Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically
Identifieur interne : 001796 ( Ncbi/Checkpoint ); précédent : 001795; suivant : 001797Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically
Auteurs : Emily S. Sena [Royaume-Uni, Australie] ; Gillian L. Currie [Royaume-Uni] ; Sarah K. Mccann [Australie] ; Malcolm R. Macleod [Royaume-Uni] ; David W. Howells [Australie]Source :
- Journal of Cerebral Blood Flow & Metabolism [ 0271-678X ] ; 2014.
Abstract
The use of systematic review and meta-analysis of preclinical studies has become more common, including those of studies describing the modeling of cerebrovascular diseases. Empirical evidence suggests that too many preclinical experiments lack methodological rigor, and this leads to inflated treatment effects. The aim of this review is to describe the concepts of systematic review and meta-analysis and consider how these tools may be used to provide empirical evidence to spur the field to improve the rigor of the conduct and reporting of preclinical research akin to their use in improving the conduct and reporting of randomized controlled trials in clinical research. As with other research domains, systematic reviews are subject to bias. Therefore, we have also suggested guidance for their conduct, reporting, and critical appraisal.
Url:
DOI: 10.1038/jcbfm.2014.28
PubMed: 24549183
PubMed Central: 4013765
Affiliations:
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Sena</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Clinical Neurosciences, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Stroke Division, Florey Institute of Neuroscience and Mental Health</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Currie, Gillian L" sort="Currie, Gillian L" uniqKey="Currie G" first="Gillian L" last="Currie">Gillian L. Currie</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Clinical Neurosciences, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mccann, Sarah K" sort="Mccann, Sarah K" uniqKey="Mccann S" first="Sarah K" last="Mccann">Sarah K. Mccann</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Stroke Division, Florey Institute of Neuroscience and Mental Health</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Macleod, Malcolm R" sort="Macleod, Malcolm R" uniqKey="Macleod M" first="Malcolm R" last="Macleod">Malcolm R. Macleod</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Clinical Neurosciences, University of Edinburgh</institution>, Edinburgh,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Howells, David W" sort="Howells, David W" uniqKey="Howells D" first="David W" last="Howells">David W. Howells</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Stroke Division, Florey Institute of Neuroscience and Mental Health</institution>, Melbourne, Victoria,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Cerebral Blood Flow & Metabolism</title><idno type="ISSN">0271-678X</idno><idno type="eISSN">1559-7016</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The use of systematic review and meta-analysis of preclinical studies has become more common, including those of studies describing the modeling of cerebrovascular diseases. Empirical evidence suggests that too many preclinical experiments lack methodological rigor, and this leads to inflated treatment effects. The aim of this review is to describe the concepts of systematic review and meta-analysis and consider how these tools may be used to provide empirical evidence to spur the field to improve the rigor of the conduct and reporting of preclinical research akin to their use in improving the conduct and reporting of randomized controlled trials in clinical research. As with other research domains, systematic reviews are subject to bias. 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Sena</name></noRegion><name sortKey="Currie, Gillian L" sort="Currie, Gillian L" uniqKey="Currie G" first="Gillian L" last="Currie">Gillian L. Currie</name><name sortKey="Macleod, Malcolm R" sort="Macleod, Malcolm R" uniqKey="Macleod M" first="Malcolm R" last="Macleod">Malcolm R. Macleod</name></country><country name="Australie"><noRegion><name sortKey="Sena, Emily S" sort="Sena, Emily S" uniqKey="Sena E" first="Emily S" last="Sena">Emily S. Sena</name></noRegion><name sortKey="Howells, David W" sort="Howells, David W" uniqKey="Howells D" first="David W" last="Howells">David W. Howells</name><name sortKey="Mccann, Sarah K" sort="Mccann, Sarah K" uniqKey="Mccann S" first="Sarah K" last="Mccann">Sarah K. Mccann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |