A Case-Control Study of Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients
Identifieur interne : 007278 ( Main/Merge ); précédent : 007277; suivant : 007279A Case-Control Study of Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients
Auteurs : C. M. Proby [Royaume-Uni] ; C. A. Harwood [Royaume-Uni] ; R. E. Neale [Australie] ; A. C. Green [Australie] ; S. Euvrard [France] ; L. Naldi [Italie] ; G. Tessari [Italie] ; M. C. W. Feltkamp [Pays-Bas] ; M. N. C. De Koning [Pays-Bas] ; W. G. V. Quint [Pays-Bas] ; T. Waterboer [Allemagne] ; M. Pawlita [Allemagne] ; S. Weissenborn [Allemagne] ; U. Wieland [Pays-Bas] ; H. Pfister [Allemagne] ; E. Stockfleth [Allemagne] ; I. Nindl [Allemagne] ; D. Abeni [Italie] ; J. Ter Schegget [Pays-Bas] ; J. N. Bouwes Bavinck [Pays-Bas]Source :
- American journal of transplantation : (Print) [ 1600-6135 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Santé publique.
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Abstract
We examined the association between betapapillomavirus (betaPV) infection and cutaneous squamous cell carcinoma (SCC) in organ transplant recipients. A total of 210 organ transplant recipients with previous SCC and 394 controls without skin cancer were included. The presence of 25 betaPV types in plucked eyebrow hairs was determined using a human papillomavirus (HPV) DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types were detected using multiplex serology. We used multivariate logistic regression models to estimate associations between various measures of betaPV infection and SCC. BetaPV DNA was highly prevalent (>94%) with multiple types frequently detected in both groups. We found a significant association between SCC and the concordant detection of both antibodies and DNA for at least one betaPV type (adjusted OR 1.6; 95% CI 1.1;2.5). A borderline-significant association with SCC was found for HPV36 (adjusted OR 2.4; CI 1.0;5.4), with similar associations for HPV5, HPV9 and HPV24. These data provide further evidence of an association between betaPV infection and SCC in organ transplant recipients. Confirmation of a betaPV profile predictive of risk for SCC may pave the way for clinically relevant pretransplant HPV screening and the development of preventive and therapeutic HPV vaccination.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A Case-Control Study of Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients</title><author><name sortKey="Proby, C M" sort="Proby, C M" uniqKey="Proby C" first="C. M." last="Proby">C. M. Proby</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Centre for Cutaneous Research, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Harwood, C A" sort="Harwood, C A" uniqKey="Harwood C" first="C. A." last="Harwood">C. A. Harwood</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Centre for Cutaneous Research, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Neale, R E" sort="Neale, R E" uniqKey="Neale R" first="R. E." last="Neale">R. E. Neale</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Cancer and Population Studies, Queensland Institute of Medical Research, 300 Herston Rd</s1><s2>4006 Brisbane</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>4006 Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Green, A C" sort="Green, A C" uniqKey="Green A" first="A. C." last="Green">A. C. Green</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Cancer and Population Studies, Queensland Institute of Medical Research, 300 Herston Rd</s1><s2>4006 Brisbane</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>4006 Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Euvrard, S" sort="Euvrard, S" uniqKey="Euvrard S" first="S." last="Euvrard">S. Euvrard</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Dermatology, Edouard Herriot Hospital, Hospices Civils de Lyon, 5, Place d'Arsonval</s1><s2>69437 Lyon</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>69437 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Naldi, L" sort="Naldi, L" uniqKey="Naldi L" first="L." last="Naldi">L. Naldi</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Dermatology and GISED Study Center, Ospedali Riuniti, Largo Barozzi, 1</s1><s2>24128 Bergamo</s2><s3>ITA</s3><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>24128 Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Tessari, G" sort="Tessari, G" uniqKey="Tessari G" first="G." last="Tessari">G. Tessari</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Dirigente medico 1 Livello, U.O.Clinica Dermatologica Azanda Ospedaliera di Verona, Ospedale Civile Maggiore</s1><s2>37126 Verona</s2><s3>ITA</s3><sZ>7 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>37126 Verona</wicri:noRegion></affiliation></author><author><name sortKey="Feltkamp, M C W" sort="Feltkamp, M C W" uniqKey="Feltkamp M" first="M. C. W." last="Feltkamp">M. C. W. Feltkamp</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Medical Microbiology, Leiden University Medical Center, Albinusdreef</s1><s2>2333ZA Leiden</s2><s3>NLD</s3><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Koning, M N C" sort="De Koning, M N C" uniqKey="De Koning M" first="M. N. C." last="De Koning">M. N. C. De Koning</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>DDL Diagnostic Laboratory, Fonteynenburghlaan 7</s1><s2>2275 CX Voorburg</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>14 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>2275 CX Voorburg</wicri:noRegion></affiliation></author><author><name sortKey="Quint, W G V" sort="Quint, W G V" uniqKey="Quint W" first="W. G. V." last="Quint">W. G. V. Quint</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>DDL Diagnostic Laboratory, Fonteynenburghlaan 7</s1><s2>2275 CX Voorburg</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>14 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>2275 CX Voorburg</wicri:noRegion></affiliation></author><author><name sortKey="Waterboer, T" sort="Waterboer, T" uniqKey="Waterboer T" first="T." last="Waterboer">T. Waterboer</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Infection and Cancer Program (F020) German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242</s1><s2>69120 Heidelberg</s2><s3>DEU</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Pawlita, M" sort="Pawlita, M" uniqKey="Pawlita M" first="M." last="Pawlita">M. Pawlita</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Infection and Cancer Program (F020) German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242</s1><s2>69120 Heidelberg</s2><s3>DEU</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Weissenborn, S" sort="Weissenborn, S" uniqKey="Weissenborn S" first="S." last="Weissenborn">S. Weissenborn</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Institute of Virology, University of Cologne, Fürst-Pückler-Str. 56</s1><s2>50935 Cologne</s2><s3>DEU</s3><sZ>13 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Wieland, U" sort="Wieland, U" uniqKey="Wieland U" first="U." last="Wieland">U. Wieland</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>DDL Diagnostic Laboratory, Fonteynenburghlaan 7</s1><s2>2275 CX Voorburg</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>14 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>2275 CX Voorburg</wicri:noRegion></affiliation></author><author><name sortKey="Pfister, H" sort="Pfister, H" uniqKey="Pfister H" first="H." last="Pfister">H. Pfister</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Institute of Virology, University of Cologne, Fürst-Pückler-Str. 56</s1><s2>50935 Cologne</s2><s3>DEU</s3><sZ>13 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Stockfleth, E" sort="Stockfleth, E" uniqKey="Stockfleth E" first="E." last="Stockfleth">E. Stockfleth</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Dermatology, University Hospital Charité, Skin Cancer Center Charité, Charitéplatz 1</s1><s2>10117 Berlin</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Nindl, I" sort="Nindl, I" uniqKey="Nindl I" first="I." last="Nindl">I. Nindl</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Dermatology, University Hospital Charité, Skin Cancer Center Charité, Charitéplatz 1</s1><s2>10117 Berlin</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Abeni, D" sort="Abeni, D" uniqKey="Abeni D" first="D." last="Abeni">D. Abeni</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Health Services Research Unit, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Via dei Monti di Creta 104</s1><s2>00167 Rome</s2><s3>ITA</s3><sZ>18 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Ter Schegget, J" sort="Ter Schegget, J" uniqKey="Ter Schegget J" first="J." last="Ter Schegget">J. Ter Schegget</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>DDL Diagnostic Laboratory, Fonteynenburghlaan 7</s1><s2>2275 CX Voorburg</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>14 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>2275 CX Voorburg</wicri:noRegion></affiliation></author><author><name sortKey="Bouwes Bavinck, J N" sort="Bouwes Bavinck, J N" uniqKey="Bouwes Bavinck J" first="J. N." last="Bouwes Bavinck">J. N. Bouwes Bavinck</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Dermatology, Leiden University Medical Center, Albinusdreef 2</s1><s2>2333ZA Leiden</s2><s3>NLD</s3><sZ>20 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0364657</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0364657 INIST</idno><idno type="RBID">Pascal:11-0364657</idno><idno type="wicri:Area/PascalFrancis/Corpus">001A55</idno><idno type="wicri:Area/PascalFrancis/Curation">004489</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001E27</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001E27</idno><idno type="wicri:doubleKey">1600-6135:2011:Proby C:a:case:control</idno><idno type="wicri:Area/Main/Merge">007278</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A Case-Control Study of Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients</title><author><name sortKey="Proby, C M" sort="Proby, C M" uniqKey="Proby C" first="C. M." last="Proby">C. M. Proby</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Centre for Cutaneous Research, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Harwood, C A" sort="Harwood, C A" uniqKey="Harwood C" first="C. A." last="Harwood">C. A. Harwood</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Centre for Cutaneous Research, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Neale, R E" sort="Neale, R E" uniqKey="Neale R" first="R. E." last="Neale">R. E. Neale</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Cancer and Population Studies, Queensland Institute of Medical Research, 300 Herston Rd</s1><s2>4006 Brisbane</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>4006 Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Green, A C" sort="Green, A C" uniqKey="Green A" first="A. C." last="Green">A. C. Green</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Cancer and Population Studies, Queensland Institute of Medical Research, 300 Herston Rd</s1><s2>4006 Brisbane</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>4006 Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Euvrard, S" sort="Euvrard, S" uniqKey="Euvrard S" first="S." last="Euvrard">S. Euvrard</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Dermatology, Edouard Herriot Hospital, Hospices Civils de Lyon, 5, Place d'Arsonval</s1><s2>69437 Lyon</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>69437 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Naldi, L" sort="Naldi, L" uniqKey="Naldi L" first="L." last="Naldi">L. Naldi</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Dermatology and GISED Study Center, Ospedali Riuniti, Largo Barozzi, 1</s1><s2>24128 Bergamo</s2><s3>ITA</s3><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>24128 Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Tessari, G" sort="Tessari, G" uniqKey="Tessari G" first="G." last="Tessari">G. Tessari</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Dirigente medico 1 Livello, U.O.Clinica Dermatologica Azanda Ospedaliera di Verona, Ospedale Civile Maggiore</s1><s2>37126 Verona</s2><s3>ITA</s3><sZ>7 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>37126 Verona</wicri:noRegion></affiliation></author><author><name sortKey="Feltkamp, M C W" sort="Feltkamp, M C W" uniqKey="Feltkamp M" first="M. C. W." last="Feltkamp">M. C. W. Feltkamp</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Medical Microbiology, Leiden University Medical Center, Albinusdreef</s1><s2>2333ZA Leiden</s2><s3>NLD</s3><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Koning, M N C" sort="De Koning, M N C" uniqKey="De Koning M" first="M. N. C." last="De Koning">M. N. C. De Koning</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>DDL Diagnostic Laboratory, Fonteynenburghlaan 7</s1><s2>2275 CX Voorburg</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>14 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>2275 CX Voorburg</wicri:noRegion></affiliation></author><author><name sortKey="Quint, W G V" sort="Quint, W G V" uniqKey="Quint W" first="W. G. V." last="Quint">W. G. V. Quint</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>DDL Diagnostic Laboratory, Fonteynenburghlaan 7</s1><s2>2275 CX Voorburg</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>14 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>2275 CX Voorburg</wicri:noRegion></affiliation></author><author><name sortKey="Waterboer, T" sort="Waterboer, T" uniqKey="Waterboer T" first="T." last="Waterboer">T. Waterboer</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Infection and Cancer Program (F020) German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242</s1><s2>69120 Heidelberg</s2><s3>DEU</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Pawlita, M" sort="Pawlita, M" uniqKey="Pawlita M" first="M." last="Pawlita">M. Pawlita</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Infection and Cancer Program (F020) German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242</s1><s2>69120 Heidelberg</s2><s3>DEU</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Weissenborn, S" sort="Weissenborn, S" uniqKey="Weissenborn S" first="S." last="Weissenborn">S. Weissenborn</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Institute of Virology, University of Cologne, Fürst-Pückler-Str. 56</s1><s2>50935 Cologne</s2><s3>DEU</s3><sZ>13 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Wieland, U" sort="Wieland, U" uniqKey="Wieland U" first="U." last="Wieland">U. Wieland</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>DDL Diagnostic Laboratory, Fonteynenburghlaan 7</s1><s2>2275 CX Voorburg</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>14 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>2275 CX Voorburg</wicri:noRegion></affiliation></author><author><name sortKey="Pfister, H" sort="Pfister, H" uniqKey="Pfister H" first="H." last="Pfister">H. Pfister</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Institute of Virology, University of Cologne, Fürst-Pückler-Str. 56</s1><s2>50935 Cologne</s2><s3>DEU</s3><sZ>13 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Stockfleth, E" sort="Stockfleth, E" uniqKey="Stockfleth E" first="E." last="Stockfleth">E. Stockfleth</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Dermatology, University Hospital Charité, Skin Cancer Center Charité, Charitéplatz 1</s1><s2>10117 Berlin</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Nindl, I" sort="Nindl, I" uniqKey="Nindl I" first="I." last="Nindl">I. Nindl</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Dermatology, University Hospital Charité, Skin Cancer Center Charité, Charitéplatz 1</s1><s2>10117 Berlin</s2><s3>DEU</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Abeni, D" sort="Abeni, D" uniqKey="Abeni D" first="D." last="Abeni">D. Abeni</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Health Services Research Unit, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Via dei Monti di Creta 104</s1><s2>00167 Rome</s2><s3>ITA</s3><sZ>18 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Ter Schegget, J" sort="Ter Schegget, J" uniqKey="Ter Schegget J" first="J." last="Ter Schegget">J. Ter Schegget</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>DDL Diagnostic Laboratory, Fonteynenburghlaan 7</s1><s2>2275 CX Voorburg</s2><s3>NLD</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>14 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>2275 CX Voorburg</wicri:noRegion></affiliation></author><author><name sortKey="Bouwes Bavinck, J N" sort="Bouwes Bavinck, J N" uniqKey="Bouwes Bavinck J" first="J. N." last="Bouwes Bavinck">J. N. Bouwes Bavinck</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Dermatology, Leiden University Medical Center, Albinusdreef 2</s1><s2>2333ZA Leiden</s2><s3>NLD</s3><sZ>20 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j" type="main">American journal of transplantation : (Print)</title><title level="j" type="abbreviated">Am. j. transplant. : (Print)</title><idno type="ISSN">1600-6135</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">American journal of transplantation : (Print)</title><title level="j" type="abbreviated">Am. j. transplant. : (Print)</title><idno type="ISSN">1600-6135</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case control study</term><term>Epidemiology</term><term>Homotransplantation</term><term>Infection</term><term>Organ</term><term>Public health</term><term>Skin cancer</term><term>Skin squamous cell carcinoma</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Infection</term><term>Etude cas témoin</term><term>Epidémiologie</term><term>Carcinome épidermoïde de la peau</term><term>Santé publique</term><term>Organe</term><term>Cancer de la peau</term><term>Homotransplantation</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Santé publique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We examined the association between betapapillomavirus (betaPV) infection and cutaneous squamous cell carcinoma (SCC) in organ transplant recipients. A total of 210 organ transplant recipients with previous SCC and 394 controls without skin cancer were included. The presence of 25 betaPV types in plucked eyebrow hairs was determined using a human papillomavirus (HPV) DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types were detected using multiplex serology. We used multivariate logistic regression models to estimate associations between various measures of betaPV infection and SCC. BetaPV DNA was highly prevalent (>94%) with multiple types frequently detected in both groups. We found a significant association between SCC and the concordant detection of both antibodies and DNA for at least one betaPV type (adjusted OR 1.6; 95% CI 1.1;2.5). A borderline-significant association with SCC was found for HPV36 (adjusted OR 2.4; CI 1.0;5.4), with similar associations for HPV5, HPV9 and HPV24. These data provide further evidence of an association between betaPV infection and SCC in organ transplant recipients. Confirmation of a betaPV profile predictive of risk for SCC may pave the way for clinically relevant pretransplant HPV screening and the development of preventive and therapeutic HPV vaccination.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Berlin</li><li>District de Cologne</li><li>District de Karlsruhe</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Latium</li><li>Rhénanie-du-Nord-Westphalie</li><li>Rhône-Alpes</li></region><settlement><li>Berlin</li><li>Cologne</li><li>Heidelberg</li><li>Leyde</li><li>Londres</li><li>Lyon</li><li>Rome</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Proby, C M" sort="Proby, C M" uniqKey="Proby C" first="C. M." last="Proby">C. M. Proby</name></region><name sortKey="Harwood, C A" sort="Harwood, C A" uniqKey="Harwood C" first="C. A." last="Harwood">C. A. Harwood</name></country><country name="Australie"><noRegion><name sortKey="Neale, R E" sort="Neale, R E" uniqKey="Neale R" first="R. E." last="Neale">R. E. Neale</name></noRegion><name sortKey="Green, A C" sort="Green, A C" uniqKey="Green A" first="A. C." last="Green">A. C. Green</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Euvrard, S" sort="Euvrard, S" uniqKey="Euvrard S" first="S." last="Euvrard">S. Euvrard</name></region></country><country name="Italie"><noRegion><name sortKey="Naldi, L" sort="Naldi, L" uniqKey="Naldi L" first="L." last="Naldi">L. Naldi</name></noRegion><name sortKey="Abeni, D" sort="Abeni, D" uniqKey="Abeni D" first="D." last="Abeni">D. Abeni</name><name sortKey="Tessari, G" sort="Tessari, G" uniqKey="Tessari G" first="G." last="Tessari">G. Tessari</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Feltkamp, M C W" sort="Feltkamp, M C W" uniqKey="Feltkamp M" first="M. C. W." last="Feltkamp">M. C. W. Feltkamp</name></region><name sortKey="Bouwes Bavinck, J N" sort="Bouwes Bavinck, J N" uniqKey="Bouwes Bavinck J" first="J. N." last="Bouwes Bavinck">J. N. Bouwes Bavinck</name><name sortKey="De Koning, M N C" sort="De Koning, M N C" uniqKey="De Koning M" first="M. N. C." last="De Koning">M. N. C. De Koning</name><name sortKey="Quint, W G V" sort="Quint, W G V" uniqKey="Quint W" first="W. G. V." last="Quint">W. G. V. Quint</name><name sortKey="Ter Schegget, J" sort="Ter Schegget, J" uniqKey="Ter Schegget J" first="J." last="Ter Schegget">J. Ter Schegget</name><name sortKey="Wieland, U" sort="Wieland, U" uniqKey="Wieland U" first="U." last="Wieland">U. Wieland</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Waterboer, T" sort="Waterboer, T" uniqKey="Waterboer T" first="T." last="Waterboer">T. Waterboer</name></region><name sortKey="Nindl, I" sort="Nindl, I" uniqKey="Nindl I" first="I." last="Nindl">I. Nindl</name><name sortKey="Pawlita, M" sort="Pawlita, M" uniqKey="Pawlita M" first="M." last="Pawlita">M. Pawlita</name><name sortKey="Pfister, H" sort="Pfister, H" uniqKey="Pfister H" first="H." last="Pfister">H. Pfister</name><name sortKey="Stockfleth, E" sort="Stockfleth, E" uniqKey="Stockfleth E" first="E." last="Stockfleth">E. Stockfleth</name><name sortKey="Weissenborn, S" sort="Weissenborn, S" uniqKey="Weissenborn S" first="S." last="Weissenborn">S. Weissenborn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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