Balancing natural killer cell activation through paired receptors.
Identifieur interne : 003120 ( Main/Merge ); précédent : 003119; suivant : 003121Balancing natural killer cell activation through paired receptors.
Auteurs : Ludovic Martinet [France] ; Mark J. Smyth [Australie]Source :
- Nature reviews. Immunology [ 1474-1741 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Activation des lymphocytes, Cellules tueuses naturelles.
- métabolisme : Cellules tueuses naturelles, Récepteurs de cellules tueuses naturelles.
- Animaux, Humains, Ligands, Transduction du signal.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Receptors, Natural Killer Cell.
- chemical : Ligands.
- immunology : Killer Cells, Natural, Lymphocyte Activation.
- metabolism : Killer Cells, Natural.
- Animals, Humans, Signal Transduction.
Abstract
Natural killer (NK) cells are innate lymphocytes that are crucial for the control of infections and malignancies. NK cells express a variety of inhibitory and activating receptors that facilitate fine discrimination between damaged and healthy cells. Among them, a family of molecules that bind nectin and nectin-like proteins has recently emerged and has been shown to function as an important regulator of NK cell functions. These molecules include CD226, T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT), CD96, and cytotoxic and regulatory T cell molecule (CRTAM). In this Review, we focus on the recent advances in our understanding of how these receptors regulate NK cell biology and of their roles in pathologies such as cancer, infection and autoimmunity.
DOI: 10.1038/nri3799
PubMed: 25743219
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pubmed:25743219Le document en format XML
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[2] School of Medicine, University of Queensland, Herston, Queensland 4006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia. 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[2] Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 1037, Cancer Research Center of Toulouse, Toulouse F-31000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia. [2] Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 1037, Cancer Research Center of Toulouse, Toulouse F-31000</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Midi-Pyrénées</region></placeName></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name><affiliation wicri:level="1"><nlm:affiliation>1] Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia. 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Immunology</title><idno type="eISSN">1474-1741</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Humans</term><term>Killer Cells, Natural (immunology)</term><term>Killer Cells, Natural (metabolism)</term><term>Ligands</term><term>Lymphocyte Activation (immunology)</term><term>Receptors, Natural Killer Cell (metabolism)</term><term>Signal Transduction</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (immunologie)</term><term>Animaux</term><term>Cellules tueuses naturelles (immunologie)</term><term>Cellules tueuses naturelles (métabolisme)</term><term>Humains</term><term>Ligands</term><term>Récepteurs de cellules tueuses naturelles (métabolisme)</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Natural Killer Cell</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Ligands</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Activation des lymphocytes</term><term>Cellules tueuses naturelles</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Killer Cells, Natural</term><term>Lymphocyte Activation</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Killer Cells, Natural</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules tueuses naturelles</term><term>Récepteurs de cellules tueuses naturelles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Ligands</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Natural killer (NK) cells are innate lymphocytes that are crucial for the control of infections and malignancies. NK cells express a variety of inhibitory and activating receptors that facilitate fine discrimination between damaged and healthy cells. Among them, a family of molecules that bind nectin and nectin-like proteins has recently emerged and has been shown to function as an important regulator of NK cell functions. These molecules include CD226, T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT), CD96, and cytotoxic and regulatory T cell molecule (CRTAM). In this Review, we focus on the recent advances in our understanding of how these receptors regulate NK cell biology and of their roles in pathologies such as cancer, infection and autoimmunity.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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