Common sequence variants on 20q11.22 confer melanoma susceptibility
Identifieur interne : 008E69 ( Main/Merge ); précédent : 008E68; suivant : 008E70Common sequence variants on 20q11.22 confer melanoma susceptibility
Auteurs : Kevin M. Brown [États-Unis] ; Stuart Macgregor ; Grant W. Montgomery ; David W. Craig [États-Unis] ; Zhen Zhen Zhao ; Kelly Iyadurai [États-Unis] ; Anjali Henders ; Nils Homer [États-Unis] ; Megan Campbell ; Mitchell Stark ; Shane Thomas ; Helen Schmid ; Elizabeth A. Holland ; Elizabeth M. Gillanders [États-Unis] ; David L. Duffy ; Judith A. Maskiell [Australie] ; Jodie Jetann ; Megan Ferguson ; Dietrich A. Stephan [États-Unis] ; Anne E. Cust [Australie] ; David Whiteman ; Adele Green ; H Kan Olsson ; Susana Puig [Espagne] ; Paola Ghiorzo [Italie] ; Johan Hansson [Suède] ; Florence Demenais [France] ; Alisa M. Goldstein [États-Unis] ; Nelleke A. Gruis [Pays-Bas] ; David E. Elder [États-Unis] ; Julia Newton Bishop [Royaume-Uni] ; Richard F. Kefford ; Graham G. Giles ; Bruce K. Armstrong [Australie] ; Joanne F. Aitken ; John L. Hopper [Australie] ; Nicholas G. Martin ; Jeffrey M. Trent [États-Unis] ; Graham J. Mann ; Nicholas K. HaywardSource :
- Nature genetics [ 1061-4036 ] ; 2008.
Abstract
We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totalling 2019 cases and 2105 controls. Using pooling we identified a novel melanoma risk locus on chromosome 20 (rs910873, rs1885120), with replication in two further samples (combined
Url:
DOI: 10.1038/ng.163
PubMed: 18488026
PubMed Central: 2755512
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Brown</name><affiliation wicri:level="2"><nlm:aff id="A1">Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. 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Holland</name><affiliation><nlm:aff id="A5">Westmead Institute of Cancer Research and Sydney Melanoma Unit, University of Sydney at Westmead Millennium Institute, Westmead, NSW 2145 Australia</nlm:aff><wicri:noCountry code="subfield">NSW 2145 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Gillanders, Elizabeth M" sort="Gillanders, Elizabeth M" uniqKey="Gillanders E" first="Elizabeth M." last="Gillanders">Elizabeth M. 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Maskiell</name><affiliation wicri:level="4"><nlm:aff id="A7">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, VIC 3052 Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Jetann, Jodie" sort="Jetann, Jodie" uniqKey="Jetann J" first="Jodie" last="Jetann">Jodie Jetann</name><affiliation><nlm:aff id="A8">Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Brisbane, QLD 4004 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4004 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Ferguson, Megan" sort="Ferguson, Megan" uniqKey="Ferguson M" first="Megan" last="Ferguson">Megan Ferguson</name><affiliation><nlm:aff id="A8">Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Brisbane, QLD 4004 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4004 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Stephan, Dietrich A" sort="Stephan, Dietrich A" uniqKey="Stephan D" first="Dietrich A." last="Stephan">Dietrich A. Stephan</name><affiliation wicri:level="2"><nlm:aff id="A3">Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Cust, Anne E" sort="Cust, Anne E" uniqKey="Cust A" first="Anne E." last="Cust">Anne E. Cust</name><affiliation wicri:level="4"><nlm:aff id="A7">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, VIC 3052 Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Whiteman, David" sort="Whiteman, David" uniqKey="Whiteman D" first="David" last="Whiteman">David Whiteman</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Green, Adele" sort="Green, Adele" uniqKey="Green A" first="Adele" last="Green">Adele Green</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name><affiliation><nlm:aff id="A9">Lund Cancer Center Department of Oncology, University Hospital, Lund, Sweden, on behalf of Lund Melanoma Group</nlm:aff><wicri:noCountry code="subfield">on behalf of Lund Melanoma Group</wicri:noCountry></affiliation></author><author><name sortKey="Puig, Susana" sort="Puig, Susana" uniqKey="Puig S" first="Susana" last="Puig">Susana Puig</name><affiliation wicri:level="4"><nlm:aff id="A10">Dermatology Department, Melanoma Unit, Hospital Clínic, Institut de Investigació Biomèdica August Pi Suñe, Universitat de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Dermatology Department, Melanoma Unit, Hospital Clínic, Institut de Investigació Biomèdica August Pi Suñe, Universitat de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Oncology, Biology, and Genetics, University of Genova, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, Biology, and Genetics, University of Genova, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Hansson, Johan" sort="Hansson, Johan" uniqKey="Hansson J" first="Johan" last="Hansson">Johan Hansson</name><affiliation wicri:level="3"><nlm:aff id="A12">Department of Oncology-Pathology, Karolinska Institute and Karolinska University Hospital, Solna, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology-Pathology, Karolinska Institute and Karolinska University Hospital, Solna, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><affiliation wicri:level="3"><nlm:aff id="A13">INSERM, U794, Fondation Jean-Dausset-CEPH, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U794, Fondation Jean-Dausset-CEPH, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name><affiliation wicri:level="2"><nlm:aff id="A14">Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name><affiliation wicri:level="3"><nlm:aff id="A15">Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Elder, David E" sort="Elder, David E" uniqKey="Elder D" first="David E." last="Elder">David E. Elder</name><affiliation wicri:level="2"><nlm:aff id="A16">Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Bishop, Julia Newton" sort="Bishop, Julia Newton" uniqKey="Bishop J" first="Julia Newton" last="Bishop">Julia Newton Bishop</name><affiliation wicri:level="1"><nlm:aff id="A17">Genetic Epidemiology Division, Cancer Research UK Clinical Centre, Leeds, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Division, Cancer Research UK Clinical Centre, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Kefford, Richard F" sort="Kefford, Richard F" uniqKey="Kefford R" first="Richard F." last="Kefford">Richard F. Kefford</name><affiliation><nlm:aff id="A5">Westmead Institute of Cancer Research and Sydney Melanoma Unit, University of Sydney at Westmead Millennium Institute, Westmead, NSW 2145 Australia</nlm:aff><wicri:noCountry code="subfield">NSW 2145 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A18">Cancer Epidemiology Centre, The Cancer Council Victoria, Carlton Victoria 3053 Australia</nlm:aff><wicri:noCountry code="subfield">Carlton Victoria 3053 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name><affiliation wicri:level="4"><nlm:aff id="A19">School of Public Health, University of Sydney, NSW 2006 Australia</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Aitken, Joanne F" sort="Aitken, Joanne F" uniqKey="Aitken J" first="Joanne F." last="Aitken">Joanne F. Aitken</name><affiliation><nlm:aff id="A8">Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Brisbane, QLD 4004 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4004 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="A7">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, VIC 3052 Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Trent, Jeffrey M" sort="Trent, Jeffrey M" uniqKey="Trent J" first="Jeffrey M." last="Trent">Jeffrey M. Trent</name><affiliation wicri:level="2"><nlm:aff id="A20">Genetic Basis of Human Disease Division, The Translational Genomics Research Institute, Phoenix, AZ, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genetic Basis of Human Disease Division, The Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name><affiliation><nlm:aff id="A5">Westmead Institute of Cancer Research and Sydney Melanoma Unit, University of Sydney at Westmead Millennium Institute, Westmead, NSW 2145 Australia</nlm:aff><wicri:noCountry code="subfield">NSW 2145 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18488026</idno><idno type="pmc">2755512</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755512</idno><idno type="RBID">PMC:2755512</idno><idno type="doi">10.1038/ng.163</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">001483</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001483</idno><idno type="wicri:Area/Pmc/Curation">001343</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001343</idno><idno type="wicri:Area/Pmc/Checkpoint">002A29</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002A29</idno><idno type="wicri:Area/Ncbi/Merge">000391</idno><idno type="wicri:Area/Ncbi/Curation">000391</idno><idno type="wicri:Area/Ncbi/Checkpoint">000391</idno><idno type="wicri:doubleKey">1061-4036:2008:Brown K:common:sequence:variants</idno><idno type="wicri:Area/Main/Merge">008E69</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common sequence variants on 20q11.22 confer melanoma susceptibility</title><author><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name><affiliation wicri:level="2"><nlm:aff id="A1">Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Craig, David W" sort="Craig, David W" uniqKey="Craig D" first="David W." last="Craig">David W. Craig</name><affiliation wicri:level="2"><nlm:aff id="A3">Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Zhao, Zhen Zhen" sort="Zhao, Zhen Zhen" uniqKey="Zhao Z" first="Zhen Zhen" last="Zhao">Zhen Zhen Zhao</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Iyadurai, Kelly" sort="Iyadurai, Kelly" uniqKey="Iyadurai K" first="Kelly" last="Iyadurai">Kelly Iyadurai</name><affiliation wicri:level="2"><nlm:aff id="A1">Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Henders, Anjali" sort="Henders, Anjali" uniqKey="Henders A" first="Anjali" last="Henders">Anjali Henders</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Homer, Nils" sort="Homer, Nils" uniqKey="Homer N" first="Nils" last="Homer">Nils Homer</name><affiliation wicri:level="2"><nlm:aff id="A4">University of California, Los Angeles, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, Los Angeles, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Campbell, Megan" sort="Campbell, Megan" uniqKey="Campbell M" first="Megan" last="Campbell">Megan Campbell</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Stark, Mitchell" sort="Stark, Mitchell" uniqKey="Stark M" first="Mitchell" last="Stark">Mitchell Stark</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Thomas, Shane" sort="Thomas, Shane" uniqKey="Thomas S" first="Shane" last="Thomas">Shane Thomas</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Schmid, Helen" sort="Schmid, Helen" uniqKey="Schmid H" first="Helen" last="Schmid">Helen Schmid</name><affiliation><nlm:aff id="A5">Westmead Institute of Cancer Research and Sydney Melanoma Unit, University of Sydney at Westmead Millennium Institute, Westmead, NSW 2145 Australia</nlm:aff><wicri:noCountry code="subfield">NSW 2145 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Holland, Elizabeth A" sort="Holland, Elizabeth A" uniqKey="Holland E" first="Elizabeth A" last="Holland">Elizabeth A. Holland</name><affiliation><nlm:aff id="A5">Westmead Institute of Cancer Research and Sydney Melanoma Unit, University of Sydney at Westmead Millennium Institute, Westmead, NSW 2145 Australia</nlm:aff><wicri:noCountry code="subfield">NSW 2145 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Gillanders, Elizabeth M" sort="Gillanders, Elizabeth M" uniqKey="Gillanders E" first="Elizabeth M." last="Gillanders">Elizabeth M. Gillanders</name><affiliation wicri:level="2"><nlm:aff id="A6">Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Duffy, David L" sort="Duffy, David L" uniqKey="Duffy D" first="David L." last="Duffy">David L. Duffy</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Maskiell, Judith A" sort="Maskiell, Judith A" uniqKey="Maskiell J" first="Judith A." last="Maskiell">Judith A. Maskiell</name><affiliation wicri:level="4"><nlm:aff id="A7">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, VIC 3052 Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Jetann, Jodie" sort="Jetann, Jodie" uniqKey="Jetann J" first="Jodie" last="Jetann">Jodie Jetann</name><affiliation><nlm:aff id="A8">Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Brisbane, QLD 4004 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4004 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Ferguson, Megan" sort="Ferguson, Megan" uniqKey="Ferguson M" first="Megan" last="Ferguson">Megan Ferguson</name><affiliation><nlm:aff id="A8">Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Brisbane, QLD 4004 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4004 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Stephan, Dietrich A" sort="Stephan, Dietrich A" uniqKey="Stephan D" first="Dietrich A." last="Stephan">Dietrich A. Stephan</name><affiliation wicri:level="2"><nlm:aff id="A3">Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Cust, Anne E" sort="Cust, Anne E" uniqKey="Cust A" first="Anne E." last="Cust">Anne E. Cust</name><affiliation wicri:level="4"><nlm:aff id="A7">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, VIC 3052 Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Whiteman, David" sort="Whiteman, David" uniqKey="Whiteman D" first="David" last="Whiteman">David Whiteman</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Green, Adele" sort="Green, Adele" uniqKey="Green A" first="Adele" last="Green">Adele Green</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name><affiliation><nlm:aff id="A9">Lund Cancer Center Department of Oncology, University Hospital, Lund, Sweden, on behalf of Lund Melanoma Group</nlm:aff><wicri:noCountry code="subfield">on behalf of Lund Melanoma Group</wicri:noCountry></affiliation></author><author><name sortKey="Puig, Susana" sort="Puig, Susana" uniqKey="Puig S" first="Susana" last="Puig">Susana Puig</name><affiliation wicri:level="4"><nlm:aff id="A10">Dermatology Department, Melanoma Unit, Hospital Clínic, Institut de Investigació Biomèdica August Pi Suñe, Universitat de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Dermatology Department, Melanoma Unit, Hospital Clínic, Institut de Investigació Biomèdica August Pi Suñe, Universitat de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Oncology, Biology, and Genetics, University of Genova, Genova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, Biology, and Genetics, University of Genova, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Hansson, Johan" sort="Hansson, Johan" uniqKey="Hansson J" first="Johan" last="Hansson">Johan Hansson</name><affiliation wicri:level="3"><nlm:aff id="A12">Department of Oncology-Pathology, Karolinska Institute and Karolinska University Hospital, Solna, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology-Pathology, Karolinska Institute and Karolinska University Hospital, Solna, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><affiliation wicri:level="3"><nlm:aff id="A13">INSERM, U794, Fondation Jean-Dausset-CEPH, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U794, Fondation Jean-Dausset-CEPH, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name><affiliation wicri:level="2"><nlm:aff id="A14">Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name><affiliation wicri:level="3"><nlm:aff id="A15">Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Elder, David E" sort="Elder, David E" uniqKey="Elder D" first="David E." last="Elder">David E. Elder</name><affiliation wicri:level="2"><nlm:aff id="A16">Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Bishop, Julia Newton" sort="Bishop, Julia Newton" uniqKey="Bishop J" first="Julia Newton" last="Bishop">Julia Newton Bishop</name><affiliation wicri:level="1"><nlm:aff id="A17">Genetic Epidemiology Division, Cancer Research UK Clinical Centre, Leeds, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Genetic Epidemiology Division, Cancer Research UK Clinical Centre, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Kefford, Richard F" sort="Kefford, Richard F" uniqKey="Kefford R" first="Richard F." last="Kefford">Richard F. Kefford</name><affiliation><nlm:aff id="A5">Westmead Institute of Cancer Research and Sydney Melanoma Unit, University of Sydney at Westmead Millennium Institute, Westmead, NSW 2145 Australia</nlm:aff><wicri:noCountry code="subfield">NSW 2145 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A18">Cancer Epidemiology Centre, The Cancer Council Victoria, Carlton Victoria 3053 Australia</nlm:aff><wicri:noCountry code="subfield">Carlton Victoria 3053 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name><affiliation wicri:level="4"><nlm:aff id="A19">School of Public Health, University of Sydney, NSW 2006 Australia</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Aitken, Joanne F" sort="Aitken, Joanne F" uniqKey="Aitken J" first="Joanne F." last="Aitken">Joanne F. Aitken</name><affiliation><nlm:aff id="A8">Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Brisbane, QLD 4004 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4004 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="A7">Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, VIC 3052 Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Trent, Jeffrey M" sort="Trent, Jeffrey M" uniqKey="Trent J" first="Jeffrey M." last="Trent">Jeffrey M. Trent</name><affiliation wicri:level="2"><nlm:aff id="A20">Genetic Basis of Human Disease Division, The Translational Genomics Research Institute, Phoenix, AZ, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genetic Basis of Human Disease Division, The Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name><affiliation><nlm:aff id="A5">Westmead Institute of Cancer Research and Sydney Melanoma Unit, University of Sydney at Westmead Millennium Institute, Westmead, NSW 2145 Australia</nlm:aff><wicri:noCountry code="subfield">NSW 2145 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><affiliation><nlm:aff id="A2">The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, QLD 4029 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4029 Australia</wicri:noCountry></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totalling 2019 cases and 2105 controls. Using pooling we identified a novel melanoma risk locus on chromosome 20 (rs910873, rs1885120), with replication in two further samples (combined <italic>P</italic> <1 × 10<sup>-15</sup>). The odds ratio is 1.75 (1.53, 2.01), with evidence for stronger association in early onset cases.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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