To what extent does anti-mullerian hormone contribute to a better prediction of live birth after IVF?
Identifieur interne : 003418 ( Main/Merge ); précédent : 003417; suivant : 003419To what extent does anti-mullerian hormone contribute to a better prediction of live birth after IVF?
Auteurs : Catherine Rongieres [France] ; Carolina Colella [France] ; Philippe Lehert [Belgique, Australie]Source :
- Journal of Assisted Reproduction and Genetics [ 1058-0468 ] ; 2014.
Abstract
We assessed the predictive value added by Anti-Mullerian Hormone (AMH) to currently validated live birth (LB) prediction models.
Based on recent data from our center, we compared the external validity of the Templeton Model (TM) and its recent improvement (TMA) to select our model of reference. The added predictive value of AMH was assessed in testing the likelihood ratio significance and the Net Reclassification Index (NRI). The surrogate utility of AMH was tested by conducting an exploratory stepwise logistic regression.
Based on 715 cycles, the original TM had poor performances (auROC C = 0.61 [0.58, 0.66], improving by fitting TM to our data (C = 0.71[0.66, 0.75]. TMA fitting proved better (C = 0.76; 95 %CI: 0.71, 0.80) and was selected as model of reference. Adding AMH to TMA or TM had no effect on discrimination (C = 0.76; 95 %CI: 0.72, 0.80), the likelihood ratio test was significant (
The added predictive value of AMH is limited. A possible surrogate/simplifying effect of AMH was found in eliminating 9/13 predictors from the model of reference. We conclude that whereas AMH does not add significant predictive value to the existing model, it contributes to simplifying the equation to reliable, easy to collect, and available in all databases predictors: age, AMH, time trend and female previous fertility history.
Url:
DOI: 10.1007/s10815-014-0348-3
PubMed: 25370179
PubMed Central: 4294874
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000A01
- to stream Pmc, to step Curation: 000978
- to stream Pmc, to step Checkpoint: 001286
- to stream Ncbi, to step Merge: 001F57
- to stream Ncbi, to step Curation: 001F57
- to stream Ncbi, to step Checkpoint: 001F57
Links to Exploration step
PMC:4294874Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">To what extent does anti-mullerian hormone contribute to a better prediction of live birth after IVF?</title>
<author><name sortKey="Rongieres, Catherine" sort="Rongieres, Catherine" uniqKey="Rongieres C" first="Catherine" last="Rongieres">Catherine Rongieres</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">ART Centre, Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ART Centre, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Colella, Carolina" sort="Colella, Carolina" uniqKey="Colella C" first="Carolina" last="Colella">Carolina Colella</name>
<affiliation wicri:level="3"><nlm:aff id="Aff4">Merck-Serono, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Merck-Serono, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lehert, Philippe" sort="Lehert, Philippe" uniqKey="Lehert P" first="Philippe" last="Lehert">Philippe Lehert</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Faculty of Economics, UCL Mons, Louvain, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Faculty of Economics, UCL Mons, Louvain</wicri:regionArea>
<wicri:noRegion>Louvain</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="Aff3">Faculty of Medicine, The University of Melbourne, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Medicine, The University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25370179</idno>
<idno type="pmc">4294874</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294874</idno>
<idno type="RBID">PMC:4294874</idno>
<idno type="doi">10.1007/s10815-014-0348-3</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000A01</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A01</idno>
<idno type="wicri:Area/Pmc/Curation">000978</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000978</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001286</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001286</idno>
<idno type="wicri:Area/Ncbi/Merge">001F57</idno>
<idno type="wicri:Area/Ncbi/Curation">001F57</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001F57</idno>
<idno type="wicri:doubleKey">1058-0468:2014:Rongieres C:to:what:extent</idno>
<idno type="wicri:Area/Main/Merge">003418</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">To what extent does anti-mullerian hormone contribute to a better prediction of live birth after IVF?</title>
<author><name sortKey="Rongieres, Catherine" sort="Rongieres, Catherine" uniqKey="Rongieres C" first="Catherine" last="Rongieres">Catherine Rongieres</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">ART Centre, Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ART Centre, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Colella, Carolina" sort="Colella, Carolina" uniqKey="Colella C" first="Carolina" last="Colella">Carolina Colella</name>
<affiliation wicri:level="3"><nlm:aff id="Aff4">Merck-Serono, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Merck-Serono, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lehert, Philippe" sort="Lehert, Philippe" uniqKey="Lehert P" first="Philippe" last="Lehert">Philippe Lehert</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Faculty of Economics, UCL Mons, Louvain, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Faculty of Economics, UCL Mons, Louvain</wicri:regionArea>
<wicri:noRegion>Louvain</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="Aff3">Faculty of Medicine, The University of Melbourne, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Medicine, The University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Assisted Reproduction and Genetics</title>
<idno type="ISSN">1058-0468</idno>
<idno type="eISSN">1573-7330</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Objective</title>
<p>We assessed the predictive value added by Anti-Mullerian Hormone (AMH) to currently validated live birth (LB) prediction models.</p>
</sec>
<sec><title>Methods</title>
<p>Based on recent data from our center, we compared the external validity of the Templeton Model (TM) and its recent improvement (TMA) to select our model of reference. The added predictive value of AMH was assessed in testing the likelihood ratio significance and the Net Reclassification Index (NRI). The surrogate utility of AMH was tested by conducting an exploratory stepwise logistic regression.</p>
</sec>
<sec><title>Results</title>
<p>Based on 715 cycles, the original TM had poor performances (auROC C = 0.61 [0.58, 0.66], improving by fitting TM to our data (C = 0.71[0.66, 0.75]. TMA fitting proved better (C = 0.76; 95 %CI: 0.71, 0.80) and was selected as model of reference. Adding AMH to TMA or TM had no effect on discrimination (C = 0.76; 95 %CI: 0.72, 0.80), the likelihood ratio test was significant (<italic>p</italic>
= 0.023), but the NRI was not (6.7 %; <italic>p</italic>
= 0.055). A stepwise exploratory logistic regression identified the effects of age, previous IVF resulting in LB, time trend and AMH, leading to a prediction model reduced to four predictors (C = 0.75 [0.70, 0.81]).</p>
</sec>
<sec><title>Conclusion</title>
<p>The added predictive value of AMH is limited. A possible surrogate/simplifying effect of AMH was found in eliminating 9/13 predictors from the model of reference. We conclude that whereas AMH does not add significant predictive value to the existing model, it contributes to simplifying the equation to reliable, easy to collect, and available in all databases predictors: age, AMH, time trend and female previous fertility history.</p>
</sec>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003418 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003418 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:4294874 |texte= To what extent does anti-mullerian hormone contribute to a better prediction of live birth after IVF? }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:25370179" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |