AustralieFrV1, Main, Merge, bibRecord, 004F56

Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study

Identifieur interne : 004F56 ( Main/Merge ); précédent : 004F55; suivant : 004F57

Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study

Auteurs : Ho-Sun Lee [France] ; Albino Barraza-Villarreal [Mexique] ; Hector Hernandez-Vargas [France] ; Peter D. Sly [Australie] ; Carine Biessy [France] ; Usha Ramakrishnan [États-Unis] ; Isabelle Romieu [France, Mexique] ; Zdenko Herceg [France]

Source :

The American journal of clinical nutrition [ 0002-9165 ] ; 2013.

RBID : Pascal:13-0271512

Descripteurs français

Pascal (Inist)
- DNA, Méthylation, Système immunitaire, Supplémentation, Gestation, Nutrition, Nourrisson.
Wicri :
- topic : Nutrition.

English descriptors

KwdEn :
- DNA, Immune system, Infant, Methylation, Nutrition, Pregnancy, Supplementation.

Abstract

Background: Early-life exposures to tobacco smoke and some dietary factors have been identified to induce epigenetic changes in genes involved in allergy and asthma development. Omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake during pregnancy could modulate key cytokines and T helper (Th) cell maturation; however, little is known about the mechanism by which ω-3 PUFA could have a beneficial effect in preventing inflammatory disorders. Objective: We sought to test whether prenatal dietary supplementation with ω-3 PUFA during pregnancy may modulate epigenetic states in the infant immune system. Design: This study was based on a randomized intervention trial conducted in Mexican pregnant women supplemented daily with 400 mg docosahexaenoic acid (DHA) or a placebo from 18 to 22 wk of gestation to parturition. We applied quantitative profiling of DNA methylation states in Thl, Th2, Th17, and regulatory T-relevant genes as well as LINE1 repetitive elements of cord blood mononuclear cells (n = 261). Results: No significant difference in promoter methylation levels was shown between ω-3 PUFA-supplemented and control groups for the genes analyzed; however, ω-3 PUFA supplementation was associated with changes in methylation levels in LINE1 repetitive elements (P = 0.03) in infants of mothers who smoked during pregnancy. Furthermore, an association between the promoter methylation levels of IFNγ and IL13 was modulated by ω-3 PUFA supplementation (P = 0.06). Conclusions: Our results indicate that maternal supplementation with ω-3 PUFA during pregnancy may modulate global methylation levels and the Th1/Th2 balance in infants. Therefore, the epigenetic mechanisms could provide attractive targets for prenatal modulation and prevention of inflammatory disorders and potentially other related diseases in childhood and adulthood.

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Pascal:13-0271512

Le document en format XML

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<front><div type="abstract" xml:lang="en">Background: Early-life exposures to tobacco smoke and some dietary factors have been identified to induce epigenetic changes in genes involved in allergy and asthma development. Omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake during pregnancy could modulate key cytokines and T helper (Th) cell maturation; however, little is known about the mechanism by which ω-3 PUFA could have a beneficial effect in preventing inflammatory disorders. Objective: We sought to test whether prenatal dietary supplementation with ω-3 PUFA during pregnancy may modulate epigenetic states in the infant immune system. Design: This study was based on a randomized intervention trial conducted in Mexican pregnant women supplemented daily with 400 mg docosahexaenoic acid (DHA) or a placebo from 18 to 22 wk of gestation to parturition. We applied quantitative profiling of DNA methylation states in Thl, Th2, Th17, and regulatory T-relevant genes as well as LINE1 repetitive elements of cord blood mononuclear cells (n = 261). Results: No significant difference in promoter methylation levels was shown between ω-3 PUFA-supplemented and control groups for the genes analyzed; however, ω-3 PUFA supplementation was associated with changes in methylation levels in LINE1 repetitive elements (P = 0.03) in infants of mothers who smoked during pregnancy. Furthermore, an association between the promoter methylation levels of IFNγ and IL13 was modulated by ω-3 PUFA supplementation (P = 0.06). Conclusions: Our results indicate that maternal supplementation with ω-3 PUFA during pregnancy may modulate global methylation levels and the Th1/Th2 balance in infants. Therefore, the epigenetic mechanisms could provide attractive targets for prenatal modulation and prevention of inflammatory disorders and potentially other related diseases in childhood and adulthood.</div>
</front>
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<name sortKey="Biessy, Carine" sort="Biessy, Carine" uniqKey="Biessy C" first="Carine" last="Biessy">Carine Biessy</name>
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<country name="Mexique"><noRegion><name sortKey="Barraza Villarreal, Albino" sort="Barraza Villarreal, Albino" uniqKey="Barraza Villarreal A" first="Albino" last="Barraza-Villarreal">Albino Barraza-Villarreal</name>
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<country name="États-Unis"><noRegion><name sortKey="Ramakrishnan, Usha" sort="Ramakrishnan, Usha" uniqKey="Ramakrishnan U" first="Usha" last="Ramakrishnan">Usha Ramakrishnan</name>
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Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study

Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri