AustralieFrV1, Main, Merge, bibRecord, 00D620

Segregation analysis of the specific response to allergens : A recessive major gene controls the specific IgE response to Timothy grass pollen

Identifieur interne : 00D620 ( Main/Merge ); précédent : 00D619; suivant : 00D621

Segregation analysis of the specific response to allergens : A recessive major gene controls the specific IgE response to Timothy grass pollen

Auteurs : M. H. Dizier [France] ; A. James [Australie] ; J. Faux [Royaume-Uni] ; M. F. Moffatt [Royaume-Uni] ; A. W. Musk [Australie] ; W. Cookson [Royaume-Uni] ; F. Demenais [France]

Source :

Genetic epidemiology [ 0741-0395 ] ; 1999.

RBID : Pascal:99-0196335

Descripteurs français

Pascal (Inist)
- Homme, Australie, Analyse ségrégation, Gène majeur, Hérédité, Etude familiale, Pollen, Immunoglobuline, IgE, Analyse quantitative, Réponse immune, Allergie, Immunité humorale, Immunogénétique.
Wicri :
- geographic : Australie.
- topic : Homme, Analyse quantitative, Allergie.

English descriptors

KwdEn :
- Allergy, Australia, Family study, Human, Humoral immunity, IgE, Immune response, Immunogenetics, Immunoglobulins, Inheritance(genetics), Major gene, Pollen, Quantitative analysis, Segregation analysis.

Abstract

Segregation analysis of the specific response to allergens (SRA) was performed in a sample of 234 randomly selected Australian families using the regressive models. Various SRA phenotypes were considered using broad and narrow definitions of these phenotypes, according to the type of test used, skin test or RAST test, and the specificity of the response to allergen. Strong evidence for familial dependencies among blood relatives was shown for most SRA phenotypes, especially when using a broad definition. There was no evidence for a Mendelian factor accounting for the familial transmission of these broadest phenotypes, which may involve multiple factors preventing the clear detection of a major effect with Mendelian transmission. However, segregation of a Mendelian recessive major gene was detected for one SRA sub-phenotype, the IgE response to a single allergen, Timothy grass pollen, measured by the RAST test. Identification of a specific SRA phenotype controlled by a major gene may have important implications for futher linkage studies.

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Pascal:99-0196335

Le document en format XML

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<term>Immune response</term>
<term>Immunogenetics</term>
<term>Immunoglobulins</term>
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<term>Etude familiale</term>
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<term>Immunoglobuline</term>
<term>IgE</term>
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<front><div type="abstract" xml:lang="en">Segregation analysis of the specific response to allergens (SRA) was performed in a sample of 234 randomly selected Australian families using the regressive models. Various SRA phenotypes were considered using broad and narrow definitions of these phenotypes, according to the type of test used, skin test or RAST test, and the specificity of the response to allergen. Strong evidence for familial dependencies among blood relatives was shown for most SRA phenotypes, especially when using a broad definition. There was no evidence for a Mendelian factor accounting for the familial transmission of these broadest phenotypes, which may involve multiple factors preventing the clear detection of a major effect with Mendelian transmission. However, segregation of a Mendelian recessive major gene was detected for one SRA sub-phenotype, the IgE response to a single allergen, Timothy grass pollen, measured by the RAST test. Identification of a specific SRA phenotype controlled by a major gene may have important implications for futher linkage studies.</div>
</front>
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<tree><country name="France"><region name="Île-de-France"><name sortKey="Dizier, M H" sort="Dizier, M H" uniqKey="Dizier M" first="M. H." last="Dizier">M. H. Dizier</name>
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Segregation analysis of the specific response to allergens : A recessive major gene controls the specific IgE response to Timothy grass pollen

Segregation analysis of the specific response to allergens : A recessive major gene controls the specific IgE response to Timothy grass pollen

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri