Improved synthesis of [(18)F]FLETT via a fully automated vacuum distillation method for [(18)F]2-fluoroethyl azide purification.
Identifieur interne : 001D09 ( Ncbi/Checkpoint ); précédent : 001D08; suivant : 001D10Improved synthesis of [(18)F]FLETT via a fully automated vacuum distillation method for [(18)F]2-fluoroethyl azide purification.
Auteurs : Uwe Ackermann [Australie] ; Lucie Plougastel [France] ; Yit Wooi Goh [Australie] ; Shinn Dee Yeoh [Australie] ; Andrew M. Scott [Australie]Source :
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [ 1872-9800 ] ; 2014.
Descripteurs français
- KwdFr :
- Analyse de panne d'appareillage, Azotures (isolement et purification), Azotures (synthèse chimique), Conception d'appareillage, Distillation (), Distillation (instrumentation), Marquage isotopique (), Marquage isotopique (instrumentation), Radio-isotopes du fluor (), Radio-isotopes du fluor (isolement et purification), Radiopharmaceutiques (isolement et purification), Radiopharmaceutiques (synthèse chimique), Robotique (), Robotique (instrumentation), Vide.
- MESH :
- isolement et purification : Azotures, Distillation, Marquage isotopique, Radio-isotopes du fluor, Radiopharmaceutiques, Robotique.
- synthèse chimique : Azotures, Radiopharmaceutiques.
- Analyse de panne d'appareillage, Conception d'appareillage, Distillation, Marquage isotopique, Radio-isotopes du fluor, Robotique, Vide.
English descriptors
- KwdEn :
- Azides (chemical synthesis), Azides (isolation & purification), Distillation (instrumentation), Distillation (methods), Equipment Design, Equipment Failure Analysis, Fluorine Radioisotopes (chemistry), Fluorine Radioisotopes (isolation & purification), Isotope Labeling (instrumentation), Isotope Labeling (methods), Radiopharmaceuticals (chemical synthesis), Radiopharmaceuticals (isolation & purification), Robotics (instrumentation), Robotics (methods), Vacuum.
- MESH :
- chemical , chemical synthesis : Azides, Radiopharmaceuticals.
- chemical , chemistry : Fluorine Radioisotopes.
- chemical , isolation & purification : Azides, Fluorine Radioisotopes, Radiopharmaceuticals.
- instrumentation : Distillation, Isotope Labeling, Robotics.
- methods : Distillation, Isotope Labeling, Robotics.
- Equipment Design, Equipment Failure Analysis, Vacuum.
Abstract
The synthesis of [(18)F]2-fluoroethyl azide and its subsequent click reaction with 5-ethynyl-2'-deoxyuridine (EDU) to form [(18)F]FLETT was performed using an iPhase FlexLab module. The implementation of a vacuum distillation method afforded [(18)F]2-fluoroethyl azide in 87±5.3% radiochemical yield. The use of Cu(CH3CN)4PF6 and TBTA as catalyst enabled us to fully automate the [(18)F]FLETT synthesis without the need for the operator to enter the radiation field. [(18)F]FLETT was produced in higher overall yield (41.3±6.5%) and shorter synthesis time (67min) than with our previously reported manual method (32.5±2.5% in 130min).
DOI: 10.1016/j.apradiso.2014.07.009
PubMed: 25113535
Affiliations:
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pubmed:25113535Le document en format XML
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<term>Distillation (methods)</term>
<term>Equipment Design</term>
<term>Equipment Failure Analysis</term>
<term>Fluorine Radioisotopes (chemistry)</term>
<term>Fluorine Radioisotopes (isolation & purification)</term>
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<term>Robotics (methods)</term>
<term>Vacuum</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de panne d'appareillage</term>
<term>Azotures (isolement et purification)</term>
<term>Azotures (synthèse chimique)</term>
<term>Conception d'appareillage</term>
<term>Distillation ()</term>
<term>Distillation (instrumentation)</term>
<term>Marquage isotopique ()</term>
<term>Marquage isotopique (instrumentation)</term>
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<front><div type="abstract" xml:lang="en">The synthesis of [(18)F]2-fluoroethyl azide and its subsequent click reaction with 5-ethynyl-2'-deoxyuridine (EDU) to form [(18)F]FLETT was performed using an iPhase FlexLab module. The implementation of a vacuum distillation method afforded [(18)F]2-fluoroethyl azide in 87±5.3% radiochemical yield. The use of Cu(CH3CN)4PF6 and TBTA as catalyst enabled us to fully automate the [(18)F]FLETT synthesis without the need for the operator to enter the radiation field. [(18)F]FLETT was produced in higher overall yield (41.3±6.5%) and shorter synthesis time (67min) than with our previously reported manual method (32.5±2.5% in 130min).</div>
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<tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Ackermann, Uwe" sort="Ackermann, Uwe" uniqKey="Ackermann U" first="Uwe" last="Ackermann">Uwe Ackermann</name>
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<country name="France"><region name="Région Bretagne"><name sortKey="Plougastel, Lucie" sort="Plougastel, Lucie" uniqKey="Plougastel L" first="Lucie" last="Plougastel">Lucie Plougastel</name>
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