Immunogenicity of a reduced dose of A/H3N2 in the 2005 southern hemisphere formulation of inactivated split influenza vaccine
Identifieur interne : 000588 ( Ncbi/Checkpoint ); précédent : 000587; suivant : 000589Immunogenicity of a reduced dose of A/H3N2 in the 2005 southern hemisphere formulation of inactivated split influenza vaccine
Auteurs : Christopher Burrell ; Robert Booy ; Nicholas Wood ; Anne-Marie Egan ; David Taverner ; Ken Williams ; Winston Liauw ; Alan Moskwa ; Stephanie Pepin-Covatta ; Melanie SavilleSource :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2008.
Abstract
Url:
DOI: 10.1111/j.1750-2659.2008.00039.x
PubMed: 19453468
PubMed Central: 4634696
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunogenicity of a reduced dose of A/H3N2 in the 2005 southern hemisphere formulation of inactivated split influenza vaccine</title><author><name sortKey="Burrell, Christopher" sort="Burrell, Christopher" uniqKey="Burrell C" first="Christopher" last="Burrell">Christopher Burrell</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Booy, Robert" sort="Booy, Robert" uniqKey="Booy R" first="Robert" last="Booy">Robert Booy</name><affiliation><nlm:aff id="a3"></nlm:aff></affiliation></author><author><name sortKey="Wood, Nicholas" sort="Wood, Nicholas" uniqKey="Wood N" first="Nicholas" last="Wood">Nicholas Wood</name><affiliation><nlm:aff id="a3"></nlm:aff></affiliation></author><author><name sortKey="Egan, Anne Arie" sort="Egan, Anne Arie" uniqKey="Egan A" first="Anne-Marie" last="Egan">Anne-Marie Egan</name><affiliation><nlm:aff id="a3"></nlm:aff></affiliation></author><author><name sortKey="Taverner, David" sort="Taverner, David" uniqKey="Taverner D" first="David" last="Taverner">David Taverner</name><affiliation><nlm:aff id="a4"></nlm:aff></affiliation></author><author><name sortKey="Williams, Ken" sort="Williams, Ken" uniqKey="Williams K" first="Ken" last="Williams">Ken Williams</name><affiliation><nlm:aff id="a5"></nlm:aff></affiliation></author><author><name sortKey="Liauw, Winston" sort="Liauw, Winston" uniqKey="Liauw W" first="Winston" last="Liauw">Winston Liauw</name><affiliation><nlm:aff id="a5"></nlm:aff></affiliation></author><author><name sortKey="Moskwa, Alan" sort="Moskwa, Alan" uniqKey="Moskwa A" first="Alan" last="Moskwa">Alan Moskwa</name><affiliation><nlm:aff id="a6"></nlm:aff></affiliation></author><author><name sortKey="Pepin Ovatta, Stephanie" sort="Pepin Ovatta, Stephanie" uniqKey="Pepin Ovatta S" first="Stephanie" last="Pepin-Covatta">Stephanie Pepin-Covatta</name><affiliation><nlm:aff id="a7"></nlm:aff></affiliation></author><author><name sortKey="Saville, Melanie" sort="Saville, Melanie" uniqKey="Saville M" first="Melanie" last="Saville">Melanie Saville</name><affiliation><nlm:aff id="a7"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19453468</idno><idno type="pmc">4634696</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634696</idno><idno type="RBID">PMC:4634696</idno><idno type="doi">10.1111/j.1750-2659.2008.00039.x</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000278</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000278</idno><idno type="wicri:Area/Pmc/Curation">000278</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000278</idno><idno type="wicri:Area/Pmc/Checkpoint">002987</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002987</idno><idno type="wicri:Area/Ncbi/Merge">000588</idno><idno type="wicri:Area/Ncbi/Curation">000588</idno><idno type="wicri:Area/Ncbi/Checkpoint">000588</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immunogenicity of a reduced dose of A/H3N2 in the 2005 southern hemisphere formulation of inactivated split influenza vaccine</title><author><name sortKey="Burrell, Christopher" sort="Burrell, Christopher" uniqKey="Burrell C" first="Christopher" last="Burrell">Christopher Burrell</name><affiliation><nlm:aff id="a1"></nlm:aff></affiliation><affiliation><nlm:aff id="a2"></nlm:aff></affiliation></author><author><name sortKey="Booy, Robert" sort="Booy, Robert" uniqKey="Booy R" first="Robert" last="Booy">Robert Booy</name><affiliation><nlm:aff id="a3"></nlm:aff></affiliation></author><author><name sortKey="Wood, Nicholas" sort="Wood, Nicholas" uniqKey="Wood N" first="Nicholas" last="Wood">Nicholas Wood</name><affiliation><nlm:aff id="a3"></nlm:aff></affiliation></author><author><name sortKey="Egan, Anne Arie" sort="Egan, Anne Arie" uniqKey="Egan A" first="Anne-Marie" last="Egan">Anne-Marie Egan</name><affiliation><nlm:aff id="a3"></nlm:aff></affiliation></author><author><name sortKey="Taverner, David" sort="Taverner, David" uniqKey="Taverner D" first="David" last="Taverner">David Taverner</name><affiliation><nlm:aff id="a4"></nlm:aff></affiliation></author><author><name sortKey="Williams, Ken" sort="Williams, Ken" uniqKey="Williams K" first="Ken" last="Williams">Ken Williams</name><affiliation><nlm:aff id="a5"></nlm:aff></affiliation></author><author><name sortKey="Liauw, Winston" sort="Liauw, Winston" uniqKey="Liauw W" first="Winston" last="Liauw">Winston Liauw</name><affiliation><nlm:aff id="a5"></nlm:aff></affiliation></author><author><name sortKey="Moskwa, Alan" sort="Moskwa, Alan" uniqKey="Moskwa A" first="Alan" last="Moskwa">Alan Moskwa</name><affiliation><nlm:aff id="a6"></nlm:aff></affiliation></author><author><name sortKey="Pepin Ovatta, Stephanie" sort="Pepin Ovatta, Stephanie" uniqKey="Pepin Ovatta S" first="Stephanie" last="Pepin-Covatta">Stephanie Pepin-Covatta</name><affiliation><nlm:aff id="a7"></nlm:aff></affiliation></author><author><name sortKey="Saville, Melanie" sort="Saville, Melanie" uniqKey="Saville M" first="Melanie" last="Saville">Melanie Saville</name><affiliation><nlm:aff id="a7"></nlm:aff></affiliation></author></analytic><series><title level="j">Influenza and Other Respiratory Viruses</title><idno type="ISSN">1750-2640</idno><idno type="eISSN">1750-2659</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background </bold> The 2005 southern hemisphere formulation of the inactivated split‐virion influenza vaccine Vaxigrip<sup>®</sup> unintentionally contained a lower concentration of haemagglutinin (HA) than European Pharmacopoeia (EP) and WHO specifications for one of the three strains.</p><p><bold>Objectives </bold> To evaluate the immunogenicity of the 2005 southern hemisphere formulation of an influenza vaccine containing 9 μg/dose of HA for A/Wellington/1/2004(H3N2) strain, and 15 μg/dose for each of the A/New Caledonia/20/99(H1N1) strain and B/Shanghai/361/2002‐like strains.</p><p><bold>Patients/methods </bold> In an open, non‐controlled multicentre clinical trial, 75 healthy adults (18–59 years) and 65 healthy older adults (≥60 years) were vaccinated once. Serum samples were obtained on D0 and 21 for haemagglutination inhibition (HAI) antibody titration.</p><p><bold>Results </bold> A high proportion of adults (64%) and elderly (68%) were already seroprotected (HAI titre of ≥40) against A/Wellington/1/2004(H3N2) before vaccination, probably due to high circulation of an antigenically similar H3N2 strain and a high 2004 vaccination rate. By D21, seroprotection rates against H3N2 attained 93·8% and 96·0% in adults and elderly respectively. The other two immunogenicity criteria for annual licensure of influenza vaccines in Europe were also met in both age groups for the H3N2 strain, and also for the H1N1 and B strains.</p><p><bold>Conclusions </bold> These results enabled the 2005 southern hemisphere vaccine to be used in expectation that it would provide satisfactory protection against influenza, despite the reduced H3N2 antigen content.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Booy, Robert" sort="Booy, Robert" uniqKey="Booy R" first="Robert" last="Booy">Robert Booy</name><name sortKey="Burrell, Christopher" sort="Burrell, Christopher" uniqKey="Burrell C" first="Christopher" last="Burrell">Christopher Burrell</name><name sortKey="Egan, Anne Arie" sort="Egan, Anne Arie" uniqKey="Egan A" first="Anne-Marie" last="Egan">Anne-Marie Egan</name><name sortKey="Liauw, Winston" sort="Liauw, Winston" uniqKey="Liauw W" first="Winston" last="Liauw">Winston Liauw</name><name sortKey="Moskwa, Alan" sort="Moskwa, Alan" uniqKey="Moskwa A" first="Alan" last="Moskwa">Alan Moskwa</name><name sortKey="Pepin Ovatta, Stephanie" sort="Pepin Ovatta, Stephanie" uniqKey="Pepin Ovatta S" first="Stephanie" last="Pepin-Covatta">Stephanie Pepin-Covatta</name><name sortKey="Saville, Melanie" sort="Saville, Melanie" uniqKey="Saville M" first="Melanie" last="Saville">Melanie Saville</name><name sortKey="Taverner, David" sort="Taverner, David" uniqKey="Taverner D" first="David" last="Taverner">David Taverner</name><name sortKey="Williams, Ken" sort="Williams, Ken" uniqKey="Williams K" first="Ken" last="Williams">Ken Williams</name><name sortKey="Wood, Nicholas" sort="Wood, Nicholas" uniqKey="Wood N" first="Nicholas" last="Wood">Nicholas Wood</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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