ak" uniqKey="Bei A">AK Bei</name>
</author>
<author><name sortKey="Theron, M" uniqKey="Theron M">M Theron</name>
</author>
<author><name sortKey="Uchikawa, M" uniqKey="Uchikawa M">M Uchikawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weiss, Ge" uniqKey="Weiss G">GE Weiss</name>
</author>
<author><name sortKey="Gilson, Pr" uniqKey="Gilson P">PR Gilson</name>
</author>
<author><name sortKey="Taechalertpaisarn, T" uniqKey="Taechalertpaisarn T">T Taechalertpaisarn</name>
</author>
<author><name sortKey="Tham, Wh" uniqKey="Tham W">WH Tham</name>
</author>
<author><name sortKey="De Jong, Nw" uniqKey="De Jong N">NW de Jong</name>
</author>
<author><name sortKey="Harvey, Kl" uniqKey="Harvey K">KL Harvey</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Paul, As" uniqKey="Paul A">AS Paul</name>
</author>
<author><name sortKey="Prinz, B" uniqKey="Prinz B">B Prinz</name>
</author>
<author><name sortKey="Kono, M" uniqKey="Kono M">M Kono</name>
</author>
<author><name sortKey="Ching, W" uniqKey="Ching W">W Ching</name>
</author>
<author><name sortKey="Heincke, D" uniqKey="Heincke D">D Heincke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bustamante, Ly" uniqKey="Bustamante L">LY Bustamante</name>
</author>
<author><name sortKey="Bartholdson, Sj" uniqKey="Bartholdson S">SJ Bartholdson</name>
</author>
<author><name sortKey="Crosnier, C" uniqKey="Crosnier C">C Crosnier</name>
</author>
<author><name sortKey="Campos, Mg" uniqKey="Campos M">MG Campos</name>
</author>
<author><name sortKey="Wanaguru, M" uniqKey="Wanaguru M">M Wanaguru</name>
</author>
<author><name sortKey="Nguon, C" uniqKey="Nguon C">C Nguon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Douglas, Ad" uniqKey="Douglas A">AD Douglas</name>
</author>
<author><name sortKey="Williams, Ar" uniqKey="Williams A">AR Williams</name>
</author>
<author><name sortKey="Illingworth, Jj" uniqKey="Illingworth J">JJ Illingworth</name>
</author>
<author><name sortKey="Kamuyu, G" uniqKey="Kamuyu G">G Kamuyu</name>
</author>
<author><name sortKey="Biswas, S" uniqKey="Biswas S">S Biswas</name>
</author>
<author><name sortKey="Goodman, Al" uniqKey="Goodman A">AL Goodman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wright, Ke" uniqKey="Wright K">KE Wright</name>
</author>
<author><name sortKey="Hjerrild, Ka" uniqKey="Hjerrild K">KA Hjerrild</name>
</author>
<author><name sortKey="Bartlett, J" uniqKey="Bartlett J">J Bartlett</name>
</author>
<author><name sortKey="Douglas, Ad" uniqKey="Douglas A">AD Douglas</name>
</author>
<author><name sortKey="Jin, J" uniqKey="Jin J">J Jin</name>
</author>
<author><name sortKey="Brown, Re" uniqKey="Brown R">RE Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name>
</author>
<author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
<author><name sortKey="Healer, J" uniqKey="Healer J">J Healer</name>
</author>
<author><name sortKey="Thompson, Jk" uniqKey="Thompson J">JK Thompson</name>
</author>
<author><name sortKey="Smith, Bj" uniqKey="Smith B">BJ Smith</name>
</author>
<author><name sortKey="Lawrence, Mc" uniqKey="Lawrence M">MC Lawrence</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Douglas, Ad" uniqKey="Douglas A">AD Douglas</name>
</author>
<author><name sortKey="Baldeviano, Gc" uniqKey="Baldeviano G">GC Baldeviano</name>
</author>
<author><name sortKey="Lucas, Cm" uniqKey="Lucas C">CM Lucas</name>
</author>
<author><name sortKey="Lugo Roman, La" uniqKey="Lugo Roman L">LA Lugo-Roman</name>
</author>
<author><name sortKey="Crosnier, C" uniqKey="Crosnier C">C Crosnier</name>
</author>
<author><name sortKey="Bartholdson, Sj" uniqKey="Bartholdson S">SJ Bartholdson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Douglas, Ad" uniqKey="Douglas A">AD Douglas</name>
</author>
<author><name sortKey="Williams, Ar" uniqKey="Williams A">AR Williams</name>
</author>
<author><name sortKey="Knuepfer, E" uniqKey="Knuepfer E">E Knuepfer</name>
</author>
<author><name sortKey="Illingworth, Jj" uniqKey="Illingworth J">JJ Illingworth</name>
</author>
<author><name sortKey="Furze, Jm" uniqKey="Furze J">JM Furze</name>
</author>
<author><name sortKey="Crosnier, C" uniqKey="Crosnier C">C Crosnier</name>
</author>
</analytic>
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</div1>
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</TEI>
<affiliations><list><country><li>Australie</li>
<li>Espagne</li>
<li>France</li>
<li>Papouasie-Nouvelle-Guinée</li>
</country>
<region><li>Catalogne</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Barcelone</li>
<li>Melbourne</li>
<li>Paris</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Franca, Camila T" sort="Franca, Camila T" uniqKey="Franca C" first="Camila T." last="França">Camila T. França</name>
</region>
<name sortKey="Franca, Camila T" sort="Franca, Camila T" uniqKey="Franca C" first="Camila T." last="França">Camila T. França</name>
<name sortKey="Gruszczyk, Jakub" sort="Gruszczyk, Jakub" uniqKey="Gruszczyk J" first="Jakub" last="Gruszczyk">Jakub Gruszczyk</name>
<name sortKey="He, Wen Qiang" sort="He, Wen Qiang" uniqKey="He W" first="Wen-Qiang" last="He">Wen-Qiang He</name>
<name sortKey="He, Wen Qiang" sort="He, Wen Qiang" uniqKey="He W" first="Wen-Qiang" last="He">Wen-Qiang He</name>
<name sortKey="Lim, Nicholas T Y" sort="Lim, Nicholas T Y" uniqKey="Lim N" first="Nicholas T. Y." last="Lim">Nicholas T. Y. Lim</name>
<name sortKey="Mueller, Ivo" sort="Mueller, Ivo" uniqKey="Mueller I" first="Ivo" last="Mueller">Ivo Mueller</name>
<name sortKey="Mueller, Ivo" sort="Mueller, Ivo" uniqKey="Mueller I" first="Ivo" last="Mueller">Ivo Mueller</name>
<name sortKey="Tham, Wai Hong" sort="Tham, Wai Hong" uniqKey="Tham W" first="Wai-Hong" last="Tham">Wai-Hong Tham</name>
<name sortKey="Tham, Wai Hong" sort="Tham, Wai Hong" uniqKey="Tham W" first="Wai-Hong" last="Tham">Wai-Hong Tham</name>
</country>
<country name="Papouasie-Nouvelle-Guinée"><noRegion><name sortKey="Lin, Enmoore" sort="Lin, Enmoore" uniqKey="Lin E" first="Enmoore" last="Lin">Enmoore Lin</name>
</noRegion>
<name sortKey="Kiniboro, Benson" sort="Kiniboro, Benson" uniqKey="Kiniboro B" first="Benson" last="Kiniboro">Benson Kiniboro</name>
<name sortKey="Siba, Peter M" sort="Siba, Peter M" uniqKey="Siba P" first="Peter M." last="Siba">Peter M. Siba</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Mueller, Ivo" sort="Mueller, Ivo" uniqKey="Mueller I" first="Ivo" last="Mueller">Ivo Mueller</name>
</region>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Mueller, Ivo" sort="Mueller, Ivo" uniqKey="Mueller I" first="Ivo" last="Mueller">Ivo Mueller</name>
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</country>
</tree>
</affiliations>
</record>
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