Alpha-synuclein REP1 variants and survival in Parkinson’s disease
Identifieur interne : 001820 ( Ncbi/Checkpoint ); précédent : 001819; suivant : 001821Alpha-synuclein REP1 variants and survival in Parkinson’s disease
Auteurs : Sun Ju Chung [Corée du Sud] ; Joanna M. Biernacka [États-Unis] ; Sebastian M. Armasu [États-Unis] ; Kari Anderson [États-Unis] ; Roberta Frigerio [États-Unis] ; Jan O. Aasly [Norvège] ; Grazia Annesi [Italie] ; Anna Rita Bentivoglio [Italie] ; Laura Brighina [Italie] ; Marie-Christine Chartier-Harlin [France] ; Stefano Goldwurm [Italie] ; Georgios Hadjigeorgiou [Grèce] ; Barbara Jasinska-Myga [Pologne, États-Unis] ; Beom Seok Jeon [Corée du Sud] ; Yun Joong Kim [Corée du Sud] ; Rejko Krüger [Allemagne] ; Suzanne Lesage [France] ; Katerina Markopoulou [États-Unis] ; George Mellick [Australie] ; Karen E. Morrison [Royaume-Uni] ; Andreas Puschmann [Suède] ; Eng-King Tan [Singapour] ; Jessie Theuns [Belgique] ; Karin Wirdefeldt [Suède] ; Zbigniew K. Wszolek [États-Unis] ; Alexis Elbaz [France] ; Demetrius M. Maraganore [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
Abstract
To determine if alpha-synuclein REP1 genotypes are associated with survival in Parkinson’s disease.
Investigators from the Genetic Epidemiology of Parkinson’s Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.
Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in Parkinson’s disease. However, there was a significant association between REP1 genotypes and age at onset of PD (Hazard Ratio = 1.06, 95% Confidence Interval = 1.01–1.10,
In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in Parkinson’s disease. Further studies of α–synuclein’s role in disease progression and long-term outcomes are needed.
Url:
DOI: 10.1002/mds.25841
PubMed: 24578302
PubMed Central: 4172351
Affiliations:
- Allemagne, Australie, Belgique, Corée du Sud, France, Grèce, Italie, Norvège, Pologne, Royaume-Uni, Singapour, Suède, États-Unis
- Angleterre, Bade-Wurtemberg, District de Tübingen, Floride, Hauts-de-France, Illinois, Latium, Lombardie, Midlands de l'Ouest, Minnesota, Nord-Pas-de-Calais, Province d'Anvers, Région capitale de Séoul, Région flamande, Svealand, Trøndelag, Île-de-France
- Anvers, Birmingham, Lille, Milan, Paris, Rome, Stockholm, Séoul, Trondheim, Tübingen, Villejuif
- Université d'Anvers, Université de Birmingham
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<affiliation wicri:level="4"><nlm:aff id="A24">Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea>
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<author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
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<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
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<affiliation wicri:level="3"><nlm:aff id="A28">Univ Versailles St-Quentin, UMRS 1018, F-94807, Villejuif, France</nlm:aff>
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<affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, NorthShore University HealthSystem, Evanston, IL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
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<wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Alpha-synuclein REP1 variants and survival in Parkinson’s disease</title>
<author><name sortKey="Chung, Sun Ju" sort="Chung, Sun Ju" uniqKey="Chung S" first="Sun Ju" last="Chung">Sun Ju Chung</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea>
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<region type="capital">Région capitale de Séoul</region>
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<author><name sortKey="Biernacka, Joanna M" sort="Biernacka, Joanna M" uniqKey="Biernacka J" first="Joanna M." last="Biernacka">Joanna M. Biernacka</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Health Sciences Research, Mayo Clinic, Rochester, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Rochester</wicri:cityArea>
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<author><name sortKey="Armasu, Sebastian M" sort="Armasu, Sebastian M" uniqKey="Armasu S" first="Sebastian M." last="Armasu">Sebastian M. Armasu</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Anderson, Kari" sort="Anderson, Kari" uniqKey="Anderson K" first="Kari" last="Anderson">Kari Anderson</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
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<wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Rochester</wicri:cityArea>
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<author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
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</author>
<author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name>
<affiliation wicri:level="3"><nlm:aff id="A4">St. Olav’s Hospital, Department of Neurology, Trondheim, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>St. Olav’s Hospital, Department of Neurology, Trondheim</wicri:regionArea>
<placeName><settlement type="city">Trondheim</settlement>
<region type="région" nuts="2">Trøndelag</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Neurological Sciences, National Research Council, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurological Sciences, National Research Council</wicri:regionArea>
<wicri:noRegion>National Research Council</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Neurology, Catholic University, Rome, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, Catholic University, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Neurology, San Gerardo Hospital, Monza, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, San Gerardo Hospital, Monza</wicri:regionArea>
<wicri:noRegion>Monza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name>
<affiliation wicri:level="3"><nlm:aff id="A8">Inserm UMR837, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm UMR837, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation><nlm:aff id="A9">Univ Lille Nord de France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name>
<affiliation wicri:level="3"><nlm:aff id="A10">Parkinson Institute, IstitutiClinici di Perfezionamento, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Parkinson Institute, IstitutiClinici di Perfezionamento, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hadjigeorgiou, Georgios" sort="Hadjigeorgiou, Georgios" uniqKey="Hadjigeorgiou G" first="Georgios" last="Hadjigeorgiou">Georgios Hadjigeorgiou</name>
<affiliation wicri:level="1"><nlm:aff id="A11">Faculty of Medicine, University of Thessalia, Larissa, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Faculty of Medicine, University of Thessalia, Larissa</wicri:regionArea>
<wicri:noRegion>Larissa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A13">Department of Neurology, Mayo Clinic, Jacksonville, FL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jeon, Beom Seok" sort="Jeon, Beom Seok" uniqKey="Jeon B" first="Beom Seok" last="Jeon">Beom Seok Jeon</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Seoul National University Hospital, Seoul, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Seoul National University Hospital, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kim, Yun Joong" sort="Kim, Yun Joong" uniqKey="Kim Y" first="Yun Joong" last="Kim">Yun Joong Kim</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Neurology, Hallym University, Seoul, Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Hallym University, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name>
<affiliation wicri:level="3"><nlm:aff id="A16">Center of Neurology and Hertie-Institute for Clinical Brain Research, Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center of Neurology and Hertie-Institute for Clinical Brain Research, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
<affiliation wicri:level="3"><nlm:aff id="A17">Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelleépinière, UMR-S975; Inserm, U975, Cnrs, UMR 7225, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelleépinière, UMR-S975; Inserm, U975, Cnrs, UMR 7225, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Markopoulou, Katerina" sort="Markopoulou, Katerina" uniqKey="Markopoulou K" first="Katerina" last="Markopoulou">Katerina Markopoulou</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, NorthShore University HealthSystem, Evanston, IL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mellick, George" sort="Mellick, George" uniqKey="Mellick G" first="George" last="Mellick">George Mellick</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD</wicri:regionArea>
<wicri:noRegion>QLD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E." last="Morrison">Karen E. Morrison</name>
<affiliation wicri:level="4"><nlm:aff id="A20">School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham UK</nlm:aff>
<orgName type="university">Université de Birmingham</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Section of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Section of Neurology, Department of Clinical Sciences, Lund University, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore General Hospital, National Neuroscience Institute, Singapore</wicri:regionArea>
<wicri:noRegion>Singapore</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name>
<affiliation wicri:level="1"><nlm:aff id="A23">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea>
<wicri:noRegion>Antwerp</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A24">Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName><settlement type="city">Anvers</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name>
<affiliation wicri:level="3"><nlm:aff id="A25">Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Department of Neurology, Mayo Clinic, Jacksonville, FL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<affiliation wicri:level="3"><nlm:aff id="A27">Inserm, Centre for Research in Epidemiology and Population Health, U1018, Social and occupational determinants of health, F-94807, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm, Centre for Research in Epidemiology and Population Health, U1018, Social and occupational determinants of health, F-94807, Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A28">Univ Versailles St-Quentin, UMRS 1018, F-94807, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ Versailles St-Quentin, UMRS 1018, F-94807, Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, NorthShore University HealthSystem, Evanston, IL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title>
<p id="P1">To determine if alpha-synuclein REP1 genotypes are associated with survival in Parkinson’s disease.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Investigators from the Genetic Epidemiology of Parkinson’s Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in Parkinson’s disease. However, there was a significant association between REP1 genotypes and age at onset of PD (Hazard Ratio = 1.06, 95% Confidence Interval = 1.01–1.10, <italic>p</italic>
value = 0.01).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in Parkinson’s disease. Further studies of α–synuclein’s role in disease progression and long-term outcomes are needed.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Belgique</li>
<li>Corée du Sud</li>
<li>France</li>
<li>Grèce</li>
<li>Italie</li>
<li>Norvège</li>
<li>Pologne</li>
<li>Royaume-Uni</li>
<li>Singapour</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Bade-Wurtemberg</li>
<li>District de Tübingen</li>
<li>Floride</li>
<li>Hauts-de-France</li>
<li>Illinois</li>
<li>Latium</li>
<li>Lombardie</li>
<li>Midlands de l'Ouest</li>
<li>Minnesota</li>
<li>Nord-Pas-de-Calais</li>
<li>Province d'Anvers</li>
<li>Région capitale de Séoul</li>
<li>Région flamande</li>
<li>Svealand</li>
<li>Trøndelag</li>
<li>Île-de-France</li>
</region>
<settlement><li>Anvers</li>
<li>Birmingham</li>
<li>Lille</li>
<li>Milan</li>
<li>Paris</li>
<li>Rome</li>
<li>Stockholm</li>
<li>Séoul</li>
<li>Trondheim</li>
<li>Tübingen</li>
<li>Villejuif</li>
</settlement>
<orgName><li>Université d'Anvers</li>
<li>Université de Birmingham</li>
</orgName>
</list>
<tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Chung, Sun Ju" sort="Chung, Sun Ju" uniqKey="Chung S" first="Sun Ju" last="Chung">Sun Ju Chung</name>
</region>
<name sortKey="Jeon, Beom Seok" sort="Jeon, Beom Seok" uniqKey="Jeon B" first="Beom Seok" last="Jeon">Beom Seok Jeon</name>
<name sortKey="Kim, Yun Joong" sort="Kim, Yun Joong" uniqKey="Kim Y" first="Yun Joong" last="Kim">Yun Joong Kim</name>
</country>
<country name="États-Unis"><region name="Minnesota"><name sortKey="Biernacka, Joanna M" sort="Biernacka, Joanna M" uniqKey="Biernacka J" first="Joanna M." last="Biernacka">Joanna M. Biernacka</name>
</region>
<name sortKey="Anderson, Kari" sort="Anderson, Kari" uniqKey="Anderson K" first="Kari" last="Anderson">Kari Anderson</name>
<name sortKey="Armasu, Sebastian M" sort="Armasu, Sebastian M" uniqKey="Armasu S" first="Sebastian M." last="Armasu">Sebastian M. Armasu</name>
<name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
<name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name>
<name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name>
<name sortKey="Markopoulou, Katerina" sort="Markopoulou, Katerina" uniqKey="Markopoulou K" first="Katerina" last="Markopoulou">Katerina Markopoulou</name>
<name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
</country>
<country name="Norvège"><region name="Trøndelag"><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name>
</region>
</country>
<country name="Italie"><noRegion><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name>
</noRegion>
<name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
<name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name>
<name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name>
</country>
<country name="France"><region name="Hauts-de-France"><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name>
</region>
<name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
</country>
<country name="Grèce"><noRegion><name sortKey="Hadjigeorgiou, Georgios" sort="Hadjigeorgiou, Georgios" uniqKey="Hadjigeorgiou G" first="Georgios" last="Hadjigeorgiou">Georgios Hadjigeorgiou</name>
</noRegion>
</country>
<country name="Pologne"><noRegion><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name>
</noRegion>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name>
</region>
</country>
<country name="Australie"><noRegion><name sortKey="Mellick, George" sort="Mellick, George" uniqKey="Mellick G" first="George" last="Mellick">George Mellick</name>
</noRegion>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E." last="Morrison">Karen E. Morrison</name>
</region>
</country>
<country name="Suède"><noRegion><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name>
</noRegion>
<name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name>
</country>
<country name="Singapour"><noRegion><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name>
</noRegion>
</country>
<country name="Belgique"><noRegion><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name>
</noRegion>
<name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name>
</country>
</tree>
</affiliations>
</record>
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