Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case–Control Consortium (PanC4)
Identifieur interne : 006610 ( Main/Merge ); précédent : 006609; suivant : 006611Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case–Control Consortium (PanC4)
Auteurs : E. Lucenteforte [Italie] ; C. La Vecchia [Italie] ; D. Silverman ; G. M. Petersen ; P. M. Bracci [États-Unis] ; B. T. Ji ; C. Bosetti ; D. Li [États-Unis] ; S. Gallinger ; A. B. Miller [Canada] ; H. B. Bueno-De-Mesquita [Pays-Bas] ; R. Talamini [Italie] ; J. Polesel [Italie] ; P. Ghadirian [Canada] ; P. A. Baghurst [Australie] ; W. Zatonski [Pologne] ; E. Fontham [États-Unis] ; W. R. Bamlet ; E. A. Holly [États-Unis] ; Y. T. Gao [République populaire de Chine] ; E. Negri ; M. Hassan [États-Unis] ; M. Cotterchio [Canada] ; J. Su ; P. Maisonneuve [Italie] ; P. Boffetta [France, États-Unis] ; E. J. Duell [France, Espagne]Source :
- Annals of Oncology [ 0923-7534 ] ; 2011.
Abstract
Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved.
To evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case–control studies (5585 cases and 11 827 controls) participating in the International Pancreatic Cancer Case–Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models.
Compared with abstainers and occasional drinkers (<1 drink per day), we observed no association for light-to-moderate alcohol consumption (≤4 drinks per day) and pancreatic cancer risk; however, associations were above unity for higher consumption levels (OR = 1.6, 95% confidence interval 1.2–2.2 for subjects drinking ≥9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area.
This collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer.
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DOI: 10.1093/annonc/mdr120
PubMed: 21536662
PubMed Central: 3265544
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Lucenteforte</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff><wicri:noCountry code="subfield">Istituto di Ricerche Farmacologiche “Mario Negri” Milan</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Occupational Health, University of Milan, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Occupational Health, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff><wicri:noCountry code="subfield">Istituto di Ricerche Farmacologiche “Mario Negri” Milan</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Occupational Health, University of Milan, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Occupational Health, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Silverman, D" sort="Silverman, D" uniqKey="Silverman D" first="D." last="Silverman">D. 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T." last="Ji">B. T. Ji</name><affiliation><nlm:aff id="aff3">National Cancer Institute, Bethesda</nlm:aff><wicri:noCountry code="subfield">Bethesda</wicri:noCountry></affiliation></author><author><name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff><wicri:noCountry code="subfield">Istituto di Ricerche Farmacologiche “Mario Negri” Milan</wicri:noCountry></affiliation></author><author><name sortKey="Li, D" sort="Li, D" uniqKey="Li D" first="D." last="Li">D. Li</name><affiliation wicri:level="3"><nlm:aff id="aff6">MD Anderson Cancer Center, Houston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MD Anderson Cancer Center, Houston</wicri:regionArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S." last="Gallinger">S. Gallinger</name><affiliation><nlm:aff id="aff7">Toronto General Hospital</nlm:aff></affiliation></author><author><name sortKey="Miller, A B" sort="Miller, A B" uniqKey="Miller A" first="A. B." last="Miller">A. B. Miller</name><affiliation wicri:level="4"><nlm:aff id="aff8">Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Dalla Lana School of Public Health, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name><affiliation><nlm:aff id="aff9">National Institute for Public Health and the Environment (RIVM), Bilthoven</nlm:aff><wicri:noCountry code="subfield">Bilthoven</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff10">Department of Gastroenterology and Hepatology, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Medical Center Utrecht (UMCU), Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Talamini, R" sort="Talamini, R" uniqKey="Talamini R" first="R." last="Talamini">R. Talamini</name><affiliation wicri:level="1"><nlm:aff id="aff11">Centro di Riferimento Oncologico (CRO) – National Cancer Institute, Aviano (PN), Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Centro di Riferimento Oncologico (CRO) – National Cancer Institute, Aviano (PN)</wicri:regionArea><wicri:noRegion>Aviano (PN)</wicri:noRegion></affiliation></author><author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name><affiliation wicri:level="1"><nlm:aff id="aff11">Centro di Riferimento Oncologico (CRO) – National Cancer Institute, Aviano (PN), Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Centro di Riferimento Oncologico (CRO) – National Cancer Institute, Aviano (PN)</wicri:regionArea><wicri:noRegion>Aviano (PN)</wicri:noRegion></affiliation></author><author><name sortKey="Ghadirian, P" sort="Ghadirian, P" uniqKey="Ghadirian P" first="P." last="Ghadirian">P. Ghadirian</name><affiliation wicri:level="3"><nlm:aff id="aff12">Epidemiology Research Unit, Research Center of the University of Montreal Hospital Centre (CRCHUM), Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Epidemiology Research Unit, Research Center of the University of Montreal Hospital Centre (CRCHUM), Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Baghurst, P A" sort="Baghurst, P A" uniqKey="Baghurst P" first="P. A." last="Baghurst">P. A. Baghurst</name><affiliation wicri:level="1"><nlm:aff id="aff13">Public Health, Women's and Children's Hospital, Adelaide, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Public Health, Women's and Children's Hospital, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Zatonski, W" sort="Zatonski, W" uniqKey="Zatonski W" first="W." last="Zatonski">W. Zatonski</name><affiliation wicri:level="1"><nlm:aff id="aff14">Cancer Center & Institute of Oncology, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Cancer Center & Institute of Oncology, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Fontham, E" sort="Fontham, E" uniqKey="Fontham E" first="E." last="Fontham">E. Fontham</name><affiliation wicri:level="1"><nlm:aff id="aff15">Louisiana State University, New Orleans, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Louisiana State University, New Orleans</wicri:regionArea><wicri:noRegion>New Orleans</wicri:noRegion></affiliation></author><author><name sortKey="Bamlet, W R" sort="Bamlet, W R" uniqKey="Bamlet W" first="W. R." last="Bamlet">W. R. Bamlet</name><affiliation><nlm:aff id="aff4">Mayo Clinic, Rochester</nlm:aff><wicri:noCountry code="subfield">Rochester</wicri:noCountry></affiliation></author><author><name sortKey="Holly, E A" sort="Holly, E A" uniqKey="Holly E" first="E. A." last="Holly">E. A. Holly</name><affiliation wicri:level="3"><nlm:aff id="aff5">University of California – San Francisco, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>University of California – San Francisco</wicri:orgArea></affiliation></author><author><name sortKey="Gao, Y T" sort="Gao, Y T" uniqKey="Gao Y" first="Y. T." last="Gao">Y. T. Gao</name><affiliation wicri:level="1"><nlm:aff id="aff16">Shanghai Cancer Institute, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Cancer Institute, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff><wicri:noCountry code="subfield">Istituto di Ricerche Farmacologiche “Mario Negri” Milan</wicri:noCountry></affiliation></author><author><name sortKey="Hassan, M" sort="Hassan, M" uniqKey="Hassan M" first="M." last="Hassan">M. Hassan</name><affiliation wicri:level="3"><nlm:aff id="aff6">MD Anderson Cancer Center, Houston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MD Anderson Cancer Center, Houston</wicri:regionArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name><affiliation wicri:level="4"><nlm:aff id="aff8">Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Dalla Lana School of Public Health, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff17">Population Studies and Surveillance, Cancer Care Ontario, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Population Studies and Surveillance, Cancer Care Ontario, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Su, J" sort="Su, J" uniqKey="Su J" first="J." last="Su">J. Su</name><affiliation><nlm:aff id="aff3">National Cancer Institute, Bethesda</nlm:aff><wicri:noCountry code="subfield">Bethesda</wicri:noCountry></affiliation></author><author><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name><affiliation wicri:level="3"><nlm:aff id="aff18">European Institute of Oncology, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>European Institute of Oncology, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><affiliation wicri:level="3"><nlm:aff id="aff19">International Prevention Research Institute, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Prevention Research Institute, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff20">The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Tisch Cancer Institute, Mount Sinai School of Medicine, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Duell, E J" sort="Duell, E J" uniqKey="Duell E" first="E. J." last="Duell">E. J. Duell</name><affiliation wicri:level="3"><nlm:aff id="aff21">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff22">Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Catalan Institute of Oncology (ICO-IDIBELL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21536662</idno><idno type="pmc">3265544</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265544</idno><idno type="RBID">PMC:3265544</idno><idno type="doi">10.1093/annonc/mdr120</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001734</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001734</idno><idno type="wicri:Area/Pmc/Curation">001594</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001594</idno><idno type="wicri:Area/Pmc/Checkpoint">002419</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002419</idno><idno type="wicri:Area/Ncbi/Merge">000A48</idno><idno type="wicri:Area/Ncbi/Curation">000A48</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A48</idno><idno type="wicri:doubleKey">0923-7534:2011:Lucenteforte E:alcohol:consumption:and</idno><idno type="wicri:Area/Main/Merge">006610</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case–Control Consortium (PanC4)</title><author><name sortKey="Lucenteforte, E" sort="Lucenteforte, E" uniqKey="Lucenteforte E" first="E." last="Lucenteforte">E. Lucenteforte</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff><wicri:noCountry code="subfield">Istituto di Ricerche Farmacologiche “Mario Negri” Milan</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Occupational Health, University of Milan, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Occupational Health, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff><wicri:noCountry code="subfield">Istituto di Ricerche Farmacologiche “Mario Negri” Milan</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Occupational Health, University of Milan, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Occupational Health, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Silverman, D" sort="Silverman, D" uniqKey="Silverman D" first="D." last="Silverman">D. Silverman</name><affiliation><nlm:aff id="aff3">National Cancer Institute, Bethesda</nlm:aff><wicri:noCountry code="subfield">Bethesda</wicri:noCountry></affiliation></author><author><name sortKey="Petersen, G M" sort="Petersen, G M" uniqKey="Petersen G" first="G. M." last="Petersen">G. M. Petersen</name><affiliation><nlm:aff id="aff4">Mayo Clinic, Rochester</nlm:aff><wicri:noCountry code="subfield">Rochester</wicri:noCountry></affiliation></author><author><name sortKey="Bracci, P M" sort="Bracci, P M" uniqKey="Bracci P" first="P. M." last="Bracci">P. M. Bracci</name><affiliation wicri:level="3"><nlm:aff id="aff5">University of California – San Francisco, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>University of California – San Francisco</wicri:orgArea></affiliation></author><author><name sortKey="Ji, B T" sort="Ji, B T" uniqKey="Ji B" first="B. T." last="Ji">B. T. Ji</name><affiliation><nlm:aff id="aff3">National Cancer Institute, Bethesda</nlm:aff><wicri:noCountry code="subfield">Bethesda</wicri:noCountry></affiliation></author><author><name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff><wicri:noCountry code="subfield">Istituto di Ricerche Farmacologiche “Mario Negri” Milan</wicri:noCountry></affiliation></author><author><name sortKey="Li, D" sort="Li, D" uniqKey="Li D" first="D." last="Li">D. Li</name><affiliation wicri:level="3"><nlm:aff id="aff6">MD Anderson Cancer Center, Houston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MD Anderson Cancer Center, Houston</wicri:regionArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S." last="Gallinger">S. Gallinger</name><affiliation><nlm:aff id="aff7">Toronto General Hospital</nlm:aff></affiliation></author><author><name sortKey="Miller, A B" sort="Miller, A B" uniqKey="Miller A" first="A. B." last="Miller">A. B. Miller</name><affiliation wicri:level="4"><nlm:aff id="aff8">Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Dalla Lana School of Public Health, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name><affiliation><nlm:aff id="aff9">National Institute for Public Health and the Environment (RIVM), Bilthoven</nlm:aff><wicri:noCountry code="subfield">Bilthoven</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff10">Department of Gastroenterology and Hepatology, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Medical Center Utrecht (UMCU), Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Talamini, R" sort="Talamini, R" uniqKey="Talamini R" first="R." last="Talamini">R. Talamini</name><affiliation wicri:level="1"><nlm:aff id="aff11">Centro di Riferimento Oncologico (CRO) – National Cancer Institute, Aviano (PN), Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Centro di Riferimento Oncologico (CRO) – National Cancer Institute, Aviano (PN)</wicri:regionArea><wicri:noRegion>Aviano (PN)</wicri:noRegion></affiliation></author><author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name><affiliation wicri:level="1"><nlm:aff id="aff11">Centro di Riferimento Oncologico (CRO) – National Cancer Institute, Aviano (PN), Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Centro di Riferimento Oncologico (CRO) – National Cancer Institute, Aviano (PN)</wicri:regionArea><wicri:noRegion>Aviano (PN)</wicri:noRegion></affiliation></author><author><name sortKey="Ghadirian, P" sort="Ghadirian, P" uniqKey="Ghadirian P" first="P." last="Ghadirian">P. Ghadirian</name><affiliation wicri:level="3"><nlm:aff id="aff12">Epidemiology Research Unit, Research Center of the University of Montreal Hospital Centre (CRCHUM), Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Epidemiology Research Unit, Research Center of the University of Montreal Hospital Centre (CRCHUM), Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Baghurst, P A" sort="Baghurst, P A" uniqKey="Baghurst P" first="P. A." last="Baghurst">P. A. Baghurst</name><affiliation wicri:level="1"><nlm:aff id="aff13">Public Health, Women's and Children's Hospital, Adelaide, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Public Health, Women's and Children's Hospital, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Zatonski, W" sort="Zatonski, W" uniqKey="Zatonski W" first="W." last="Zatonski">W. Zatonski</name><affiliation wicri:level="1"><nlm:aff id="aff14">Cancer Center & Institute of Oncology, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Cancer Center & Institute of Oncology, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Fontham, E" sort="Fontham, E" uniqKey="Fontham E" first="E." last="Fontham">E. Fontham</name><affiliation wicri:level="1"><nlm:aff id="aff15">Louisiana State University, New Orleans, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Louisiana State University, New Orleans</wicri:regionArea><wicri:noRegion>New Orleans</wicri:noRegion></affiliation></author><author><name sortKey="Bamlet, W R" sort="Bamlet, W R" uniqKey="Bamlet W" first="W. R." last="Bamlet">W. R. Bamlet</name><affiliation><nlm:aff id="aff4">Mayo Clinic, Rochester</nlm:aff><wicri:noCountry code="subfield">Rochester</wicri:noCountry></affiliation></author><author><name sortKey="Holly, E A" sort="Holly, E A" uniqKey="Holly E" first="E. A." last="Holly">E. A. Holly</name><affiliation wicri:level="3"><nlm:aff id="aff5">University of California – San Francisco, San Francisco</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>University of California – San Francisco</wicri:orgArea></affiliation></author><author><name sortKey="Gao, Y T" sort="Gao, Y T" uniqKey="Gao Y" first="Y. T." last="Gao">Y. T. Gao</name><affiliation wicri:level="1"><nlm:aff id="aff16">Shanghai Cancer Institute, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Cancer Institute, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name><affiliation><nlm:aff id="aff1">Department of Epidemiology, Istituto di Ricerche Farmacologiche “Mario Negri” Milan</nlm:aff><wicri:noCountry code="subfield">Istituto di Ricerche Farmacologiche “Mario Negri” Milan</wicri:noCountry></affiliation></author><author><name sortKey="Hassan, M" sort="Hassan, M" uniqKey="Hassan M" first="M." last="Hassan">M. Hassan</name><affiliation wicri:level="3"><nlm:aff id="aff6">MD Anderson Cancer Center, Houston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MD Anderson Cancer Center, Houston</wicri:regionArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name><affiliation wicri:level="4"><nlm:aff id="aff8">Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Dalla Lana School of Public Health, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff17">Population Studies and Surveillance, Cancer Care Ontario, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Population Studies and Surveillance, Cancer Care Ontario, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Su, J" sort="Su, J" uniqKey="Su J" first="J." last="Su">J. Su</name><affiliation><nlm:aff id="aff3">National Cancer Institute, Bethesda</nlm:aff><wicri:noCountry code="subfield">Bethesda</wicri:noCountry></affiliation></author><author><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name><affiliation wicri:level="3"><nlm:aff id="aff18">European Institute of Oncology, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>European Institute of Oncology, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name><affiliation wicri:level="3"><nlm:aff id="aff19">International Prevention Research Institute, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Prevention Research Institute, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff20">The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Tisch Cancer Institute, Mount Sinai School of Medicine, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Duell, E J" sort="Duell, E J" uniqKey="Duell E" first="E. J." last="Duell">E. J. Duell</name><affiliation wicri:level="3"><nlm:aff id="aff21">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff22">Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Catalan Institute of Oncology (ICO-IDIBELL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></analytic><series><title level="j">Annals of Oncology</title><idno type="ISSN">0923-7534</idno><idno type="eISSN">1569-8041</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved.</p></sec><sec><title>Methods:</title><p>To evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case–control studies (5585 cases and 11 827 controls) participating in the International Pancreatic Cancer Case–Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models.</p></sec><sec><title>Results:</title><p>Compared with abstainers and occasional drinkers (<1 drink per day), we observed no association for light-to-moderate alcohol consumption (≤4 drinks per day) and pancreatic cancer risk; however, associations were above unity for higher consumption levels (OR = 1.6, 95% confidence interval 1.2–2.2 for subjects drinking ≥9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area.</p></sec><sec><title>Conclusion:</title><p>This collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer.</p></sec></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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