Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study12345
Identifieur interne : 001305 ( Ncbi/Checkpoint ); précédent : 001304; suivant : 001306Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study12345
Auteurs : Ho-Sun Lee ; Albino Barraza-Villarreal ; Hector Hernandez-Vargas ; Peter D. Sly ; Carine Biessy ; Usha Ramakrishnan ; Isabelle Romieu ; Zdenko HercegSource :
- The American Journal of Clinical Nutrition [ 0002-9165 ] ; 2013.
Abstract
Url:
DOI: 10.3945/ajcn.112.052241
PubMed: 23761484
PubMed Central: 3712555
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>3</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>4</sup></xref><xref ref-type="corresp" rid="cor1"><sup>5</sup></xref></title><author><name sortKey="Lee, Ho Sun" sort="Lee, Ho Sun" uniqKey="Lee H" first="Ho-Sun" last="Lee">Ho-Sun Lee</name></author><author><name sortKey="Barraza Villarreal, Albino" sort="Barraza Villarreal, Albino" uniqKey="Barraza Villarreal A" first="Albino" last="Barraza-Villarreal">Albino Barraza-Villarreal</name></author><author><name sortKey="Hernandez Vargas, Hector" sort="Hernandez Vargas, Hector" uniqKey="Hernandez Vargas H" first="Hector" last="Hernandez-Vargas">Hector Hernandez-Vargas</name></author><author><name sortKey="Sly, Peter D" sort="Sly, Peter D" uniqKey="Sly P" first="Peter D" last="Sly">Peter D. Sly</name></author><author><name sortKey="Biessy, Carine" sort="Biessy, Carine" uniqKey="Biessy C" first="Carine" last="Biessy">Carine Biessy</name></author><author><name sortKey="Ramakrishnan, Usha" sort="Ramakrishnan, Usha" uniqKey="Ramakrishnan U" first="Usha" last="Ramakrishnan">Usha Ramakrishnan</name></author><author><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name></author><author><name sortKey="Herceg, Zdenko" sort="Herceg, Zdenko" uniqKey="Herceg Z" first="Zdenko" last="Herceg">Zdenko Herceg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23761484</idno><idno type="pmc">3712555</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712555</idno><idno type="RBID">PMC:3712555</idno><idno type="doi">10.3945/ajcn.112.052241</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001675</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001675</idno><idno type="wicri:Area/Pmc/Curation">001535</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001535</idno><idno type="wicri:Area/Pmc/Checkpoint">001A08</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001A08</idno><idno type="wicri:Area/Ncbi/Merge">001305</idno><idno type="wicri:Area/Ncbi/Curation">001305</idno><idno type="wicri:Area/Ncbi/Checkpoint">001305</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>3</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>4</sup></xref><xref ref-type="corresp" rid="cor1"><sup>5</sup></xref></title><author><name sortKey="Lee, Ho Sun" sort="Lee, Ho Sun" uniqKey="Lee H" first="Ho-Sun" last="Lee">Ho-Sun Lee</name></author><author><name sortKey="Barraza Villarreal, Albino" sort="Barraza Villarreal, Albino" uniqKey="Barraza Villarreal A" first="Albino" last="Barraza-Villarreal">Albino Barraza-Villarreal</name></author><author><name sortKey="Hernandez Vargas, Hector" sort="Hernandez Vargas, Hector" uniqKey="Hernandez Vargas H" first="Hector" last="Hernandez-Vargas">Hector Hernandez-Vargas</name></author><author><name sortKey="Sly, Peter D" sort="Sly, Peter D" uniqKey="Sly P" first="Peter D" last="Sly">Peter D. Sly</name></author><author><name sortKey="Biessy, Carine" sort="Biessy, Carine" uniqKey="Biessy C" first="Carine" last="Biessy">Carine Biessy</name></author><author><name sortKey="Ramakrishnan, Usha" sort="Ramakrishnan, Usha" uniqKey="Ramakrishnan U" first="Usha" last="Ramakrishnan">Usha Ramakrishnan</name></author><author><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name></author><author><name sortKey="Herceg, Zdenko" sort="Herceg, Zdenko" uniqKey="Herceg Z" first="Zdenko" last="Herceg">Zdenko Herceg</name></author></analytic><series><title level="j">The American Journal of Clinical Nutrition</title><idno type="ISSN">0002-9165</idno><idno type="eISSN">1938-3207</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Early-life exposures to tobacco smoke and some dietary factors have been identified to induce epigenetic changes in genes involved in allergy and asthma development. Omega-3 (n−3) polyunsaturated fatty acid (PUFA) intake during pregnancy could modulate key cytokines and T helper (Th) cell maturation; however, little is known about the mechanism by which ω-3 PUFA could have a beneficial effect in preventing inflammatory disorders.</p><p><bold>Objective:</bold> We sought to test whether prenatal dietary supplementation with ω-3 PUFA during pregnancy may modulate epigenetic states in the infant immune system.</p><p><bold>Design:</bold> This study was based on a randomized intervention trial conducted in Mexican pregnant women supplemented daily with 400 mg docosahexaenoic acid (DHA) or a placebo from 18 to 22 wk of gestation to parturition. We applied quantitative profiling of DNA methylation states in Th1, Th2, Th17, and regulatory T–relevant genes as well as <italic>LINE1</italic> repetitive elements of cord blood mononuclear cells (<italic>n</italic> = 261).</p><p><bold>Results:</bold> No significant difference in promoter methylation levels was shown between ω-3 PUFA–supplemented and control groups for the genes analyzed; however, ω-3 PUFA supplementation was associated with changes in methylation levels in <italic>LINE1</italic> repetitive elements (<italic>P</italic> = 0.03) in infants of mothers who smoked during pregnancy. Furthermore, an association between the promoter methylation levels of <italic>IFNγ</italic> and <italic>IL13</italic> was modulated by ω-3 PUFA supplementation (<italic>P</italic> = 0.06).</p><p><bold>Conclusions:</bold> Our results indicate that maternal supplementation with ω-3 PUFA during pregnancy may modulate global methylation levels and the Th1/Th2 balance in infants. Therefore, the epigenetic mechanisms could provide attractive targets for prenatal modulation and prevention of inflammatory disorders and potentially other related diseases in childhood and adulthood.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Barraza Villarreal, Albino" sort="Barraza Villarreal, Albino" uniqKey="Barraza Villarreal A" first="Albino" last="Barraza-Villarreal">Albino Barraza-Villarreal</name><name sortKey="Biessy, Carine" sort="Biessy, Carine" uniqKey="Biessy C" first="Carine" last="Biessy">Carine Biessy</name><name sortKey="Herceg, Zdenko" sort="Herceg, Zdenko" uniqKey="Herceg Z" first="Zdenko" last="Herceg">Zdenko Herceg</name><name sortKey="Hernandez Vargas, Hector" sort="Hernandez Vargas, Hector" uniqKey="Hernandez Vargas H" first="Hector" last="Hernandez-Vargas">Hector Hernandez-Vargas</name><name sortKey="Lee, Ho Sun" sort="Lee, Ho Sun" uniqKey="Lee H" first="Ho-Sun" last="Lee">Ho-Sun Lee</name><name sortKey="Ramakrishnan, Usha" sort="Ramakrishnan, Usha" uniqKey="Ramakrishnan U" first="Usha" last="Ramakrishnan">Usha Ramakrishnan</name><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name><name sortKey="Sly, Peter D" sort="Sly, Peter D" uniqKey="Sly P" first="Peter D" last="Sly">Peter D. 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