G Protein–Coupled Receptor Heteromers
Identifieur interne : 002C89 ( Ncbi/Checkpoint ); précédent : 002C88; suivant : 002C90G Protein–Coupled Receptor Heteromers
Auteurs : Ivone Gomes [États-Unis] ; Mohammed Akli Ayoub [France] ; Wakako Fujita [États-Unis] ; Werner C. Jaeger [Australie] ; Kevin D. G. Pfleger [Australie] ; Lakshmi A. Devi [États-Unis]Source :
- Annual review of pharmacology and toxicology [ 0362-1642 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Protéines membranaires, Récepteurs couplés aux protéines G.
- physiologie : Transduction du signal.
- Animaux, Découverte de médicament, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Membrane Proteins, Receptors, G-Protein-Coupled.
- methods : Drug Discovery.
- physiology : Signal Transduction.
- Animals, Humans.
Abstract
G protein–coupled receptors (GPCRs) compose one of the largest families of membrane proteins involved in intracellular signaling. They are involved in numerous physiological and pathological processes and are prime candidates for drug development. Over the past decade, an increasing number of studies have reported heteromerization between GPCRs. Many investigations in heterologous systems have provided important indications of potential novel pharmacology; however, the physiological relevance of these findings has yet to be established with endogenous receptors in native tissues. In this review, we focus on family A GPCRs and describe the techniques and criteria to assess their heteromerization. We conclude that advances in approaches to study receptor complex functionality in heterologous systems, coupled with techniques that enable specific examination of native receptor heteromers in vivo, are likely to establish GPCR heteromers as novel therapeutic targets.
Url:
DOI: 10.1146/annurev-pharmtox-011613-135952
PubMed: 26514203
PubMed Central: 5147582
Affiliations:
- Australie, France, États-Unis
- Centre-Val de Loire, Région Centre, État de New York
- Nouzilly, Orleans
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001F60
- to stream Pmc, to step Curation: 001E14
- to stream Pmc, to step Checkpoint: 000F86
- to stream PubMed, to step Corpus: 002415
- to stream PubMed, to step Curation: 002369
- to stream PubMed, to step Checkpoint: 002369
- to stream Ncbi, to step Merge: 002C89
- to stream Ncbi, to step Curation: 002C89
Links to Exploration step
PMC:5147582Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">G Protein–Coupled Receptor Heteromers</title><author><name sortKey="Gomes, Ivone" sort="Gomes, Ivone" uniqKey="Gomes I" first="Ivone" last="Gomes">Ivone Gomes</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York</wicri:cityArea></affiliation></author><author><name sortKey="Ayoub, Mohammed Akli" sort="Ayoub, Mohammed Akli" uniqKey="Ayoub M" first="Mohammed Akli" last="Ayoub">Mohammed Akli Ayoub</name><affiliation wicri:level="1"><nlm:aff id="A2">Biologie et Bioinformatique des Systèmes de Signalisation (BIOS) Group, INRA, UMR85, Unité Physiologie de la Reproduction et des Comportements; CNRS, UMR7247, F-37380 Nouzilly, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Biologie et Bioinformatique des Systèmes de Signalisation (BIOS) Group, INRA, UMR85, Unité Physiologie de la Reproduction et des Comportements; CNRS, UMR7247, F-37380 Nouzilly</wicri:regionArea><wicri:noRegion>37380 Nouzilly</wicri:noRegion><wicri:noRegion>37380 Nouzilly</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">LE STUDIUM Loire Valley Institute for Advanced Studies, F-45000 Orleans, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>LE STUDIUM Loire Valley Institute for Advanced Studies, F-45000 Orleans</wicri:regionArea><wicri:noRegion>45000 Orleans</wicri:noRegion><wicri:noRegion>45000 Orleans</wicri:noRegion></affiliation></author><author><name sortKey="Fujita, Wakako" sort="Fujita, Wakako" uniqKey="Fujita W" first="Wakako" last="Fujita">Wakako Fujita</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York</wicri:cityArea></affiliation></author><author><name sortKey="Jaeger, Werner C" sort="Jaeger, Werner C" uniqKey="Jaeger W" first="Werner C." last="Jaeger">Werner C. Jaeger</name><affiliation wicri:level="1"><nlm:aff id="A4">Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Centre for Medical Research, The University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Research, The University of Western Australia, Crawley, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation></author><author><name sortKey="Pfleger, Kevin D G" sort="Pfleger, Kevin D G" uniqKey="Pfleger K" first="Kevin D. G." last="Pfleger">Kevin D. G. Pfleger</name><affiliation wicri:level="1"><nlm:aff id="A4">Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Centre for Medical Research, The University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Research, The University of Western Australia, Crawley, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Dimerix Bioscience Limited, Nedlands, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Dimerix Bioscience Limited, Nedlands, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation></author><author><name sortKey="Devi, Lakshmi A" sort="Devi, Lakshmi A" uniqKey="Devi L" first="Lakshmi A." last="Devi">Lakshmi A. Devi</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26514203</idno><idno type="pmc">5147582</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147582</idno><idno type="RBID">PMC:5147582</idno><idno type="doi">10.1146/annurev-pharmtox-011613-135952</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001F60</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F60</idno><idno type="wicri:Area/Pmc/Curation">001E14</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001E14</idno><idno type="wicri:Area/Pmc/Checkpoint">000F86</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F86</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002415</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002415</idno><idno type="wicri:Area/PubMed/Curation">002369</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002369</idno><idno type="wicri:Area/PubMed/Checkpoint">002369</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002369</idno><idno type="wicri:Area/Ncbi/Merge">002C89</idno><idno type="wicri:Area/Ncbi/Curation">002C89</idno><idno type="wicri:Area/Ncbi/Checkpoint">002C89</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">G Protein–Coupled Receptor Heteromers</title><author><name sortKey="Gomes, Ivone" sort="Gomes, Ivone" uniqKey="Gomes I" first="Ivone" last="Gomes">Ivone Gomes</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York</wicri:cityArea></affiliation></author><author><name sortKey="Ayoub, Mohammed Akli" sort="Ayoub, Mohammed Akli" uniqKey="Ayoub M" first="Mohammed Akli" last="Ayoub">Mohammed Akli Ayoub</name><affiliation wicri:level="3"><nlm:aff id="A2">Biologie et Bioinformatique des Systèmes de Signalisation (BIOS) Group, INRA, UMR85, Unité Physiologie de la Reproduction et des Comportements; CNRS, UMR7247, F-37380 Nouzilly, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Biologie et Bioinformatique des Systèmes de Signalisation (BIOS) Group, INRA, UMR85, Unité Physiologie de la Reproduction et des Comportements; CNRS, UMR7247, F-37380 Nouzilly</wicri:regionArea><placeName><region type="region" nuts="2">Centre-Val de Loire</region><region type="old region" nuts="2">Région Centre</region><settlement type="city">Nouzilly</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A3">LE STUDIUM Loire Valley Institute for Advanced Studies, F-45000 Orleans, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>LE STUDIUM Loire Valley Institute for Advanced Studies, F-45000 Orleans</wicri:regionArea><placeName><region type="region" nuts="2">Centre-Val de Loire</region><region type="old region" nuts="2">Région Centre</region><settlement type="city">Orleans</settlement></placeName></affiliation></author><author><name sortKey="Fujita, Wakako" sort="Fujita, Wakako" uniqKey="Fujita W" first="Wakako" last="Fujita">Wakako Fujita</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York</wicri:cityArea></affiliation></author><author><name sortKey="Jaeger, Werner C" sort="Jaeger, Werner C" uniqKey="Jaeger W" first="Werner C." last="Jaeger">Werner C. Jaeger</name><affiliation wicri:level="1"><nlm:aff id="A4">Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Centre for Medical Research, The University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Research, The University of Western Australia, Crawley, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation></author><author><name sortKey="Pfleger, Kevin D G" sort="Pfleger, Kevin D G" uniqKey="Pfleger K" first="Kevin D. G." last="Pfleger">Kevin D. G. Pfleger</name><affiliation wicri:level="1"><nlm:aff id="A4">Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Centre for Medical Research, The University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Research, The University of Western Australia, Crawley, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Dimerix Bioscience Limited, Nedlands, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Dimerix Bioscience Limited, Nedlands, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation></author><author><name sortKey="Devi, Lakshmi A" sort="Devi, Lakshmi A" uniqKey="Devi L" first="Lakshmi A." last="Devi">Lakshmi A. Devi</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York</wicri:cityArea></affiliation></author></analytic><series><title level="j">Annual review of pharmacology and toxicology</title><idno type="ISSN">0362-1642</idno><idno type="eISSN">1545-4304</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Drug Discovery (methods)</term><term>Humans</term><term>Membrane Proteins (metabolism)</term><term>Receptors, G-Protein-Coupled (metabolism)</term><term>Signal Transduction (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Découverte de médicament ()</term><term>Humains</term><term>Protéines membranaires (métabolisme)</term><term>Récepteurs couplés aux protéines G (métabolisme)</term><term>Transduction du signal (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Membrane Proteins</term><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Discovery</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines membranaires</term><term>Récepteurs couplés aux protéines G</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Découverte de médicament</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">G protein–coupled receptors (GPCRs) compose one of the largest families of membrane proteins involved in intracellular signaling. They are involved in numerous physiological and pathological processes and are prime candidates for drug development. Over the past decade, an increasing number of studies have reported heteromerization between GPCRs. Many investigations in heterologous systems have provided important indications of potential novel pharmacology; however, the physiological relevance of these findings has yet to be established with endogenous receptors in native tissues. In this review, we focus on family A GPCRs and describe the techniques and criteria to assess their heteromerization. We conclude that advances in approaches to study receptor complex functionality in heterologous systems, coupled with techniques that enable specific examination of native receptor heteromers in vivo, are likely to establish GPCR heteromers as novel therapeutic targets.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>États-Unis</li></country><region><li>Centre-Val de Loire</li><li>Région Centre</li><li>État de New York</li></region><settlement><li>Nouzilly</li><li>Orleans</li></settlement></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Gomes, Ivone" sort="Gomes, Ivone" uniqKey="Gomes I" first="Ivone" last="Gomes">Ivone Gomes</name></region><name sortKey="Devi, Lakshmi A" sort="Devi, Lakshmi A" uniqKey="Devi L" first="Lakshmi A." last="Devi">Lakshmi A. Devi</name><name sortKey="Fujita, Wakako" sort="Fujita, Wakako" uniqKey="Fujita W" first="Wakako" last="Fujita">Wakako Fujita</name></country><country name="France"><region name="Centre-Val de Loire"><name sortKey="Ayoub, Mohammed Akli" sort="Ayoub, Mohammed Akli" uniqKey="Ayoub M" first="Mohammed Akli" last="Ayoub">Mohammed Akli Ayoub</name></region><name sortKey="Ayoub, Mohammed Akli" sort="Ayoub, Mohammed Akli" uniqKey="Ayoub M" first="Mohammed Akli" last="Ayoub">Mohammed Akli Ayoub</name></country><country name="Australie"><noRegion><name sortKey="Jaeger, Werner C" sort="Jaeger, Werner C" uniqKey="Jaeger W" first="Werner C." last="Jaeger">Werner C. Jaeger</name></noRegion><name sortKey="Jaeger, Werner C" sort="Jaeger, Werner C" uniqKey="Jaeger W" first="Werner C." last="Jaeger">Werner C. Jaeger</name><name sortKey="Pfleger, Kevin D G" sort="Pfleger, Kevin D G" uniqKey="Pfleger K" first="Kevin D. G." last="Pfleger">Kevin D. G. Pfleger</name><name sortKey="Pfleger, Kevin D G" sort="Pfleger, Kevin D G" uniqKey="Pfleger K" first="Kevin D. G." last="Pfleger">Kevin D. G. Pfleger</name><name sortKey="Pfleger, Kevin D G" sort="Pfleger, Kevin D G" uniqKey="Pfleger K" first="Kevin D. G." last="Pfleger">Kevin D. G. Pfleger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002C89 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 002C89 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= PMC:5147582
|texte= G Protein–Coupled Receptor Heteromers
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:26514203" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |