Maraviroc, as a Switch Option, in HIV-1-infected Individuals With Stable, Well-controlled HIV Replication and R5-tropic Virus on Their First Nucleoside/Nucleotide Reverse Transcriptase Inhibitor Plus Ritonavir-boosted Protease Inhibitor Regimen: Week 48 Results of the Randomized, Multicenter MARCH Study.
Identifieur interne : 003369 ( Ncbi/Checkpoint ); précédent : 003368; suivant : 003370Maraviroc, as a Switch Option, in HIV-1-infected Individuals With Stable, Well-controlled HIV Replication and R5-tropic Virus on Their First Nucleoside/Nucleotide Reverse Transcriptase Inhibitor Plus Ritonavir-boosted Protease Inhibitor Regimen: Week 48 Results of the Randomized, Multicenter MARCH Study.
Auteurs : Sarah Lilian Pett [Royaume-Uni] ; Janaki Amin [Australie] ; Andrejz Horban [Pologne] ; Jaime Andrade-Villanueva [Mexique] ; Marcelo Losso ; Norma Porteiro [Argentine] ; Juan Sierra Madero [Mexique] ; Waldo Belloso [Argentine] ; Elise Tu [Australie] ; David Silk [Australie] ; Anthony Kelleher [Australie] ; Richard Harrigan [Canada] ; Andrew Clark [Royaume-Uni] ; Wataru Sugiura [Japon] ; Marcelo Wolff [Chili] ; John Gill [Canada] ; Jose Gatell [Espagne] ; Martin Fisher [Royaume-Uni] ; Amanda Clarke [Royaume-Uni] ; Kiat Ruxrungtham ; Thierry Prazuck [France] ; Rolf Kaiser [Allemagne] ; Ian Woolley [Australie] ; Juan Alberto Arnaiz [Espagne] ; David Cooper [Australie] ; Jürgen K. Rockstroh [Allemagne] ; Patrick Mallon [Irlande (pays)] ; Sean Emery [Australie]Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Charge virale, Comorbidité, Cyclohexanes (usage thérapeutique), Femelle, Humains, Infections à VIH (traitement médicamenteux), Infections à VIH (virologie), Infections à VIH (épidémiologie), Inhibiteurs de fusion du VIH (usage thérapeutique), Inhibiteurs de la transcriptase inverse (usage thérapeutique), Inhibiteurs de protéase du VIH (usage thérapeutique), Mâle, Ritonavir (usage thérapeutique), Réplication virale, Résultat thérapeutique, Triazoles (usage thérapeutique).
- MESH :
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Cyclohexanes, Inhibiteurs de fusion du VIH, Inhibiteurs de la transcriptase inverse, Inhibiteurs de protéase du VIH, Ritonavir, Triazoles.
- virologie : Infections à VIH.
- épidémiologie : Infections à VIH.
- Adulte, Adulte d'âge moyen, Charge virale, Comorbidité, Femelle, Humains, Mâle, Réplication virale, Résultat thérapeutique.
English descriptors
- KwdEn :
- Adult, Comorbidity, Cyclohexanes (therapeutic use), Female, HIV Fusion Inhibitors (therapeutic use), HIV Infections (drug therapy), HIV Infections (epidemiology), HIV Infections (virology), HIV Protease Inhibitors (therapeutic use), Humans, Male, Middle Aged, Reverse Transcriptase Inhibitors (therapeutic use), Ritonavir (therapeutic use), Treatment Outcome, Triazoles (therapeutic use), Viral Load, Virus Replication.
- MESH :
- chemical , therapeutic use : Cyclohexanes, HIV Fusion Inhibitors, HIV Protease Inhibitors, Reverse Transcriptase Inhibitors, Ritonavir, Triazoles.
- drug therapy : HIV Infections.
- epidemiology : HIV Infections.
- virology : HIV Infections.
- Adult, Comorbidity, Female, Humans, Male, Middle Aged, Treatment Outcome, Viral Load, Virus Replication.
Abstract
Alternative combination antiretroviral therapies in virologically suppressed human immunodeficiency virus (HIV)-infected patients experiencing side effects and/or at ongoing risk of important comorbidities from current therapy are needed. Maraviroc (MVC), a chemokine receptor 5 antagonist, is a potential alternative component of therapy in those with R5-tropic virus.
DOI: 10.1093/cid/ciw207
PubMed: 27048747
Affiliations:
- Allemagne, Argentine, Australie, Canada, Chili, Espagne, France, Irlande (pays), Japon, Mexique, Pologne, Royaume-Uni
- Angleterre, Catalogne, Grand Londres, Nouvelle-Galles du Sud, Victoria (État)
- Barcelone, Londres, Melbourne, Sydney
- University College de Londres
Links toward previous steps (curation, corpus...)
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- to stream PubMed, to step Curation: 001B82
- to stream PubMed, to step Checkpoint: 001B82
- to stream Ncbi, to step Merge: 003369
- to stream Ncbi, to step Curation: 003369
Links to Exploration step
pubmed:27048747Le document en format XML
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type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Kelleher, Anthony" sort="Kelleher, Anthony" uniqKey="Kelleher A" first="Anthony" last="Kelleher">Anthony Kelleher</name><affiliation wicri:level="3"><nlm:affiliation>The Kirby Institute, University of New South Wales, Sydney, Australia St Vincent's Hospital, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney, Australia St Vincent's Hospital, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Harrigan, Richard" sort="Harrigan, Richard" uniqKey="Harrigan R" first="Richard" last="Harrigan">Richard Harrigan</name><affiliation wicri:level="1"><nlm:affiliation>British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>British Columbia Centre for Excellence in HIV/AIDS, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Clark, Andrew" sort="Clark, Andrew" uniqKey="Clark A" first="Andrew" last="Clark">Andrew Clark</name><affiliation wicri:level="3"><nlm:affiliation>ViiV Healthcare Ltd, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>ViiV Healthcare Ltd, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sugiura, Wataru" sort="Sugiura, Wataru" uniqKey="Sugiura W" first="Wataru" last="Sugiura">Wataru Sugiura</name><affiliation wicri:level="1"><nlm:affiliation>Nagoya Medical Centre, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Nagoya Medical Centre</wicri:regionArea></affiliation></author><author><name sortKey="Wolff, Marcelo" sort="Wolff, Marcelo" uniqKey="Wolff M" first="Marcelo" last="Wolff">Marcelo Wolff</name><affiliation wicri:level="1"><nlm:affiliation>Fundacion Arriaran, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Fundacion Arriaran, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Gill, John" sort="Gill, John" uniqKey="Gill J" first="John" last="Gill">John Gill</name><affiliation wicri:level="1"><nlm:affiliation>Southern Alberta Clinic, Calgary, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Southern Alberta Clinic, Calgary</wicri:regionArea><wicri:noRegion>Calgary</wicri:noRegion></affiliation></author><author><name sortKey="Gatell, Jose" sort="Gatell, Jose" uniqKey="Gatell J" first="Jose" last="Gatell">Jose Gatell</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Clinic de Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinic de Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Fisher, Martin" sort="Fisher, Martin" uniqKey="Fisher M" first="Martin" last="Fisher">Martin Fisher</name><affiliation wicri:level="1"><nlm:affiliation>Brighton and Sussex University Hospitals National Health Service Trust, Brighton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Brighton and Sussex University Hospitals National Health Service Trust, Brighton</wicri:regionArea><wicri:noRegion>Brighton</wicri:noRegion></affiliation></author><author><name sortKey="Clarke, Amanda" sort="Clarke, Amanda" uniqKey="Clarke A" first="Amanda" last="Clarke">Amanda Clarke</name><affiliation wicri:level="1"><nlm:affiliation>Brighton and Sussex University Hospitals National Health Service Trust, Brighton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Brighton and Sussex University Hospitals National Health Service Trust, Brighton</wicri:regionArea><wicri:noRegion>Brighton</wicri:noRegion></affiliation></author><author><name sortKey="Ruxrungtham, Kiat" sort="Ruxrungtham, Kiat" uniqKey="Ruxrungtham K" first="Kiat" last="Ruxrungtham">Kiat Ruxrungtham</name><affiliation><nlm:affiliation>HIV Netherlands, Australia, Thailand Research Collaboration, Bangkok.</nlm:affiliation><wicri:noCountry code="subField">Bangkok</wicri:noCountry></affiliation></author><author><name sortKey="Prazuck, Thierry" sort="Prazuck, Thierry" uniqKey="Prazuck T" first="Thierry" last="Prazuck">Thierry Prazuck</name><affiliation wicri:level="1"><nlm:affiliation>Orleans Hospital (Centre Hospitalier Regional D'Orleans Orleans La Source), France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Orleans Hospital (Centre Hospitalier Regional D'Orleans Orleans La Source)</wicri:regionArea></affiliation></author><author><name sortKey="Kaiser, Rolf" sort="Kaiser, Rolf" uniqKey="Kaiser R" first="Rolf" last="Kaiser">Rolf Kaiser</name><affiliation wicri:level="1"><nlm:affiliation>Institut für Virologie, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Virologie, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Woolley, Ian" sort="Woolley, Ian" uniqKey="Woolley I" first="Ian" last="Woolley">Ian Woolley</name><affiliation wicri:level="3"><nlm:affiliation>Monash Medical Centre, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Medical Centre, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Arnaiz, Juan Alberto" sort="Arnaiz, Juan Alberto" uniqKey="Arnaiz J" first="Juan Alberto" last="Arnaiz">Juan Alberto Arnaiz</name><affiliation wicri:level="3"><nlm:affiliation>Fundacion Clinic Spain Clinical Trials Unit, Barcelona.</nlm:affiliation><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><wicri:orgArea>Fundacion Clinic Spain Clinical Trials Unit</wicri:orgArea></affiliation></author><author><name sortKey="Cooper, David" sort="Cooper, David" uniqKey="Cooper D" first="David" last="Cooper">David Cooper</name><affiliation wicri:level="3"><nlm:affiliation>The Kirby Institute, University of New South Wales, Sydney, Australia St Vincent's Hospital, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney, Australia St Vincent's Hospital, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Rockstroh, Jurgen K" sort="Rockstroh, Jurgen K" uniqKey="Rockstroh J" first="Jürgen K" last="Rockstroh">Jürgen K. Rockstroh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine I, University Hospital Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine I, University Hospital Bonn</wicri:regionArea><wicri:noRegion>University Hospital Bonn</wicri:noRegion><wicri:noRegion>University Hospital Bonn</wicri:noRegion><wicri:noRegion>University Hospital Bonn</wicri:noRegion></affiliation></author><author><name sortKey="Mallon, Patrick" sort="Mallon, Patrick" uniqKey="Mallon P" first="Patrick" last="Mallon">Patrick Mallon</name><affiliation wicri:level="1"><nlm:affiliation>Mater Misericordiae University Hospital, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Mater Misericordiae University Hospital, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Emery, Sean" sort="Emery, Sean" uniqKey="Emery S" first="Sean" last="Emery">Sean Emery</name><affiliation wicri:level="3"><nlm:affiliation>The Kirby Institute, University of New South Wales, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27048747</idno><idno type="pmid">27048747</idno><idno type="doi">10.1093/cid/ciw207</idno><idno type="wicri:Area/PubMed/Corpus">001C06</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C06</idno><idno type="wicri:Area/PubMed/Curation">001B82</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B82</idno><idno 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Clinical Trials and Methodology Clinical Research Group, Infection and Population Health, University College London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney, Australia Medical Research Council Clinical Trials Unit, Institute of Clinical Trials and Methodology Clinical Research Group, Infection and Population Health, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Amin, Janaki" sort="Amin, Janaki" uniqKey="Amin J" first="Janaki" last="Amin">Janaki Amin</name><affiliation wicri:level="3"><nlm:affiliation>The Kirby Institute, University of New South Wales, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Horban, Andrejz" sort="Horban, Andrejz" uniqKey="Horban A" first="Andrejz" last="Horban">Andrejz Horban</name><affiliation wicri:level="1"><nlm:affiliation>Wojewodzki Szpital Zakazny Centrum Diagnostyki i Terapii AIDS, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Wojewodzki Szpital Zakazny Centrum Diagnostyki i Terapii AIDS, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Andrade Villanueva, Jaime" sort="Andrade Villanueva, Jaime" uniqKey="Andrade Villanueva J" first="Jaime" last="Andrade-Villanueva">Jaime Andrade-Villanueva</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Civil de Guadalajara "Fray Antonio Alcalde," Jalisco, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Hospital Civil de Guadalajara "Fray Antonio Alcalde," Jalisco</wicri:regionArea><wicri:noRegion>" Jalisco</wicri:noRegion></affiliation></author><author><name sortKey="Losso, Marcelo" sort="Losso, Marcelo" uniqKey="Losso M" first="Marcelo" last="Losso">Marcelo Losso</name><affiliation><nlm:affiliation>Hospital General de Agudos J M Ramos Mejia Fundación IBIS Coordinacion de Investigacion Clinica Academica en Latinoamerica.</nlm:affiliation><wicri:noCountry code="no comma">Hospital General de Agudos J M Ramos Mejia Fundación IBIS Coordinacion de Investigacion Clinica Academica en Latinoamerica.</wicri:noCountry></affiliation></author><author><name sortKey="Porteiro, Norma" sort="Porteiro, Norma" uniqKey="Porteiro N" first="Norma" last="Porteiro">Norma Porteiro</name><affiliation wicri:level="1"><nlm:affiliation>Fundación Infectologia de Atencion Ambulatoria, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Fundación Infectologia de Atencion Ambulatoria, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Sierra Madero, Juan" sort="Sierra Madero, Juan" uniqKey="Sierra Madero J" first="Juan" last="Sierra Madero">Juan Sierra Madero</name><affiliation wicri:level="1"><nlm:affiliation>Instituto Nacional de Ciencias Medicas y Nutriciòn Salvador Zubiran, Tlalpan, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Ciencias Medicas y Nutriciòn Salvador Zubiran, Tlalpan</wicri:regionArea><wicri:noRegion>Tlalpan</wicri:noRegion></affiliation></author><author><name sortKey="Belloso, Waldo" sort="Belloso, Waldo" uniqKey="Belloso W" first="Waldo" last="Belloso">Waldo Belloso</name><affiliation wicri:level="1"><nlm:affiliation>Fundación IBIS Coordinacion de Investigacion Clinica Academica en Latinoamerica Hospital Italiano de Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Fundación IBIS Coordinacion de Investigacion Clinica Academica en Latinoamerica Hospital Italiano de Buenos Aires</wicri:regionArea></affiliation></author><author><name sortKey="Tu, Elise" sort="Tu, Elise" uniqKey="Tu E" first="Elise" last="Tu">Elise Tu</name><affiliation wicri:level="3"><nlm:affiliation>The Kirby Institute, University of New South Wales, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Silk, David" sort="Silk, David" uniqKey="Silk D" first="David" last="Silk">David Silk</name><affiliation wicri:level="3"><nlm:affiliation>The Kirby Institute, University of New South Wales, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Kelleher, Anthony" sort="Kelleher, Anthony" uniqKey="Kelleher A" first="Anthony" last="Kelleher">Anthony Kelleher</name><affiliation wicri:level="3"><nlm:affiliation>The Kirby Institute, University of New South Wales, Sydney, Australia St Vincent's Hospital, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney, Australia St Vincent's Hospital, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Harrigan, Richard" sort="Harrigan, Richard" uniqKey="Harrigan R" first="Richard" last="Harrigan">Richard Harrigan</name><affiliation wicri:level="1"><nlm:affiliation>British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>British Columbia Centre for Excellence in HIV/AIDS, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Clark, Andrew" sort="Clark, Andrew" uniqKey="Clark A" first="Andrew" last="Clark">Andrew Clark</name><affiliation wicri:level="3"><nlm:affiliation>ViiV Healthcare Ltd, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>ViiV Healthcare Ltd, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sugiura, Wataru" sort="Sugiura, Wataru" uniqKey="Sugiura W" first="Wataru" last="Sugiura">Wataru Sugiura</name><affiliation wicri:level="1"><nlm:affiliation>Nagoya Medical Centre, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Nagoya Medical Centre</wicri:regionArea></affiliation></author><author><name sortKey="Wolff, Marcelo" sort="Wolff, Marcelo" uniqKey="Wolff M" first="Marcelo" last="Wolff">Marcelo Wolff</name><affiliation wicri:level="1"><nlm:affiliation>Fundacion Arriaran, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Fundacion Arriaran, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Gill, John" sort="Gill, John" uniqKey="Gill J" first="John" last="Gill">John Gill</name><affiliation wicri:level="1"><nlm:affiliation>Southern Alberta Clinic, Calgary, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Southern Alberta Clinic, Calgary</wicri:regionArea><wicri:noRegion>Calgary</wicri:noRegion></affiliation></author><author><name sortKey="Gatell, Jose" sort="Gatell, Jose" uniqKey="Gatell J" first="Jose" last="Gatell">Jose Gatell</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Clinic de Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinic de Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Fisher, Martin" sort="Fisher, Martin" uniqKey="Fisher M" first="Martin" last="Fisher">Martin Fisher</name><affiliation wicri:level="1"><nlm:affiliation>Brighton and Sussex University Hospitals National Health Service Trust, Brighton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Brighton and Sussex University Hospitals National Health Service Trust, Brighton</wicri:regionArea><wicri:noRegion>Brighton</wicri:noRegion></affiliation></author><author><name sortKey="Clarke, Amanda" sort="Clarke, Amanda" uniqKey="Clarke A" first="Amanda" last="Clarke">Amanda Clarke</name><affiliation wicri:level="1"><nlm:affiliation>Brighton and Sussex University Hospitals National Health Service Trust, Brighton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Brighton and Sussex University Hospitals National Health Service Trust, Brighton</wicri:regionArea><wicri:noRegion>Brighton</wicri:noRegion></affiliation></author><author><name sortKey="Ruxrungtham, Kiat" sort="Ruxrungtham, Kiat" uniqKey="Ruxrungtham K" first="Kiat" last="Ruxrungtham">Kiat Ruxrungtham</name><affiliation><nlm:affiliation>HIV Netherlands, Australia, Thailand Research Collaboration, Bangkok.</nlm:affiliation><wicri:noCountry code="subField">Bangkok</wicri:noCountry></affiliation></author><author><name sortKey="Prazuck, Thierry" sort="Prazuck, Thierry" uniqKey="Prazuck T" first="Thierry" last="Prazuck">Thierry Prazuck</name><affiliation wicri:level="1"><nlm:affiliation>Orleans Hospital (Centre Hospitalier Regional D'Orleans Orleans La Source), France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Orleans Hospital (Centre Hospitalier Regional D'Orleans Orleans La Source)</wicri:regionArea></affiliation></author><author><name sortKey="Kaiser, Rolf" sort="Kaiser, Rolf" uniqKey="Kaiser R" first="Rolf" last="Kaiser">Rolf Kaiser</name><affiliation wicri:level="1"><nlm:affiliation>Institut für Virologie, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Virologie, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Woolley, Ian" sort="Woolley, Ian" uniqKey="Woolley I" first="Ian" last="Woolley">Ian Woolley</name><affiliation wicri:level="3"><nlm:affiliation>Monash Medical Centre, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Medical Centre, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Arnaiz, Juan Alberto" sort="Arnaiz, Juan Alberto" uniqKey="Arnaiz J" first="Juan Alberto" last="Arnaiz">Juan Alberto Arnaiz</name><affiliation wicri:level="3"><nlm:affiliation>Fundacion Clinic Spain Clinical Trials Unit, Barcelona.</nlm:affiliation><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><wicri:orgArea>Fundacion Clinic Spain Clinical Trials Unit</wicri:orgArea></affiliation></author><author><name sortKey="Cooper, David" sort="Cooper, David" uniqKey="Cooper D" first="David" last="Cooper">David Cooper</name><affiliation wicri:level="3"><nlm:affiliation>The Kirby Institute, University of New South Wales, Sydney, Australia St Vincent's Hospital, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney, Australia St Vincent's Hospital, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Rockstroh, Jurgen K" sort="Rockstroh, Jurgen K" uniqKey="Rockstroh J" first="Jürgen K" last="Rockstroh">Jürgen K. Rockstroh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine I, University Hospital Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine I, University Hospital Bonn</wicri:regionArea><wicri:noRegion>University Hospital Bonn</wicri:noRegion><wicri:noRegion>University Hospital Bonn</wicri:noRegion><wicri:noRegion>University Hospital Bonn</wicri:noRegion></affiliation></author><author><name sortKey="Mallon, Patrick" sort="Mallon, Patrick" uniqKey="Mallon P" first="Patrick" last="Mallon">Patrick Mallon</name><affiliation wicri:level="1"><nlm:affiliation>Mater Misericordiae University Hospital, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Mater Misericordiae University Hospital, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Emery, Sean" sort="Emery, Sean" uniqKey="Emery S" first="Sean" last="Emery">Sean Emery</name><affiliation wicri:level="3"><nlm:affiliation>The Kirby Institute, University of New South Wales, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="eISSN">1537-6591</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Comorbidity</term><term>Cyclohexanes (therapeutic use)</term><term>Female</term><term>HIV Fusion Inhibitors (therapeutic use)</term><term>HIV Infections (drug therapy)</term><term>HIV Infections (epidemiology)</term><term>HIV Infections (virology)</term><term>HIV Protease Inhibitors (therapeutic use)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reverse Transcriptase Inhibitors (therapeutic use)</term><term>Ritonavir (therapeutic use)</term><term>Treatment Outcome</term><term>Triazoles (therapeutic use)</term><term>Viral Load</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Charge virale</term><term>Comorbidité</term><term>Cyclohexanes (usage thérapeutique)</term><term>Femelle</term><term>Humains</term><term>Infections à VIH (traitement médicamenteux)</term><term>Infections à VIH (virologie)</term><term>Infections à VIH (épidémiologie)</term><term>Inhibiteurs de fusion du VIH (usage thérapeutique)</term><term>Inhibiteurs de la transcriptase inverse (usage thérapeutique)</term><term>Inhibiteurs de protéase du VIH (usage thérapeutique)</term><term>Mâle</term><term>Ritonavir (usage thérapeutique)</term><term>Réplication virale</term><term>Résultat thérapeutique</term><term>Triazoles (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Cyclohexanes</term><term>HIV Fusion Inhibitors</term><term>HIV Protease Inhibitors</term><term>Reverse Transcriptase Inhibitors</term><term>Ritonavir</term><term>Triazoles</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Cyclohexanes</term><term>Inhibiteurs de fusion du VIH</term><term>Inhibiteurs de la transcriptase inverse</term><term>Inhibiteurs de protéase du VIH</term><term>Ritonavir</term><term>Triazoles</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Comorbidity</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term><term>Viral Load</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Charge virale</term><term>Comorbidité</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Réplication virale</term><term>Résultat thérapeutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alternative combination antiretroviral therapies in virologically suppressed human immunodeficiency virus (HIV)-infected patients experiencing side effects and/or at ongoing risk of important comorbidities from current therapy are needed. Maraviroc (MVC), a chemokine receptor 5 antagonist, is a potential alternative component of therapy in those with R5-tropic virus.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Argentine</li><li>Australie</li><li>Canada</li><li>Chili</li><li>Espagne</li><li>France</li><li>Irlande (pays)</li><li>Japon</li><li>Mexique</li><li>Pologne</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Catalogne</li><li>Grand Londres</li><li>Nouvelle-Galles du Sud</li><li>Victoria (État)</li></region><settlement><li>Barcelone</li><li>Londres</li><li>Melbourne</li><li>Sydney</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><noCountry><name sortKey="Losso, Marcelo" sort="Losso, Marcelo" uniqKey="Losso M" first="Marcelo" last="Losso">Marcelo Losso</name><name sortKey="Ruxrungtham, Kiat" sort="Ruxrungtham, Kiat" uniqKey="Ruxrungtham K" first="Kiat" last="Ruxrungtham">Kiat Ruxrungtham</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Pett, Sarah Lilian" sort="Pett, Sarah Lilian" uniqKey="Pett S" first="Sarah Lilian" last="Pett">Sarah Lilian Pett</name></region><name sortKey="Clark, Andrew" sort="Clark, Andrew" uniqKey="Clark A" first="Andrew" last="Clark">Andrew Clark</name><name sortKey="Clarke, Amanda" sort="Clarke, Amanda" uniqKey="Clarke A" first="Amanda" last="Clarke">Amanda Clarke</name><name sortKey="Fisher, Martin" sort="Fisher, Martin" uniqKey="Fisher M" first="Martin" last="Fisher">Martin Fisher</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Amin, Janaki" sort="Amin, Janaki" uniqKey="Amin J" first="Janaki" last="Amin">Janaki Amin</name></region><name sortKey="Cooper, David" sort="Cooper, David" uniqKey="Cooper D" first="David" last="Cooper">David Cooper</name><name sortKey="Emery, Sean" sort="Emery, Sean" uniqKey="Emery S" first="Sean" last="Emery">Sean Emery</name><name sortKey="Kelleher, Anthony" sort="Kelleher, Anthony" uniqKey="Kelleher A" first="Anthony" last="Kelleher">Anthony Kelleher</name><name sortKey="Silk, David" sort="Silk, David" uniqKey="Silk D" first="David" last="Silk">David Silk</name><name sortKey="Tu, Elise" sort="Tu, Elise" uniqKey="Tu E" first="Elise" last="Tu">Elise Tu</name><name sortKey="Woolley, Ian" sort="Woolley, Ian" uniqKey="Woolley I" first="Ian" last="Woolley">Ian Woolley</name></country><country name="Pologne"><noRegion><name sortKey="Horban, Andrejz" sort="Horban, Andrejz" uniqKey="Horban A" first="Andrejz" last="Horban">Andrejz Horban</name></noRegion></country><country name="Mexique"><noRegion><name sortKey="Andrade Villanueva, Jaime" sort="Andrade Villanueva, Jaime" uniqKey="Andrade Villanueva J" first="Jaime" last="Andrade-Villanueva">Jaime Andrade-Villanueva</name></noRegion><name sortKey="Sierra Madero, Juan" sort="Sierra Madero, Juan" uniqKey="Sierra Madero J" first="Juan" last="Sierra Madero">Juan Sierra Madero</name></country><country name="Argentine"><noRegion><name sortKey="Porteiro, Norma" sort="Porteiro, Norma" uniqKey="Porteiro N" first="Norma" last="Porteiro">Norma Porteiro</name></noRegion><name sortKey="Belloso, Waldo" sort="Belloso, Waldo" uniqKey="Belloso W" first="Waldo" last="Belloso">Waldo Belloso</name></country><country name="Canada"><noRegion><name sortKey="Harrigan, Richard" sort="Harrigan, Richard" uniqKey="Harrigan R" first="Richard" last="Harrigan">Richard Harrigan</name></noRegion><name sortKey="Gill, John" sort="Gill, John" uniqKey="Gill J" first="John" last="Gill">John Gill</name></country><country name="Japon"><noRegion><name sortKey="Sugiura, Wataru" sort="Sugiura, Wataru" uniqKey="Sugiura W" first="Wataru" last="Sugiura">Wataru Sugiura</name></noRegion></country><country name="Chili"><noRegion><name sortKey="Wolff, Marcelo" sort="Wolff, Marcelo" uniqKey="Wolff M" first="Marcelo" last="Wolff">Marcelo Wolff</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Gatell, Jose" sort="Gatell, Jose" uniqKey="Gatell J" first="Jose" last="Gatell">Jose Gatell</name></noRegion><name sortKey="Arnaiz, Juan Alberto" sort="Arnaiz, Juan Alberto" uniqKey="Arnaiz J" first="Juan Alberto" last="Arnaiz">Juan Alberto Arnaiz</name></country><country name="France"><noRegion><name sortKey="Prazuck, Thierry" sort="Prazuck, Thierry" uniqKey="Prazuck T" first="Thierry" last="Prazuck">Thierry Prazuck</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Kaiser, Rolf" sort="Kaiser, Rolf" uniqKey="Kaiser R" first="Rolf" last="Kaiser">Rolf Kaiser</name></noRegion><name sortKey="Rockstroh, Jurgen K" sort="Rockstroh, Jurgen K" uniqKey="Rockstroh J" first="Jürgen K" last="Rockstroh">Jürgen K. Rockstroh</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Mallon, Patrick" sort="Mallon, Patrick" uniqKey="Mallon P" first="Patrick" last="Mallon">Patrick Mallon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Maraviroc, as a Switch Option, in HIV-1-infected Individuals With Stable, Well-controlled HIV Replication and R5-tropic Virus on Their First Nucleoside/Nucleotide Reverse Transcriptase Inhibitor Plus Ritonavir-boosted Protease Inhibitor Regimen: Week 48 Results of the Randomized, Multicenter MARCH Study.
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