Is Nelfinavir Exposure Associated with Cancer Incidence in HIV-positive individuals?
Identifieur interne : 003107 ( Ncbi/Checkpoint ); précédent : 003106; suivant : 003108Is Nelfinavir Exposure Associated with Cancer Incidence in HIV-positive individuals?
Auteurs : David C. Boettiger [Australie] ; Caroline A. Sabin [Royaume-Uni] ; Andrew Grulich [Australie] ; Lene Ryom [Danemark] ; Fabrice Bonnet [France] ; Peter Reiss [Pays-Bas] ; Antonella D Rminio Monforte [Italie] ; Ole Kirk [Danemark] ; Andrew Phillips [Royaume-Uni] ; Mark Bower [Royaume-Uni] ; Gerd F Tkenheuer [Allemagne] ; Jens D. Lundgren [Danemark] ; Matthew Law [Australie]Source :
- AIDS (London, England) [ 0269-9370 ] ; 2016.
Abstract
Nelfinavir exhibits potent anti-cancer properties against a range of tumours. However, in 2006/07, nelfinavir supplies were accidently contaminated with a carcinogen. This analysis investigated the association between nelfinavir use and cancer risk in HIV-positive persons.
Observational cohort study.
D:A:D study data was analyzed using Poisson regression models to examine associations between cancer incidence and cumulative nelfinavir exposure, current nelfinavir exposure, and exposure to nelfinavir between 1/Jul/2006–30/Jun/2007.
A total of 42,006 individuals (50% white, 73% male) contributed 303,005 person-years of follow-up between 1/Jan/2004–1/Feb/2014. At study enrolment, median age was 40 (interquartile range [IQR] 33–46) years and 8,305 individuals had a history of nelfinavir use (median duration 1.7 [IQR 0.7–3.4] years). During follow-up, nelfinavir was used by 2,476 individuals for a median of 1.7 (IQR 0.7–3.8) years; 1,063 were exposed to nelfinavir between 1/Jul/2006–30/Jun/2007. Overall, 2,279 cancers were diagnosed at a rate of 0.75 (95% confidence interval [95%CI] 0.72–0.78) per 100 person-years. Neither greater cumulative exposure to nelfinavir (adjusted risk ratio [aRR] 0.93 for every additional 5 years, 95%CI 0.82–1.06, p=0.26) nor current use of nelfinavir (aRR 0.98 vs. other protease inhibitor use, 95%CI 0.68–1.41, p=0.92) were associated with cancer risk. The adjusted risk of cancer for participants exposed to nelfinavir between 1/Jul/2006–30/Jun/2007 compared to those receiving other treatment over this period was 1.07 (95%CI 0.78–1.46, p=0.68).
Nelfinavir use was not associated with a lower cancer incidence than other protease inhibitor regimens. As of Feb/2014, exposure to the 2006/07 contamination of nelfinavir does not appear to be associated with increased cancer incidence.
Url:
DOI: 10.1097/QAD.0000000000001053
PubMed: 26854812
PubMed Central: 4889546
Affiliations:
- Allemagne, Australie, Danemark, France, Italie, Pays-Bas, Royaume-Uni
- Angleterre, Aquitaine, District de Cologne, Grand Londres, Hollande-Septentrionale, Lombardie, Nouvelle-Aquitaine, Nouvelle-Galles du Sud, Rhénanie-du-Nord-Westphalie
- Amsterdam, Bordeaux, Cologne, Londres, Milan, Sydney
- Université d'Amsterdam, Université de Bordeaux
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PMC:4889546Le document en format XML
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<author><name sortKey="D Rminio Monforte, Antonella" sort="D Rminio Monforte, Antonella" uniqKey="D Rminio Monforte A" first="Antonella" last="D Rminio Monforte">Antonella D Rminio Monforte</name>
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<author><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name>
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<author><name sortKey="Bower, Mark" sort="Bower, Mark" uniqKey="Bower M" first="Mark" last="Bower">Mark Bower</name>
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<author><name sortKey="F Tkenheuer, Gerd" sort="F Tkenheuer, Gerd" uniqKey="F Tkenheuer G" first="Gerd" last="F Tkenheuer">Gerd F Tkenheuer</name>
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<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D" last="Lundgren">Jens D. Lundgren</name>
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<author><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name>
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<wicri:regionArea>The Kirby Institute, UNSW Australia, Sydney</wicri:regionArea>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">Nelfinavir exhibits potent anti-cancer properties against a range of tumours. However, in 2006/07, nelfinavir supplies were accidently contaminated with a carcinogen. This analysis investigated the association between nelfinavir use and cancer risk in HIV-positive persons.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P2">Observational cohort study.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P3">D:A:D study data was analyzed using Poisson regression models to examine associations between cancer incidence and cumulative nelfinavir exposure, current nelfinavir exposure, and exposure to nelfinavir between 1/Jul/2006–30/Jun/2007.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">A total of 42,006 individuals (50% white, 73% male) contributed 303,005 person-years of follow-up between 1/Jan/2004–1/Feb/2014. At study enrolment, median age was 40 (interquartile range [IQR] 33–46) years and 8,305 individuals had a history of nelfinavir use (median duration 1.7 [IQR 0.7–3.4] years). During follow-up, nelfinavir was used by 2,476 individuals for a median of 1.7 (IQR 0.7–3.8) years; 1,063 were exposed to nelfinavir between 1/Jul/2006–30/Jun/2007. Overall, 2,279 cancers were diagnosed at a rate of 0.75 (95% confidence interval [95%CI] 0.72–0.78) per 100 person-years. Neither greater cumulative exposure to nelfinavir (adjusted risk ratio [aRR] 0.93 for every additional 5 years, 95%CI 0.82–1.06, p=0.26) nor current use of nelfinavir (aRR 0.98 vs. other protease inhibitor use, 95%CI 0.68–1.41, p=0.92) were associated with cancer risk. The adjusted risk of cancer for participants exposed to nelfinavir between 1/Jul/2006–30/Jun/2007 compared to those receiving other treatment over this period was 1.07 (95%CI 0.78–1.46, p=0.68).</p>
</sec>
<sec id="S5"><title>Conclusions</title>
<p id="P5">Nelfinavir use was not associated with a lower cancer incidence than other protease inhibitor regimens. As of Feb/2014, exposure to the 2006/07 contamination of nelfinavir does not appear to be associated with increased cancer incidence.</p>
</sec>
</div>
</front>
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<li>Royaume-Uni</li>
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<li>Lombardie</li>
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<li>Nouvelle-Galles du Sud</li>
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<tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Boettiger, David C" sort="Boettiger, David C" uniqKey="Boettiger D" first="David C" last="Boettiger">David C. Boettiger</name>
</region>
<name sortKey="Grulich, Andrew" sort="Grulich, Andrew" uniqKey="Grulich A" first="Andrew" last="Grulich">Andrew Grulich</name>
<name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A" last="Sabin">Caroline A. Sabin</name>
</region>
<name sortKey="Bower, Mark" sort="Bower, Mark" uniqKey="Bower M" first="Mark" last="Bower">Mark Bower</name>
<name sortKey="Phillips, Andrew" sort="Phillips, Andrew" uniqKey="Phillips A" first="Andrew" last="Phillips">Andrew Phillips</name>
</country>
<country name="Danemark"><noRegion><name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name>
</noRegion>
<name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name>
<name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D" last="Lundgren">Jens D. Lundgren</name>
</country>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name>
</region>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name>
</region>
</country>
<country name="Italie"><region name="Lombardie"><name sortKey="D Rminio Monforte, Antonella" sort="D Rminio Monforte, Antonella" uniqKey="D Rminio Monforte A" first="Antonella" last="D Rminio Monforte">Antonella D Rminio Monforte</name>
</region>
</country>
<country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="F Tkenheuer, Gerd" sort="F Tkenheuer, Gerd" uniqKey="F Tkenheuer G" first="Gerd" last="F Tkenheuer">Gerd F Tkenheuer</name>
</region>
</country>
</tree>
</affiliations>
</record>
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