Independent and joint effects of the MAPT and SNCA genes in Parkinson disease
Identifieur interne : 006786 ( Main/Merge ); précédent : 006785; suivant : 006787Independent and joint effects of the MAPT and SNCA genes in Parkinson disease
Auteurs : Alexis Elbaz [France] ; Owen A. Ross [États-Unis] ; John P. A. Ioannidis [Grèce, États-Unis] ; Alexandra I. Soto-Ortolaza [États-Unis] ; Frédéric Moisan [France] ; Jan Aasly [Norvège] ; Grazia Annesi [Italie] ; Maria Bozi [Grèce] ; Laura Brighina [Italie] ; Marie-Christine Chartier-Harlin [France] ; Alain Destée [France] ; Carlo Ferrarese [Italie] ; Alessandro Ferraris [Italie] ; J. Mark Gibson [Irlande (pays)] ; Suzana Gispert [Allemagne] ; Georgios M. Hadjigeorgiou [Grèce] ; Barbara Jasinska-Myga [Pologne] ; Christine Klein [Allemagne] ; Rejko Krüger [Allemagne] ; Jean-Charles Lambert [France] ; Katja Lohmann [Allemagne] ; Simone Van De Loo [Allemagne] ; Marie-Anne Loriot [France] ; Timothy Lynch [Irlande (pays)] ; George D. Mellick [Australie] ; Eugénie Mutez [France] ; Christer Nilsson [Suède] ; Grzegorz Opala [Pologne] ; Andreas Puschmann [Suède] ; Aldo Quattrone [Italie] ; Manu Sharma [Allemagne] ; Peter A. Silburn [Australie] ; Leonidas Stefanis [Grèce] ; Ryan J. Uitti [États-Unis] ; Enza Maria Valente [Italie] ; Carles Vilari O-Güell [États-Unis, Canada] ; Karin Wirdefeldt [Suède] ; Zbigniew K. Wszolek [États-Unis] ; Georgia Xiromerisiou [Grèce] ; Demetrius M. Maraganore [États-Unis] ; Matthew J. Farrer [États-Unis, Canada]Source :
- Annals of Neurology [ 0364-5134 ] ; 2011-05.
Descripteurs français
- Wicri :
- topic : épidémiologie, Neurologie, Thessalie.
English descriptors
- KwdEn :
- Additive, Additive coding, Additive model, Additive scale, Akaike information criterion, Allele, Association studies, Association study, Biomedical research, Brain pathology, Compositional epistasis, Confidence interval, Dominant coding, Dominant model, Elbaz, Epidemiol, Epidemiology, Forest plots, Funding, Genet, Genetic epidemiology, Genetic susceptibility, Genotype, Haplotype, Heterogeneity, Information figure, Information table, Interaction, Interaction analyses, Joint effects, Large sample size, Larissa, Lille, Linear regression models, Logistic, Logistic regression, Lund, Mapt, Mapt haplotype, Mapt snps, Marginal association, Mayo, Mayo clinic, Minor allele, Multiplicative, Multiplicative interaction, Multiplicative model, National research council, Neurol, Neurology, Parkinson, Parkinson disease, Polymorphism, Primary analyses, Progressive supranuclear palsy, Recessive, Same model, Significance level, Significant association, Single nucleotide polymorphism, Skane university hospital, Snca, Snca gene, Snca haplotypes, Snca snps, Snp, Statistical interaction, Susceptibility, Thessaly, Ukpdbb, Univariate analyses.
- Teeft :
- Additive, Additive coding, Additive model, Additive scale, Akaike information criterion, Allele, Association studies, Association study, Biomedical research, Brain pathology, Compositional epistasis, Confidence interval, Dominant coding, Dominant model, Elbaz, Epidemiol, Epidemiology, Forest plots, Funding, Genet, Genetic epidemiology, Genetic susceptibility, Genotype, Haplotype, Heterogeneity, Information figure, Information table, Interaction, Interaction analyses, Joint effects, Large sample size, Larissa, Lille, Linear regression models, Logistic, Logistic regression, Lund, Mapt, Mapt haplotype, Mapt snps, Marginal association, Mayo, Mayo clinic, Minor allele, Multiplicative, Multiplicative interaction, Multiplicative model, National research council, Neurol, Neurology, Parkinson, Parkinson disease, Polymorphism, Primary analyses, Progressive supranuclear palsy, Recessive, Same model, Significance level, Significant association, Single nucleotide polymorphism, Skane university hospital, Snca, Snca gene, Snca haplotypes, Snca snps, Snp, Statistical interaction, Susceptibility, Thessaly, Ukpdbb, Univariate analyses.
Abstract
We studied the independent and joint effects of the genes encoding alpha‐synuclein (SNCA) and microtubule‐associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta‐analysis of individual data from case–control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium.
Url:
- https://api.istex.fr/document/E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082599
DOI: 10.1002/ana.22321
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Soto-Ortolaza</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, F‐75013, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation wicri:level="3"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, St Olav Hospital, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurological Sciences, National Research Council, Cosenza</wicri:regionArea><wicri:noRegion>Cosenza</wicri:noRegion></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation wicri:level="3"><country xml:lang="fr">Grèce</country><wicri:regionArea>General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>University Hospital, CHRU, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research and Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Jasinska Yga, Barbara" sort="Jasinska Yga, Barbara" uniqKey="Jasinska Yga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Lambert, Jean Harles" sort="Lambert, Jean Harles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U744, Pasteur Institute from Lille, University of Lille‐Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Loriot, Marie Nne" sort="Loriot, Marie Nne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR‐S 775, Molecular basis of response to xenobiotics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Assistance‐Publique Hôpitaux de Paris, Georges Pompidou European Hospital (HEGP), Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>University Hospital, CHRU, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurology, Skåne University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University Magna Graecia, Catanzaro and Neuroimaging Research Unit, National Research Council, Germaneto</wicri:regionArea><wicri:noRegion>Germaneto</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation wicri:level="3"><country xml:lang="fr">Grèce</country><wicri:regionArea>Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens and Second Department of Neurology, University of Athens Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Vilari O Ell, Carles" sort="Vilari O Ell, Carles" uniqKey="Vilari O Ell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research and Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Annals of Neurology</title><title level="j" type="alt">ANNALS OF NEUROLOGY</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><biblScope unit="vol">69</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="778">778</biblScope><biblScope unit="page" to="792">792</biblScope><biblScope unit="page-count">15</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-05">2011-05</date></imprint><idno type="ISSN">0364-5134</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Additive</term><term>Additive coding</term><term>Additive model</term><term>Additive scale</term><term>Akaike information criterion</term><term>Allele</term><term>Association studies</term><term>Association study</term><term>Biomedical research</term><term>Brain pathology</term><term>Compositional epistasis</term><term>Confidence interval</term><term>Dominant coding</term><term>Dominant model</term><term>Elbaz</term><term>Epidemiol</term><term>Epidemiology</term><term>Forest plots</term><term>Funding</term><term>Genet</term><term>Genetic epidemiology</term><term>Genetic susceptibility</term><term>Genotype</term><term>Haplotype</term><term>Heterogeneity</term><term>Information figure</term><term>Information table</term><term>Interaction</term><term>Interaction analyses</term><term>Joint effects</term><term>Large sample size</term><term>Larissa</term><term>Lille</term><term>Linear regression models</term><term>Logistic</term><term>Logistic regression</term><term>Lund</term><term>Mapt</term><term>Mapt haplotype</term><term>Mapt snps</term><term>Marginal association</term><term>Mayo</term><term>Mayo clinic</term><term>Minor allele</term><term>Multiplicative</term><term>Multiplicative interaction</term><term>Multiplicative model</term><term>National research council</term><term>Neurol</term><term>Neurology</term><term>Parkinson</term><term>Parkinson disease</term><term>Polymorphism</term><term>Primary analyses</term><term>Progressive supranuclear palsy</term><term>Recessive</term><term>Same model</term><term>Significance level</term><term>Significant association</term><term>Single nucleotide polymorphism</term><term>Skane university hospital</term><term>Snca</term><term>Snca gene</term><term>Snca haplotypes</term><term>Snca snps</term><term>Snp</term><term>Statistical interaction</term><term>Susceptibility</term><term>Thessaly</term><term>Ukpdbb</term><term>Univariate analyses</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Additive</term><term>Additive coding</term><term>Additive model</term><term>Additive scale</term><term>Akaike information criterion</term><term>Allele</term><term>Association studies</term><term>Association study</term><term>Biomedical research</term><term>Brain pathology</term><term>Compositional epistasis</term><term>Confidence interval</term><term>Dominant coding</term><term>Dominant model</term><term>Elbaz</term><term>Epidemiol</term><term>Epidemiology</term><term>Forest plots</term><term>Funding</term><term>Genet</term><term>Genetic epidemiology</term><term>Genetic susceptibility</term><term>Genotype</term><term>Haplotype</term><term>Heterogeneity</term><term>Information figure</term><term>Information table</term><term>Interaction</term><term>Interaction analyses</term><term>Joint effects</term><term>Large sample size</term><term>Larissa</term><term>Lille</term><term>Linear regression models</term><term>Logistic</term><term>Logistic regression</term><term>Lund</term><term>Mapt</term><term>Mapt haplotype</term><term>Mapt snps</term><term>Marginal association</term><term>Mayo</term><term>Mayo clinic</term><term>Minor allele</term><term>Multiplicative</term><term>Multiplicative interaction</term><term>Multiplicative model</term><term>National research council</term><term>Neurol</term><term>Neurology</term><term>Parkinson</term><term>Parkinson disease</term><term>Polymorphism</term><term>Primary analyses</term><term>Progressive supranuclear palsy</term><term>Recessive</term><term>Same model</term><term>Significance level</term><term>Significant association</term><term>Single nucleotide polymorphism</term><term>Skane university hospital</term><term>Snca</term><term>Snca gene</term><term>Snca haplotypes</term><term>Snca snps</term><term>Snp</term><term>Statistical interaction</term><term>Susceptibility</term><term>Thessaly</term><term>Ukpdbb</term><term>Univariate analyses</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>épidémiologie</term><term>Neurologie</term><term>Thessalie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">We studied the independent and joint effects of the genes encoding alpha‐synuclein (SNCA) and microtubule‐associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta‐analysis of individual data from case–control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium.</div></front></TEI><double doi="10.1002/ana.22321"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Independent and joint effects of the MAPT and SNCA genes in Parkinson disease</title><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name></author><author><name sortKey="Soto Rtolaza, Alexandra I" sort="Soto Rtolaza, Alexandra I" uniqKey="Soto Rtolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name></author><author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation><country>France</country><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name></author><author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name></author><author><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name></author><author><name sortKey="Jasinska Yga, Barbara" sort="Jasinska Yga, Barbara" uniqKey="Jasinska Yga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name></author><author><name sortKey="Lambert, Jean Harles" sort="Lambert, Jean Harles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name></author><author><name sortKey="Loriot, Marie Nne" sort="Loriot, Marie Nne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name></author><author><name sortKey="Vilari O Ell, Carles" sort="Vilari O Ell, Carles" uniqKey="Vilari O Ell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/ana.22321</idno><idno type="url">https://api.istex.fr/document/E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002B00</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002B00</idno><idno type="wicri:Area/Istex/Curation">002B00</idno><idno type="wicri:Area/Istex/Checkpoint">000829</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000829</idno><idno type="wicri:doubleKey">0364-5134:2011:Elbaz A:independent:and:joint</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Independent and joint effects of the <hi rend="italic">MAPT</hi> and <hi rend="italic">SNCA</hi> genes in Parkinson disease</title><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, F‐75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Correspondence address: INSERM U708, Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris Cedex 13</wicri:regionArea><wicri:noRegion>75651 Paris Cedex 13</wicri:noRegion><wicri:noRegion>75651 Paris Cedex 13</wicri:noRegion></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Soto Rtolaza, Alexandra I" sort="Soto Rtolaza, Alexandra I" uniqKey="Soto Rtolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, F‐75013, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation wicri:level="3"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, St Olav Hospital, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurological Sciences, National Research Council, Cosenza</wicri:regionArea><wicri:noRegion>Cosenza</wicri:noRegion></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation wicri:level="3"><country xml:lang="fr">Grèce</country><wicri:regionArea>General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>University Hospital, CHRU, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research and Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Jasinska Yga, Barbara" sort="Jasinska Yga, Barbara" uniqKey="Jasinska Yga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Lambert, Jean Harles" sort="Lambert, Jean Harles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U744, Pasteur Institute from Lille, University of Lille‐Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Loriot, Marie Nne" sort="Loriot, Marie Nne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR‐S 775, Molecular basis of response to xenobiotics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Assistance‐Publique Hôpitaux de Paris, Georges Pompidou European Hospital (HEGP), Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>University Hospital, CHRU, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurology, Skåne University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University Magna Graecia, Catanzaro and Neuroimaging Research Unit, National Research Council, Germaneto</wicri:regionArea><wicri:noRegion>Germaneto</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation wicri:level="3"><country xml:lang="fr">Grèce</country><wicri:regionArea>Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens and Second Department of Neurology, University of Athens Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Vilari O Ell, Carles" sort="Vilari O Ell, Carles" uniqKey="Vilari O Ell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research and Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Annals of Neurology</title><title level="j" type="alt">ANNALS OF NEUROLOGY</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><biblScope unit="vol">69</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="778">778</biblScope><biblScope unit="page" to="792">792</biblScope><biblScope unit="page-count">15</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-05">2011-05</date></imprint><idno type="ISSN">0364-5134</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Additive</term><term>Additive coding</term><term>Additive model</term><term>Additive scale</term><term>Akaike information criterion</term><term>Allele</term><term>Association studies</term><term>Association study</term><term>Biomedical research</term><term>Brain pathology</term><term>Compositional epistasis</term><term>Confidence interval</term><term>Dominant coding</term><term>Dominant model</term><term>Elbaz</term><term>Epidemiol</term><term>Epidemiology</term><term>Forest plots</term><term>Funding</term><term>Genet</term><term>Genetic epidemiology</term><term>Genetic susceptibility</term><term>Genotype</term><term>Haplotype</term><term>Heterogeneity</term><term>Information figure</term><term>Information table</term><term>Interaction</term><term>Interaction analyses</term><term>Joint effects</term><term>Large sample size</term><term>Larissa</term><term>Lille</term><term>Linear regression models</term><term>Logistic</term><term>Logistic regression</term><term>Lund</term><term>Mapt</term><term>Mapt haplotype</term><term>Mapt snps</term><term>Marginal association</term><term>Mayo</term><term>Mayo clinic</term><term>Minor allele</term><term>Multiplicative</term><term>Multiplicative interaction</term><term>Multiplicative model</term><term>National research council</term><term>Neurol</term><term>Neurology</term><term>Parkinson</term><term>Parkinson disease</term><term>Polymorphism</term><term>Primary analyses</term><term>Progressive supranuclear palsy</term><term>Recessive</term><term>Same model</term><term>Significance level</term><term>Significant association</term><term>Single nucleotide polymorphism</term><term>Skane university hospital</term><term>Snca</term><term>Snca gene</term><term>Snca haplotypes</term><term>Snca snps</term><term>Snp</term><term>Statistical interaction</term><term>Susceptibility</term><term>Thessaly</term><term>Ukpdbb</term><term>Univariate analyses</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Additive</term><term>Additive coding</term><term>Additive model</term><term>Additive scale</term><term>Akaike information criterion</term><term>Allele</term><term>Association studies</term><term>Association study</term><term>Biomedical research</term><term>Brain pathology</term><term>Compositional epistasis</term><term>Confidence interval</term><term>Dominant coding</term><term>Dominant model</term><term>Elbaz</term><term>Epidemiol</term><term>Epidemiology</term><term>Forest plots</term><term>Funding</term><term>Genet</term><term>Genetic epidemiology</term><term>Genetic susceptibility</term><term>Genotype</term><term>Haplotype</term><term>Heterogeneity</term><term>Information figure</term><term>Information table</term><term>Interaction</term><term>Interaction analyses</term><term>Joint effects</term><term>Large sample size</term><term>Larissa</term><term>Lille</term><term>Linear regression models</term><term>Logistic</term><term>Logistic regression</term><term>Lund</term><term>Mapt</term><term>Mapt haplotype</term><term>Mapt snps</term><term>Marginal association</term><term>Mayo</term><term>Mayo clinic</term><term>Minor allele</term><term>Multiplicative</term><term>Multiplicative interaction</term><term>Multiplicative model</term><term>National research council</term><term>Neurol</term><term>Neurology</term><term>Parkinson</term><term>Parkinson disease</term><term>Polymorphism</term><term>Primary analyses</term><term>Progressive supranuclear palsy</term><term>Recessive</term><term>Same model</term><term>Significance level</term><term>Significant association</term><term>Single nucleotide polymorphism</term><term>Skane university hospital</term><term>Snca</term><term>Snca gene</term><term>Snca haplotypes</term><term>Snca snps</term><term>Snp</term><term>Statistical interaction</term><term>Susceptibility</term><term>Thessaly</term><term>Ukpdbb</term><term>Univariate analyses</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>épidémiologie</term><term>Neurologie</term><term>Thessalie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">We studied the independent and joint effects of the genes encoding alpha‐synuclein (SNCA) and microtubule‐associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta‐analysis of individual data from case–control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium.</div></front></TEI></ISTEX><PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Independent and joint effects of the <italic>MAPT</italic> and <italic>SNCA</italic> genes in Parkinson's disease</title><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="3"><nlm:aff id="A1"> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation wicri:level="1"><nlm:aff id="A4"> Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A5"> Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Soto Ortolaza, Alexandra I" sort="Soto Ortolaza, Alexandra I" uniqKey="Soto Ortolaza A" first="Alexandra I" last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation wicri:level="3"><nlm:aff id="A1"> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation wicri:level="3"><nlm:aff id="A6"> Department of Neurology; St Olav Hospital, Trondheim, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Neurology; St Olav Hospital, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation wicri:level="1"><nlm:aff id="A7"> Institute of Neurological Sciences, National Research Council, Cosenza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Institute of Neurological Sciences, National Research Council, Cosenza</wicri:regionArea><wicri:noRegion>Cosenza</wicri:noRegion></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation wicri:level="1"><nlm:aff id="A8"> General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation wicri:level="1"><nlm:aff id="A9"> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea><wicri:noRegion>59045, Lille</wicri:noRegion><wicri:noRegion>59045, Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea><wicri:noRegion>59000, Lille</wicri:noRegion><wicri:noRegion>59000, Lille</wicri:noRegion></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea><wicri:noRegion>59045, Lille</wicri:noRegion><wicri:noRegion>59045, Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea><wicri:noRegion>59000, Lille</wicri:noRegion><wicri:noRegion>59000, Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A12"> CHRU, F-59037, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CHRU, F-59037, Lille</wicri:regionArea><wicri:noRegion>59037, Lille</wicri:noRegion><wicri:noRegion>59037, Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation wicri:level="1"><nlm:aff id="A9"> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name><affiliation wicri:level="1"><nlm:aff id="A13"> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation wicri:level="1"><nlm:aff id="A14"> Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea> Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name><affiliation wicri:level="1"><nlm:aff id="A15"> Dept. Neurology, Goethe University Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Dept. Neurology, Goethe University Frankfurt am Main</wicri:regionArea><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><nlm:aff id="A16"> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17"> Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation wicri:level="1"><nlm:aff id="A18"> Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea> Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><nlm:aff id="A19"> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:regionArea><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="3"><nlm:aff id="A20"> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="3"><nlm:aff id="A21"> INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, UDSL, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, UDSL, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><affiliation wicri:level="1"><nlm:aff id="A19"> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:regionArea><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name><affiliation wicri:level="1"><nlm:aff id="A15"> Dept. Neurology, Goethe University Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Dept. Neurology, Goethe University Frankfurt am Main</wicri:regionArea><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion></affiliation></author><author><name sortKey="Loriot, Marie Anne" sort="Loriot, Marie Anne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name><affiliation wicri:level="1"><nlm:aff id="A22"> INSERM, UMR-S 775, Bases moléculaires de la réponse aux xénobiotiques, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, UMR-S 775, Bases moléculaires de la réponse aux xénobiotiques, 45 rue des Saints-Pères, 75270 Paris Cedex 06</wicri:regionArea><wicri:noRegion>75270 Paris Cedex 06</wicri:noRegion><wicri:noRegion>75270 Paris Cedex 06</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A23"> Université Paris Descartes, F-75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université Paris Descartes, F-75005, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A24"> Assistance-Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Biochimie, Pharmacogénétique et Oncologie Moléculaire, 20 rue Leblanc, 75908 Paris Cedex 15, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Assistance-Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Biochimie, Pharmacogénétique et Oncologie Moléculaire, 20 rue Leblanc, 75908 Paris Cedex 15</wicri:regionArea><wicri:noRegion>75908 Paris Cedex 15</wicri:noRegion><wicri:noRegion>75908 Paris Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation wicri:level="1"><nlm:aff id="A25"> Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea> Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin</wicri:regionArea><wicri:noRegion>University College Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><nlm:aff id="A26"> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A27"> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A28"> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea><wicri:noRegion>59045, Lille</wicri:noRegion><wicri:noRegion>59045, Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea><wicri:noRegion>59000, Lille</wicri:noRegion><wicri:noRegion>59000, Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A12"> CHRU, F-59037, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CHRU, F-59037, Lille</wicri:regionArea><wicri:noRegion>59037, Lille</wicri:noRegion><wicri:noRegion>59037, Lille</wicri:noRegion></affiliation></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><affiliation wicri:level="1"><nlm:aff id="A29"> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University</wicri:regionArea><wicri:noRegion>Lund University</wicri:noRegion></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation wicri:level="1"><nlm:aff id="A18"> Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea> Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation wicri:level="1"><nlm:aff id="A29"> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University</wicri:regionArea><wicri:noRegion>Lund University</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A30"> Department of Neurology, Skåne University Hospital, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Neurology, Skåne University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><nlm:aff id="A31"> Institute of Neurology, University Magna Graecia, Catanzaro, and Neuroimaging Research Unit, National Research Council, Germaneto, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Institute of Neurology, University Magna Graecia, Catanzaro, and Neuroimaging Research Unit, National Research Council, Germaneto</wicri:regionArea><wicri:noRegion>Germaneto</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation wicri:level="3"><nlm:aff id="A20"> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><nlm:aff id="A26"> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A27"> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A28"> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A32"> School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation wicri:level="1"><nlm:aff id="A33"> Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, and Second Department of Neurology, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, and Second Department of Neurology, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="2"><nlm:aff id="A34"> Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="1"><nlm:aff id="A13"> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A37"> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC</wicri:regionArea><wicri:noRegion>V5Z4H4 BC</wicri:noRegion></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation wicri:level="3"><nlm:aff id="A35"> Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="2"><nlm:aff id="A34"> Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><nlm:aff id="A16"> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17"> Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><nlm:aff id="A36"> Department of Neurology, NorthShore University HealthSystem, Evanston, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, NorthShore University HealthSystem, Evanston, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A37"> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC</wicri:regionArea><wicri:noRegion>V5Z4H4 BC</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21391235</idno><idno type="pmc">3082599</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082599</idno><idno type="RBID">PMC:3082599</idno><idno type="doi">10.1002/ana.22321</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001455</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001455</idno><idno type="wicri:Area/Pmc/Curation">001315</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001315</idno><idno type="wicri:Area/Pmc/Checkpoint">002270</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002270</idno><idno type="wicri:Area/Ncbi/Merge">000A12</idno><idno type="wicri:Area/Ncbi/Curation">000A12</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A12</idno><idno type="wicri:doubleKey">0364-5134:2011:Elbaz A:independent:and:joint</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Independent and joint effects of the <italic>MAPT</italic> and <italic>SNCA</italic> genes in Parkinson's disease</title><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="3"><nlm:aff id="A1"> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation wicri:level="1"><nlm:aff id="A4"> Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A5"> Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Soto Ortolaza, Alexandra I" sort="Soto Ortolaza, Alexandra I" uniqKey="Soto Ortolaza A" first="Alexandra I" last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation wicri:level="3"><nlm:aff id="A1"> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation wicri:level="3"><nlm:aff id="A6"> Department of Neurology; St Olav Hospital, Trondheim, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Neurology; St Olav Hospital, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation wicri:level="1"><nlm:aff id="A7"> Institute of Neurological Sciences, National Research Council, Cosenza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Institute of Neurological Sciences, National Research Council, Cosenza</wicri:regionArea><wicri:noRegion>Cosenza</wicri:noRegion></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation wicri:level="1"><nlm:aff id="A8"> General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation wicri:level="1"><nlm:aff id="A9"> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea><wicri:noRegion>59045, Lille</wicri:noRegion><wicri:noRegion>59045, Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea><wicri:noRegion>59000, Lille</wicri:noRegion><wicri:noRegion>59000, Lille</wicri:noRegion></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea><wicri:noRegion>59045, Lille</wicri:noRegion><wicri:noRegion>59045, Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea><wicri:noRegion>59000, Lille</wicri:noRegion><wicri:noRegion>59000, Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A12"> CHRU, F-59037, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CHRU, F-59037, Lille</wicri:regionArea><wicri:noRegion>59037, Lille</wicri:noRegion><wicri:noRegion>59037, Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation wicri:level="1"><nlm:aff id="A9"> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name><affiliation wicri:level="1"><nlm:aff id="A13"> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation wicri:level="1"><nlm:aff id="A14"> Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea> Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name><affiliation wicri:level="1"><nlm:aff id="A15"> Dept. Neurology, Goethe University Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Dept. Neurology, Goethe University Frankfurt am Main</wicri:regionArea><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><nlm:aff id="A16"> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17"> Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation wicri:level="1"><nlm:aff id="A18"> Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea> Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><nlm:aff id="A19"> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:regionArea><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="3"><nlm:aff id="A20"> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="3"><nlm:aff id="A21"> INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, UDSL, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, UDSL, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><affiliation wicri:level="1"><nlm:aff id="A19"> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:regionArea><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name><affiliation wicri:level="1"><nlm:aff id="A15"> Dept. Neurology, Goethe University Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Dept. Neurology, Goethe University Frankfurt am Main</wicri:regionArea><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion></affiliation></author><author><name sortKey="Loriot, Marie Anne" sort="Loriot, Marie Anne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name><affiliation wicri:level="1"><nlm:aff id="A22"> INSERM, UMR-S 775, Bases moléculaires de la réponse aux xénobiotiques, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, UMR-S 775, Bases moléculaires de la réponse aux xénobiotiques, 45 rue des Saints-Pères, 75270 Paris Cedex 06</wicri:regionArea><wicri:noRegion>75270 Paris Cedex 06</wicri:noRegion><wicri:noRegion>75270 Paris Cedex 06</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A23"> Université Paris Descartes, F-75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université Paris Descartes, F-75005, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A24"> Assistance-Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Biochimie, Pharmacogénétique et Oncologie Moléculaire, 20 rue Leblanc, 75908 Paris Cedex 15, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Assistance-Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Biochimie, Pharmacogénétique et Oncologie Moléculaire, 20 rue Leblanc, 75908 Paris Cedex 15</wicri:regionArea><wicri:noRegion>75908 Paris Cedex 15</wicri:noRegion><wicri:noRegion>75908 Paris Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation wicri:level="1"><nlm:aff id="A25"> Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea> Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin</wicri:regionArea><wicri:noRegion>University College Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><nlm:aff id="A26"> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A27"> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A28"> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea><wicri:noRegion>59045, Lille</wicri:noRegion><wicri:noRegion>59045, Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea><wicri:noRegion>59000, Lille</wicri:noRegion><wicri:noRegion>59000, Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A12"> CHRU, F-59037, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CHRU, F-59037, Lille</wicri:regionArea><wicri:noRegion>59037, Lille</wicri:noRegion><wicri:noRegion>59037, Lille</wicri:noRegion></affiliation></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><affiliation wicri:level="1"><nlm:aff id="A29"> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University</wicri:regionArea><wicri:noRegion>Lund University</wicri:noRegion></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation wicri:level="1"><nlm:aff id="A18"> Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea> Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation wicri:level="1"><nlm:aff id="A29"> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University</wicri:regionArea><wicri:noRegion>Lund University</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A30"> Department of Neurology, Skåne University Hospital, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Neurology, Skåne University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><nlm:aff id="A31"> Institute of Neurology, University Magna Graecia, Catanzaro, and Neuroimaging Research Unit, National Research Council, Germaneto, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Institute of Neurology, University Magna Graecia, Catanzaro, and Neuroimaging Research Unit, National Research Council, Germaneto</wicri:regionArea><wicri:noRegion>Germaneto</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation wicri:level="3"><nlm:aff id="A20"> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><nlm:aff id="A26"> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A27"> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A28"> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A32"> School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation wicri:level="1"><nlm:aff id="A33"> Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, and Second Department of Neurology, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, and Second Department of Neurology, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="2"><nlm:aff id="A34"> Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="1"><nlm:aff id="A13"> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A37"> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC</wicri:regionArea><wicri:noRegion>V5Z4H4 BC</wicri:noRegion></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation wicri:level="3"><nlm:aff id="A35"> Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="2"><nlm:aff id="A34"> Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><nlm:aff id="A16"> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17"> Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><nlm:aff id="A36"> Department of Neurology, NorthShore University HealthSystem, Evanston, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, NorthShore University HealthSystem, Evanston, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A37"> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC</wicri:regionArea><wicri:noRegion>V5Z4H4 BC</wicri:noRegion></affiliation></author></analytic><series><title level="j">Annals of neurology</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">We studied the independent and joint effects of the genes encoding alpha-synuclein (<italic>SNCA</italic>) and microtubule associated protein tau (<italic>MAPT</italic>) in Parkinson's disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">Participants of Caucasian ancestry were genotyped for a total of four <italic>SNCA</italic> (rs2583988, rs181489, rs356219, rs11931074) and two <italic>MAPT</italic> (rs1052553, rs242557) SNPs. Individual and joint effects of <italic>SNCA</italic> and <italic>MAPT</italic> SNPs were investigated using fixed- and random-effects logistic regression models. Interactions were studied both on a multiplicative and an additive scale, and using a case-control and case-only approach.</p></sec><sec id="S3"><title>Results</title><p id="P3">Fifteen GEO-PD sites contributed a total of 5302 cases and 4161 controls. All four <italic>SNCA</italic> SNPs and the <italic>MAPT</italic> H1-haplotype defining SNP (rs1052553) displayed a highly significant marginal association with PD at the significance level adjusted for multiple comparisons. For <italic>SNCA</italic>, the strongest associations were observed for SNPs located at the 3′ end of the gene. There was no evidence of statistical interaction between any of the four <italic>SNCA</italic> SNPs and rs1052553 or rs242557, neither on the multiplicative nor on the additive scale.</p></sec><sec id="S4"><title>Interpretation</title><p id="P4">This study confirms the association between PD and both <italic>SNCA</italic> SNPs and the H1 <italic>MAPT</italic> haplotype. It shows, based on a variety of approaches, that the joint action of variants in these two loci is consistent with independent effects of the genes without additional interacting effects.</p></sec></div></front></TEI></PMC></double></record>Pour manipuler ce document sous Unix (Dilib)
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