Analysis of KRAS/NRAS Mutations in a Phase III Study of Panitumumab with FOLFIRI Compared with FOLFIRI Alone as Second-line Treatment for Metastatic Colorectal Cancer.
Identifieur interne : 002A22 ( Ncbi/Checkpoint ); précédent : 002A21; suivant : 002A23Analysis of KRAS/NRAS Mutations in a Phase III Study of Panitumumab with FOLFIRI Compared with FOLFIRI Alone as Second-line Treatment for Metastatic Colorectal Cancer.
Auteurs : Marc Peeters [Belgique] ; Kelly S. Oliner [États-Unis] ; Timothy J. Price [Australie] ; Andrés Cervantes [Espagne] ; Alberto F. Sobrero [Italie] ; Michel Ducreux [France] ; Yevhen Hotko [Ukraine] ; Thierry André [France] ; Emily Chan [États-Unis] ; Florian Lordick [Allemagne] ; Cornelis J A. Punt [Pays-Bas] ; Andrew H. Strickland [Australie] ; Gregory Wilson [Royaume-Uni] ; Tudor E. Ciuleanu [Roumanie] ; Laslo Roman [Russie] ; Eric Van Cutsem [Belgique] ; Pei He [États-Unis] ; Hua Yu [États-Unis] ; Reija Koukakis [Suisse] ; Jan-Henrik Terwey [Suisse] ; Andre S. Jung [États-Unis] ; Roger Sidhu [États-Unis] ; Scott D. Patterson [États-Unis]Source :
- Clinical cancer research : an official journal of the American Association for Cancer Research [ 1078-0432 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Analyse de mutations d'ADN, Analyse de survie, Anticorps monoclonaux (administration et posologie), Camptothécine (analogues et dérivés), Camptothécine (effets indésirables), Camptothécine (usage thérapeutique), Exons, Femelle, Fluorouracil (effets indésirables), Fluorouracil (usage thérapeutique), Gènes ras, Humains, Leucovorine (effets indésirables), Leucovorine (usage thérapeutique), Modèles de hasards proportionnels, Mutation, Mâle, Métastase tumorale, Protocoles de polychimiothérapie antinéoplasique (effets indésirables), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Protéines proto-oncogènes B-raf (génétique), Reprise du traitement, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs colorectales (anatomopathologie), Tumeurs colorectales (génétique), Tumeurs colorectales (mortalité), Tumeurs colorectales (traitement médicamenteux).
- MESH :
- administration et posologie : Anticorps monoclonaux.
- analogues et dérivés : Camptothécine.
- anatomopathologie : Tumeurs colorectales.
- effets indésirables : Camptothécine, Fluorouracil, Leucovorine, Protocoles de polychimiothérapie antinéoplasique.
- génétique : Protéines proto-oncogènes B-raf, Tumeurs colorectales.
- mortalité : Tumeurs colorectales.
- traitement médicamenteux : Tumeurs colorectales.
- usage thérapeutique : Camptothécine, Fluorouracil, Leucovorine, Protocoles de polychimiothérapie antinéoplasique.
- Adulte, Adulte d'âge moyen, Analyse de mutations d'ADN, Analyse de survie, Exons, Femelle, Gènes ras, Humains, Modèles de hasards proportionnels, Mutation, Mâle, Métastase tumorale, Reprise du traitement, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal (administration & dosage), Antineoplastic Combined Chemotherapy Protocols (adverse effects), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Camptothecin (adverse effects), Camptothecin (analogs & derivatives), Camptothecin (therapeutic use), Colorectal Neoplasms (drug therapy), Colorectal Neoplasms (genetics), Colorectal Neoplasms (mortality), Colorectal Neoplasms (pathology), DNA Mutational Analysis, Exons, Female, Fluorouracil (adverse effects), Fluorouracil (therapeutic use), Genes, ras, Humans, Leucovorin (adverse effects), Leucovorin (therapeutic use), Male, Middle Aged, Mutation, Neoplasm Metastasis, Proportional Hazards Models, Proto-Oncogene Proteins B-raf (genetics), Retreatment, Survival Analysis, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal.
- adverse effects : Antineoplastic Combined Chemotherapy Protocols, Camptothecin, Fluorouracil, Leucovorin.
- chemical , analogs & derivatives : Camptothecin.
- drug therapy : Colorectal Neoplasms.
- genetics : Colorectal Neoplasms, Proto-Oncogene Proteins B-raf.
- mortality : Colorectal Neoplasms.
- pathology : Colorectal Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols, Camptothecin, Fluorouracil, Leucovorin.
- Adult, Aged, Aged, 80 and over, DNA Mutational Analysis, Exons, Female, Genes, ras, Humans, Male, Middle Aged, Mutation, Neoplasm Metastasis, Proportional Hazards Models, Retreatment, Survival Analysis, Treatment Outcome.
Abstract
We evaluated the influence of RAS mutation status on the treatment effect of panitumumab in a prospective-retrospective analysis of a randomized, multicenter phase III study of panitumumab plus fluorouracil, leucovorin, and irinotecan (FOLFIRI) versus FOLFIRI alone as second-line therapy in patients with metastatic colorectal cancer (mCRC; ClinicalTrials.gov, NCT0039183).
DOI: 10.1158/1078-0432.CCR-15-0526
PubMed: 26341920
Affiliations:
- Allemagne, Australie, Belgique, Espagne, France, Italie, Pays-Bas, Roumanie, Royaume-Uni, Russie, Suisse, Ukraine, États-Unis
- Angleterre, Californie, District de Leipzig, Grand Manchester, Hollande-Septentrionale, Saxe (Land), Tennessee, Île-de-France
- Amsterdam, Leipzig, Manchester, Paris
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002625
- to stream PubMed, to step Curation: 002556
- to stream PubMed, to step Checkpoint: 002556
- to stream Ncbi, to step Merge: 002A22
- to stream Ncbi, to step Curation: 002A22
Links to Exploration step
pubmed:26341920Le document en format XML
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Punt</name><affiliation wicri:level="3"><nlm:affiliation>Academic Medical Center, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Strickland, Andrew H" sort="Strickland, Andrew H" uniqKey="Strickland A" first="Andrew H" last="Strickland">Andrew H. Strickland</name><affiliation wicri:level="1"><nlm:affiliation>Monash Medical Center, East Bentleigh, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Medical Center, East Bentleigh</wicri:regionArea><wicri:noRegion>East Bentleigh</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, Gregory" sort="Wilson, Gregory" uniqKey="Wilson G" first="Gregory" last="Wilson">Gregory Wilson</name><affiliation wicri:level="3"><nlm:affiliation>Christie Hospital, Manchester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Christie Hospital, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Ciuleanu, Tudor E" sort="Ciuleanu, Tudor E" uniqKey="Ciuleanu T" first="Tudor E" last="Ciuleanu">Tudor E. Ciuleanu</name><affiliation wicri:level="1"><nlm:affiliation>Institutul Oncologic Ion Chiricuta and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Institutul Oncologic Ion Chiricuta and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca</wicri:regionArea><wicri:noRegion>Cluj Napoca</wicri:noRegion></affiliation></author><author><name sortKey="Roman, Laslo" sort="Roman, Laslo" uniqKey="Roman L" first="Laslo" last="Roman">Laslo Roman</name><affiliation wicri:level="1"><nlm:affiliation>Leningrad Regional Oncology Dispensary, Saint Petersburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Leningrad Regional Oncology Dispensary, Saint Petersburg</wicri:regionArea><wicri:noRegion>Saint Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Van Cutsem, Eric" sort="Van Cutsem, Eric" uniqKey="Van Cutsem E" first="Eric" last="Van Cutsem">Eric Van Cutsem</name><affiliation wicri:level="1"><nlm:affiliation>University Hospitals and KU Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>University Hospitals and KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="He, Pei" sort="He, Pei" uniqKey="He P" first="Pei" last="He">Pei He</name><affiliation wicri:level="2"><nlm:affiliation>Amgen Inc., Thousand Oaks, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen Inc., Thousand Oaks, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yu, Hua" sort="Yu, Hua" uniqKey="Yu H" first="Hua" last="Yu">Hua Yu</name><affiliation wicri:level="2"><nlm:affiliation>Amgen Inc., Thousand Oaks, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen Inc., Thousand Oaks, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Koukakis, Reija" sort="Koukakis, Reija" uniqKey="Koukakis R" first="Reija" last="Koukakis">Reija Koukakis</name><affiliation wicri:level="1"><nlm:affiliation>Amgen (Europe) GmbH, Zug, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Amgen (Europe) GmbH, Zug</wicri:regionArea><wicri:noRegion>Zug</wicri:noRegion></affiliation></author><author><name sortKey="Terwey, Jan Henrik" sort="Terwey, Jan Henrik" uniqKey="Terwey J" first="Jan-Henrik" last="Terwey">Jan-Henrik Terwey</name><affiliation wicri:level="1"><nlm:affiliation>Amgen (Europe) GmbH, Zug, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Amgen (Europe) GmbH, Zug</wicri:regionArea><wicri:noRegion>Zug</wicri:noRegion></affiliation></author><author><name sortKey="Jung, Andre S" sort="Jung, Andre S" uniqKey="Jung A" first="Andre S" last="Jung">Andre S. Jung</name><affiliation wicri:level="2"><nlm:affiliation>Amgen Inc., Thousand Oaks, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen Inc., Thousand Oaks, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sidhu, Roger" sort="Sidhu, Roger" uniqKey="Sidhu R" first="Roger" last="Sidhu">Roger Sidhu</name><affiliation wicri:level="2"><nlm:affiliation>Amgen Inc., Thousand Oaks, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen Inc., Thousand Oaks, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Patterson, Scott D" sort="Patterson, Scott D" uniqKey="Patterson S" first="Scott D" last="Patterson">Scott D. Patterson</name><affiliation wicri:level="2"><nlm:affiliation>Amgen Inc., Thousand Oaks, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen Inc., Thousand Oaks, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26341920</idno><idno type="pmid">26341920</idno><idno type="doi">10.1158/1078-0432.CCR-15-0526</idno><idno type="wicri:Area/PubMed/Corpus">002625</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002625</idno><idno type="wicri:Area/PubMed/Curation">002556</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002556</idno><idno type="wicri:Area/PubMed/Checkpoint">002556</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002556</idno><idno type="wicri:Area/Ncbi/Merge">002A22</idno><idno type="wicri:Area/Ncbi/Curation">002A22</idno><idno type="wicri:Area/Ncbi/Checkpoint">002A22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Analysis of KRAS/NRAS Mutations in a Phase III Study of Panitumumab with FOLFIRI Compared with FOLFIRI Alone as Second-line Treatment for Metastatic Colorectal Cancer.</title><author><name sortKey="Peeters, Marc" sort="Peeters, Marc" uniqKey="Peeters M" first="Marc" last="Peeters">Marc Peeters</name><affiliation wicri:level="1"><nlm:affiliation>Antwerp University Hospital and University of Antwerp, Edegem, Belgium. Marc.Peeters@uza.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Antwerp University Hospital and University of Antwerp, Edegem</wicri:regionArea><wicri:noRegion>Edegem</wicri:noRegion></affiliation></author><author><name sortKey="Oliner, Kelly S" sort="Oliner, Kelly S" uniqKey="Oliner K" first="Kelly S" last="Oliner">Kelly S. Oliner</name><affiliation wicri:level="2"><nlm:affiliation>Amgen Inc., Thousand Oaks, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen Inc., Thousand Oaks, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Price, Timothy J" sort="Price, Timothy J" uniqKey="Price T" first="Timothy J" last="Price">Timothy J. Price</name><affiliation wicri:level="1"><nlm:affiliation>Queen Elizabeth Hospital and University of Adelaide, Woodville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queen Elizabeth Hospital and University of Adelaide, Woodville</wicri:regionArea><wicri:noRegion>Woodville</wicri:noRegion></affiliation></author><author><name sortKey="Cervantes, Andres" sort="Cervantes, Andres" uniqKey="Cervantes A" first="Andrés" last="Cervantes">Andrés Cervantes</name><affiliation wicri:level="1"><nlm:affiliation>Biomedical Research Institute INCLIVA, University of Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Biomedical Research Institute INCLIVA, University of Valencia</wicri:regionArea><wicri:noRegion>University of Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Sobrero, Alberto F" sort="Sobrero, Alberto F" uniqKey="Sobrero A" first="Alberto F" last="Sobrero">Alberto F. Sobrero</name><affiliation wicri:level="1"><nlm:affiliation>Ospedale San Martino, Genova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale San Martino, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Ducreux, Michel" sort="Ducreux, Michel" uniqKey="Ducreux M" first="Michel" last="Ducreux">Michel Ducreux</name><affiliation wicri:level="3"><nlm:affiliation>Institut Gustave Roussy, Villejuif, and Paris-Sud University, Le Kremlin Bicêtre, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Gustave Roussy, Villejuif, and Paris-Sud University, Le Kremlin Bicêtre, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hotko, Yevhen" sort="Hotko, Yevhen" uniqKey="Hotko Y" first="Yevhen" last="Hotko">Yevhen Hotko</name><affiliation wicri:level="1"><nlm:affiliation>Uzhgorod National University, Uzhgorod, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Uzhgorod National University, Uzhgorod</wicri:regionArea><wicri:noRegion>Uzhgorod</wicri:noRegion></affiliation></author><author><name sortKey="Andre, Thierry" sort="Andre, Thierry" uniqKey="Andre T" first="Thierry" last="André">Thierry André</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Saint Antoine and Université Pierre et Marie Curie (UMPC; Paris VI), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Saint Antoine and Université Pierre et Marie Curie (UMPC; Paris VI), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chan, Emily" sort="Chan, Emily" uniqKey="Chan E" first="Emily" last="Chan">Emily Chan</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt University Medical Center, Nashville, Tennessee, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Lordick, Florian" sort="Lordick, Florian" uniqKey="Lordick F" first="Florian" last="Lordick">Florian Lordick</name><affiliation wicri:level="3"><nlm:affiliation>University Cancer Center, Leipzig, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Cancer Center, Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Punt, Cornelis J A" sort="Punt, Cornelis J A" uniqKey="Punt C" first="Cornelis J A" last="Punt">Cornelis J A. Punt</name><affiliation wicri:level="3"><nlm:affiliation>Academic Medical Center, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Strickland, Andrew H" sort="Strickland, Andrew H" uniqKey="Strickland A" first="Andrew H" last="Strickland">Andrew H. Strickland</name><affiliation wicri:level="1"><nlm:affiliation>Monash Medical Center, East Bentleigh, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Medical Center, East Bentleigh</wicri:regionArea><wicri:noRegion>East Bentleigh</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, Gregory" sort="Wilson, Gregory" uniqKey="Wilson G" first="Gregory" last="Wilson">Gregory Wilson</name><affiliation wicri:level="3"><nlm:affiliation>Christie Hospital, Manchester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Christie Hospital, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Ciuleanu, Tudor E" sort="Ciuleanu, Tudor E" uniqKey="Ciuleanu T" first="Tudor E" last="Ciuleanu">Tudor E. Ciuleanu</name><affiliation wicri:level="1"><nlm:affiliation>Institutul Oncologic Ion Chiricuta and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Institutul Oncologic Ion Chiricuta and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca</wicri:regionArea><wicri:noRegion>Cluj Napoca</wicri:noRegion></affiliation></author><author><name sortKey="Roman, Laslo" sort="Roman, Laslo" uniqKey="Roman L" first="Laslo" last="Roman">Laslo Roman</name><affiliation wicri:level="1"><nlm:affiliation>Leningrad Regional Oncology Dispensary, Saint Petersburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Leningrad Regional Oncology Dispensary, Saint Petersburg</wicri:regionArea><wicri:noRegion>Saint Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Van Cutsem, Eric" sort="Van Cutsem, Eric" uniqKey="Van Cutsem E" first="Eric" last="Van Cutsem">Eric Van Cutsem</name><affiliation wicri:level="1"><nlm:affiliation>University Hospitals and KU Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>University Hospitals and KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="He, Pei" sort="He, Pei" uniqKey="He P" first="Pei" last="He">Pei He</name><affiliation wicri:level="2"><nlm:affiliation>Amgen Inc., Thousand Oaks, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen Inc., Thousand Oaks, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yu, Hua" sort="Yu, Hua" uniqKey="Yu H" first="Hua" last="Yu">Hua Yu</name><affiliation wicri:level="2"><nlm:affiliation>Amgen Inc., Thousand Oaks, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen Inc., Thousand Oaks, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Koukakis, Reija" sort="Koukakis, Reija" uniqKey="Koukakis R" first="Reija" last="Koukakis">Reija Koukakis</name><affiliation wicri:level="1"><nlm:affiliation>Amgen (Europe) GmbH, Zug, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Amgen (Europe) GmbH, Zug</wicri:regionArea><wicri:noRegion>Zug</wicri:noRegion></affiliation></author><author><name sortKey="Terwey, Jan Henrik" sort="Terwey, Jan Henrik" uniqKey="Terwey J" first="Jan-Henrik" last="Terwey">Jan-Henrik Terwey</name><affiliation wicri:level="1"><nlm:affiliation>Amgen (Europe) GmbH, Zug, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Amgen (Europe) GmbH, Zug</wicri:regionArea><wicri:noRegion>Zug</wicri:noRegion></affiliation></author><author><name sortKey="Jung, Andre S" sort="Jung, Andre S" uniqKey="Jung A" first="Andre S" last="Jung">Andre S. Jung</name><affiliation wicri:level="2"><nlm:affiliation>Amgen Inc., Thousand Oaks, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen Inc., Thousand Oaks, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sidhu, Roger" sort="Sidhu, Roger" uniqKey="Sidhu R" first="Roger" last="Sidhu">Roger Sidhu</name><affiliation wicri:level="2"><nlm:affiliation>Amgen Inc., Thousand Oaks, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen Inc., Thousand Oaks, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Patterson, Scott D" sort="Patterson, Scott D" uniqKey="Patterson S" first="Scott D" last="Patterson">Scott D. Patterson</name><affiliation wicri:level="2"><nlm:affiliation>Amgen Inc., Thousand Oaks, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen Inc., Thousand Oaks, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Clinical cancer research : an official journal of the American Association for Cancer Research</title><idno type="ISSN">1078-0432</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antibodies, Monoclonal (administration & dosage)</term><term>Antineoplastic Combined Chemotherapy Protocols (adverse effects)</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Camptothecin (adverse effects)</term><term>Camptothecin (analogs & derivatives)</term><term>Camptothecin (therapeutic use)</term><term>Colorectal Neoplasms (drug therapy)</term><term>Colorectal Neoplasms (genetics)</term><term>Colorectal Neoplasms (mortality)</term><term>Colorectal Neoplasms (pathology)</term><term>DNA Mutational Analysis</term><term>Exons</term><term>Female</term><term>Fluorouracil (adverse effects)</term><term>Fluorouracil (therapeutic use)</term><term>Genes, ras</term><term>Humans</term><term>Leucovorin (adverse effects)</term><term>Leucovorin (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Neoplasm Metastasis</term><term>Proportional Hazards Models</term><term>Proto-Oncogene Proteins B-raf (genetics)</term><term>Retreatment</term><term>Survival Analysis</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de mutations d'ADN</term><term>Analyse de survie</term><term>Anticorps monoclonaux (administration et posologie)</term><term>Camptothécine (analogues et dérivés)</term><term>Camptothécine (effets indésirables)</term><term>Camptothécine (usage thérapeutique)</term><term>Exons</term><term>Femelle</term><term>Fluorouracil (effets indésirables)</term><term>Fluorouracil (usage thérapeutique)</term><term>Gènes ras</term><term>Humains</term><term>Leucovorine (effets indésirables)</term><term>Leucovorine (usage thérapeutique)</term><term>Modèles de hasards proportionnels</term><term>Mutation</term><term>Mâle</term><term>Métastase tumorale</term><term>Protocoles de polychimiothérapie antinéoplasique (effets indésirables)</term><term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term><term>Protéines proto-oncogènes B-raf (génétique)</term><term>Reprise du traitement</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs colorectales (anatomopathologie)</term><term>Tumeurs colorectales (génétique)</term><term>Tumeurs colorectales (mortalité)</term><term>Tumeurs colorectales (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anticorps monoclonaux</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term><term>Camptothecin</term><term>Fluorouracil</term><term>Leucovorin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Camptothecin</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Camptothécine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs colorectales</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Camptothécine</term><term>Fluorouracil</term><term>Leucovorine</term><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Colorectal Neoplasms</term><term>Proto-Oncogene Proteins B-raf</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines proto-oncogènes B-raf</term><term>Tumeurs colorectales</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Tumeurs colorectales</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term><term>Camptothecin</term><term>Fluorouracil</term><term>Leucovorin</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs colorectales</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Camptothécine</term><term>Fluorouracil</term><term>Leucovorine</term><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>DNA Mutational Analysis</term><term>Exons</term><term>Female</term><term>Genes, ras</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Neoplasm Metastasis</term><term>Proportional Hazards Models</term><term>Retreatment</term><term>Survival Analysis</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de mutations d'ADN</term><term>Analyse de survie</term><term>Exons</term><term>Femelle</term><term>Gènes ras</term><term>Humains</term><term>Modèles de hasards proportionnels</term><term>Mutation</term><term>Mâle</term><term>Métastase tumorale</term><term>Reprise du traitement</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We evaluated the influence of RAS mutation status on the treatment effect of panitumumab in a prospective-retrospective analysis of a randomized, multicenter phase III study of panitumumab plus fluorouracil, leucovorin, and irinotecan (FOLFIRI) versus FOLFIRI alone as second-line therapy in patients with metastatic colorectal cancer (mCRC; ClinicalTrials.gov, NCT0039183).</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Roumanie</li><li>Royaume-Uni</li><li>Russie</li><li>Suisse</li><li>Ukraine</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>District de Leipzig</li><li>Grand Manchester</li><li>Hollande-Septentrionale</li><li>Saxe (Land)</li><li>Tennessee</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Leipzig</li><li>Manchester</li><li>Paris</li></settlement></list><tree><country name="Belgique"><noRegion><name sortKey="Peeters, Marc" sort="Peeters, Marc" uniqKey="Peeters M" first="Marc" last="Peeters">Marc Peeters</name></noRegion><name sortKey="Van Cutsem, Eric" sort="Van Cutsem, Eric" uniqKey="Van Cutsem E" first="Eric" last="Van Cutsem">Eric Van Cutsem</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Oliner, Kelly S" sort="Oliner, Kelly S" uniqKey="Oliner K" first="Kelly S" last="Oliner">Kelly S. Oliner</name></region><name sortKey="Chan, Emily" sort="Chan, Emily" uniqKey="Chan E" first="Emily" last="Chan">Emily Chan</name><name sortKey="He, Pei" sort="He, Pei" uniqKey="He P" first="Pei" last="He">Pei He</name><name sortKey="Jung, Andre S" sort="Jung, Andre S" uniqKey="Jung A" first="Andre S" last="Jung">Andre S. Jung</name><name sortKey="Patterson, Scott D" sort="Patterson, Scott D" uniqKey="Patterson S" first="Scott D" last="Patterson">Scott D. Patterson</name><name sortKey="Sidhu, Roger" sort="Sidhu, Roger" uniqKey="Sidhu R" first="Roger" last="Sidhu">Roger Sidhu</name><name sortKey="Yu, Hua" sort="Yu, Hua" uniqKey="Yu H" first="Hua" last="Yu">Hua Yu</name></country><country name="Australie"><noRegion><name sortKey="Price, Timothy J" sort="Price, Timothy J" uniqKey="Price T" first="Timothy J" last="Price">Timothy J. Price</name></noRegion><name sortKey="Strickland, Andrew H" sort="Strickland, Andrew H" uniqKey="Strickland A" first="Andrew H" last="Strickland">Andrew H. Strickland</name></country><country name="Espagne"><noRegion><name sortKey="Cervantes, Andres" sort="Cervantes, Andres" uniqKey="Cervantes A" first="Andrés" last="Cervantes">Andrés Cervantes</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Sobrero, Alberto F" sort="Sobrero, Alberto F" uniqKey="Sobrero A" first="Alberto F" last="Sobrero">Alberto F. Sobrero</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Ducreux, Michel" sort="Ducreux, Michel" uniqKey="Ducreux M" first="Michel" last="Ducreux">Michel Ducreux</name></region><name sortKey="Andre, Thierry" sort="Andre, Thierry" uniqKey="Andre T" first="Thierry" last="André">Thierry André</name></country><country name="Ukraine"><noRegion><name sortKey="Hotko, Yevhen" sort="Hotko, Yevhen" uniqKey="Hotko Y" first="Yevhen" last="Hotko">Yevhen Hotko</name></noRegion></country><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Lordick, Florian" sort="Lordick, Florian" uniqKey="Lordick F" first="Florian" last="Lordick">Florian Lordick</name></region></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Punt, Cornelis J A" sort="Punt, Cornelis J A" uniqKey="Punt C" first="Cornelis J A" last="Punt">Cornelis J A. Punt</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Wilson, Gregory" sort="Wilson, Gregory" uniqKey="Wilson G" first="Gregory" last="Wilson">Gregory Wilson</name></region></country><country name="Roumanie"><noRegion><name sortKey="Ciuleanu, Tudor E" sort="Ciuleanu, Tudor E" uniqKey="Ciuleanu T" first="Tudor E" last="Ciuleanu">Tudor E. Ciuleanu</name></noRegion></country><country name="Russie"><noRegion><name sortKey="Roman, Laslo" sort="Roman, Laslo" uniqKey="Roman L" first="Laslo" last="Roman">Laslo Roman</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Koukakis, Reija" sort="Koukakis, Reija" uniqKey="Koukakis R" first="Reija" last="Koukakis">Reija Koukakis</name></noRegion><name sortKey="Terwey, Jan Henrik" sort="Terwey, Jan Henrik" uniqKey="Terwey J" first="Jan-Henrik" last="Terwey">Jan-Henrik Terwey</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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