The role of interleukin 2 in autoimmunity
Identifieur interne : 00F047 ( Main/Merge ); précédent : 00F046; suivant : 00F048The role of interleukin 2 in autoimmunity
Auteurs : Guido Kroemer [Australie, France] ; Georg Wick [Australie]Source :
- Immunology Today [ 0167-5699 ] ; 1989.
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Abstract
Abstract: In addition to playing a major role in physiological immune responses against foreign antigens, the interleukin 2 (IL-2)-IL-2 receptor (IL-2R) system may also be implicated in autoimmune phenomena. Initial studies on the role of IL-2 in autoimmunity indicate a deficiency in the production of this lymphokine in autoimmune disease. Here, Guido Kroemer and Georg Wick review recent data supporting the notion that an excess of endogenous or exogenous IL-2 may aggravate autoaggression by triggering autoreactive effector cells, and they speculate that IL-2 might favor the de novo development of autoimmunity by breaking autotolerance.
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DOI: 10.1016/0167-5699(89)90262-4
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