Variants associated with Gaucher disease in multiple system atrophy
Identifieur interne : 002655 ( Main/Merge ); précédent : 002654; suivant : 002656Variants associated with Gaucher disease in multiple system atrophy
Auteurs : Jun Mitsui [Japon] ; Takashi Matsukawa [Japon] ; Hidenao Sasaki [Japon] ; Ichiro Yabe [Japon] ; Masaaki Matsushima [Japon] ; Alexandra Dürr [France] ; Alexis Brice [France] ; Hiroshi Takashima [Japon] ; Akio Kikuchi [Japon] ; Masashi Aoki [Japon] ; Hiroyuki Ishiura [Japon] ; Tsutomu Yasuda [Japon] ; Hidetoshi Date [Japon] ; Budrul Ahsan [Japon] ; Atsushi Iwata [Japon] ; Jun Goto [Japon] ; Yaeko Ichikawa [Japon] ; Yasuo Nakahara [Japon] ; Yoshio Momose [Japon] ; Yuji Takahashi [Japon] ; Kenju Hara [Japon] ; Akiyoshi Kakita [Japon] ; Mitsunori Yamada [Japon] ; Hitoshi Takahashi [Japon] ; Osamu Onodera [Japon] ; Masatoyo Nishizawa [Japon] ; Hirohisa Watanabe [Japon] ; Mizuki Ito [Japon] ; Gen Sobue [Japon] ; Kinya Ishikawa [Japon] ; Hidehiro Mizusawa [Japon] ; Kazuaki Kanai [Japon] ; Takamichi Hattori [Japon] ; Satoshi Kuwabara [Japon] ; Kimihito Arai [Japon] ; Shigeru Koyano [Japon] ; Yoshiyuki Kuroiwa [Japon] ; Kazuko Hasegawa [Japon] ; Tatsuhiko Yuasa [Japon] ; Kenichi Yasui [Japon] ; Kenji Nakashima [Japon] ; Hijiri Ito [Japon] ; Yuishin Izumi [Japon] ; Ryuji Kaji [Japon] ; Takeo Kato [Japon] ; Susumu Kusunoki [Japon] ; Yasushi Osaki [Japon] ; Masahiro Horiuchi [Japon] ; Tomoyoshi Kondo [Japon] ; Shigeo Murayama [Japon] ; Nobutaka Hattori [Japon] ; Mitsutoshi Yamamoto [Japon] ; Miho Murata [Japon] ; Wataru Satake [Japon] ; Tatsushi Toda [Japon] ; Alessandro Filla [Italie] ; Thomas Klockgether [Allemagne] ; Ullrich Wüllner [Allemagne] ; Garth Nicholson [Australie] ; Sid Gilman [États-Unis] ; Caroline M. Tanner [États-Unis] ; Walter A. Kukull [États-Unis] ; Mathew B. Stern [États-Unis] ; Virginia M-Y Lee [États-Unis] ; John Q. Trojanowski [États-Unis] ; Eliezer Masliah [États-Unis] ; Phillip A. Low [États-Unis] ; Paola Sandroni [États-Unis] ; Laurie J. Ozelius [États-Unis] ; Tatiana Foroud [États-Unis] ; Shoji Tsuji [Japon]Source :
- Annals of Clinical and Translational Neurology [ 2328-9503 ] ; 2015.
Abstract
Glucocerebrosidase gene (
We sequenced coding regions and flanking splice sites of
In the Japanese series, we found nine carriers among the MSA patients (1.65%) and eight carriers among the control subjects (0.89%). In the European series, we found three carriers among the MSA patients (1.35%) and two carriers among the control subjects (0.63%). In the North American series, we found five carriers among the MSA patients (2.91%) and one carrier among the control subjects (0.34%). Subjecting each series to a Mantel–Haenszel analysis yielded a pooled odds ratio (OR) of 2.44 (95% confidence interval [CI], 1.14–5.21) and a
The findings indicate that, as in PD and DLB, Gaucher-disease-causing
Url:
DOI: 10.1002/acn3.185
PubMed: 25909086
PubMed Central: 4402086
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sort="Matsushima, Masaaki" uniqKey="Matsushima M" first="Masaaki" last="Matsushima">Masaaki Matsushima</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neurology, Hokkaido University Graduate School of Medicine</institution><addr-line>Sapporo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Sapporo</wicri:regionArea></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name><affiliation wicri:level="3"><nlm:aff id="au3"><institution>AP-HP, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Inserm, U 1127, Cnrs, UMR 7225, 3- Sorbonne Université, UPMC Univ Paris 06, UM 75, ICM</institution><addr-line>F-75013, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>F-75013, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old 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id="au4"><institution>Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences</institution><addr-line>Kagoshima, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Kagoshima</wicri:regionArea></affiliation></author><author><name sortKey="Kikuchi, Akio" sort="Kikuchi, Akio" uniqKey="Kikuchi A" first="Akio" last="Kikuchi">Akio Kikuchi</name><affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Neurology, Tohoku University School of Medicine</institution><addr-line>Sendai, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Sendai</wicri:regionArea></affiliation></author><author><name sortKey="Aoki, Masashi" sort="Aoki, Masashi" uniqKey="Aoki M" first="Masashi" last="Aoki">Masashi Aoki</name><affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Neurology, Tohoku University School of Medicine</institution><addr-line>Sendai, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Sendai</wicri:regionArea></affiliation></author><author><name sortKey="Ishiura, Hiroyuki" sort="Ishiura, Hiroyuki" uniqKey="Ishiura H" first="Hiroyuki" last="Ishiura">Hiroyuki Ishiura</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Yasuda, Tsutomu" sort="Yasuda, Tsutomu" uniqKey="Yasuda T" first="Tsutomu" last="Yasuda">Tsutomu Yasuda</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Date, Hidetoshi" sort="Date, Hidetoshi" uniqKey="Date H" first="Hidetoshi" last="Date">Hidetoshi Date</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Ahsan, Budrul" sort="Ahsan, Budrul" uniqKey="Ahsan B" first="Budrul" last="Ahsan">Budrul Ahsan</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Iwata, Atsushi" sort="Iwata, Atsushi" uniqKey="Iwata A" first="Atsushi" last="Iwata">Atsushi Iwata</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Goto, Jun" sort="Goto, Jun" uniqKey="Goto J" first="Jun" last="Goto">Jun Goto</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Ichikawa, Yaeko" sort="Ichikawa, Yaeko" uniqKey="Ichikawa Y" first="Yaeko" last="Ichikawa">Yaeko Ichikawa</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Nakahara, Yasuo" sort="Nakahara, Yasuo" uniqKey="Nakahara Y" first="Yasuo" last="Nakahara">Yasuo Nakahara</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Momose, Yoshio" sort="Momose, Yoshio" uniqKey="Momose Y" first="Yoshio" last="Momose">Yoshio Momose</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Takahashi, Yuji" sort="Takahashi, Yuji" uniqKey="Takahashi Y" first="Yuji" last="Takahashi">Yuji Takahashi</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Hara, Kenju" sort="Hara, Kenju" uniqKey="Hara K" first="Kenju" last="Hara">Kenju Hara</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, Brain Research Institute, Niigata University</institution><addr-line>Niigata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Niigata</wicri:regionArea></affiliation></author><author><name sortKey="Kakita, Akiyoshi" sort="Kakita, Akiyoshi" uniqKey="Kakita A" first="Akiyoshi" last="Kakita">Akiyoshi Kakita</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>Department of Pathology, Brain Research Institute, Niigata University</institution><addr-line>Niigata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Niigata</wicri:regionArea></affiliation></author><author><name sortKey="Yamada, Mitsunori" sort="Yamada, Mitsunori" uniqKey="Yamada M" first="Mitsunori" last="Yamada">Mitsunori Yamada</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>Department of Pathology, Brain Research Institute, Niigata University</institution><addr-line>Niigata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Niigata</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au8"><institution>Department of Clinical Research, Saigata Medical Center, National Hospital Organization</institution><addr-line>Niigata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Niigata</wicri:regionArea></affiliation></author><author><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>Department of Pathology, Brain Research Institute, Niigata University</institution><addr-line>Niigata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Niigata</wicri:regionArea></affiliation></author><author><name sortKey="Onodera, Osamu" sort="Onodera, Osamu" uniqKey="Onodera O" first="Osamu" last="Onodera">Osamu Onodera</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, Brain Research Institute, Niigata University</institution><addr-line>Niigata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Niigata</wicri:regionArea></affiliation></author><author><name sortKey="Nishizawa, Masatoyo" sort="Nishizawa, Masatoyo" uniqKey="Nishizawa M" first="Masatoyo" last="Nishizawa">Masatoyo Nishizawa</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, Brain Research Institute, Niigata University</institution><addr-line>Niigata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Niigata</wicri:regionArea></affiliation></author><author><name sortKey="Watanabe, Hirohisa" sort="Watanabe, Hirohisa" uniqKey="Watanabe H" first="Hirohisa" last="Watanabe">Hirohisa Watanabe</name><affiliation wicri:level="1"><nlm:aff id="au9"><institution>Department of Neurology, Nagoya University Graduate School of Medicine</institution><addr-line>Nagoya, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Nagoya</wicri:regionArea></affiliation></author><author><name sortKey="Ito, Mizuki" sort="Ito, Mizuki" uniqKey="Ito M" first="Mizuki" last="Ito">Mizuki Ito</name><affiliation wicri:level="1"><nlm:aff id="au9"><institution>Department of Neurology, Nagoya University Graduate School of Medicine</institution><addr-line>Nagoya, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Nagoya</wicri:regionArea></affiliation></author><author><name sortKey="Sobue, Gen" sort="Sobue, Gen" uniqKey="Sobue G" first="Gen" last="Sobue">Gen Sobue</name><affiliation wicri:level="1"><nlm:aff id="au9"><institution>Department of Neurology, Nagoya University Graduate School of Medicine</institution><addr-line>Nagoya, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Nagoya</wicri:regionArea></affiliation></author><author><name sortKey="Ishikawa, Kinya" sort="Ishikawa, Kinya" uniqKey="Ishikawa K" first="Kinya" last="Ishikawa">Kinya Ishikawa</name><affiliation wicri:level="1"><nlm:aff id="au10"><institution>Department of Neurology and Neurological Science, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Mizusawa, Hidehiro" sort="Mizusawa, Hidehiro" uniqKey="Mizusawa H" first="Hidehiro" last="Mizusawa">Hidehiro Mizusawa</name><affiliation wicri:level="1"><nlm:aff id="au10"><institution>Department of Neurology and Neurological Science, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Kanai, Kazuaki" sort="Kanai, Kazuaki" uniqKey="Kanai K" first="Kazuaki" last="Kanai">Kazuaki Kanai</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Department of Neurology, Chiba University School of Medicine</institution><addr-line>Chiba, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Chiba</wicri:regionArea></affiliation></author><author><name sortKey="Hattori, Takamichi" sort="Hattori, Takamichi" uniqKey="Hattori T" first="Takamichi" last="Hattori">Takamichi Hattori</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Department of Neurology, Chiba University School of Medicine</institution><addr-line>Chiba, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Chiba</wicri:regionArea></affiliation></author><author><name sortKey="Kuwabara, Satoshi" sort="Kuwabara, Satoshi" uniqKey="Kuwabara S" first="Satoshi" last="Kuwabara">Satoshi Kuwabara</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Department of Neurology, Chiba University School of Medicine</institution><addr-line>Chiba, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Chiba</wicri:regionArea></affiliation></author><author><name sortKey="Arai, Kimihito" sort="Arai, Kimihito" uniqKey="Arai K" first="Kimihito" last="Arai">Kimihito Arai</name><affiliation wicri:level="1"><nlm:aff id="au12"><institution>Division of Neurology, National Hospital Organization, Chiba East Hospital</institution><addr-line>Chiba, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Chiba</wicri:regionArea></affiliation></author><author><name sortKey="Koyano, Shigeru" sort="Koyano, Shigeru" uniqKey="Koyano S" first="Shigeru" last="Koyano">Shigeru Koyano</name><affiliation wicri:level="1"><nlm:aff id="au13"><institution>Department of Clinical Neurology and Stroke Medicine, Graduate School of Medicine, Yokohama City University</institution><addr-line>Yokohama, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Yokohama</wicri:regionArea></affiliation></author><author><name sortKey="Kuroiwa, Yoshiyuki" sort="Kuroiwa, Yoshiyuki" uniqKey="Kuroiwa Y" first="Yoshiyuki" last="Kuroiwa">Yoshiyuki Kuroiwa</name><affiliation wicri:level="1"><nlm:aff id="au14"><institution>Department of Neurology, Teikyo University School of Medicine University Hospital</institution><addr-line>Mizonokuchi, Kawasaki, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Mizonokuchi, Kawasaki</wicri:regionArea><wicri:noRegion>Kawasaki</wicri:noRegion></affiliation></author><author><name sortKey="Hasegawa, Kazuko" sort="Hasegawa, Kazuko" uniqKey="Hasegawa K" first="Kazuko" last="Hasegawa">Kazuko Hasegawa</name><affiliation wicri:level="1"><nlm:aff id="au15"><institution>Division of Neurology, National Hospital Organization, Sagamihara National Hospital</institution><addr-line>Sagamihara, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Sagamihara</wicri:regionArea></affiliation></author><author><name sortKey="Yuasa, Tatsuhiko" sort="Yuasa, Tatsuhiko" uniqKey="Yuasa T" first="Tatsuhiko" last="Yuasa">Tatsuhiko Yuasa</name><affiliation wicri:level="1"><nlm:aff id="au16"><institution>Department of Neurology, Kamagaya-Chiba Medical Center for Intractable Neurological Disease, Kamagaya General Hospital</institution><addr-line>Chiba, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Chiba</wicri:regionArea></affiliation></author><author><name sortKey="Yasui, Kenichi" sort="Yasui, Kenichi" uniqKey="Yasui K" first="Kenichi" last="Yasui">Kenichi Yasui</name><affiliation wicri:level="1"><nlm:aff id="au17"><institution>Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University</institution><addr-line>Yonago, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Yonago</wicri:regionArea></affiliation></author><author><name sortKey="Nakashima, Kenji" sort="Nakashima, Kenji" uniqKey="Nakashima K" first="Kenji" last="Nakashima">Kenji Nakashima</name><affiliation wicri:level="1"><nlm:aff id="au17"><institution>Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University</institution><addr-line>Yonago, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Yonago</wicri:regionArea></affiliation></author><author><name sortKey="Ito, Hijiri" sort="Ito, Hijiri" uniqKey="Ito H" first="Hijiri" last="Ito">Hijiri Ito</name><affiliation wicri:level="1"><nlm:aff id="au18"><institution>Department of Neurology, Mifukai Vihara Hananosato Hospital</institution><addr-line>Hiroshima, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Hiroshima</wicri:regionArea></affiliation></author><author><name sortKey="Izumi, Yuishin" sort="Izumi, Yuishin" uniqKey="Izumi Y" first="Yuishin" last="Izumi">Yuishin Izumi</name><affiliation wicri:level="1"><nlm:aff id="au19"><institution>Department of Clinical Neuroscience, Institute of Health Biosciences, University of Tokushima Graduate School</institution><addr-line>Tokushima, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokushima</wicri:regionArea></affiliation></author><author><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name><affiliation wicri:level="1"><nlm:aff id="au19"><institution>Department of Clinical Neuroscience, Institute of Health Biosciences, University of Tokushima Graduate School</institution><addr-line>Tokushima, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokushima</wicri:regionArea></affiliation></author><author><name sortKey="Kato, Takeo" sort="Kato, Takeo" uniqKey="Kato T" first="Takeo" last="Kato">Takeo Kato</name><affiliation wicri:level="1"><nlm:aff id="au20"><institution>Departments of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University</institution><addr-line>Yamagata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Yamagata</wicri:regionArea></affiliation></author><author><name sortKey="Kusunoki, Susumu" sort="Kusunoki, Susumu" uniqKey="Kusunoki S" first="Susumu" last="Kusunoki">Susumu Kusunoki</name><affiliation wicri:level="1"><nlm:aff id="au21"><institution>Department of Neurology, Kinki University School of Medicine</institution><addr-line>Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Osaka</wicri:regionArea></affiliation></author><author><name sortKey="Osaki, Yasushi" sort="Osaki, Yasushi" uniqKey="Osaki Y" first="Yasushi" last="Osaki">Yasushi Osaki</name><affiliation wicri:level="1"><nlm:aff id="au22"><institution>Department of Geriatrics, Cardiology and Neurology, Kochi Medical School</institution><addr-line>Nankoku, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Nankoku</wicri:regionArea></affiliation></author><author><name sortKey="Horiuchi, Masahiro" sort="Horiuchi, Masahiro" uniqKey="Horiuchi M" first="Masahiro" last="Horiuchi">Masahiro Horiuchi</name><affiliation wicri:level="1"><nlm:aff id="au23"><institution>Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine</institution><addr-line>Kawasaki, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Kawasaki</wicri:regionArea></affiliation></author><author><name sortKey="Kondo, Tomoyoshi" sort="Kondo, Tomoyoshi" uniqKey="Kondo T" first="Tomoyoshi" last="Kondo">Tomoyoshi Kondo</name><affiliation wicri:level="1"><nlm:aff id="au24"><institution>Department of Neurology, Wakayama Medical University</institution><addr-line>Wakayama, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Wakayama</wicri:regionArea></affiliation></author><author><name sortKey="Murayama, Shigeo" sort="Murayama, Shigeo" uniqKey="Murayama S" first="Shigeo" last="Murayama">Shigeo Murayama</name><affiliation wicri:level="1"><nlm:aff id="au25"><institution>Department of Neuropathology and the Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation wicri:level="1"><nlm:aff id="au26"><institution>Department of Neurology, Juntendo University School of Medicine</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Yamamoto, Mitsutoshi" sort="Yamamoto, Mitsutoshi" uniqKey="Yamamoto M" first="Mitsutoshi" last="Yamamoto">Mitsutoshi Yamamoto</name><affiliation wicri:level="1"><nlm:aff id="au27"><institution>Department of Neurology, Kagawa Prefectural Central Hospital</institution><addr-line>Takamatsu, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Takamatsu</wicri:regionArea></affiliation></author><author><name sortKey="Murata, Miho" sort="Murata, Miho" uniqKey="Murata M" first="Miho" last="Murata">Miho Murata</name><affiliation wicri:level="1"><nlm:aff id="au28"><institution>Department of Neurology, National Center Hospital of Neurology and Psychiatry</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Satake, Wataru" sort="Satake, Wataru" uniqKey="Satake W" first="Wataru" last="Satake">Wataru Satake</name><affiliation wicri:level="1"><nlm:aff id="au29"><institution>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine</institution><addr-line>Kobe, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Kobe</wicri:regionArea></affiliation></author><author><name sortKey="Toda, Tatsushi" sort="Toda, Tatsushi" uniqKey="Toda T" first="Tatsushi" last="Toda">Tatsushi Toda</name><affiliation wicri:level="1"><nlm:aff id="au29"><institution>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine</institution><addr-line>Kobe, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Kobe</wicri:regionArea></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation wicri:level="1"><nlm:aff id="au30"><institution>Department of Neurological Sciences, University Federico II</institution><addr-line>Naples, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Naples</wicri:regionArea></affiliation></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation wicri:level="1"><nlm:aff id="au31"><institution>Department of Neurology, University of Bonn and German Center for Neurodegenerative Diseases (DZNE)</institution><addr-line>Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Wullner, Ullrich" sort="Wullner, Ullrich" uniqKey="Wullner U" first="Ullrich" last="Wüllner">Ullrich Wüllner</name><affiliation wicri:level="1"><nlm:aff id="au31"><institution>Department of Neurology, University of Bonn and German Center for Neurodegenerative Diseases (DZNE)</institution><addr-line>Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Nicholson, Garth" sort="Nicholson, Garth" uniqKey="Nicholson G" first="Garth" last="Nicholson">Garth Nicholson</name><affiliation wicri:level="1"><nlm:aff id="au32"><institution>Concord Hospital, University of Sydney at the Australian and New Zealand Army Corps (ANZAC) Research Institute</institution><addr-line>Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Gilman, Sid" sort="Gilman, Sid" uniqKey="Gilman S" first="Sid" last="Gilman">Sid Gilman</name><affiliation wicri:level="2"><nlm:aff id="au33"><institution>Department of Neurology, University of Michigan</institution><addr-line>Ann Arbor, Michigan</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name><affiliation wicri:level="2"><nlm:aff id="au34"><institution>Parkinson's Disease Research Education and Clinical Center, San Francisco Veteran's Affairs Medical Center</institution><addr-line>San Francisco, California</addr-line></nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A" last="Kukull">Walter A. Kukull</name><affiliation wicri:level="2"><nlm:aff id="au35"><institution>Department of Epidemiology, University of Washington School of Public Health</institution><addr-line>Seattle, Washington</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Stern, Mathew B" sort="Stern, Mathew B" uniqKey="Stern M" first="Mathew B" last="Stern">Mathew B. Stern</name><affiliation wicri:level="2"><nlm:aff id="au36"><institution>Parkinson's Disease and Movement Disorders Center, Department of Neurology, Perelman School of Medicine at the University of Pennsylvania</institution><addr-line>Philadelphia, Pennsylvania</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Lee, Virginia M Y" sort="Lee, Virginia M Y" uniqKey="Lee V" first="Virginia M-Y" last="Lee">Virginia M-Y Lee</name><affiliation wicri:level="2"><nlm:aff id="au37"><institution>Institute on Aging, Udall Parkinson's Research Center, Center for Neurodegenerative Disease Research and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania</institution><addr-line>Philadelphia, Pennsylvania</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q" last="Trojanowski">John Q. Trojanowski</name><affiliation wicri:level="2"><nlm:aff id="au37"><institution>Institute on Aging, Udall Parkinson's Research Center, Center for Neurodegenerative Disease Research and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania</institution><addr-line>Philadelphia, Pennsylvania</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Masliah, Eliezer" sort="Masliah, Eliezer" uniqKey="Masliah E" first="Eliezer" last="Masliah">Eliezer Masliah</name><affiliation wicri:level="2"><nlm:aff id="au38"><institution>Department of Neurosciences, University of California San Diego</institution><addr-line>San Diego, California</addr-line></nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Low, Phillip A" sort="Low, Phillip A" uniqKey="Low P" first="Phillip A" last="Low">Phillip A. Low</name><affiliation wicri:level="2"><nlm:aff id="au39"><institution>Department of Neurology, Mayo Clinic</institution><addr-line>Rochester, Minnesota</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Sandroni, Paola" sort="Sandroni, Paola" uniqKey="Sandroni P" first="Paola" last="Sandroni">Paola Sandroni</name><affiliation wicri:level="2"><nlm:aff id="au39"><institution>Department of Neurology, Mayo Clinic</institution><addr-line>Rochester, Minnesota</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Ozelius, Laurie J" sort="Ozelius, Laurie J" uniqKey="Ozelius L" first="Laurie J" last="Ozelius">Laurie J. Ozelius</name><affiliation wicri:level="2"><nlm:aff id="au40"><institution>Departments of Genetics and Genomic Sciences and Neurology, Icahn School of Medicine at Mount Sinai</institution><addr-line>New York, New York</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>New York</wicri:cityArea></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="2"><nlm:aff id="au41"><institution>Department of Medical and Molecular Genetics, Indiana University School of Medicine</institution><addr-line>Indianapolis, Indiana</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Indianapolis</wicri:cityArea></affiliation></author><author><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25909086</idno><idno type="pmc">4402086</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402086</idno><idno type="RBID">PMC:4402086</idno><idno type="doi">10.1002/acn3.185</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002238</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002238</idno><idno type="wicri:Area/Pmc/Curation">002088</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002088</idno><idno type="wicri:Area/Pmc/Checkpoint">000C47</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C47</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002E27</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002E27</idno><idno type="wicri:Area/PubMed/Curation">002D51</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002D51</idno><idno type="wicri:Area/PubMed/Checkpoint">002D51</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002D51</idno><idno type="wicri:Area/Ncbi/Merge">002498</idno><idno type="wicri:Area/Ncbi/Curation">002498</idno><idno type="wicri:Area/Ncbi/Checkpoint">002498</idno><idno type="wicri:doubleKey">2328-9503:2015:Mitsui J:variants:associated:with</idno><idno type="wicri:Area/Main/Merge">002655</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Variants associated with Gaucher disease in multiple system atrophy</title><author><name sortKey="Mitsui, Jun" sort="Mitsui, Jun" uniqKey="Mitsui J" first="Jun" last="Mitsui">Jun Mitsui</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Matsukawa, Takashi" sort="Matsukawa, Takashi" uniqKey="Matsukawa T" first="Takashi" last="Matsukawa">Takashi Matsukawa</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Sasaki, Hidenao" sort="Sasaki, Hidenao" uniqKey="Sasaki H" first="Hidenao" last="Sasaki">Hidenao Sasaki</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neurology, Hokkaido University Graduate School of Medicine</institution><addr-line>Sapporo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Sapporo</wicri:regionArea></affiliation></author><author><name sortKey="Yabe, Ichiro" sort="Yabe, Ichiro" uniqKey="Yabe I" first="Ichiro" last="Yabe">Ichiro Yabe</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neurology, Hokkaido University Graduate School of Medicine</institution><addr-line>Sapporo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Sapporo</wicri:regionArea></affiliation></author><author><name sortKey="Matsushima, Masaaki" sort="Matsushima, Masaaki" uniqKey="Matsushima M" first="Masaaki" last="Matsushima">Masaaki Matsushima</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neurology, Hokkaido University Graduate School of Medicine</institution><addr-line>Sapporo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Sapporo</wicri:regionArea></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name><affiliation wicri:level="3"><nlm:aff id="au3"><institution>AP-HP, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Inserm, U 1127, Cnrs, UMR 7225, 3- Sorbonne Université, UPMC Univ Paris 06, UM 75, ICM</institution><addr-line>F-75013, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>F-75013, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="3"><nlm:aff id="au3"><institution>AP-HP, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Inserm, U 1127, Cnrs, UMR 7225, 3- Sorbonne Université, UPMC Univ Paris 06, UM 75, ICM</institution><addr-line>F-75013, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>F-75013, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Takashima, Hiroshi" sort="Takashima, Hiroshi" uniqKey="Takashima H" first="Hiroshi" last="Takashima">Hiroshi Takashima</name><affiliation wicri:level="1"><nlm:aff id="au4"><institution>Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences</institution><addr-line>Kagoshima, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Kagoshima</wicri:regionArea></affiliation></author><author><name sortKey="Kikuchi, Akio" sort="Kikuchi, Akio" uniqKey="Kikuchi A" first="Akio" last="Kikuchi">Akio Kikuchi</name><affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Neurology, Tohoku University School of Medicine</institution><addr-line>Sendai, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Sendai</wicri:regionArea></affiliation></author><author><name sortKey="Aoki, Masashi" sort="Aoki, Masashi" uniqKey="Aoki M" first="Masashi" last="Aoki">Masashi Aoki</name><affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Neurology, Tohoku University School of Medicine</institution><addr-line>Sendai, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Sendai</wicri:regionArea></affiliation></author><author><name sortKey="Ishiura, Hiroyuki" sort="Ishiura, Hiroyuki" uniqKey="Ishiura H" first="Hiroyuki" last="Ishiura">Hiroyuki Ishiura</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Yasuda, Tsutomu" sort="Yasuda, Tsutomu" uniqKey="Yasuda T" first="Tsutomu" last="Yasuda">Tsutomu Yasuda</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Date, Hidetoshi" sort="Date, Hidetoshi" uniqKey="Date H" first="Hidetoshi" last="Date">Hidetoshi Date</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Ahsan, Budrul" sort="Ahsan, Budrul" uniqKey="Ahsan B" first="Budrul" last="Ahsan">Budrul Ahsan</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Iwata, Atsushi" sort="Iwata, Atsushi" uniqKey="Iwata A" first="Atsushi" last="Iwata">Atsushi Iwata</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Goto, Jun" sort="Goto, Jun" uniqKey="Goto J" first="Jun" last="Goto">Jun Goto</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Ichikawa, Yaeko" sort="Ichikawa, Yaeko" uniqKey="Ichikawa Y" first="Yaeko" last="Ichikawa">Yaeko Ichikawa</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Nakahara, Yasuo" sort="Nakahara, Yasuo" uniqKey="Nakahara Y" first="Yasuo" last="Nakahara">Yasuo Nakahara</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Momose, Yoshio" sort="Momose, Yoshio" uniqKey="Momose Y" first="Yoshio" last="Momose">Yoshio Momose</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Takahashi, Yuji" sort="Takahashi, Yuji" uniqKey="Takahashi Y" first="Yuji" last="Takahashi">Yuji Takahashi</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Hara, Kenju" sort="Hara, Kenju" uniqKey="Hara K" first="Kenju" last="Hara">Kenju Hara</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, Brain Research Institute, Niigata University</institution><addr-line>Niigata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Niigata</wicri:regionArea></affiliation></author><author><name sortKey="Kakita, Akiyoshi" sort="Kakita, Akiyoshi" uniqKey="Kakita A" first="Akiyoshi" last="Kakita">Akiyoshi Kakita</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>Department of Pathology, Brain Research Institute, Niigata University</institution><addr-line>Niigata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Niigata</wicri:regionArea></affiliation></author><author><name sortKey="Yamada, Mitsunori" sort="Yamada, Mitsunori" uniqKey="Yamada M" first="Mitsunori" last="Yamada">Mitsunori Yamada</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>Department of Pathology, Brain Research Institute, Niigata University</institution><addr-line>Niigata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Niigata</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au8"><institution>Department of Clinical Research, Saigata Medical Center, National Hospital Organization</institution><addr-line>Niigata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Niigata</wicri:regionArea></affiliation></author><author><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>Department of Pathology, Brain Research Institute, Niigata University</institution><addr-line>Niigata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Niigata</wicri:regionArea></affiliation></author><author><name sortKey="Onodera, Osamu" sort="Onodera, Osamu" uniqKey="Onodera O" first="Osamu" last="Onodera">Osamu Onodera</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, Brain Research Institute, Niigata University</institution><addr-line>Niigata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Niigata</wicri:regionArea></affiliation></author><author><name sortKey="Nishizawa, Masatoyo" sort="Nishizawa, Masatoyo" uniqKey="Nishizawa M" first="Masatoyo" last="Nishizawa">Masatoyo Nishizawa</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, Brain Research Institute, Niigata University</institution><addr-line>Niigata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Niigata</wicri:regionArea></affiliation></author><author><name sortKey="Watanabe, Hirohisa" sort="Watanabe, Hirohisa" uniqKey="Watanabe H" first="Hirohisa" last="Watanabe">Hirohisa Watanabe</name><affiliation wicri:level="1"><nlm:aff id="au9"><institution>Department of Neurology, Nagoya University Graduate School of Medicine</institution><addr-line>Nagoya, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Nagoya</wicri:regionArea></affiliation></author><author><name sortKey="Ito, Mizuki" sort="Ito, Mizuki" uniqKey="Ito M" first="Mizuki" last="Ito">Mizuki Ito</name><affiliation wicri:level="1"><nlm:aff id="au9"><institution>Department of Neurology, Nagoya University Graduate School of Medicine</institution><addr-line>Nagoya, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Nagoya</wicri:regionArea></affiliation></author><author><name sortKey="Sobue, Gen" sort="Sobue, Gen" uniqKey="Sobue G" first="Gen" last="Sobue">Gen Sobue</name><affiliation wicri:level="1"><nlm:aff id="au9"><institution>Department of Neurology, Nagoya University Graduate School of Medicine</institution><addr-line>Nagoya, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Nagoya</wicri:regionArea></affiliation></author><author><name sortKey="Ishikawa, Kinya" sort="Ishikawa, Kinya" uniqKey="Ishikawa K" first="Kinya" last="Ishikawa">Kinya Ishikawa</name><affiliation wicri:level="1"><nlm:aff id="au10"><institution>Department of Neurology and Neurological Science, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Mizusawa, Hidehiro" sort="Mizusawa, Hidehiro" uniqKey="Mizusawa H" first="Hidehiro" last="Mizusawa">Hidehiro Mizusawa</name><affiliation wicri:level="1"><nlm:aff id="au10"><institution>Department of Neurology and Neurological Science, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Kanai, Kazuaki" sort="Kanai, Kazuaki" uniqKey="Kanai K" first="Kazuaki" last="Kanai">Kazuaki Kanai</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Department of Neurology, Chiba University School of Medicine</institution><addr-line>Chiba, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Chiba</wicri:regionArea></affiliation></author><author><name sortKey="Hattori, Takamichi" sort="Hattori, Takamichi" uniqKey="Hattori T" first="Takamichi" last="Hattori">Takamichi Hattori</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Department of Neurology, Chiba University School of Medicine</institution><addr-line>Chiba, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Chiba</wicri:regionArea></affiliation></author><author><name sortKey="Kuwabara, Satoshi" sort="Kuwabara, Satoshi" uniqKey="Kuwabara S" first="Satoshi" last="Kuwabara">Satoshi Kuwabara</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Department of Neurology, Chiba University School of Medicine</institution><addr-line>Chiba, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Chiba</wicri:regionArea></affiliation></author><author><name sortKey="Arai, Kimihito" sort="Arai, Kimihito" uniqKey="Arai K" first="Kimihito" last="Arai">Kimihito Arai</name><affiliation wicri:level="1"><nlm:aff id="au12"><institution>Division of Neurology, National Hospital Organization, Chiba East Hospital</institution><addr-line>Chiba, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Chiba</wicri:regionArea></affiliation></author><author><name sortKey="Koyano, Shigeru" sort="Koyano, Shigeru" uniqKey="Koyano S" first="Shigeru" last="Koyano">Shigeru Koyano</name><affiliation wicri:level="1"><nlm:aff id="au13"><institution>Department of Clinical Neurology and Stroke Medicine, Graduate School of Medicine, Yokohama City University</institution><addr-line>Yokohama, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Yokohama</wicri:regionArea></affiliation></author><author><name sortKey="Kuroiwa, Yoshiyuki" sort="Kuroiwa, Yoshiyuki" uniqKey="Kuroiwa Y" first="Yoshiyuki" last="Kuroiwa">Yoshiyuki Kuroiwa</name><affiliation wicri:level="1"><nlm:aff id="au14"><institution>Department of Neurology, Teikyo University School of Medicine University Hospital</institution><addr-line>Mizonokuchi, Kawasaki, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Mizonokuchi, Kawasaki</wicri:regionArea><wicri:noRegion>Kawasaki</wicri:noRegion></affiliation></author><author><name sortKey="Hasegawa, Kazuko" sort="Hasegawa, Kazuko" uniqKey="Hasegawa K" first="Kazuko" last="Hasegawa">Kazuko Hasegawa</name><affiliation wicri:level="1"><nlm:aff id="au15"><institution>Division of Neurology, National Hospital Organization, Sagamihara National Hospital</institution><addr-line>Sagamihara, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Sagamihara</wicri:regionArea></affiliation></author><author><name sortKey="Yuasa, Tatsuhiko" sort="Yuasa, Tatsuhiko" uniqKey="Yuasa T" first="Tatsuhiko" last="Yuasa">Tatsuhiko Yuasa</name><affiliation wicri:level="1"><nlm:aff id="au16"><institution>Department of Neurology, Kamagaya-Chiba Medical Center for Intractable Neurological Disease, Kamagaya General Hospital</institution><addr-line>Chiba, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Chiba</wicri:regionArea></affiliation></author><author><name sortKey="Yasui, Kenichi" sort="Yasui, Kenichi" uniqKey="Yasui K" first="Kenichi" last="Yasui">Kenichi Yasui</name><affiliation wicri:level="1"><nlm:aff id="au17"><institution>Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University</institution><addr-line>Yonago, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Yonago</wicri:regionArea></affiliation></author><author><name sortKey="Nakashima, Kenji" sort="Nakashima, Kenji" uniqKey="Nakashima K" first="Kenji" last="Nakashima">Kenji Nakashima</name><affiliation wicri:level="1"><nlm:aff id="au17"><institution>Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University</institution><addr-line>Yonago, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Yonago</wicri:regionArea></affiliation></author><author><name sortKey="Ito, Hijiri" sort="Ito, Hijiri" uniqKey="Ito H" first="Hijiri" last="Ito">Hijiri Ito</name><affiliation wicri:level="1"><nlm:aff id="au18"><institution>Department of Neurology, Mifukai Vihara Hananosato Hospital</institution><addr-line>Hiroshima, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Hiroshima</wicri:regionArea></affiliation></author><author><name sortKey="Izumi, Yuishin" sort="Izumi, Yuishin" uniqKey="Izumi Y" first="Yuishin" last="Izumi">Yuishin Izumi</name><affiliation wicri:level="1"><nlm:aff id="au19"><institution>Department of Clinical Neuroscience, Institute of Health Biosciences, University of Tokushima Graduate School</institution><addr-line>Tokushima, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokushima</wicri:regionArea></affiliation></author><author><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name><affiliation wicri:level="1"><nlm:aff id="au19"><institution>Department of Clinical Neuroscience, Institute of Health Biosciences, University of Tokushima Graduate School</institution><addr-line>Tokushima, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokushima</wicri:regionArea></affiliation></author><author><name sortKey="Kato, Takeo" sort="Kato, Takeo" uniqKey="Kato T" first="Takeo" last="Kato">Takeo Kato</name><affiliation wicri:level="1"><nlm:aff id="au20"><institution>Departments of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University</institution><addr-line>Yamagata, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Yamagata</wicri:regionArea></affiliation></author><author><name sortKey="Kusunoki, Susumu" sort="Kusunoki, Susumu" uniqKey="Kusunoki S" first="Susumu" last="Kusunoki">Susumu Kusunoki</name><affiliation wicri:level="1"><nlm:aff id="au21"><institution>Department of Neurology, Kinki University School of Medicine</institution><addr-line>Osaka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Osaka</wicri:regionArea></affiliation></author><author><name sortKey="Osaki, Yasushi" sort="Osaki, Yasushi" uniqKey="Osaki Y" first="Yasushi" last="Osaki">Yasushi Osaki</name><affiliation wicri:level="1"><nlm:aff id="au22"><institution>Department of Geriatrics, Cardiology and Neurology, Kochi Medical School</institution><addr-line>Nankoku, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Nankoku</wicri:regionArea></affiliation></author><author><name sortKey="Horiuchi, Masahiro" sort="Horiuchi, Masahiro" uniqKey="Horiuchi M" first="Masahiro" last="Horiuchi">Masahiro Horiuchi</name><affiliation wicri:level="1"><nlm:aff id="au23"><institution>Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine</institution><addr-line>Kawasaki, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Kawasaki</wicri:regionArea></affiliation></author><author><name sortKey="Kondo, Tomoyoshi" sort="Kondo, Tomoyoshi" uniqKey="Kondo T" first="Tomoyoshi" last="Kondo">Tomoyoshi Kondo</name><affiliation wicri:level="1"><nlm:aff id="au24"><institution>Department of Neurology, Wakayama Medical University</institution><addr-line>Wakayama, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Wakayama</wicri:regionArea></affiliation></author><author><name sortKey="Murayama, Shigeo" sort="Murayama, Shigeo" uniqKey="Murayama S" first="Shigeo" last="Murayama">Shigeo Murayama</name><affiliation wicri:level="1"><nlm:aff id="au25"><institution>Department of Neuropathology and the Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation wicri:level="1"><nlm:aff id="au26"><institution>Department of Neurology, Juntendo University School of Medicine</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Yamamoto, Mitsutoshi" sort="Yamamoto, Mitsutoshi" uniqKey="Yamamoto M" first="Mitsutoshi" last="Yamamoto">Mitsutoshi Yamamoto</name><affiliation wicri:level="1"><nlm:aff id="au27"><institution>Department of Neurology, Kagawa Prefectural Central Hospital</institution><addr-line>Takamatsu, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Takamatsu</wicri:regionArea></affiliation></author><author><name sortKey="Murata, Miho" sort="Murata, Miho" uniqKey="Murata M" first="Miho" last="Murata">Miho Murata</name><affiliation wicri:level="1"><nlm:aff id="au28"><institution>Department of Neurology, National Center Hospital of Neurology and Psychiatry</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Satake, Wataru" sort="Satake, Wataru" uniqKey="Satake W" first="Wataru" last="Satake">Wataru Satake</name><affiliation wicri:level="1"><nlm:aff id="au29"><institution>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine</institution><addr-line>Kobe, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Kobe</wicri:regionArea></affiliation></author><author><name sortKey="Toda, Tatsushi" sort="Toda, Tatsushi" uniqKey="Toda T" first="Tatsushi" last="Toda">Tatsushi Toda</name><affiliation wicri:level="1"><nlm:aff id="au29"><institution>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine</institution><addr-line>Kobe, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Kobe</wicri:regionArea></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation wicri:level="1"><nlm:aff id="au30"><institution>Department of Neurological Sciences, University Federico II</institution><addr-line>Naples, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Naples</wicri:regionArea></affiliation></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation wicri:level="1"><nlm:aff id="au31"><institution>Department of Neurology, University of Bonn and German Center for Neurodegenerative Diseases (DZNE)</institution><addr-line>Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Wullner, Ullrich" sort="Wullner, Ullrich" uniqKey="Wullner U" first="Ullrich" last="Wüllner">Ullrich Wüllner</name><affiliation wicri:level="1"><nlm:aff id="au31"><institution>Department of Neurology, University of Bonn and German Center for Neurodegenerative Diseases (DZNE)</institution><addr-line>Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Nicholson, Garth" sort="Nicholson, Garth" uniqKey="Nicholson G" first="Garth" last="Nicholson">Garth Nicholson</name><affiliation wicri:level="1"><nlm:aff id="au32"><institution>Concord Hospital, University of Sydney at the Australian and New Zealand Army Corps (ANZAC) Research Institute</institution><addr-line>Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Gilman, Sid" sort="Gilman, Sid" uniqKey="Gilman S" first="Sid" last="Gilman">Sid Gilman</name><affiliation wicri:level="2"><nlm:aff id="au33"><institution>Department of Neurology, University of Michigan</institution><addr-line>Ann Arbor, Michigan</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name><affiliation wicri:level="2"><nlm:aff id="au34"><institution>Parkinson's Disease Research Education and Clinical Center, San Francisco Veteran's Affairs Medical Center</institution><addr-line>San Francisco, California</addr-line></nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A" last="Kukull">Walter A. Kukull</name><affiliation wicri:level="2"><nlm:aff id="au35"><institution>Department of Epidemiology, University of Washington School of Public Health</institution><addr-line>Seattle, Washington</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Stern, Mathew B" sort="Stern, Mathew B" uniqKey="Stern M" first="Mathew B" last="Stern">Mathew B. Stern</name><affiliation wicri:level="2"><nlm:aff id="au36"><institution>Parkinson's Disease and Movement Disorders Center, Department of Neurology, Perelman School of Medicine at the University of Pennsylvania</institution><addr-line>Philadelphia, Pennsylvania</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Lee, Virginia M Y" sort="Lee, Virginia M Y" uniqKey="Lee V" first="Virginia M-Y" last="Lee">Virginia M-Y Lee</name><affiliation wicri:level="2"><nlm:aff id="au37"><institution>Institute on Aging, Udall Parkinson's Research Center, Center for Neurodegenerative Disease Research and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania</institution><addr-line>Philadelphia, Pennsylvania</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q" last="Trojanowski">John Q. Trojanowski</name><affiliation wicri:level="2"><nlm:aff id="au37"><institution>Institute on Aging, Udall Parkinson's Research Center, Center for Neurodegenerative Disease Research and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania</institution><addr-line>Philadelphia, Pennsylvania</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Masliah, Eliezer" sort="Masliah, Eliezer" uniqKey="Masliah E" first="Eliezer" last="Masliah">Eliezer Masliah</name><affiliation wicri:level="2"><nlm:aff id="au38"><institution>Department of Neurosciences, University of California San Diego</institution><addr-line>San Diego, California</addr-line></nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Low, Phillip A" sort="Low, Phillip A" uniqKey="Low P" first="Phillip A" last="Low">Phillip A. Low</name><affiliation wicri:level="2"><nlm:aff id="au39"><institution>Department of Neurology, Mayo Clinic</institution><addr-line>Rochester, Minnesota</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Sandroni, Paola" sort="Sandroni, Paola" uniqKey="Sandroni P" first="Paola" last="Sandroni">Paola Sandroni</name><affiliation wicri:level="2"><nlm:aff id="au39"><institution>Department of Neurology, Mayo Clinic</institution><addr-line>Rochester, Minnesota</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Ozelius, Laurie J" sort="Ozelius, Laurie J" uniqKey="Ozelius L" first="Laurie J" last="Ozelius">Laurie J. Ozelius</name><affiliation wicri:level="2"><nlm:aff id="au40"><institution>Departments of Genetics and Genomic Sciences and Neurology, Icahn School of Medicine at Mount Sinai</institution><addr-line>New York, New York</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>New York</wicri:cityArea></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="2"><nlm:aff id="au41"><institution>Department of Medical and Molecular Genetics, Indiana University School of Medicine</institution><addr-line>Indianapolis, Indiana</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Indianapolis</wicri:cityArea></affiliation></author><author><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author></analytic><series><title level="j">Annals of Clinical and Translational Neurology</title><idno type="ISSN">2328-9503</idno><idno type="eISSN">2328-9503</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>Glucocerebrosidase gene (<italic>GBA</italic>) variants that cause Gaucher disease are associated with Parkinson disease (PD) and dementia with Lewy bodies (DLB). To investigate the role of <italic>GBA</italic> variants in multiple system atrophy (MSA), we analyzed <italic>GBA</italic> variants in a large case–control series.</p></sec><sec><title>Methods</title><p>We sequenced coding regions and flanking splice sites of <italic>GBA</italic> in 969 MSA patients (574 Japanese, 223 European, and 172 North American) and 1509 control subjects (900 Japanese, 315 European, and 294 North American). We focused solely on Gaucher-disease-causing <italic>GBA</italic> variants.</p></sec><sec><title>Results</title><p>In the Japanese series, we found nine carriers among the MSA patients (1.65%) and eight carriers among the control subjects (0.89%). In the European series, we found three carriers among the MSA patients (1.35%) and two carriers among the control subjects (0.63%). In the North American series, we found five carriers among the MSA patients (2.91%) and one carrier among the control subjects (0.34%). Subjecting each series to a Mantel–Haenszel analysis yielded a pooled odds ratio (OR) of 2.44 (95% confidence interval [CI], 1.14–5.21) and a <italic>P</italic>-value of 0.029 without evidence of significant heterogeneity. Logistic regression analysis yielded similar results, with an adjusted OR of 2.43 (95% CI 1.15–5.37) and a <italic>P</italic>-value of 0.022. Subtype analysis showed that Gaucher-disease-causing <italic>GBA</italic> variants are significantly associated with MSA cerebellar subtype (MSA-C) patients (<italic>P </italic>=<italic> </italic>7.3 × 10<sup>−3</sup>).</p></sec><sec><title>Interpretation</title><p>The findings indicate that, as in PD and DLB, Gaucher-disease-causing <italic>GBA</italic> variants are associated with MSA.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gilman, S" uniqKey="Gilman S">S Gilman</name></author><author><name sortKey="Wenning, Gk" uniqKey="Wenning G">GK Wenning</name></author><author><name sortKey="Low, Pa" uniqKey="Low P">PA Low</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Papp, Mi" uniqKey="Papp M">MI Papp</name></author><author><name sortKey="Kahn, Je" uniqKey="Kahn J">JE Kahn</name></author><author><name sortKey="Lantos, Pl" uniqKey="Lantos P">PL Lantos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakazato, Y" uniqKey="Nakazato Y">Y Nakazato</name></author><author><name sortKey="Yamazaki, H" uniqKey="Yamazaki H">H Yamazaki</name></author><author><name sortKey="Hirato, J" uniqKey="Hirato J">J Hirato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tu, Ph" uniqKey="Tu P">PH Tu</name></author><author><name sortKey="Galvin, Je" uniqKey="Galvin J">JE Galvin</name></author><author><name sortKey="Baba, M" uniqKey="Baba M">M Baba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wakabayashi, K" uniqKey="Wakabayashi K">K Wakabayashi</name></author><author><name sortKey="Yoshimoto, M" uniqKey="Yoshimoto M">M Yoshimoto</name></author><author><name sortKey="Tsuji, S" uniqKey="Tsuji S">S Tsuji</name></author><author><name sortKey="Takahashi, H" uniqKey="Takahashi H">H Takahashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Chalabi, A" uniqKey="Al Chalabi A">A Al-Chalabi</name></author><author><name sortKey="Durr, A" uniqKey="Durr A">A Durr</name></author><author><name sortKey="Wood, Nw" uniqKey="Wood N">NW Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scholz, Sw" uniqKey="Scholz S">SW Scholz</name></author><author><name sortKey="Houlden, H" uniqKey="Houlden H">H Houlden</name></author><author><name sortKey="Schulte, C" uniqKey="Schulte C">C Schulte</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Spillantini, Mg" uniqKey="Spillantini M">MG Spillantini</name></author><author><name sortKey="Schmidt, Ml" uniqKey="Schmidt M">ML Schmidt</name></author><author><name sortKey="Lee, Vm" uniqKey="Lee V">VM Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goedert, M" uniqKey="Goedert M">M Goedert</name></author><author><name sortKey="Spillantini, Mg" uniqKey="Spillantini M">MG Spillantini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kiely, Ap" uniqKey="Kiely A">AP Kiely</name></author><author><name sortKey="Asi, Yt" uniqKey="Asi Y">YT Asi</name></author><author><name sortKey="Kara, E" uniqKey="Kara E">E Kara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pasanen, P" uniqKey="Pasanen P">P Pasanen</name></author><author><name sortKey="Myllykangas, L" uniqKey="Myllykangas L">L Myllykangas</name></author><author><name sortKey="Siitonen, M" uniqKey="Siitonen M">M Siitonen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vidal, Js" uniqKey="Vidal J">JS Vidal</name></author><author><name sortKey="Vidailhet, M" uniqKey="Vidailhet M">M Vidailhet</name></author><author><name sortKey="Derkinderen, P" uniqKey="Derkinderen P">P Derkinderen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nee, Le" uniqKey="Nee L">LE Nee</name></author><author><name sortKey="Gomez, Mr" uniqKey="Gomez M">MR Gomez</name></author><author><name sortKey="Dambrosia, J" uniqKey="Dambrosia J">J Dambrosia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujioka, S" uniqKey="Fujioka S">S Fujioka</name></author><author><name sortKey="Ogaki, K" uniqKey="Ogaki K">K Ogaki</name></author><author><name sortKey="Tacik, Pm" uniqKey="Tacik P">PM Tacik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mitsui, J" uniqKey="Mitsui J">J Mitsui</name></author><author><name sortKey="Mizuta, I" uniqKey="Mizuta I">I Mizuta</name></author><author><name sortKey="Toyoda, A" uniqKey="Toyoda A">A Toyoda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sidransky, E" uniqKey="Sidransky E">E Sidransky</name></author><author><name sortKey="Nalls, Ma" uniqKey="Nalls M">MA Nalls</name></author><author><name sortKey="Aasly, Jo" uniqKey="Aasly J">JO Aasly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nalls, Ma" uniqKey="Nalls M">MA Nalls</name></author><author><name sortKey="Duran, R" uniqKey="Duran R">R Duran</name></author><author><name sortKey="Lopez, G" uniqKey="Lopez G">G Lopez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goker Alpan, O" uniqKey="Goker Alpan O">O Goker-Alpan</name></author><author><name sortKey="Schiffmann, R" uniqKey="Schiffmann R">R Schiffmann</name></author><author><name sortKey="Lamarca, Me" uniqKey="Lamarca M">ME LaMarca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koprivica, V" uniqKey="Koprivica V">V Koprivica</name></author><author><name sortKey="Stone, Dl" uniqKey="Stone D">DL Stone</name></author><author><name sortKey="Park, Jk" uniqKey="Park J">JK Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsuji, S" uniqKey="Tsuji S">S Tsuji</name></author><author><name sortKey="Choudary, Pv" uniqKey="Choudary P">PV Choudary</name></author><author><name sortKey="Martin, Bm" uniqKey="Martin B">BM Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stone, Dl" uniqKey="Stone D">DL Stone</name></author><author><name sortKey="Carey, Wf" uniqKey="Carey W">WF Carey</name></author><author><name sortKey="Christodoulou, J" uniqKey="Christodoulou J">J Christodoulou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Mj" uniqKey="Kim M">MJ Kim</name></author><author><name sortKey="Suh, Jt" uniqKey="Suh J">JT Suh</name></author><author><name sortKey="Lee, Hj" uniqKey="Lee H">HJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Gs" uniqKey="He G">GS He</name></author><author><name sortKey="Grace, Me" uniqKey="Grace M">ME Grace</name></author><author><name sortKey="Grabowski, Ga" uniqKey="Grabowski G">GA Grabowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cormand, B" uniqKey="Cormand B">B Cormand</name></author><author><name sortKey="Grinberg, D" uniqKey="Grinberg D">D Grinberg</name></author><author><name sortKey="Gort, L" uniqKey="Gort L">L Gort</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amaral, O" uniqKey="Amaral O">O Amaral</name></author><author><name sortKey="Marcao, A" uniqKey="Marcao A">A Marcão</name></author><author><name sortKey="Sa Miranda, M" uniqKey="Sa Miranda M">M Sá Miranda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michelakakis, H" uniqKey="Michelakakis H">H Michelakakis</name></author><author><name sortKey="Dimitriou, E" uniqKey="Dimitriou E">E Dimitriou</name></author><author><name sortKey="Van Weely, S" uniqKey="Van Weely S">S Van Weely</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walley, Aj" uniqKey="Walley A">AJ Walley</name></author><author><name sortKey="Barth, Ml" uniqKey="Barth M">ML Barth</name></author><author><name sortKey="Ellis, I" uniqKey="Ellis I">I Ellis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uchiyama, A" uniqKey="Uchiyama A">A Uchiyama</name></author><author><name sortKey="Tomatsu, S" uniqKey="Tomatsu S">S Tomatsu</name></author><author><name sortKey="Kondo, N" uniqKey="Kondo N">N Kondo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horowitz, M" uniqKey="Horowitz M">M Horowitz</name></author><author><name sortKey="Pasmanik Chor, M" uniqKey="Pasmanik Chor M">M Pasmanik-Chor</name></author><author><name sortKey="Ron, I" uniqKey="Ron I">I Ron</name></author><author><name sortKey="Kolodny, Eh" uniqKey="Kolodny E">EH Kolodny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Segarane, B" uniqKey="Segarane B">B Segarane</name></author><author><name sortKey="Li, A" uniqKey="Li A">A Li</name></author><author><name sortKey="Paudel, R" uniqKey="Paudel R">R Paudel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jamrozik, Z" uniqKey="Jamrozik Z">Z Jamrozik</name></author><author><name sortKey="Lugowska, A" uniqKey="Lugowska A">A Lugowska</name></author><author><name sortKey="Slawek, J" uniqKey="Slawek J">J Slawek</name></author><author><name sortKey="Kwiecinski, H" uniqKey="Kwiecinski H">H Kwiecinski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, Qy" uniqKey="Sun Q">QY Sun</name></author><author><name sortKey="Guo, Jf" uniqKey="Guo J">JF Guo</name></author><author><name sortKey="Han, Ww" uniqKey="Han W">WW Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Srulijes, K" uniqKey="Srulijes K">K Srulijes</name></author><author><name sortKey="Hauser, Ak" uniqKey="Hauser A">AK Hauser</name></author><author><name sortKey="Guella, I" uniqKey="Guella I">I Guella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schondorf, Dc" uniqKey="Schondorf D">DC Schöndorf</name></author><author><name sortKey="Aureli, M" uniqKey="Aureli M">M Aureli</name></author><author><name sortKey="Mcallister, Fe" uniqKey="Mcallister F">FE McAllister</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murphy, Ke" uniqKey="Murphy K">KE Murphy</name></author><author><name sortKey="Gysbers, Am" uniqKey="Gysbers A">AM Gysbers</name></author><author><name sortKey="Abbott, Sk" uniqKey="Abbott S">SK Abbott</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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