AustralieFrV1, Main, Merge, bibRecord, 008E56

Early Responsiveness of Women with Osteoporosis to Teriparatide After Therapy with Alendronate or Risedronate

Identifieur interne : 008E56 ( Main/Merge ); précédent : 008E55; suivant : 008E57

Early Responsiveness of Women with Osteoporosis to Teriparatide After Therapy with Alendronate or Risedronate

Auteurs : Paul D. Miller ; Pierre D. Delmas ; Robert Lindsay ; Nelson B. Watts ; Marjorie Luckey ; Jonathan Adachi ; Kenneth Saag ; Susan L. Greenspan ; Ego Seeman ; Steven Boonen ; Suzanne Meeves ; Thomas F. Lang ; John P. Bilezikian

Source :

The Journal of Clinical Endocrinology and Metabolism [ 0021-972X ] ; 2008.

RBID : PMC:5399468

Abstract

Background: Anabolic responsiveness to teriparatide can be blunted or delayed in patients previously treated with alendronate. The extent of this effect is different for other antiresorptives. This study evaluated the early anabolic effects of teriparatide in postmenopausal women with osteoporosis previously treated with alendronate or risedronate.

Methods: Patients treated for at least 24 months with alendronate or risedronate discontinued their bisphosphonate and received teriparatide for 12 months. The primary endpoint was a comparison of changes from baseline in N-terminal propeptide of type 1 collagen after 3 months between prior bisphosphonate groups. We also examined changes in other bone turnover markers, bone mineral density (BMD), and relationships between early changes in bone turnover markers and 12-month areal and volumetric BMD.

Results: In the prior risedronate group, the N-terminal propeptide of type 1 collagen increase was significantly greater after 3 months of teriparatide than in the prior alendronate group (mean ± se, 86.0 ± 5.6 vs. 61.2 ± 5.3 ng/ml, respectively; P < 0.001). Findings were similar for the other bone turnover markers. The changes in areal BMD and trabecular spine volumetric BMD were also greater in the prior risedronate group (P < 0.05). Early changes in bone turnover markers correlated with changes in trabecular spine volumetric BMD at 12 months (Spearman r = 0.45). Teriparatide was well tolerated.

Conclusion: This nonrandomized but prospective study suggests that there may be differences in anabolic responsiveness to teriparatide as a function of the type of prior bisphosphonate exposure.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399468

DOI: 10.1210/jc.2008-0353
PubMed: 18682511
PubMed Central: 5399468

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PMC:5399468

Le document en format XML

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<author><name sortKey="Miller, Paul D" sort="Miller, Paul D" uniqKey="Miller P" first="Paul D." last="Miller">Paul D. Miller</name>
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<author><name sortKey="Delmas, Pierre D" sort="Delmas, Pierre D" uniqKey="Delmas P" first="Pierre D." last="Delmas">Pierre D. Delmas</name>
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<author><name sortKey="Lindsay, Robert" sort="Lindsay, Robert" uniqKey="Lindsay R" first="Robert" last="Lindsay">Robert Lindsay</name>
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<author><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B." last="Watts">Nelson B. Watts</name>
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<author><name sortKey="Luckey, Marjorie" sort="Luckey, Marjorie" uniqKey="Luckey M" first="Marjorie" last="Luckey">Marjorie Luckey</name>
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<author><name sortKey="Saag, Kenneth" sort="Saag, Kenneth" uniqKey="Saag K" first="Kenneth" last="Saag">Kenneth Saag</name>
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<author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L." last="Greenspan">Susan L. Greenspan</name>
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<author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name>
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<author><name sortKey="Meeves, Suzanne" sort="Meeves, Suzanne" uniqKey="Meeves S" first="Suzanne" last="Meeves">Suzanne Meeves</name>
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<author><name sortKey="Lang, Thomas F" sort="Lang, Thomas F" uniqKey="Lang T" first="Thomas F." last="Lang">Thomas F. Lang</name>
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<author><name sortKey="Bilezikian, John P" sort="Bilezikian, John P" uniqKey="Bilezikian J" first="John P." last="Bilezikian">John P. Bilezikian</name>
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<author><name sortKey="Miller, Paul D" sort="Miller, Paul D" uniqKey="Miller P" first="Paul D." last="Miller">Paul D. Miller</name>
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<author><name sortKey="Lindsay, Robert" sort="Lindsay, Robert" uniqKey="Lindsay R" first="Robert" last="Lindsay">Robert Lindsay</name>
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<author><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B." last="Watts">Nelson B. Watts</name>
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<author><name sortKey="Luckey, Marjorie" sort="Luckey, Marjorie" uniqKey="Luckey M" first="Marjorie" last="Luckey">Marjorie Luckey</name>
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<author><name sortKey="Adachi, Jonathan" sort="Adachi, Jonathan" uniqKey="Adachi J" first="Jonathan" last="Adachi">Jonathan Adachi</name>
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<author><name sortKey="Saag, Kenneth" sort="Saag, Kenneth" uniqKey="Saag K" first="Kenneth" last="Saag">Kenneth Saag</name>
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<author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L." last="Greenspan">Susan L. Greenspan</name>
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<author><name sortKey="Seeman, Ego" sort="Seeman, Ego" uniqKey="Seeman E" first="Ego" last="Seeman">Ego Seeman</name>
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<author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name>
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<author><name sortKey="Meeves, Suzanne" sort="Meeves, Suzanne" uniqKey="Meeves S" first="Suzanne" last="Meeves">Suzanne Meeves</name>
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<author><name sortKey="Lang, Thomas F" sort="Lang, Thomas F" uniqKey="Lang T" first="Thomas F." last="Lang">Thomas F. Lang</name>
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<author><name sortKey="Bilezikian, John P" sort="Bilezikian, John P" uniqKey="Bilezikian J" first="John P." last="Bilezikian">John P. Bilezikian</name>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Anabolic responsiveness to teriparatide can be blunted or
delayed in patients previously treated with alendronate. The extent of this effect is
different for other antiresorptives. This study evaluated the early anabolic effects of
teriparatide in postmenopausal women with osteoporosis previously treated with alendronate
or risedronate.</p>
<p><bold>Methods:</bold> Patients treated for at least 24 months with alendronate or
risedronate discontinued their bisphosphonate and received teriparatide for 12 months. The
primary endpoint was a comparison of changes from baseline in N-terminal propeptide of
type 1 collagen after 3 months between prior bisphosphonate groups. We also examined
changes in other bone turnover markers, bone mineral density (BMD), and relationships
between early changes in bone turnover markers and 12-month areal and volumetric BMD.</p>
<p><bold>Results:</bold> In the prior risedronate group, the N-terminal propeptide of type 1
collagen increase was significantly greater after 3 months of teriparatide than in the
prior alendronate group (mean ± <sc>se</sc>
, 86.0 ± 5.6 <italic>vs</italic>. 61.2 ± 5.3
ng/ml, respectively; <italic>P</italic> < 0.001). Findings were similar for the other
bone turnover markers. The changes in areal BMD and trabecular spine volumetric BMD were
also greater in the prior risedronate group (<italic>P</italic> < 0.05). Early changes
in bone turnover markers correlated with changes in trabecular spine volumetric BMD at 12
months (Spearman r = 0.45). Teriparatide was well tolerated.</p>
<p><bold>Conclusion:</bold> This nonrandomized but prospective study suggests that there may
be differences in anabolic responsiveness to teriparatide as a function of the type of
prior bisphosphonate exposure.</p>
</div>
</front>
</TEI>
</record>

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Early Responsiveness of Women with Osteoporosis to Teriparatide After Therapy with Alendronate or Risedronate

Early Responsiveness of Women with Osteoporosis to Teriparatide After Therapy with Alendronate or Risedronate

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Abstract

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