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The Global Longitudinal Study of Osteoporosis in Women (GLOW): rationale and study design

Identifieur interne : 000590 ( Ncbi/Checkpoint ); précédent : 000589; suivant : 000591

The Global Longitudinal Study of Osteoporosis in Women (GLOW): rationale and study design

Auteurs : F. H. Hooven [États-Unis] ; J. D. Adachi [Canada] ; S. Adami [Italie] ; S. Boonen [Belgique] ; J. Compston [Royaume-Uni] ; C. Cooper [Royaume-Uni] ; P. Delmas ; A. Diez-Perez [Espagne] ; S. Gehlbach [États-Unis] ; S. L. Greenspan [États-Unis] ; A. Lacroix [États-Unis] ; R. Lindsay [États-Unis] ; J. C. Netelenbos [Pays-Bas] ; J. Pfeilschifter [Allemagne] ; C. Roux [France] ; K. G. Saag [États-Unis] ; P. Sambrook ; S. Silverman [États-Unis] ; E. Siris [États-Unis] ; N. B. Watts [États-Unis] ; F. A. Anderson [États-Unis]

Source :

RBID : PMC:2690851

Abstract

Summary

The Global Longitudinal study of Osteoporosis in Women (GLOW) is a prospective cohort study involving 723 physicians and 60,393 women subjects ≥55 years. The data will provide insights into the management of fracture risk in older women over 5 years, patient experience with prevention and treatment, and distribution of risk among older women on an international basis.

Introduction

Data from cohort studies describing the distribution of osteoporosis-related fractures and risk factors are not directly comparable and do not compare regional differences in patterns of patient management and fracture outcomes.

Methods

The GLOW is a prospective, multinational, observational cohort study. Practices typical of each region were identified through primary care networks organized for administrative, research, or educational purposes. Noninstitutionalized patients visiting each practice within the previous 2 years were eligible. Self-administered questionnaires were mailed, with 2:1 oversampling of women ≥65 years. Follow-up questionnaires will be sent at 12-month intervals for 5 years.

Results

A total of 723 physicians at 17 sites in ten countries agreed to participate. Baseline surveys were mailed (October 2006 to February 2008) to 140,416 subjects. After the exclusion of 3,265 women who were ineligible or had died, 60,393 agreed to participate.

Conclusions

GLOW will provide contemporary information on patterns of management of fracture risk in older women over a 5-year period. The collection of data in a similar manner in ten countries will permit comparisons of patient experience with prevention and treatment and provide insights into the distribution of risk among older women on an international basis.


Url:
DOI: 10.1007/s00198-009-0958-2
PubMed: 19468663
PubMed Central: 2690851


Affiliations:


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PMC:2690851

Le document en format XML

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<name sortKey="Saag, K G" sort="Saag, K G" uniqKey="Saag K" first="K. G." last="Saag">K. G. Saag</name>
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<author>
<name sortKey="Pfeilschifter, J" sort="Pfeilschifter, J" uniqKey="Pfeilschifter J" first="J." last="Pfeilschifter">J. Pfeilschifter</name>
<affiliation wicri:level="1">
<nlm:aff id="Aff15">Alfried Krupp Krankenhaus, Department of Internal Medicine III, Essen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Alfried Krupp Krankenhaus, Department of Internal Medicine III, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Roux, C" sort="Roux, C" uniqKey="Roux C" first="C." last="Roux">C. Roux</name>
<affiliation wicri:level="3">
<nlm:aff id="Aff16">Centre D’Evaluation Des Maladies Osseuses, Hôpital Cochin, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre D’Evaluation Des Maladies Osseuses, Hôpital Cochin, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Saag, K G" sort="Saag, K G" uniqKey="Saag K" first="K. G." last="Saag">K. G. Saag</name>
<affiliation wicri:level="2">
<nlm:aff id="Aff17">Division of Clinical Immunology and Rheumatology, University of Alabama-Birmingham, Birmingham, AL USA</nlm:aff>
<country>États-Unis</country>
<placeName>
<region type="state">Alabama</region>
</placeName>
<wicri:cityArea>Division of Clinical Immunology and Rheumatology, University of Alabama-Birmingham, Birmingham</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Sambrook, P" sort="Sambrook, P" uniqKey="Sambrook P" first="P." last="Sambrook">P. Sambrook</name>
<affiliation>
<nlm:aff id="Aff18">University of Sydney-Royal North Shore Hospital, St. Leonards, Sydney, New South Wales Australia</nlm:aff>
<wicri:noCountry code="subfield">New South Wales Australia</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Silverman, S" sort="Silverman, S" uniqKey="Silverman S" first="S." last="Silverman">S. Silverman</name>
<affiliation wicri:level="2">
<nlm:aff id="Aff19">Department of Rheumatology, David Geffen School of Medicine, Los Angeles, CA USA</nlm:aff>
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Rheumatology, David Geffen School of Medicine, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Siris, E" sort="Siris, E" uniqKey="Siris E" first="E." last="Siris">E. Siris</name>
<affiliation wicri:level="2">
<nlm:aff id="Aff20">Columbia University Medical Center, New York, NY USA</nlm:aff>
<country>États-Unis</country>
<placeName>
<region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Columbia University Medical Center, New York</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Watts, N B" sort="Watts, N B" uniqKey="Watts N" first="N. B." last="Watts">N. B. Watts</name>
<affiliation wicri:level="2">
<nlm:aff id="Aff21">Bone Health and Osteoporosis Center, University of Cincinnati, Cincinnati, OH USA</nlm:aff>
<country>États-Unis</country>
<placeName>
<region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Bone Health and Osteoporosis Center, University of Cincinnati, Cincinnati</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Anderson, F A" sort="Anderson, F A" uniqKey="Anderson F" first="F. A." last="Anderson">F. A. Anderson</name>
<affiliation wicri:level="2">
<nlm:aff id="Aff1">Center for Outcomes Research, University of Massachusetts Medical School, 365 Plantation Street, Suite 185, Worcester, MA 01605 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Center for Outcomes Research, University of Massachusetts Medical School, 365 Plantation Street, Suite 185, Worcester</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Osteoporosis International</title>
<idno type="ISSN">0937-941X</idno>
<idno type="eISSN">1433-2965</idno>
<imprint>
<date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec>
<title>Summary</title>
<p>The Global Longitudinal study of Osteoporosis in Women (GLOW) is a prospective cohort study involving 723 physicians and 60,393 women subjects ≥55 years. The data will provide insights into the management of fracture risk in older women over 5 years, patient experience with prevention and treatment, and distribution of risk among older women on an international basis.</p>
</sec>
<sec>
<title>Introduction</title>
<p>Data from cohort studies describing the distribution of osteoporosis-related fractures and risk factors are not directly comparable and do not compare regional differences in patterns of patient management and fracture outcomes.</p>
</sec>
<sec>
<title>Methods</title>
<p>The GLOW is a prospective, multinational, observational cohort study. Practices typical of each region were identified through primary care networks organized for administrative, research, or educational purposes. Noninstitutionalized patients visiting each practice within the previous 2 years were eligible. Self-administered questionnaires were mailed, with 2:1 oversampling of women ≥65 years. Follow-up questionnaires will be sent at 12-month intervals for 5 years.</p>
</sec>
<sec>
<title>Results</title>
<p>A total of 723 physicians at 17 sites in ten countries agreed to participate. Baseline surveys were mailed (October 2006 to February 2008) to 140,416 subjects. After the exclusion of 3,265 women who were ineligible or had died, 60,393 agreed to participate.</p>
</sec>
<sec>
<title>Conclusions</title>
<p>GLOW will provide contemporary information on patterns of management of fracture risk in older women over a 5-year period. The collection of data in a similar manner in ten countries will permit comparisons of patient experience with prevention and treatment and provide insights into the distribution of risk among older women on an international basis.</p>
</sec>
</div>
</front>
<back>
<div1 type="bibliography">
<listBibl>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
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<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations>
<list>
<country>
<li>Allemagne</li>
<li>Belgique</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region>
<li>Alabama</li>
<li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Californie</li>
<li>Catalogne</li>
<li>Hollande-Septentrionale</li>
<li>Massachusetts</li>
<li>Ohio</li>
<li>Ontario</li>
<li>Oxfordshire</li>
<li>Pennsylvanie</li>
<li>Washington (État)</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
<settlement>
<li>Amsterdam</li>
<li>Barcelone</li>
<li>Cambridge</li>
<li>Hamilton (Ontario)</li>
<li>Oxford</li>
<li>Paris</li>
</settlement>
<orgName>
<li>Université McMaster</li>
<li>Université d'Oxford</li>
<li>Université de Cambridge</li>
</orgName>
</list>
<tree>
<noCountry>
<name sortKey="Delmas, P" sort="Delmas, P" uniqKey="Delmas P" first="P." last="Delmas">P. Delmas</name>
<name sortKey="Sambrook, P" sort="Sambrook, P" uniqKey="Sambrook P" first="P." last="Sambrook">P. Sambrook</name>
</noCountry>
<country name="États-Unis">
<region name="Massachusetts">
<name sortKey="Hooven, F H" sort="Hooven, F H" uniqKey="Hooven F" first="F. H." last="Hooven">F. H. Hooven</name>
</region>
<name sortKey="Anderson, F A" sort="Anderson, F A" uniqKey="Anderson F" first="F. A." last="Anderson">F. A. Anderson</name>
<name sortKey="Gehlbach, S" sort="Gehlbach, S" uniqKey="Gehlbach S" first="S." last="Gehlbach">S. Gehlbach</name>
<name sortKey="Greenspan, S L" sort="Greenspan, S L" uniqKey="Greenspan S" first="S. L." last="Greenspan">S. L. Greenspan</name>
<name sortKey="Lacroix, A" sort="Lacroix, A" uniqKey="Lacroix A" first="A." last="Lacroix">A. Lacroix</name>
<name sortKey="Lindsay, R" sort="Lindsay, R" uniqKey="Lindsay R" first="R." last="Lindsay">R. Lindsay</name>
<name sortKey="Saag, K G" sort="Saag, K G" uniqKey="Saag K" first="K. G." last="Saag">K. G. Saag</name>
<name sortKey="Silverman, S" sort="Silverman, S" uniqKey="Silverman S" first="S." last="Silverman">S. Silverman</name>
<name sortKey="Siris, E" sort="Siris, E" uniqKey="Siris E" first="E." last="Siris">E. Siris</name>
<name sortKey="Watts, N B" sort="Watts, N B" uniqKey="Watts N" first="N. B." last="Watts">N. B. Watts</name>
</country>
<country name="Canada">
<region name="Ontario">
<name sortKey="Adachi, J D" sort="Adachi, J D" uniqKey="Adachi J" first="J. D." last="Adachi">J. D. Adachi</name>
</region>
</country>
<country name="Italie">
<noRegion>
<name sortKey="Adami, S" sort="Adami, S" uniqKey="Adami S" first="S." last="Adami">S. Adami</name>
</noRegion>
</country>
<country name="Belgique">
<noRegion>
<name sortKey="Boonen, S" sort="Boonen, S" uniqKey="Boonen S" first="S." last="Boonen">S. Boonen</name>
</noRegion>
</country>
<country name="Royaume-Uni">
<region name="Angleterre">
<name sortKey="Compston, J" sort="Compston, J" uniqKey="Compston J" first="J." last="Compston">J. Compston</name>
</region>
<name sortKey="Cooper, C" sort="Cooper, C" uniqKey="Cooper C" first="C." last="Cooper">C. Cooper</name>
<name sortKey="Cooper, C" sort="Cooper, C" uniqKey="Cooper C" first="C." last="Cooper">C. Cooper</name>
</country>
<country name="Espagne">
<region name="Catalogne">
<name sortKey="Diez Perez, A" sort="Diez Perez, A" uniqKey="Diez Perez A" first="A." last="Diez-Perez">A. Diez-Perez</name>
</region>
</country>
<country name="Pays-Bas">
<region name="Hollande-Septentrionale">
<name sortKey="Netelenbos, J C" sort="Netelenbos, J C" uniqKey="Netelenbos J" first="J. C." last="Netelenbos">J. C. Netelenbos</name>
</region>
</country>
<country name="Allemagne">
<noRegion>
<name sortKey="Pfeilschifter, J" sort="Pfeilschifter, J" uniqKey="Pfeilschifter J" first="J." last="Pfeilschifter">J. Pfeilschifter</name>
</noRegion>
</country>
<country name="France">
<region name="Île-de-France">
<name sortKey="Roux, C" sort="Roux, C" uniqKey="Roux C" first="C." last="Roux">C. Roux</name>
</region>
</country>
</tree>
</affiliations>
</record>

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