Reducing Current Spread by Use of a Novel Pulse Shape for Electrical Stimulation of the Auditory Nerve
Identifieur interne : 002F30 ( Ncbi/Checkpoint ); précédent : 002F29; suivant : 002F31Reducing Current Spread by Use of a Novel Pulse Shape for Electrical Stimulation of the Auditory Nerve
Auteurs : Jimena Ballestero [Royaume-Uni] ; Matthieu Recugnat [Royaume-Uni] ; Jonathan Laudanski [France] ; Katie E. Smith [Royaume-Uni] ; Daniel J. Jagger [Royaume-Uni] ; Daniel Gnansia [France] ; David Mcalpine [Royaume-Uni]Source :
- Trends in Hearing [ 2331-2165 ] ; 2015.
Abstract
Improving the electrode-neuron interface to reduce current spread between individual electrodes has been identified as one of the main objectives in the search for future improvements in cochlear-implant performance. Here, we address this problem by presenting a novel stimulation strategy that takes account of the biophysical properties of the auditory neurons (spiral ganglion neurons, SGNs) stimulated in electrical hearing. This new strategy employs a ramped pulse shape, where the maximum amplitude is achieved through a linear slope in the injected current. We present the theoretical framework that supports this new strategy and that suggests it will improve the modulation of SGNs’ activity by exploiting their sensitivity to the rising slope of current pulses. The theoretical consequence of this sensitivity to the slope is a reduction in the spread of excitation within the cochlea and, consequently, an increase in the neural dynamic range. To explore the impact of the novel stimulation method on neural activity, we performed in vitro recordings of SGNs in culture. We show that the stimulus efficacy required to evoke action potentials in SGNs falls as the stimulus slope decreases. This work lays the foundation for a novel, and more biomimetic, stimulation strategy with considerable potential for implementation in cochlear-implant technology.
Url:
DOI: 10.1177/2331216515619763
PubMed: 26721928
PubMed Central: 4771040
Affiliations:
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Here, we address this problem by presenting a novel stimulation strategy that takes account of the biophysical properties of the auditory neurons (spiral ganglion neurons, SGNs) stimulated in electrical hearing. This new strategy employs a ramped pulse shape, where the maximum amplitude is achieved through a linear slope in the injected current. We present the theoretical framework that supports this new strategy and that suggests it will improve the modulation of SGNs’ activity by exploiting their sensitivity to the rising slope of current pulses. The theoretical consequence of this sensitivity to the slope is a reduction in the spread of excitation within the cochlea and, consequently, an increase in the neural dynamic range. To explore the impact of the novel stimulation method on neural activity, we performed in vitro recordings of SGNs in culture. We show that the stimulus efficacy required to evoke action potentials in SGNs falls as the stimulus slope decreases. This work lays the foundation for a novel, and more biomimetic, stimulation strategy with considerable potential for implementation in cochlear-implant technology.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Azouz, R" uniqKey="Azouz R">R. Azouz</name></author><author><name sortKey="Gray, C M" uniqKey="Gray C">C. M. Gray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bahmer, A" uniqKey="Bahmer A">A. Bahmer</name></author><author><name sortKey="Baumann, U" uniqKey="Baumann U">U. Baumann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bahmer, A" uniqKey="Bahmer A">A. Bahmer</name></author><author><name sortKey="Baumann, U" uniqKey="Baumann U">U. Baumann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bierer, J A" uniqKey="Bierer J">J. A. Bierer</name></author><author><name sortKey="Faulkner, K F" uniqKey="Faulkner K">K. 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Moser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shannon, R V" uniqKey="Shannon R">R. V. Shannon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shannon, R V" uniqKey="Shannon R">R. V. Shannon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, K E" uniqKey="Smith K">K. E. Smith</name></author><author><name sortKey="Browne, L" uniqKey="Browne L">L. Browne</name></author><author><name sortKey="Selwood, D L" uniqKey="Selwood D">D. L. Selwood</name></author><author><name sortKey="Mcalpine, D" uniqKey="Mcalpine D">D. McAlpine</name></author><author><name sortKey="Jagger, D J" uniqKey="Jagger D">D. J. Jagger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snyder, R L" uniqKey="Snyder R">R. L. Snyder</name></author><author><name sortKey="Bierer, J A" uniqKey="Bierer J">J. A. Bierer</name></author><author><name sortKey="Middlebrooks, J C" uniqKey="Middlebrooks J">J. C. Middlebrooks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, F G" uniqKey="Zeng F">F. G. Zeng</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ballestero, Jimena" sort="Ballestero, Jimena" uniqKey="Ballestero J" first="Jimena" last="Ballestero">Jimena Ballestero</name></region><name sortKey="Jagger, Daniel J" sort="Jagger, Daniel J" uniqKey="Jagger D" first="Daniel J." last="Jagger">Daniel J. Jagger</name><name sortKey="Mcalpine, David" sort="Mcalpine, David" uniqKey="Mcalpine D" first="David" last="Mcalpine">David Mcalpine</name><name sortKey="Recugnat, Matthieu" sort="Recugnat, Matthieu" uniqKey="Recugnat M" first="Matthieu" last="Recugnat">Matthieu Recugnat</name><name sortKey="Smith, Katie E" sort="Smith, Katie E" uniqKey="Smith K" first="Katie E." last="Smith">Katie E. Smith</name></country><country name="France"><noRegion><name sortKey="Laudanski, Jonathan" sort="Laudanski, Jonathan" uniqKey="Laudanski J" first="Jonathan" last="Laudanski">Jonathan Laudanski</name></noRegion><name sortKey="Gnansia, Daniel" sort="Gnansia, Daniel" uniqKey="Gnansia D" first="Daniel" last="Gnansia">Daniel Gnansia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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