AustralieFrV1, Ncbi, Checkpoint, bibRecord, 003094

Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy

Identifieur interne : 003094 ( Ncbi/Checkpoint ); précédent : 003093; suivant : 003095

Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy

Auteurs : Jérôme J. Devaux ; Yumako Miura ; Yuki Fukami ; Takayuki Inoue ; Constance Manso ; Maya Belghazi ; Kenji Sekiguchi ; Norito Kokubun ; Hiroo Ichikawa ; Anna Hiu Yi Wong ; Nobuhiro Yuki

Source :

Neurology [ 0028-3878 ] ; 2016.

RBID : PMC:4793783

Descripteurs français

English descriptors

KwdEn :
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Autoantibodies (blood), Autoantibodies (immunology), Biomarkers (blood), Cell Adhesion Molecules (blood), Cell Adhesion Molecules (immunology), Child, Female, Humans, Immunoglobulin G (blood), Immunoglobulin G (immunology), Incidence, Japan (epidemiology), Male, Middle Aged, Nerve Growth Factors (blood), Nerve Growth Factors (immunology), Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (blood), Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (diagnosis), Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (epidemiology), Risk Assessment (methods), Young Adult.
MESH :
- chemical , blood : Autoantibodies, Biomarkers, Cell Adhesion Molecules, Immunoglobulin G, Nerve Growth Factors.
- chemical , immunology : Autoantibodies, Cell Adhesion Molecules, Immunoglobulin G, Nerve Growth Factors.
- geographic , epidemiology : Japan.
- blood : Polyradiculoneuropathy, Chronic Inflammatory Demyelinating.
- diagnosis : Polyradiculoneuropathy, Chronic Inflammatory Demyelinating.
- epidemiology : Polyradiculoneuropathy, Chronic Inflammatory Demyelinating.
- methods : Risk Assessment.
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Child, Female, Humans, Incidence, Male, Middle Aged, Young Adult.

Abstract

Objective:

We report the clinical and serologic features of Japanese patients with chronic inflammatory demyelinating polyneuropathy (CIDP) displaying anti-neurofascin-155 (NF155) immunoglobulin G4 (IgG4) antibodies.

Methods:

In sera from 533 patients with CIDP, anti-NF155 IgG4 antibodies were detected by ELISA. Binding of IgG antibodies to central and peripheral nerves was tested.

Results:

Anti-NF155 IgG4 antibodies were identified in 38 patients (7%) with CIDP, but not in disease controls or normal participants. These patients were younger at onset as compared to 100 anti-NF155–negative patients with CIDP. Twenty-eight patients (74%) presented with sensory ataxia, 16 (42%) showed tremor, 5 (13%) presented with cerebellar ataxia associated with nystagmus, 3 (8%) had demyelinating lesions in the CNS, and 20 of 25 (80%) had poor response to IV immunoglobulin. The clinical features of the antibody-positive patients were statistically more frequent as compared to negative patients with CIDP (n = 100). Anti-NF155 IgG antibodies targeted similarly central and peripheral paranodes.

Conclusion:

Anti-NF155 IgG4 antibodies were associated with a subgroup of patients with CIDP showing a younger age at onset, ataxia, tremor, CNS demyelination, and a poor response to IV immunoglobulin. The autoantibodies may serve as a biomarker to improve patients' diagnosis and guide treatments.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793783

DOI: 10.1212/WNL.0000000000002418
PubMed: 26843559
PubMed Central: 4793783

Affiliations:

Links to Exploration step

PMC:4793783

Le document en format XML

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<term>Adult</term>
<term>Age Distribution</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Autoantibodies (blood)</term>
<term>Autoantibodies (immunology)</term>
<term>Biomarkers (blood)</term>
<term>Cell Adhesion Molecules (blood)</term>
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<term>Child</term>
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<term>Humans</term>
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<term>Immunoglobulin G (immunology)</term>
<term>Incidence</term>
<term>Japan (epidemiology)</term>
<term>Male</term>
<term>Middle Aged</term>
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<term>Nerve Growth Factors (immunology)</term>
<term>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (blood)</term>
<term>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (diagnosis)</term>
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<term>Risk Assessment (methods)</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Autoanticorps (immunologie)</term>
<term>Autoanticorps (sang)</term>
<term>Enfant</term>
<term>Facteurs de croissance nerveuse (immunologie)</term>
<term>Facteurs de croissance nerveuse (sang)</term>
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<term>Humains</term>
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<term>Japon (épidémiologie)</term>
<term>Jeune adulte</term>
<term>Marqueurs biologiques (sang)</term>
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<term>Mâle</term>
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<term>Polyradiculonévrite inflammatoire démyélinisante chronique (sang)</term>
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<term>Sujet âgé de 80 ans ou plus</term>
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<term>Immunoglobulin G</term>
<term>Nerve Growth Factors</term>
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<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Autoantibodies</term>
<term>Cell Adhesion Molecules</term>
<term>Immunoglobulin G</term>
<term>Nerve Growth Factors</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Japan</term>
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<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating</term>
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<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Polyradiculonévrite inflammatoire démyélinisante chronique</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating</term>
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<term>Facteurs de croissance nerveuse</term>
<term>Immunoglobuline G</term>
<term>Molécules d'adhérence cellulaire</term>
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<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Autoanticorps</term>
<term>Facteurs de croissance nerveuse</term>
<term>Immunoglobuline G</term>
<term>Marqueurs biologiques</term>
<term>Molécules d'adhérence cellulaire</term>
<term>Polyradiculonévrite inflammatoire démyélinisante chronique</term>
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<term>Aged, 80 and over</term>
<term>Child</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>We report the clinical and serologic features of Japanese patients with chronic inflammatory demyelinating polyneuropathy (CIDP) displaying anti-neurofascin-155 (NF155) immunoglobulin G4 (IgG4) antibodies.</p>
</sec>
<sec><title>Methods:</title>
<p>In sera from 533 patients with CIDP, anti-NF155 IgG4 antibodies were detected by ELISA. Binding of IgG antibodies to central and peripheral nerves was tested.</p>
</sec>
<sec><title>Results:</title>
<p>Anti-NF155 IgG4 antibodies were identified in 38 patients (7%) with CIDP, but not in disease controls or normal participants. These patients were younger at onset as compared to 100 anti-NF155–negative patients with CIDP. Twenty-eight patients (74%) presented with sensory ataxia, 16 (42%) showed tremor, 5 (13%) presented with cerebellar ataxia associated with nystagmus, 3 (8%) had demyelinating lesions in the CNS, and 20 of 25 (80%) had poor response to IV immunoglobulin. The clinical features of the antibody-positive patients were statistically more frequent as compared to negative patients with CIDP (n = 100). Anti-NF155 IgG antibodies targeted similarly central and peripheral paranodes.</p>
</sec>
<sec><title>Conclusion:</title>
<p>Anti-NF155 IgG4 antibodies were associated with a subgroup of patients with CIDP showing a younger age at onset, ataxia, tremor, CNS demyelination, and a poor response to IV immunoglobulin. The autoantibodies may serve as a biomarker to improve patients' diagnosis and guide treatments.</p>
</sec>
</div>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Belghazi, Maya" sort="Belghazi, Maya" uniqKey="Belghazi M" first="Maya" last="Belghazi">Maya Belghazi</name>
<name sortKey="Devaux, Jerome J" sort="Devaux, Jerome J" uniqKey="Devaux J" first="Jérôme J." last="Devaux">Jérôme J. Devaux</name>
<name sortKey="Fukami, Yuki" sort="Fukami, Yuki" uniqKey="Fukami Y" first="Yuki" last="Fukami">Yuki Fukami</name>
<name sortKey="Ichikawa, Hiroo" sort="Ichikawa, Hiroo" uniqKey="Ichikawa H" first="Hiroo" last="Ichikawa">Hiroo Ichikawa</name>
<name sortKey="Inoue, Takayuki" sort="Inoue, Takayuki" uniqKey="Inoue T" first="Takayuki" last="Inoue">Takayuki Inoue</name>
<name sortKey="Kokubun, Norito" sort="Kokubun, Norito" uniqKey="Kokubun N" first="Norito" last="Kokubun">Norito Kokubun</name>
<name sortKey="Manso, Constance" sort="Manso, Constance" uniqKey="Manso C" first="Constance" last="Manso">Constance Manso</name>
<name sortKey="Miura, Yumako" sort="Miura, Yumako" uniqKey="Miura Y" first="Yumako" last="Miura">Yumako Miura</name>
<name sortKey="Sekiguchi, Kenji" sort="Sekiguchi, Kenji" uniqKey="Sekiguchi K" first="Kenji" last="Sekiguchi">Kenji Sekiguchi</name>
<name sortKey="Wong, Anna Hiu Yi" sort="Wong, Anna Hiu Yi" uniqKey="Wong A" first="Anna Hiu Yi" last="Wong">Anna Hiu Yi Wong</name>
<name sortKey="Yuki, Nobuhiro" sort="Yuki, Nobuhiro" uniqKey="Yuki N" first="Nobuhiro" last="Yuki">Nobuhiro Yuki</name>
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Serveur d'exploration sur les relations entre la France et l'Australie

Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy

Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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