Hyperfractionated or Accelerated Radiotherapy in Lung Cancer: An Individual Patient Data Meta-Analysis
Identifieur interne : 000E81 ( Ncbi/Checkpoint ); précédent : 000E80; suivant : 000E82Hyperfractionated or Accelerated Radiotherapy in Lung Cancer: An Individual Patient Data Meta-Analysis
Auteurs : Audrey Mauguen [Pays-Bas] ; Cécile Le Péchoux [Pays-Bas] ; Michele I. Saunders [Pays-Bas] ; Steven E. Schild [Pays-Bas] ; Andrew T. Turrisi [Pays-Bas] ; Michael Baumann [Pays-Bas] ; William T. Sause [Pays-Bas] ; David Ball [Pays-Bas] ; Chandra P. Belani [Pays-Bas] ; James A. Bonner [Pays-Bas] ; Aleksander Zajusz [Pays-Bas] ; Suzanne E. Dahlberg [Pays-Bas] ; Matthew Nankivell [Pays-Bas] ; Sumithra J. Mandrekar [Pays-Bas] ; Rebecca Paulus [Pays-Bas] ; Katarzyna Behrendt [Pays-Bas] ; Rainer Koch [Pays-Bas] ; James F. Bishop [Pays-Bas] ; Stanley Dische [Pays-Bas] ; Rodrigo Arriagada [Pays-Bas] ; Dirk De Ruysscher [Pays-Bas] ; Jean-Pierre Pignon [Pays-Bas]Source :
- Journal of Clinical Oncology [ 0732-183X ] ; 2012.
Abstract
In lung cancer, randomized trials assessing hyperfractionated or accelerated radiotherapy seem to yield conflicting results regarding the effects on overall (OS) or progression-free survival (PFS). The Meta-Analysis of Radiotherapy in Lung Cancer Collaborative Group decided to address the role of modified radiotherapy fractionation.
We performed an individual patient data meta-analysis in patients with nonmetastatic lung cancer, which included trials comparing modified radiotherapy with conventional radiotherapy.
In non–small-cell lung cancer (NSCLC; 10 trials, 2,000 patients), modified fractionation improved OS as compared with conventional schedules (hazard ratio [HR] = 0.88, 95% CI, 0.80 to 0.97;
Patients with nonmetastatic NSCLC derived a significant OS benefit from accelerated or hyperfractionated radiotherapy; a similar but nonsignificant trend was observed for SCLC. As expected, there was increased acute esophageal toxicity.
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DOI: 10.1200/JCO.2012.41.6677
PubMed: 22753901
PubMed Central: 4934452
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hyperfractionated or Accelerated Radiotherapy in Lung Cancer: An Individual Patient Data Meta-Analysis</title><author><name sortKey="Mauguen, Audrey" sort="Mauguen, Audrey" uniqKey="Mauguen A" first="Audrey" last="Mauguen">Audrey Mauguen</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Le Pechoux, Cecile" sort="Le Pechoux, Cecile" uniqKey="Le Pechoux C" first="Cécile" last="Le Péchoux">Cécile Le Péchoux</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Saunders, Michele I" sort="Saunders, Michele I" uniqKey="Saunders M" first="Michele I." last="Saunders">Michele I. Saunders</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Schild, Steven E" sort="Schild, Steven E" uniqKey="Schild S" first="Steven E." last="Schild">Steven E. Schild</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Turrisi, Andrew T" sort="Turrisi, Andrew T" uniqKey="Turrisi A" first="Andrew T." last="Turrisi">Andrew T. Turrisi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Baumann, Michael" sort="Baumann, Michael" uniqKey="Baumann M" first="Michael" last="Baumann">Michael Baumann</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Sause, William T" sort="Sause, William T" uniqKey="Sause W" first="William T." last="Sause">William T. Sause</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Ball, David" sort="Ball, David" uniqKey="Ball D" first="David" last="Ball">David Ball</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Belani, Chandra P" sort="Belani, Chandra P" uniqKey="Belani C" first="Chandra P." last="Belani">Chandra P. Belani</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Bonner, James A" sort="Bonner, James A" uniqKey="Bonner J" first="James A." last="Bonner">James A. Bonner</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Zajusz, Aleksander" sort="Zajusz, Aleksander" uniqKey="Zajusz A" first="Aleksander" last="Zajusz">Aleksander Zajusz</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Dahlberg, Suzanne E" sort="Dahlberg, Suzanne E" uniqKey="Dahlberg S" first="Suzanne E." last="Dahlberg">Suzanne E. Dahlberg</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Nankivell, Matthew" sort="Nankivell, Matthew" uniqKey="Nankivell M" first="Matthew" last="Nankivell">Matthew Nankivell</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Mandrekar, Sumithra J" sort="Mandrekar, Sumithra J" uniqKey="Mandrekar S" first="Sumithra J." last="Mandrekar">Sumithra J. Mandrekar</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Paulus, Rebecca" sort="Paulus, Rebecca" uniqKey="Paulus R" first="Rebecca" last="Paulus">Rebecca Paulus</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Behrendt, Katarzyna" sort="Behrendt, Katarzyna" uniqKey="Behrendt K" first="Katarzyna" last="Behrendt">Katarzyna Behrendt</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Koch, Rainer" sort="Koch, Rainer" uniqKey="Koch R" first="Rainer" last="Koch">Rainer Koch</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Bishop, James F" sort="Bishop, James F" uniqKey="Bishop J" first="James F." last="Bishop">James F. Bishop</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Dische, Stanley" sort="Dische, Stanley" uniqKey="Dische S" first="Stanley" last="Dische">Stanley Dische</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Arriagada, Rodrigo" sort="Arriagada, Rodrigo" uniqKey="Arriagada R" first="Rodrigo" last="Arriagada">Rodrigo Arriagada</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="De Ruysscher, Dirk" sort="De Ruysscher, Dirk" uniqKey="De Ruysscher D" first="Dirk" last="De Ruysscher">Dirk De Ruysscher</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Pignon, Jean Pierre" sort="Pignon, Jean Pierre" uniqKey="Pignon J" first="Jean-Pierre" last="Pignon">Jean-Pierre Pignon</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22753901</idno><idno type="pmc">4934452</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934452</idno><idno type="RBID">PMC:4934452</idno><idno type="doi">10.1200/JCO.2012.41.6677</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000652</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000652</idno><idno type="wicri:Area/Pmc/Curation">000651</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000651</idno><idno type="wicri:Area/Pmc/Checkpoint">001F05</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001F05</idno><idno type="wicri:Area/Ncbi/Merge">000E81</idno><idno type="wicri:Area/Ncbi/Curation">000E81</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E81</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hyperfractionated or Accelerated Radiotherapy in Lung Cancer: An Individual Patient Data Meta-Analysis</title><author><name sortKey="Mauguen, Audrey" sort="Mauguen, Audrey" uniqKey="Mauguen A" first="Audrey" last="Mauguen">Audrey Mauguen</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Le Pechoux, Cecile" sort="Le Pechoux, Cecile" uniqKey="Le Pechoux C" first="Cécile" last="Le Péchoux">Cécile Le Péchoux</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Saunders, Michele I" sort="Saunders, Michele I" uniqKey="Saunders M" first="Michele I." last="Saunders">Michele I. Saunders</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Schild, Steven E" sort="Schild, Steven E" uniqKey="Schild S" first="Steven E." last="Schild">Steven E. Schild</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Turrisi, Andrew T" sort="Turrisi, Andrew T" uniqKey="Turrisi A" first="Andrew T." last="Turrisi">Andrew T. Turrisi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Baumann, Michael" sort="Baumann, Michael" uniqKey="Baumann M" first="Michael" last="Baumann">Michael Baumann</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Sause, William T" sort="Sause, William T" uniqKey="Sause W" first="William T." last="Sause">William T. Sause</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Ball, David" sort="Ball, David" uniqKey="Ball D" first="David" last="Ball">David Ball</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Belani, Chandra P" sort="Belani, Chandra P" uniqKey="Belani C" first="Chandra P." last="Belani">Chandra P. Belani</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Bonner, James A" sort="Bonner, James A" uniqKey="Bonner J" first="James A." last="Bonner">James A. Bonner</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Zajusz, Aleksander" sort="Zajusz, Aleksander" uniqKey="Zajusz A" first="Aleksander" last="Zajusz">Aleksander Zajusz</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Dahlberg, Suzanne E" sort="Dahlberg, Suzanne E" uniqKey="Dahlberg S" first="Suzanne E." last="Dahlberg">Suzanne E. Dahlberg</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Nankivell, Matthew" sort="Nankivell, Matthew" uniqKey="Nankivell M" first="Matthew" last="Nankivell">Matthew Nankivell</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Mandrekar, Sumithra J" sort="Mandrekar, Sumithra J" uniqKey="Mandrekar S" first="Sumithra J." last="Mandrekar">Sumithra J. Mandrekar</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Paulus, Rebecca" sort="Paulus, Rebecca" uniqKey="Paulus R" first="Rebecca" last="Paulus">Rebecca Paulus</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Behrendt, Katarzyna" sort="Behrendt, Katarzyna" uniqKey="Behrendt K" first="Katarzyna" last="Behrendt">Katarzyna Behrendt</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Koch, Rainer" sort="Koch, Rainer" uniqKey="Koch R" first="Rainer" last="Koch">Rainer Koch</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Bishop, James F" sort="Bishop, James F" uniqKey="Bishop J" first="James F." last="Bishop">James F. Bishop</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Dische, Stanley" sort="Dische, Stanley" uniqKey="Dische S" first="Stanley" last="Dische">Stanley Dische</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Arriagada, Rodrigo" sort="Arriagada, Rodrigo" uniqKey="Arriagada R" first="Rodrigo" last="Arriagada">Rodrigo Arriagada</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="De Ruysscher, Dirk" sort="De Ruysscher, Dirk" uniqKey="De Ruysscher D" first="Dirk" last="De Ruysscher">Dirk De Ruysscher</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Pignon, Jean Pierre" sort="Pignon, Jean Pierre" uniqKey="Pignon J" first="Jean-Pierre" last="Pignon">Jean-Pierre Pignon</name><affiliation wicri:level="1"><nlm:aff id="aff1">Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Audrey Mauguen, Cécile Le Péchoux, Rodrigo Arriagada, and Jean-Pierre Pignon, Institut de Cancérologie Gustave-Roussy, Villejuif, France; Michele I. Saunders and Stanley Dische, University College London and Marie Curie Research Wing, Mount Vernon Hospital, Northwood Middlesex; Matthew Nankivell, Medical Research Council Clinical Trials Unit, London, United Kingdom; Steven E. Schild, Mayo Clinic, Phoenix, AZ; Andrew T. Turrisi, Sinai Grace Hospital, Detroit, MI; Michael Baumann and Rainer Koch, University Hospital and Medical Faculty Carl Gustav Carus, Dresden, Germany; William T. Sause, Intermountain Medical Center, Murray, UT; David Ball, University of Melbourne, East Melbourne, Victoria; James F. Bishop, Victorian Comprehensive Cancer Centre, Melbourne, Australia; Chandra P. Belani, Penn State Milton S. Hershey Medical Center, Hershey; Rebecca Paulus, Radiation Therapy Oncology Group, Philadelphia, PA; James A. Bonner, University of Alabama–Birmingham, Birmingham, AL; Aleksander Zajusz and Katarzyna Behrendt, Maria Sklodowska–Curie Memorial Cancer Center, Gliwice Branch, Poland; Suzanne E. Dahlberg, Dana-Farber Cancer Institute, Boston, MA; Sumithra J. Mandrekar, Mayo Clinic and North Central Cancer Treatment Group, Rochester, MN; Rodrigo Arriagada, Karolinska Institutet, Stockholm, Sweden; and Dirk De Ruysscher, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Clinical Oncology</title><idno type="ISSN">0732-183X</idno><idno type="eISSN">1527-7755</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>In lung cancer, randomized trials assessing hyperfractionated or accelerated radiotherapy seem to yield conflicting results regarding the effects on overall (OS) or progression-free survival (PFS). The Meta-Analysis of Radiotherapy in Lung Cancer Collaborative Group decided to address the role of modified radiotherapy fractionation.</p></sec><sec><title>Material and Methods</title><p>We performed an individual patient data meta-analysis in patients with nonmetastatic lung cancer, which included trials comparing modified radiotherapy with conventional radiotherapy.</p></sec><sec><title>Results</title><p>In non–small-cell lung cancer (NSCLC; 10 trials, 2,000 patients), modified fractionation improved OS as compared with conventional schedules (hazard ratio [HR] = 0.88, 95% CI, 0.80 to 0.97; <italic>P</italic> = .009), resulting in an absolute benefit of 2.5% (8.3% to 10.8%) at 5 years. No evidence of heterogeneity between trials was found. There was no evidence of a benefit on PFS (HR = 0.94; 95% CI, 0.86 to 1.03; <italic>P</italic> = .19). Modified radiotherapy reduced deaths resulting from lung cancer (HR = 0.89; 95% CI, 0.81 to 0.98; <italic>P</italic> = .02), and there was a nonsignificant reduction of non–lung cancer deaths (HR = 0.87; 95% CI, 0.66 to 1.15; <italic>P</italic> = .33). In small-cell lung cancer (SCLC; two trials, 685 patients), similar results were found: OS, HR = 0.87, 95% CI, 0.74 to 1.02, <italic>P</italic> = .08; PFS, HR = 0.88, 95% CI, 0.75 to 1.03, <italic>P</italic> = .11. In both NSCLC and SCLC, the use of modified radiotherapy increased the risk of acute esophageal toxicity (odds ratio [OR] = 2.44 in NSCLC and OR = 2.41 in SCLC; <italic>P</italic> < .001) but did not have an impact on the risk of other acute toxicities.</p></sec><sec><title>Conclusion</title><p>Patients with nonmetastatic NSCLC derived a significant OS benefit from accelerated or hyperfractionated radiotherapy; a similar but nonsignificant trend was observed for SCLC. As expected, there was increased acute esophageal toxicity.</p></sec></div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Mauguen, Audrey" sort="Mauguen, Audrey" uniqKey="Mauguen A" first="Audrey" last="Mauguen">Audrey Mauguen</name></noRegion><name sortKey="Arriagada, Rodrigo" sort="Arriagada, Rodrigo" uniqKey="Arriagada R" first="Rodrigo" last="Arriagada">Rodrigo Arriagada</name><name sortKey="Ball, David" sort="Ball, David" uniqKey="Ball D" first="David" last="Ball">David Ball</name><name sortKey="Baumann, Michael" sort="Baumann, Michael" uniqKey="Baumann M" first="Michael" last="Baumann">Michael Baumann</name><name sortKey="Behrendt, Katarzyna" sort="Behrendt, Katarzyna" uniqKey="Behrendt K" first="Katarzyna" last="Behrendt">Katarzyna Behrendt</name><name sortKey="Belani, Chandra P" sort="Belani, Chandra P" uniqKey="Belani C" first="Chandra P." last="Belani">Chandra P. Belani</name><name sortKey="Bishop, James F" sort="Bishop, James F" uniqKey="Bishop J" first="James F." last="Bishop">James F. Bishop</name><name sortKey="Bonner, James A" sort="Bonner, James A" uniqKey="Bonner J" first="James A." last="Bonner">James A. Bonner</name><name sortKey="Dahlberg, Suzanne E" sort="Dahlberg, Suzanne E" uniqKey="Dahlberg S" first="Suzanne E." last="Dahlberg">Suzanne E. Dahlberg</name><name sortKey="De Ruysscher, Dirk" sort="De Ruysscher, Dirk" uniqKey="De Ruysscher D" first="Dirk" last="De Ruysscher">Dirk De Ruysscher</name><name sortKey="Dische, Stanley" sort="Dische, Stanley" uniqKey="Dische S" first="Stanley" last="Dische">Stanley Dische</name><name sortKey="Koch, Rainer" sort="Koch, Rainer" uniqKey="Koch R" first="Rainer" last="Koch">Rainer Koch</name><name sortKey="Le Pechoux, Cecile" sort="Le Pechoux, Cecile" uniqKey="Le Pechoux C" first="Cécile" last="Le Péchoux">Cécile Le Péchoux</name><name sortKey="Mandrekar, Sumithra J" sort="Mandrekar, Sumithra J" uniqKey="Mandrekar S" first="Sumithra J." last="Mandrekar">Sumithra J. Mandrekar</name><name sortKey="Nankivell, Matthew" sort="Nankivell, Matthew" uniqKey="Nankivell M" first="Matthew" last="Nankivell">Matthew Nankivell</name><name sortKey="Paulus, Rebecca" sort="Paulus, Rebecca" uniqKey="Paulus R" first="Rebecca" last="Paulus">Rebecca Paulus</name><name sortKey="Pignon, Jean Pierre" sort="Pignon, Jean Pierre" uniqKey="Pignon J" first="Jean-Pierre" last="Pignon">Jean-Pierre Pignon</name><name sortKey="Saunders, Michele I" sort="Saunders, Michele I" uniqKey="Saunders M" first="Michele I." last="Saunders">Michele I. Saunders</name><name sortKey="Sause, William T" sort="Sause, William T" uniqKey="Sause W" first="William T." last="Sause">William T. Sause</name><name sortKey="Schild, Steven E" sort="Schild, Steven E" uniqKey="Schild S" first="Steven E." last="Schild">Steven E. Schild</name><name sortKey="Turrisi, Andrew T" sort="Turrisi, Andrew T" uniqKey="Turrisi A" first="Andrew T." last="Turrisi">Andrew T. Turrisi</name><name sortKey="Zajusz, Aleksander" sort="Zajusz, Aleksander" uniqKey="Zajusz A" first="Aleksander" last="Zajusz">Aleksander Zajusz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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