A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models.
Identifieur interne : 002F44 ( Ncbi/Checkpoint ); précédent : 002F43; suivant : 002F45A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models.
Auteurs : P. Gharagozloo [Oman] ; A. Gutiérrez-Adán [Espagne] ; A. Champroux [France] ; A. Noblanc [France] ; A. Kocer [France] ; A. Calle [Espagne] ; S. Pérez-Cerezales [Espagne] ; E. Pericuesta [Espagne] ; A. Polhemus [États-Unis] ; A. Moazamian [États-Unis] ; J R Drevet [France] ; R J Aitken [Australie]Source :
- Human reproduction (Oxford, England) [ 1460-2350 ] ; 2016.
Descripteurs français
- KwdFr :
- Altération de l'ADN, Analyse du sperme, Animaux, Antioxydants (pharmacologie), Désoxyguanosine (analogues et dérivés), Désoxyguanosine (métabolisme), Femelle, Glutathione peroxidase (génétique), Grossesse, Infertilité masculine (génétique), Infertilité masculine (traitement médicamenteux), Issue de la grossesse, Marqueurs biologiques (métabolisme), Modèles animaux, Mâle, Souris, Souris de lignée C57BL, Souris knockout, Spermatozoïdes (), Spermatozoïdes (métabolisme), Stress oxydatif, Taux de grossesse.
- MESH :
- analogues et dérivés : Désoxyguanosine.
- génétique : Glutathione peroxidase, Infertilité masculine.
- métabolisme : Désoxyguanosine, Marqueurs biologiques, Spermatozoïdes.
- pharmacologie : Antioxydants.
- traitement médicamenteux : Infertilité masculine.
- Altération de l'ADN, Analyse du sperme, Animaux, Femelle, Grossesse, Issue de la grossesse, Modèles animaux, Mâle, Souris, Souris de lignée C57BL, Souris knockout, Spermatozoïdes, Stress oxydatif, Taux de grossesse.
English descriptors
- KwdEn :
- Animals, Antioxidants (pharmacology), Biomarkers (metabolism), DNA Damage, Deoxyguanosine (analogs & derivatives), Deoxyguanosine (metabolism), Female, Glutathione Peroxidase (genetics), Infertility, Male (drug therapy), Infertility, Male (genetics), Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Animal, Oxidative Stress, Pregnancy, Pregnancy Outcome, Pregnancy Rate, Semen Analysis, Spermatozoa (drug effects), Spermatozoa (metabolism).
- MESH :
- chemical , analogs & derivatives : Deoxyguanosine.
- chemical , genetics : Glutathione Peroxidase.
- chemical , metabolism : Biomarkers, Deoxyguanosine.
- chemical , pharmacology : Antioxidants.
- drug effects : Spermatozoa.
- drug therapy : Infertility, Male.
- genetics : Infertility, Male.
- metabolism : Spermatozoa.
- Animals, DNA Damage, Female, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Animal, Oxidative Stress, Pregnancy, Pregnancy Outcome, Pregnancy Rate, Semen Analysis.
Abstract
Does a novel antioxidant formulation designed to restore redox balance within the male reproductive tract, reduce sperm DNA damage and increase pregnancy rates in mouse models of sperm oxidative stress?
DOI: 10.1093/humrep/dev302
PubMed: 26732620
Affiliations:
- Australie, Espagne, France, Oman, États-Unis
- Auvergne (région administrative), Auvergne-Rhône-Alpes, Communauté de Madrid, New Jersey
- Madrid
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002309
- to stream PubMed, to step Curation: 002283
- to stream PubMed, to step Checkpoint: 002283
- to stream Ncbi, to step Merge: 002F44
- to stream Ncbi, to step Curation: 002F44
Links to Exploration step
pubmed:26732620Le document en format XML
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Champroux</name><affiliation wicri:level="1"><nlm:affiliation>GReD Lab CNRS UMR6293-INSERM U1103 Université Blaise Pascal-Clermont II, Clermont-Ferrand 63001, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GReD Lab CNRS UMR6293-INSERM U1103 Université Blaise Pascal-Clermont II, Clermont-Ferrand 63001</wicri:regionArea><wicri:noRegion>63001</wicri:noRegion><wicri:noRegion>63001</wicri:noRegion></affiliation></author><author><name sortKey="Noblanc, A" sort="Noblanc, A" uniqKey="Noblanc A" first="A" last="Noblanc">A. Noblanc</name><affiliation wicri:level="1"><nlm:affiliation>GReD Lab CNRS UMR6293-INSERM U1103 Université Blaise Pascal-Clermont II, Clermont-Ferrand 63001, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GReD Lab CNRS UMR6293-INSERM U1103 Université Blaise Pascal-Clermont II, Clermont-Ferrand 63001</wicri:regionArea><wicri:noRegion>63001</wicri:noRegion><wicri:noRegion>63001</wicri:noRegion></affiliation></author><author><name sortKey="Kocer, A" sort="Kocer, A" uniqKey="Kocer A" first="A" last="Kocer">A. 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Pericuesta</name><affiliation wicri:level="1"><nlm:affiliation>INIA, Animal Reproduction, Madrid 28040, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>INIA, Animal Reproduction, Madrid 28040</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Polhemus, A" sort="Polhemus, A" uniqKey="Polhemus A" first="A" last="Polhemus">A. Polhemus</name><affiliation wicri:level="2"><nlm:affiliation>CellOxess LLC, 15 Roszel Road, Princeton, NJ 08540, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>CellOxess LLC, 15 Roszel Road, Princeton, NJ 08540</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Moazamian, A" sort="Moazamian, A" uniqKey="Moazamian A" first="A" last="Moazamian">A. Moazamian</name><affiliation wicri:level="2"><nlm:affiliation>CellOxess LLC, 15 Roszel Road, Princeton, NJ 08540, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>CellOxess LLC, 15 Roszel Road, Princeton, NJ 08540</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Drevet, J R" sort="Drevet, J R" uniqKey="Drevet J" first="J R" last="Drevet">J R Drevet</name><affiliation wicri:level="3"><nlm:affiliation>GReD Lab CNRS UMR6293-INSERM U1103 Université Blaise Pascal-Clermont II, Clermont-Ferrand 63001, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GReD Lab CNRS UMR6293-INSERM U1103 Université Blaise Pascal-Clermont II, Clermont-Ferrand 63001</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region></placeName></affiliation></author><author><name sortKey="Aitken, R J" sort="Aitken, R J" uniqKey="Aitken R" first="R J" last="Aitken">R J Aitken</name><affiliation wicri:level="1"><nlm:affiliation>Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia The University of Newcastle, University Drive, Callaghan, NSW 2308</wicri:regionArea><wicri:noRegion>NSW 2308</wicri:noRegion></affiliation></author></analytic><series><title level="j">Human reproduction (Oxford, England)</title><idno type="eISSN">1460-2350</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antioxidants (pharmacology)</term><term>Biomarkers (metabolism)</term><term>DNA Damage</term><term>Deoxyguanosine (analogs & derivatives)</term><term>Deoxyguanosine (metabolism)</term><term>Female</term><term>Glutathione Peroxidase (genetics)</term><term>Infertility, Male (drug therapy)</term><term>Infertility, Male (genetics)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Models, Animal</term><term>Oxidative Stress</term><term>Pregnancy</term><term>Pregnancy Outcome</term><term>Pregnancy Rate</term><term>Semen Analysis</term><term>Spermatozoa (drug effects)</term><term>Spermatozoa (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Altération de l'ADN</term><term>Analyse du sperme</term><term>Animaux</term><term>Antioxydants (pharmacologie)</term><term>Désoxyguanosine (analogues et dérivés)</term><term>Désoxyguanosine (métabolisme)</term><term>Femelle</term><term>Glutathione peroxidase (génétique)</term><term>Grossesse</term><term>Infertilité masculine (génétique)</term><term>Infertilité masculine (traitement médicamenteux)</term><term>Issue de la grossesse</term><term>Marqueurs biologiques (métabolisme)</term><term>Modèles animaux</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris knockout</term><term>Spermatozoïdes ()</term><term>Spermatozoïdes (métabolisme)</term><term>Stress oxydatif</term><term>Taux de grossesse</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Deoxyguanosine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glutathione Peroxidase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term><term>Deoxyguanosine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antioxidants</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Désoxyguanosine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Spermatozoa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Infertility, Male</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Infertility, Male</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glutathione peroxidase</term><term>Infertilité masculine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Spermatozoa</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Désoxyguanosine</term><term>Marqueurs biologiques</term><term>Spermatozoïdes</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antioxydants</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infertilité masculine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>DNA Damage</term><term>Female</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Models, Animal</term><term>Oxidative Stress</term><term>Pregnancy</term><term>Pregnancy Outcome</term><term>Pregnancy Rate</term><term>Semen Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Altération de l'ADN</term><term>Analyse du sperme</term><term>Animaux</term><term>Femelle</term><term>Grossesse</term><term>Issue de la grossesse</term><term>Modèles animaux</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris knockout</term><term>Spermatozoïdes</term><term>Stress oxydatif</term><term>Taux de grossesse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Does a novel antioxidant formulation designed to restore redox balance within the male reproductive tract, reduce sperm DNA damage and increase pregnancy rates in mouse models of sperm oxidative stress?</div></front></TEI><affiliations><list><country><li>Australie</li><li>Espagne</li><li>France</li><li>Oman</li><li>États-Unis</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li><li>Communauté de Madrid</li><li>New Jersey</li></region><settlement><li>Madrid</li></settlement></list><tree><country name="Oman"><noRegion><name sortKey="Gharagozloo, P" sort="Gharagozloo, P" uniqKey="Gharagozloo P" first="P" last="Gharagozloo">P. Gharagozloo</name></noRegion></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Gutierrez Adan, A" sort="Gutierrez Adan, A" uniqKey="Gutierrez Adan A" first="A" last="Gutiérrez-Adán">A. Gutiérrez-Adán</name></region><name sortKey="Calle, A" sort="Calle, A" uniqKey="Calle A" first="A" last="Calle">A. Calle</name><name sortKey="Perez Cerezales, S" sort="Perez Cerezales, S" uniqKey="Perez Cerezales S" first="S" last="Pérez-Cerezales">S. Pérez-Cerezales</name><name sortKey="Pericuesta, E" sort="Pericuesta, E" uniqKey="Pericuesta E" first="E" last="Pericuesta">E. Pericuesta</name></country><country name="France"><noRegion><name sortKey="Champroux, A" sort="Champroux, A" uniqKey="Champroux A" first="A" last="Champroux">A. Champroux</name></noRegion><name sortKey="Drevet, J R" sort="Drevet, J R" uniqKey="Drevet J" first="J R" last="Drevet">J R Drevet</name><name sortKey="Kocer, A" sort="Kocer, A" uniqKey="Kocer A" first="A" last="Kocer">A. Kocer</name><name sortKey="Noblanc, A" sort="Noblanc, A" uniqKey="Noblanc A" first="A" last="Noblanc">A. Noblanc</name></country><country name="États-Unis"><region name="New Jersey"><name sortKey="Polhemus, A" sort="Polhemus, A" uniqKey="Polhemus A" first="A" last="Polhemus">A. Polhemus</name></region><name sortKey="Moazamian, A" sort="Moazamian, A" uniqKey="Moazamian A" first="A" last="Moazamian">A. Moazamian</name></country><country name="Australie"><noRegion><name sortKey="Aitken, R J" sort="Aitken, R J" uniqKey="Aitken R" first="R J" last="Aitken">R J Aitken</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|clé= pubmed:26732620
|texte= A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models.
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