Maraviroc, as a Switch Option, in HIV-1-infected Individuals With Stable, Well-controlled HIV Replication and R5-tropic Virus on Their First Nucleoside/Nucleotide Reverse Transcriptase Inhibitor Plus Ritonavir-boosted Protease Inhibitor Regimen: Week 48 Results of the Randomized, Multicenter MARCH Study.
Identifieur interne : 003369 ( Ncbi/Checkpoint ); précédent : 003368; suivant : 003370Maraviroc, as a Switch Option, in HIV-1-infected Individuals With Stable, Well-controlled HIV Replication and R5-tropic Virus on Their First Nucleoside/Nucleotide Reverse Transcriptase Inhibitor Plus Ritonavir-boosted Protease Inhibitor Regimen: Week 48 Results of the Randomized, Multicenter MARCH Study.
Auteurs : Sarah Lilian Pett [Royaume-Uni] ; Janaki Amin [Australie] ; Andrejz Horban [Pologne] ; Jaime Andrade-Villanueva [Mexique] ; Marcelo Losso ; Norma Porteiro [Argentine] ; Juan Sierra Madero [Mexique] ; Waldo Belloso [Argentine] ; Elise Tu [Australie] ; David Silk [Australie] ; Anthony Kelleher [Australie] ; Richard Harrigan [Canada] ; Andrew Clark [Royaume-Uni] ; Wataru Sugiura [Japon] ; Marcelo Wolff [Chili] ; John Gill [Canada] ; Jose Gatell [Espagne] ; Martin Fisher [Royaume-Uni] ; Amanda Clarke [Royaume-Uni] ; Kiat Ruxrungtham ; Thierry Prazuck [France] ; Rolf Kaiser [Allemagne] ; Ian Woolley [Australie] ; Juan Alberto Arnaiz [Espagne] ; David Cooper [Australie] ; Jürgen K. Rockstroh [Allemagne] ; Patrick Mallon [Irlande (pays)] ; Sean Emery [Australie]Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Charge virale, Comorbidité, Cyclohexanes (usage thérapeutique), Femelle, Humains, Infections à VIH (traitement médicamenteux), Infections à VIH (virologie), Infections à VIH (épidémiologie), Inhibiteurs de fusion du VIH (usage thérapeutique), Inhibiteurs de la transcriptase inverse (usage thérapeutique), Inhibiteurs de protéase du VIH (usage thérapeutique), Mâle, Ritonavir (usage thérapeutique), Réplication virale, Résultat thérapeutique, Triazoles (usage thérapeutique).
- MESH :
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Cyclohexanes, Inhibiteurs de fusion du VIH, Inhibiteurs de la transcriptase inverse, Inhibiteurs de protéase du VIH, Ritonavir, Triazoles.
- virologie : Infections à VIH.
- épidémiologie : Infections à VIH.
- Adulte, Adulte d'âge moyen, Charge virale, Comorbidité, Femelle, Humains, Mâle, Réplication virale, Résultat thérapeutique.
English descriptors
- KwdEn :
- Adult, Comorbidity, Cyclohexanes (therapeutic use), Female, HIV Fusion Inhibitors (therapeutic use), HIV Infections (drug therapy), HIV Infections (epidemiology), HIV Infections (virology), HIV Protease Inhibitors (therapeutic use), Humans, Male, Middle Aged, Reverse Transcriptase Inhibitors (therapeutic use), Ritonavir (therapeutic use), Treatment Outcome, Triazoles (therapeutic use), Viral Load, Virus Replication.
- MESH :
- chemical , therapeutic use : Cyclohexanes, HIV Fusion Inhibitors, HIV Protease Inhibitors, Reverse Transcriptase Inhibitors, Ritonavir, Triazoles.
- drug therapy : HIV Infections.
- epidemiology : HIV Infections.
- virology : HIV Infections.
- Adult, Comorbidity, Female, Humans, Male, Middle Aged, Treatment Outcome, Viral Load, Virus Replication.
Abstract
Alternative combination antiretroviral therapies in virologically suppressed human immunodeficiency virus (HIV)-infected patients experiencing side effects and/or at ongoing risk of important comorbidities from current therapy are needed. Maraviroc (MVC), a chemokine receptor 5 antagonist, is a potential alternative component of therapy in those with R5-tropic virus.
DOI: 10.1093/cid/ciw207
PubMed: 27048747
Affiliations:
- Allemagne, Argentine, Australie, Canada, Chili, Espagne, France, Irlande (pays), Japon, Mexique, Pologne, Royaume-Uni
- Angleterre, Catalogne, Grand Londres, Nouvelle-Galles du Sud, Victoria (État)
- Barcelone, Londres, Melbourne, Sydney
- University College de Londres
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001C06
- to stream PubMed, to step Curation: 001B82
- to stream PubMed, to step Checkpoint: 001B82
- to stream Ncbi, to step Merge: 003369
- to stream Ncbi, to step Curation: 003369
Links to Exploration step
pubmed:27048747Le document en format XML
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<author><name sortKey="Belloso, Waldo" sort="Belloso, Waldo" uniqKey="Belloso W" first="Waldo" last="Belloso">Waldo Belloso</name>
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<author><name sortKey="Harrigan, Richard" sort="Harrigan, Richard" uniqKey="Harrigan R" first="Richard" last="Harrigan">Richard Harrigan</name>
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<author><name sortKey="Clark, Andrew" sort="Clark, Andrew" uniqKey="Clark A" first="Andrew" last="Clark">Andrew Clark</name>
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<author><name sortKey="Gill, John" sort="Gill, John" uniqKey="Gill J" first="John" last="Gill">John Gill</name>
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<author><name sortKey="Fisher, Martin" sort="Fisher, Martin" uniqKey="Fisher M" first="Martin" last="Fisher">Martin Fisher</name>
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<author><name sortKey="Clarke, Amanda" sort="Clarke, Amanda" uniqKey="Clarke A" first="Amanda" last="Clarke">Amanda Clarke</name>
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<author><name sortKey="Ruxrungtham, Kiat" sort="Ruxrungtham, Kiat" uniqKey="Ruxrungtham K" first="Kiat" last="Ruxrungtham">Kiat Ruxrungtham</name>
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<author><name sortKey="Prazuck, Thierry" sort="Prazuck, Thierry" uniqKey="Prazuck T" first="Thierry" last="Prazuck">Thierry Prazuck</name>
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<author><name sortKey="Kaiser, Rolf" sort="Kaiser, Rolf" uniqKey="Kaiser R" first="Rolf" last="Kaiser">Rolf Kaiser</name>
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<author><name sortKey="Woolley, Ian" sort="Woolley, Ian" uniqKey="Woolley I" first="Ian" last="Woolley">Ian Woolley</name>
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<author><name sortKey="Arnaiz, Juan Alberto" sort="Arnaiz, Juan Alberto" uniqKey="Arnaiz J" first="Juan Alberto" last="Arnaiz">Juan Alberto Arnaiz</name>
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<author><name sortKey="Cooper, David" sort="Cooper, David" uniqKey="Cooper D" first="David" last="Cooper">David Cooper</name>
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</placeName>
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<author><name sortKey="Rockstroh, Jurgen K" sort="Rockstroh, Jurgen K" uniqKey="Rockstroh J" first="Jürgen K" last="Rockstroh">Jürgen K. Rockstroh</name>
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<author><name sortKey="Mallon, Patrick" sort="Mallon, Patrick" uniqKey="Mallon P" first="Patrick" last="Mallon">Patrick Mallon</name>
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<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Mater Misericordiae University Hospital, Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
</affiliation>
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<author><name sortKey="Emery, Sean" sort="Emery, Sean" uniqKey="Emery S" first="Sean" last="Emery">Sean Emery</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Maraviroc, as a Switch Option, in HIV-1-infected Individuals With Stable, Well-controlled HIV Replication and R5-tropic Virus on Their First Nucleoside/Nucleotide Reverse Transcriptase Inhibitor Plus Ritonavir-boosted Protease Inhibitor Regimen: Week 48 Results of the Randomized, Multicenter MARCH Study.</title>
<author><name sortKey="Pett, Sarah Lilian" sort="Pett, Sarah Lilian" uniqKey="Pett S" first="Sarah Lilian" last="Pett">Sarah Lilian Pett</name>
<affiliation wicri:level="4"><nlm:affiliation>The Kirby Institute, University of New South Wales, Sydney, Australia Medical Research Council Clinical Trials Unit, Institute of Clinical Trials and Methodology Clinical Research Group, Infection and Population Health, University College London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney, Australia Medical Research Council Clinical Trials Unit, Institute of Clinical Trials and Methodology Clinical Research Group, Infection and Population Health, University College London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
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</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Amin, Janaki" sort="Amin, Janaki" uniqKey="Amin J" first="Janaki" last="Amin">Janaki Amin</name>
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<wicri:regionArea>The Kirby Institute, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
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</placeName>
</affiliation>
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<author><name sortKey="Horban, Andrejz" sort="Horban, Andrejz" uniqKey="Horban A" first="Andrejz" last="Horban">Andrejz Horban</name>
<affiliation wicri:level="1"><nlm:affiliation>Wojewodzki Szpital Zakazny Centrum Diagnostyki i Terapii AIDS, Warsaw, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
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<wicri:noRegion>Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Andrade Villanueva, Jaime" sort="Andrade Villanueva, Jaime" uniqKey="Andrade Villanueva J" first="Jaime" last="Andrade-Villanueva">Jaime Andrade-Villanueva</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Civil de Guadalajara "Fray Antonio Alcalde," Jalisco, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Hospital Civil de Guadalajara "Fray Antonio Alcalde," Jalisco</wicri:regionArea>
<wicri:noRegion>" Jalisco</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Losso, Marcelo" sort="Losso, Marcelo" uniqKey="Losso M" first="Marcelo" last="Losso">Marcelo Losso</name>
<affiliation><nlm:affiliation>Hospital General de Agudos J M Ramos Mejia Fundación IBIS Coordinacion de Investigacion Clinica Academica en Latinoamerica.</nlm:affiliation>
<wicri:noCountry code="no comma">Hospital General de Agudos J M Ramos Mejia Fundación IBIS Coordinacion de Investigacion Clinica Academica en Latinoamerica.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Porteiro, Norma" sort="Porteiro, Norma" uniqKey="Porteiro N" first="Norma" last="Porteiro">Norma Porteiro</name>
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<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Fundación Infectologia de Atencion Ambulatoria, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sierra Madero, Juan" sort="Sierra Madero, Juan" uniqKey="Sierra Madero J" first="Juan" last="Sierra Madero">Juan Sierra Madero</name>
<affiliation wicri:level="1"><nlm:affiliation>Instituto Nacional de Ciencias Medicas y Nutriciòn Salvador Zubiran, Tlalpan, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
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<wicri:regionArea>Hospital Clinic de Barcelona</wicri:regionArea>
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<author><name sortKey="Fisher, Martin" sort="Fisher, Martin" uniqKey="Fisher M" first="Martin" last="Fisher">Martin Fisher</name>
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</author>
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</affiliation>
</author>
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<author><name sortKey="Rockstroh, Jurgen K" sort="Rockstroh, Jurgen K" uniqKey="Rockstroh J" first="Jürgen K" last="Rockstroh">Jürgen K. Rockstroh</name>
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<wicri:noRegion>University Hospital Bonn</wicri:noRegion>
<wicri:noRegion>University Hospital Bonn</wicri:noRegion>
<wicri:noRegion>University Hospital Bonn</wicri:noRegion>
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</author>
<author><name sortKey="Mallon, Patrick" sort="Mallon, Patrick" uniqKey="Mallon P" first="Patrick" last="Mallon">Patrick Mallon</name>
<affiliation wicri:level="1"><nlm:affiliation>Mater Misericordiae University Hospital, Dublin, Ireland.</nlm:affiliation>
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</author>
<author><name sortKey="Emery, Sean" sort="Emery, Sean" uniqKey="Emery S" first="Sean" last="Emery">Sean Emery</name>
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<series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title>
<idno type="eISSN">1537-6591</idno>
<imprint><date when="2016" type="published">2016</date>
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<term>Comorbidity</term>
<term>Cyclohexanes (therapeutic use)</term>
<term>Female</term>
<term>HIV Fusion Inhibitors (therapeutic use)</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (epidemiology)</term>
<term>HIV Infections (virology)</term>
<term>HIV Protease Inhibitors (therapeutic use)</term>
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<term>Reverse Transcriptase Inhibitors (therapeutic use)</term>
<term>Ritonavir (therapeutic use)</term>
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<term>Viral Load</term>
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<term>Cyclohexanes (usage thérapeutique)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à VIH (traitement médicamenteux)</term>
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<term>HIV Fusion Inhibitors</term>
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<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term>
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<front><div type="abstract" xml:lang="en">Alternative combination antiretroviral therapies in virologically suppressed human immunodeficiency virus (HIV)-infected patients experiencing side effects and/or at ongoing risk of important comorbidities from current therapy are needed. Maraviroc (MVC), a chemokine receptor 5 antagonist, is a potential alternative component of therapy in those with R5-tropic virus.</div>
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