AustralieFrV1, Main, Merge, bibRecord, 007A21

The Paediatric Rheumatology International Trials Organisation Provisional Criteria for the Evaluation of Response to Therapy in Juvenile Dermatomyositis

Identifieur interne : 007A21 ( Main/Merge ); précédent : 007A20; suivant : 007A22

The Paediatric Rheumatology International Trials Organisation Provisional Criteria for the Evaluation of Response to Therapy in Juvenile Dermatomyositis

Auteurs : Nicolino Ruperto [Italie] ; Angela Pistorio [Italie] ; Angelo Ravelli [Italie] ; Lisa G. Rider [États-Unis] ; Clarissa Pilkington [Royaume-Uni] ; Sheila Oliveira [Brésil] ; Nico Wulffraat [Pays-Bas] ; Graciela Espada [Argentine] ; Stella Garay [Argentine] ; Ruben Cuttica [Argentine] ; Michael Hofer [Suisse] ; Pierre Quartier [France] ; Jose Melo-Gomes [Portugal] ; Ann M. Reed [États-Unis] ; Malgorzata Wierzbowska [Pologne] ; Brian M. Feldman [Canada] ; Miroslav Harjacek [Croatie] ; Hans-Iko Huppertz [Allemagne] ; Susan Nielsen [Danemark] ; Berit Flato [Norvège] ; Pekka Lahdenne [Finlande] ; Harmut Michels [Allemagne] ; Kevin J. Murray [Australie] ; Lynn Punaro [États-Unis] ; Robert Rennebohm [Canada] ; Ricardo Russo ; Zsolt Balogh ; Madeleine Rooney ; Lauren M. Pachman ; Carol Wallace ; Philip Hashkes ; Daniel J. Lovell ; Edward H. Giannini ; Boel Andersson Gare ; Alberto Martini [Italie]

Source :

Arthritis care and research [ 0893-7524 ] ; 2010.

RBID : Pascal:11-0009007

Descripteurs français

Pascal (Inist)
- Rhumatologie, Traitement, Dermatomyosite, Enfant, Adolescent.
Wicri :
- topic : Enfant.

English descriptors

KwdEn :
- Adolescent, Child, Dermatomyositis, Rheumatology, Treatment.

Abstract

Objective. To develop a provisional definition for the evaluation of response to therapy in juvenile dermatomyositis (DM) based on the Paediatric Rheumatology International Trials Organisation juvenile DM core set of variables. Methods. Thirty-seven experienced pediatric rheumatologists from 27 countries achieved consensus on 128 difficult patient profiles as clinically improved or not improved using a stepwise approach (patient's rating, statistical analysis, definition selection). Using the physicians' consensus ratings as the "gold standard measure," chi-square, sensitivity, specificity, false-positive and-negative rates, area under the receiver operating characteristic curve, and kappa agreement for candidate definitions of improvement were calculated. Definitions with kappa values >0.8 were multiplied by the face validity score to select the top definitions. Results. The top definition of improvement was at least 20% improvement from baseline in 3 of 6 core set variables with no more than 1 of the remaining worsening by more than 30%, which cannot be muscle strength. The second-highest scoring definition was at least 20% improvement from baseline in 3 of 6 core set variables with no more than 2 of the remaining worsening by more than 25%, which cannot be muscle strength (definition P1 selected by the International Myositis Assessment and Clinical Studies group). The third is similar to the second with the maximum amount of worsening set to 30%. This indicates convergent validity of the process. Conclusion. We propose a provisional data-driven definition of improvement that reflects well the consensus rating of experienced clinicians, which incorporates clinically meaningful change in core set variables in a composite end point for the evaluation of global response to therapy in juvenile DM.

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Le document en format XML

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<author><name sortKey="Espada, Graciela" sort="Espada, Graciela" uniqKey="Espada G" first="Graciela" last="Espada">Graciela Espada</name>
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<author><name sortKey="Cuttica, Ruben" sort="Cuttica, Ruben" uniqKey="Cuttica R" first="Ruben" last="Cuttica">Ruben Cuttica</name>
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<author><name sortKey="Hofer, Michael" sort="Hofer, Michael" uniqKey="Hofer M" first="Michael" last="Hofer">Michael Hofer</name>
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<author><name sortKey="Quartier, Pierre" sort="Quartier, Pierre" uniqKey="Quartier P" first="Pierre" last="Quartier">Pierre Quartier</name>
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<author><name sortKey="Melo Gomes, Jose" sort="Melo Gomes, Jose" uniqKey="Melo Gomes J" first="Jose" last="Melo-Gomes">Jose Melo-Gomes</name>
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<s2>Lisbon</s2>
<s3>PRT</s3>
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<author><name sortKey="Reed, Ann M" sort="Reed, Ann M" uniqKey="Reed A" first="Ann M." last="Reed">Ann M. Reed</name>
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<author><name sortKey="Wierzbowska, Malgorzata" sort="Wierzbowska, Malgorzata" uniqKey="Wierzbowska M" first="Malgorzata" last="Wierzbowska">Malgorzata Wierzbowska</name>
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<country>Pologne</country>
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<author><name sortKey="Feldman, Brian M" sort="Feldman, Brian M" uniqKey="Feldman B" first="Brian M." last="Feldman">Brian M. Feldman</name>
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<country>Canada</country>
<wicri:noRegion>University of Toronto and The Hospital for Sick Children</wicri:noRegion>
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<author><name sortKey="Harjacek, Miroslav" sort="Harjacek, Miroslav" uniqKey="Harjacek M" first="Miroslav" last="Harjacek">Miroslav Harjacek</name>
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</inist:fA14>
<country>Croatie</country>
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</author>
<author><name sortKey="Huppertz, Hans Iko" sort="Huppertz, Hans Iko" uniqKey="Huppertz H" first="Hans-Iko" last="Huppertz">Hans-Iko Huppertz</name>
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<author><name sortKey="Nielsen, Susan" sort="Nielsen, Susan" uniqKey="Nielsen S" first="Susan" last="Nielsen">Susan Nielsen</name>
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</affiliation>
</author>
<author><name sortKey="Flato, Berit" sort="Flato, Berit" uniqKey="Flato B" first="Berit" last="Flato">Berit Flato</name>
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<author><name sortKey="Lahdenne, Pekka" sort="Lahdenne, Pekka" uniqKey="Lahdenne P" first="Pekka" last="Lahdenne">Pekka Lahdenne</name>
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<author><name sortKey="Michels, Harmut" sort="Michels, Harmut" uniqKey="Michels H" first="Harmut" last="Michels">Harmut Michels</name>
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<author><name sortKey="Murray, Kevin J" sort="Murray, Kevin J" uniqKey="Murray K" first="Kevin J." last="Murray">Kevin J. Murray</name>
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<author><name sortKey="Punaro, Lynn" sort="Punaro, Lynn" uniqKey="Punaro L" first="Lynn" last="Punaro">Lynn Punaro</name>
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<s3>USA</s3>
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<placeName><settlement type="city">Dallas</settlement>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rennebohm, Robert" sort="Rennebohm, Robert" uniqKey="Rennebohm R" first="Robert" last="Rennebohm">Robert Rennebohm</name>
<affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Alberta Children's Hospital</s1>
<s2>Calgary, Alberta</s2>
<s3>CAN</s3>
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</inist:fA14>
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</affiliation>
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<author><name sortKey="Russo, Ricardo" sort="Russo, Ricardo" uniqKey="Russo R" first="Ricardo" last="Russo">Ricardo Russo</name>
</author>
<author><name sortKey="Balogh, Zsolt" sort="Balogh, Zsolt" uniqKey="Balogh Z" first="Zsolt" last="Balogh">Zsolt Balogh</name>
</author>
<author><name sortKey="Rooney, Madeleine" sort="Rooney, Madeleine" uniqKey="Rooney M" first="Madeleine" last="Rooney">Madeleine Rooney</name>
</author>
<author><name sortKey="Pachman, Lauren M" sort="Pachman, Lauren M" uniqKey="Pachman L" first="Lauren M." last="Pachman">Lauren M. Pachman</name>
</author>
<author><name sortKey="Wallace, Carol" sort="Wallace, Carol" uniqKey="Wallace C" first="Carol" last="Wallace">Carol Wallace</name>
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<author><name sortKey="Hashkes, Philip" sort="Hashkes, Philip" uniqKey="Hashkes P" first="Philip" last="Hashkes">Philip Hashkes</name>
</author>
<author><name sortKey="Lovell, Daniel J" sort="Lovell, Daniel J" uniqKey="Lovell D" first="Daniel J." last="Lovell">Daniel J. Lovell</name>
</author>
<author><name sortKey="Giannini, Edward H" sort="Giannini, Edward H" uniqKey="Giannini E" first="Edward H." last="Giannini">Edward H. Giannini</name>
</author>
<author><name sortKey="Andersson Gare, Boel" sort="Andersson Gare, Boel" uniqKey="Andersson Gare B" first="Boel" last="Andersson Gare">Boel Andersson Gare</name>
</author>
<author><name sortKey="Martini, Alberto" sort="Martini, Alberto" uniqKey="Martini A" first="Alberto" last="Martini">Alberto Martini</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The Paediatric Rheumatology International Trials Organisation Provisional Criteria for the Evaluation of Response to Therapy in Juvenile Dermatomyositis</title>
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<author><name sortKey="Pistorio, Angela" sort="Pistorio, Angela" uniqKey="Pistorio A" first="Angela" last="Pistorio">Angela Pistorio</name>
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<author><name sortKey="Ravelli, Angelo" sort="Ravelli, Angelo" uniqKey="Ravelli A" first="Angelo" last="Ravelli">Angelo Ravelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>IRCCS G. Gaslini, Pediatria II, Reumatologia, and Università degli Studi</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
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<author><name sortKey="Rider, Lisa G" sort="Rider, Lisa G" uniqKey="Rider L" first="Lisa G." last="Rider">Lisa G. Rider</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>National Institute of Environmental Health Sciences, NIH</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
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<placeName><region type="state">Maryland</region>
</placeName>
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</author>
<author><name sortKey="Pilkington, Clarissa" sort="Pilkington, Clarissa" uniqKey="Pilkington C" first="Clarissa" last="Pilkington">Clarissa Pilkington</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Great Ormond Street Hospital for Sick Children</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oliveira, Sheila" sort="Oliveira, Sheila" uniqKey="Oliveira S" first="Sheila" last="Oliveira">Sheila Oliveira</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira</s1>
<s2>Rio de Janeiro</s2>
<s3>BRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Brésil</country>
<placeName><settlement type="city">Rio de Janeiro</settlement>
<region type="state">État de Rio de Janeiro</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wulffraat, Nico" sort="Wulffraat, Nico" uniqKey="Wulffraat N" first="Nico" last="Wulffraat">Nico Wulffraat</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Wilhelmina Kinderziekenhuis</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Espada, Graciela" sort="Espada, Graciela" uniqKey="Espada G" first="Graciela" last="Espada">Graciela Espada</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Hospital de Ninos Ricardo Gutierrez</s1>
<s2>Buenos Aires</s2>
<s3>ARG</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Argentine</country>
<wicri:noRegion>Hospital de Ninos Ricardo Gutierrez</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garay, Stella" sort="Garay, Stella" uniqKey="Garay S" first="Stella" last="Garay">Stella Garay</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Hospital Sor Maria Ludovica</s1>
<s2>La Plata</s2>
<s3>ARG</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Argentine</country>
<wicri:noRegion>Hospital Sor Maria Ludovica</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cuttica, Ruben" sort="Cuttica, Ruben" uniqKey="Cuttica R" first="Ruben" last="Cuttica">Ruben Cuttica</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Hospital General de Ninos Pedro de Elizalde</s1>
<s2>Buenos Aires</s2>
<s3>ARG</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Argentine</country>
<wicri:noRegion>Hospital General de Ninos Pedro de Elizalde</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofer, Michael" sort="Hofer, Michael" uniqKey="Hofer M" first="Michael" last="Hofer">Michael Hofer</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Centre Multisite Romand de Rhumatologie Pediatrique</s1>
<s2>Lausanne</s2>
<s3>CHE</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quartier, Pierre" sort="Quartier, Pierre" uniqKey="Quartier P" first="Pierre" last="Quartier">Pierre Quartier</name>
<affiliation wicri:level="4"><inist:fA14 i1="12"><s1>Universite Paris-Descartes, Hopital Necker-Enfants Malades</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
</author>
<author><name sortKey="Melo Gomes, Jose" sort="Melo Gomes, Jose" uniqKey="Melo Gomes J" first="Jose" last="Melo-Gomes">Jose Melo-Gomes</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Instituto Portugues de Reumatologia</s1>
<s2>Lisbon</s2>
<s3>PRT</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Portugal</country>
<wicri:noRegion>Instituto Portugues de Reumatologia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reed, Ann M" sort="Reed, Ann M" uniqKey="Reed A" first="Ann M." last="Reed">Ann M. Reed</name>
<affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Mayo Clinic School of Medicine and Mayo Foundation</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wierzbowska, Malgorzata" sort="Wierzbowska, Malgorzata" uniqKey="Wierzbowska M" first="Malgorzata" last="Wierzbowska">Malgorzata Wierzbowska</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Institute of Rheumatology</s1>
<s2>Warsaw</s2>
<s3>POL</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Pologne</country>
<wicri:noRegion>Institute of Rheumatology</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Feldman, Brian M" sort="Feldman, Brian M" uniqKey="Feldman B" first="Brian M." last="Feldman">Brian M. Feldman</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>University of Toronto and The Hospital for Sick Children</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>University of Toronto and The Hospital for Sick Children</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Harjacek, Miroslav" sort="Harjacek, Miroslav" uniqKey="Harjacek M" first="Miroslav" last="Harjacek">Miroslav Harjacek</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Children's Hospital Zagreb</s1>
<s2>Zagreb</s2>
<s3>HRV</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Croatie</country>
<wicri:noRegion>Children's Hospital Zagreb</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huppertz, Hans Iko" sort="Huppertz, Hans Iko" uniqKey="Huppertz H" first="Hans-Iko" last="Huppertz">Hans-Iko Huppertz</name>
<affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Klinikum Bremen-Mitte</s1>
<s2>Bremen</s2>
<s3>DEU</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="3">Brême (Land)</region>
<settlement type="city">Brême</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nielsen, Susan" sort="Nielsen, Susan" uniqKey="Nielsen S" first="Susan" last="Nielsen">Susan Nielsen</name>
<affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Juliane Marie Centret, Rigshospitalet</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Flato, Berit" sort="Flato, Berit" uniqKey="Flato B" first="Berit" last="Flato">Berit Flato</name>
<affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Rikshospitalet University Hospital</s1>
<s2>Oslo</s2>
<s3>NOR</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Norvège</country>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lahdenne, Pekka" sort="Lahdenne, Pekka" uniqKey="Lahdenne P" first="Pekka" last="Lahdenne">Pekka Lahdenne</name>
<affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Hospital for Children and Adolescents</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Hospital for Children and Adolescents</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Michels, Harmut" sort="Michels, Harmut" uniqKey="Michels H" first="Harmut" last="Michels">Harmut Michels</name>
<affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Rheumakinderklinik</s1>
<s2>Garmisch-Parten-kirchen</s2>
<s3>DEU</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Garmisch-Parten-kirchen</wicri:noRegion>
<wicri:noRegion>Rheumakinderklinik</wicri:noRegion>
<wicri:noRegion>Rheumakinderklinik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Murray, Kevin J" sort="Murray, Kevin J" uniqKey="Murray K" first="Kevin J." last="Murray">Kevin J. Murray</name>
<affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Princess Margaret Hospital for Children</s1>
<s2>Perth, Western Australia</s2>
<s3>AUS</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Princess Margaret Hospital for Children</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Punaro, Lynn" sort="Punaro, Lynn" uniqKey="Punaro L" first="Lynn" last="Punaro">Lynn Punaro</name>
<affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Texas Scottish Rite Hospital</s1>
<s2>Dallas</s2>
<s3>USA</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Dallas</settlement>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rennebohm, Robert" sort="Rennebohm, Robert" uniqKey="Rennebohm R" first="Robert" last="Rennebohm">Robert Rennebohm</name>
<affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Alberta Children's Hospital</s1>
<s2>Calgary, Alberta</s2>
<s3>CAN</s3>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Alberta Children's Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Russo, Ricardo" sort="Russo, Ricardo" uniqKey="Russo R" first="Ricardo" last="Russo">Ricardo Russo</name>
</author>
<author><name sortKey="Balogh, Zsolt" sort="Balogh, Zsolt" uniqKey="Balogh Z" first="Zsolt" last="Balogh">Zsolt Balogh</name>
</author>
<author><name sortKey="Rooney, Madeleine" sort="Rooney, Madeleine" uniqKey="Rooney M" first="Madeleine" last="Rooney">Madeleine Rooney</name>
</author>
<author><name sortKey="Pachman, Lauren M" sort="Pachman, Lauren M" uniqKey="Pachman L" first="Lauren M." last="Pachman">Lauren M. Pachman</name>
</author>
<author><name sortKey="Wallace, Carol" sort="Wallace, Carol" uniqKey="Wallace C" first="Carol" last="Wallace">Carol Wallace</name>
</author>
<author><name sortKey="Hashkes, Philip" sort="Hashkes, Philip" uniqKey="Hashkes P" first="Philip" last="Hashkes">Philip Hashkes</name>
</author>
<author><name sortKey="Lovell, Daniel J" sort="Lovell, Daniel J" uniqKey="Lovell D" first="Daniel J." last="Lovell">Daniel J. Lovell</name>
</author>
<author><name sortKey="Giannini, Edward H" sort="Giannini, Edward H" uniqKey="Giannini E" first="Edward H." last="Giannini">Edward H. Giannini</name>
</author>
<author><name sortKey="Andersson Gare, Boel" sort="Andersson Gare, Boel" uniqKey="Andersson Gare B" first="Boel" last="Andersson Gare">Boel Andersson Gare</name>
</author>
<author><name sortKey="Martini, Alberto" sort="Martini, Alberto" uniqKey="Martini A" first="Alberto" last="Martini">Alberto Martini</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>IRCCS G. Gaslini, Pediatria II, Reumatologia, and Università degli Studi</s1>
<s2>Genoa</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>35 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Arthritis care and research</title>
<title level="j" type="abbreviated">Arthritis care res.</title>
<idno type="ISSN">0893-7524</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Arthritis care and research</title>
<title level="j" type="abbreviated">Arthritis care res.</title>
<idno type="ISSN">0893-7524</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Child</term>
<term>Dermatomyositis</term>
<term>Rheumatology</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Rhumatologie</term>
<term>Traitement</term>
<term>Dermatomyosite</term>
<term>Enfant</term>
<term>Adolescent</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective. To develop a provisional definition for the evaluation of response to therapy in juvenile dermatomyositis (DM) based on the Paediatric Rheumatology International Trials Organisation juvenile DM core set of variables. Methods. Thirty-seven experienced pediatric rheumatologists from 27 countries achieved consensus on 128 difficult patient profiles as clinically improved or not improved using a stepwise approach (patient's rating, statistical analysis, definition selection). Using the physicians' consensus ratings as the "gold standard measure," chi-square, sensitivity, specificity, false-positive and-negative rates, area under the receiver operating characteristic curve, and kappa agreement for candidate definitions of improvement were calculated. Definitions with kappa values >0.8 were multiplied by the face validity score to select the top definitions. Results. The top definition of improvement was at least 20% improvement from baseline in 3 of 6 core set variables with no more than 1 of the remaining worsening by more than 30%, which cannot be muscle strength. The second-highest scoring definition was at least 20% improvement from baseline in 3 of 6 core set variables with no more than 2 of the remaining worsening by more than 25%, which cannot be muscle strength (definition P1 selected by the International Myositis Assessment and Clinical Studies group). The third is similar to the second with the maximum amount of worsening set to 30%. This indicates convergent validity of the process. Conclusion. We propose a provisional data-driven definition of improvement that reflects well the consensus rating of experienced clinicians, which incorporates clinically meaningful change in core set variables in a composite end point for the evaluation of global response to therapy in juvenile DM.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Argentine</li>
<li>Australie</li>
<li>Brésil</li>
<li>Canada</li>
<li>Croatie</li>
<li>Danemark</li>
<li>Finlande</li>
<li>France</li>
<li>Italie</li>
<li>Norvège</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>Portugal</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Brême (Land)</li>
<li>Canton de Vaud</li>
<li>Grand Londres</li>
<li>Hovedstaden</li>
<li>Maryland</li>
<li>Minnesota</li>
<li>Texas</li>
<li>Utrecht (province)</li>
<li>État de Rio de Janeiro</li>
<li>Île-de-France</li>
<li>Østlandet</li>
</region>
<settlement><li>Brême</li>
<li>Copenhague</li>
<li>Dallas</li>
<li>Lausanne</li>
<li>Londres</li>
<li>Oslo</li>
<li>Paris</li>
<li>Rio de Janeiro</li>
<li>Utrecht</li>
</settlement>
<orgName><li>Université Paris-Descartes</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Andersson Gare, Boel" sort="Andersson Gare, Boel" uniqKey="Andersson Gare B" first="Boel" last="Andersson Gare">Boel Andersson Gare</name>
<name sortKey="Balogh, Zsolt" sort="Balogh, Zsolt" uniqKey="Balogh Z" first="Zsolt" last="Balogh">Zsolt Balogh</name>
<name sortKey="Giannini, Edward H" sort="Giannini, Edward H" uniqKey="Giannini E" first="Edward H." last="Giannini">Edward H. Giannini</name>
<name sortKey="Hashkes, Philip" sort="Hashkes, Philip" uniqKey="Hashkes P" first="Philip" last="Hashkes">Philip Hashkes</name>
<name sortKey="Lovell, Daniel J" sort="Lovell, Daniel J" uniqKey="Lovell D" first="Daniel J." last="Lovell">Daniel J. Lovell</name>
<name sortKey="Pachman, Lauren M" sort="Pachman, Lauren M" uniqKey="Pachman L" first="Lauren M." last="Pachman">Lauren M. Pachman</name>
<name sortKey="Rooney, Madeleine" sort="Rooney, Madeleine" uniqKey="Rooney M" first="Madeleine" last="Rooney">Madeleine Rooney</name>
<name sortKey="Russo, Ricardo" sort="Russo, Ricardo" uniqKey="Russo R" first="Ricardo" last="Russo">Ricardo Russo</name>
<name sortKey="Wallace, Carol" sort="Wallace, Carol" uniqKey="Wallace C" first="Carol" last="Wallace">Carol Wallace</name>
</noCountry>
<country name="Italie"><noRegion><name sortKey="Ruperto, Nicolino" sort="Ruperto, Nicolino" uniqKey="Ruperto N" first="Nicolino" last="Ruperto">Nicolino Ruperto</name>
</noRegion>
<name sortKey="Martini, Alberto" sort="Martini, Alberto" uniqKey="Martini A" first="Alberto" last="Martini">Alberto Martini</name>
<name sortKey="Pistorio, Angela" sort="Pistorio, Angela" uniqKey="Pistorio A" first="Angela" last="Pistorio">Angela Pistorio</name>
<name sortKey="Ravelli, Angelo" sort="Ravelli, Angelo" uniqKey="Ravelli A" first="Angelo" last="Ravelli">Angelo Ravelli</name>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="Rider, Lisa G" sort="Rider, Lisa G" uniqKey="Rider L" first="Lisa G." last="Rider">Lisa G. Rider</name>
</region>
<name sortKey="Punaro, Lynn" sort="Punaro, Lynn" uniqKey="Punaro L" first="Lynn" last="Punaro">Lynn Punaro</name>
<name sortKey="Reed, Ann M" sort="Reed, Ann M" uniqKey="Reed A" first="Ann M." last="Reed">Ann M. Reed</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Pilkington, Clarissa" sort="Pilkington, Clarissa" uniqKey="Pilkington C" first="Clarissa" last="Pilkington">Clarissa Pilkington</name>
</region>
</country>
<country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="Oliveira, Sheila" sort="Oliveira, Sheila" uniqKey="Oliveira S" first="Sheila" last="Oliveira">Sheila Oliveira</name>
</region>
</country>
<country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Wulffraat, Nico" sort="Wulffraat, Nico" uniqKey="Wulffraat N" first="Nico" last="Wulffraat">Nico Wulffraat</name>
</region>
</country>
<country name="Argentine"><noRegion><name sortKey="Espada, Graciela" sort="Espada, Graciela" uniqKey="Espada G" first="Graciela" last="Espada">Graciela Espada</name>
</noRegion>
<name sortKey="Cuttica, Ruben" sort="Cuttica, Ruben" uniqKey="Cuttica R" first="Ruben" last="Cuttica">Ruben Cuttica</name>
<name sortKey="Garay, Stella" sort="Garay, Stella" uniqKey="Garay S" first="Stella" last="Garay">Stella Garay</name>
</country>
<country name="Suisse"><region name="Canton de Vaud"><name sortKey="Hofer, Michael" sort="Hofer, Michael" uniqKey="Hofer M" first="Michael" last="Hofer">Michael Hofer</name>
</region>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Quartier, Pierre" sort="Quartier, Pierre" uniqKey="Quartier P" first="Pierre" last="Quartier">Pierre Quartier</name>
</region>
</country>
<country name="Portugal"><noRegion><name sortKey="Melo Gomes, Jose" sort="Melo Gomes, Jose" uniqKey="Melo Gomes J" first="Jose" last="Melo-Gomes">Jose Melo-Gomes</name>
</noRegion>
</country>
<country name="Pologne"><noRegion><name sortKey="Wierzbowska, Malgorzata" sort="Wierzbowska, Malgorzata" uniqKey="Wierzbowska M" first="Malgorzata" last="Wierzbowska">Malgorzata Wierzbowska</name>
</noRegion>
</country>
<country name="Canada"><noRegion><name sortKey="Feldman, Brian M" sort="Feldman, Brian M" uniqKey="Feldman B" first="Brian M." last="Feldman">Brian M. Feldman</name>
</noRegion>
<name sortKey="Rennebohm, Robert" sort="Rennebohm, Robert" uniqKey="Rennebohm R" first="Robert" last="Rennebohm">Robert Rennebohm</name>
</country>
<country name="Croatie"><noRegion><name sortKey="Harjacek, Miroslav" sort="Harjacek, Miroslav" uniqKey="Harjacek M" first="Miroslav" last="Harjacek">Miroslav Harjacek</name>
</noRegion>
</country>
<country name="Allemagne"><region name="Brême (Land)"><name sortKey="Huppertz, Hans Iko" sort="Huppertz, Hans Iko" uniqKey="Huppertz H" first="Hans-Iko" last="Huppertz">Hans-Iko Huppertz</name>
</region>
<name sortKey="Michels, Harmut" sort="Michels, Harmut" uniqKey="Michels H" first="Harmut" last="Michels">Harmut Michels</name>
</country>
<country name="Danemark"><region name="Hovedstaden"><name sortKey="Nielsen, Susan" sort="Nielsen, Susan" uniqKey="Nielsen S" first="Susan" last="Nielsen">Susan Nielsen</name>
</region>
</country>
<country name="Norvège"><region name="Østlandet"><name sortKey="Flato, Berit" sort="Flato, Berit" uniqKey="Flato B" first="Berit" last="Flato">Berit Flato</name>
</region>
</country>
<country name="Finlande"><noRegion><name sortKey="Lahdenne, Pekka" sort="Lahdenne, Pekka" uniqKey="Lahdenne P" first="Pekka" last="Lahdenne">Pekka Lahdenne</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Murray, Kevin J" sort="Murray, Kevin J" uniqKey="Murray K" first="Kevin J." last="Murray">Kevin J. Murray</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     Pascal:11-0009007
   |texte=   The Paediatric Rheumatology International Trials Organisation Provisional Criteria for the Evaluation of Response to Therapy in Juvenile Dermatomyositis
}}

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	Serveur d'exploration sur les relations entre la France et l'Australie
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Serveur d'exploration sur les relations entre la France et l'Australie

The Paediatric Rheumatology International Trials Organisation Provisional Criteria for the Evaluation of Response to Therapy in Juvenile Dermatomyositis

The Paediatric Rheumatology International Trials Organisation Provisional Criteria for the Evaluation of Response to Therapy in Juvenile Dermatomyositis

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