AustralieFrV1, Main, Merge, bibRecord, 004507

Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage

Identifieur interne : 004507 ( Main/Merge ); précédent : 004506; suivant : 004508

Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage

Auteurs : Pierre B. Cattenoz [Australie, France] ; Ryan J. Taft [Australie] ; Eric Westhof [France] ; John S. Mattick [Australie]

Source :

RNA [ 1355-8382 ] ; 2013.

RBID : PMC:3543087

Abstract

Adenosine to inosine (A > I) RNA editing, which is catalyzed by the ADAR family of proteins, is one of the fundamental mechanisms by which transcriptomic diversity is generated. Indeed, a number of genome-wide analyses have shown that A > I editing is not limited to a few mRNAs, as originally thought, but occurs widely across the transcriptome, especially in the brain. Importantly, there is increasing evidence that A > I editing is essential for animal development and nervous system function. To more efficiently characterize the complete catalog of ADAR events in the mammalian transcriptome the authors developed a high-throughput protocol to identify A > I editing sites, which exploits the capacity of glyoxal to protect guanosine, but not inosine, from RNAse T1 treatment. Using this method they identified 665 editing sites in mouse brain RNA, including most known sites and suite of novel sites that include nonsynonymous changes to protein-coding genes and hyperediting of genes known to regulate p53.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543087

DOI: 10.1261/rna.036202.112
PubMed: 23264566
PubMed Central: 3543087

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to stream Ncbi, to step Merge: 001070
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PMC:3543087

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Adenosine to inosine (A > I) RNA editing, which is catalyzed by the ADAR family of proteins, is one of the fundamental mechanisms by which transcriptomic diversity is generated. Indeed, a number of genome-wide analyses have shown that A > I editing is not limited to a few mRNAs, as originally thought, but occurs widely across the transcriptome, especially in the brain. Importantly, there is increasing evidence that A > I editing is essential for animal development and nervous system function. To more efficiently characterize the complete catalog of ADAR events in the mammalian transcriptome the authors developed a high-throughput protocol to identify A > I editing sites, which exploits the capacity of glyoxal to protect guanosine, but not inosine, from RNAse T1 treatment. Using this method they identified 665 editing sites in mouse brain RNA, including most known sites and suite of novel sites that include nonsynonymous changes to protein-coding genes and hyperediting of genes known to regulate p53.</p>
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Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage

Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki