Variants associated with Gaucher disease in multiple system atrophy
Identifieur interne : 002655 ( Main/Merge ); précédent : 002654; suivant : 002656Variants associated with Gaucher disease in multiple system atrophy
Auteurs : Jun Mitsui [Japon] ; Takashi Matsukawa [Japon] ; Hidenao Sasaki [Japon] ; Ichiro Yabe [Japon] ; Masaaki Matsushima [Japon] ; Alexandra Dürr [France] ; Alexis Brice [France] ; Hiroshi Takashima [Japon] ; Akio Kikuchi [Japon] ; Masashi Aoki [Japon] ; Hiroyuki Ishiura [Japon] ; Tsutomu Yasuda [Japon] ; Hidetoshi Date [Japon] ; Budrul Ahsan [Japon] ; Atsushi Iwata [Japon] ; Jun Goto [Japon] ; Yaeko Ichikawa [Japon] ; Yasuo Nakahara [Japon] ; Yoshio Momose [Japon] ; Yuji Takahashi [Japon] ; Kenju Hara [Japon] ; Akiyoshi Kakita [Japon] ; Mitsunori Yamada [Japon] ; Hitoshi Takahashi [Japon] ; Osamu Onodera [Japon] ; Masatoyo Nishizawa [Japon] ; Hirohisa Watanabe [Japon] ; Mizuki Ito [Japon] ; Gen Sobue [Japon] ; Kinya Ishikawa [Japon] ; Hidehiro Mizusawa [Japon] ; Kazuaki Kanai [Japon] ; Takamichi Hattori [Japon] ; Satoshi Kuwabara [Japon] ; Kimihito Arai [Japon] ; Shigeru Koyano [Japon] ; Yoshiyuki Kuroiwa [Japon] ; Kazuko Hasegawa [Japon] ; Tatsuhiko Yuasa [Japon] ; Kenichi Yasui [Japon] ; Kenji Nakashima [Japon] ; Hijiri Ito [Japon] ; Yuishin Izumi [Japon] ; Ryuji Kaji [Japon] ; Takeo Kato [Japon] ; Susumu Kusunoki [Japon] ; Yasushi Osaki [Japon] ; Masahiro Horiuchi [Japon] ; Tomoyoshi Kondo [Japon] ; Shigeo Murayama [Japon] ; Nobutaka Hattori [Japon] ; Mitsutoshi Yamamoto [Japon] ; Miho Murata [Japon] ; Wataru Satake [Japon] ; Tatsushi Toda [Japon] ; Alessandro Filla [Italie] ; Thomas Klockgether [Allemagne] ; Ullrich Wüllner [Allemagne] ; Garth Nicholson [Australie] ; Sid Gilman [États-Unis] ; Caroline M. Tanner [États-Unis] ; Walter A. Kukull [États-Unis] ; Mathew B. Stern [États-Unis] ; Virginia M-Y Lee [États-Unis] ; John Q. Trojanowski [États-Unis] ; Eliezer Masliah [États-Unis] ; Phillip A. Low [États-Unis] ; Paola Sandroni [États-Unis] ; Laurie J. Ozelius [États-Unis] ; Tatiana Foroud [États-Unis] ; Shoji Tsuji [Japon]Source :
- Annals of Clinical and Translational Neurology [ 2328-9503 ] ; 2015.
Abstract
Glucocerebrosidase gene (
We sequenced coding regions and flanking splice sites of
In the Japanese series, we found nine carriers among the MSA patients (1.65%) and eight carriers among the control subjects (0.89%). In the European series, we found three carriers among the MSA patients (1.35%) and two carriers among the control subjects (0.63%). In the North American series, we found five carriers among the MSA patients (2.91%) and one carrier among the control subjects (0.34%). Subjecting each series to a Mantel–Haenszel analysis yielded a pooled odds ratio (OR) of 2.44 (95% confidence interval [CI], 1.14–5.21) and a
The findings indicate that, as in PD and DLB, Gaucher-disease-causing
Url:
DOI: 10.1002/acn3.185
PubMed: 25909086
PubMed Central: 4402086
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<author><name sortKey="Matsukawa, Takashi" sort="Matsukawa, Takashi" uniqKey="Matsukawa T" first="Takashi" last="Matsukawa">Takashi Matsukawa</name>
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<author><name sortKey="Sasaki, Hidenao" sort="Sasaki, Hidenao" uniqKey="Sasaki H" first="Hidenao" last="Sasaki">Hidenao Sasaki</name>
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<author><name sortKey="Yabe, Ichiro" sort="Yabe, Ichiro" uniqKey="Yabe I" first="Ichiro" last="Yabe">Ichiro Yabe</name>
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<author><name sortKey="Matsushima, Masaaki" sort="Matsushima, Masaaki" uniqKey="Matsushima M" first="Masaaki" last="Matsushima">Masaaki Matsushima</name>
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<author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name>
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<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
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<author><name sortKey="Takashima, Hiroshi" sort="Takashima, Hiroshi" uniqKey="Takashima H" first="Hiroshi" last="Takashima">Hiroshi Takashima</name>
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<author><name sortKey="Kikuchi, Akio" sort="Kikuchi, Akio" uniqKey="Kikuchi A" first="Akio" last="Kikuchi">Akio Kikuchi</name>
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<author><name sortKey="Aoki, Masashi" sort="Aoki, Masashi" uniqKey="Aoki M" first="Masashi" last="Aoki">Masashi Aoki</name>
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<author><name sortKey="Ishiura, Hiroyuki" sort="Ishiura, Hiroyuki" uniqKey="Ishiura H" first="Hiroyuki" last="Ishiura">Hiroyuki Ishiura</name>
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<author><name sortKey="Yasuda, Tsutomu" sort="Yasuda, Tsutomu" uniqKey="Yasuda T" first="Tsutomu" last="Yasuda">Tsutomu Yasuda</name>
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<author><name sortKey="Date, Hidetoshi" sort="Date, Hidetoshi" uniqKey="Date H" first="Hidetoshi" last="Date">Hidetoshi Date</name>
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<addr-line>Tokyo, Japan</addr-line>
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<author><name sortKey="Ahsan, Budrul" sort="Ahsan, Budrul" uniqKey="Ahsan B" first="Budrul" last="Ahsan">Budrul Ahsan</name>
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<author><name sortKey="Iwata, Atsushi" sort="Iwata, Atsushi" uniqKey="Iwata A" first="Atsushi" last="Iwata">Atsushi Iwata</name>
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<author><name sortKey="Goto, Jun" sort="Goto, Jun" uniqKey="Goto J" first="Jun" last="Goto">Jun Goto</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
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<author><name sortKey="Ichikawa, Yaeko" sort="Ichikawa, Yaeko" uniqKey="Ichikawa Y" first="Yaeko" last="Ichikawa">Yaeko Ichikawa</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
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<author><name sortKey="Nakahara, Yasuo" sort="Nakahara, Yasuo" uniqKey="Nakahara Y" first="Yasuo" last="Nakahara">Yasuo Nakahara</name>
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<author><name sortKey="Momose, Yoshio" sort="Momose, Yoshio" uniqKey="Momose Y" first="Yoshio" last="Momose">Yoshio Momose</name>
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<author><name sortKey="Takahashi, Yuji" sort="Takahashi, Yuji" uniqKey="Takahashi Y" first="Yuji" last="Takahashi">Yuji Takahashi</name>
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<author><name sortKey="Hara, Kenju" sort="Hara, Kenju" uniqKey="Hara K" first="Kenju" last="Hara">Kenju Hara</name>
<affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, Brain Research Institute, Niigata University</institution>
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<author><name sortKey="Kakita, Akiyoshi" sort="Kakita, Akiyoshi" uniqKey="Kakita A" first="Akiyoshi" last="Kakita">Akiyoshi Kakita</name>
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<addr-line>Niigata, Japan</addr-line>
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<country xml:lang="fr">Japon</country>
<wicri:regionArea>Niigata</wicri:regionArea>
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<author><name sortKey="Yamada, Mitsunori" sort="Yamada, Mitsunori" uniqKey="Yamada M" first="Mitsunori" last="Yamada">Mitsunori Yamada</name>
<affiliation wicri:level="1"><nlm:aff id="au7"><institution>Department of Pathology, Brain Research Institute, Niigata University</institution>
<addr-line>Niigata, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Niigata</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="au8"><institution>Department of Clinical Research, Saigata Medical Center, National Hospital Organization</institution>
<addr-line>Niigata, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Niigata</wicri:regionArea>
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<author><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name>
<affiliation wicri:level="1"><nlm:aff id="au7"><institution>Department of Pathology, Brain Research Institute, Niigata University</institution>
<addr-line>Niigata, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Niigata</wicri:regionArea>
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</author>
<author><name sortKey="Onodera, Osamu" sort="Onodera, Osamu" uniqKey="Onodera O" first="Osamu" last="Onodera">Osamu Onodera</name>
<affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, Brain Research Institute, Niigata University</institution>
<addr-line>Niigata, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Niigata</wicri:regionArea>
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</author>
<author><name sortKey="Nishizawa, Masatoyo" sort="Nishizawa, Masatoyo" uniqKey="Nishizawa M" first="Masatoyo" last="Nishizawa">Masatoyo Nishizawa</name>
<affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, Brain Research Institute, Niigata University</institution>
<addr-line>Niigata, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Niigata</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Watanabe, Hirohisa" sort="Watanabe, Hirohisa" uniqKey="Watanabe H" first="Hirohisa" last="Watanabe">Hirohisa Watanabe</name>
<affiliation wicri:level="1"><nlm:aff id="au9"><institution>Department of Neurology, Nagoya University Graduate School of Medicine</institution>
<addr-line>Nagoya, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Nagoya</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ito, Mizuki" sort="Ito, Mizuki" uniqKey="Ito M" first="Mizuki" last="Ito">Mizuki Ito</name>
<affiliation wicri:level="1"><nlm:aff id="au9"><institution>Department of Neurology, Nagoya University Graduate School of Medicine</institution>
<addr-line>Nagoya, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Nagoya</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sobue, Gen" sort="Sobue, Gen" uniqKey="Sobue G" first="Gen" last="Sobue">Gen Sobue</name>
<affiliation wicri:level="1"><nlm:aff id="au9"><institution>Department of Neurology, Nagoya University Graduate School of Medicine</institution>
<addr-line>Nagoya, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Nagoya</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ishikawa, Kinya" sort="Ishikawa, Kinya" uniqKey="Ishikawa K" first="Kinya" last="Ishikawa">Kinya Ishikawa</name>
<affiliation wicri:level="1"><nlm:aff id="au10"><institution>Department of Neurology and Neurological Science, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mizusawa, Hidehiro" sort="Mizusawa, Hidehiro" uniqKey="Mizusawa H" first="Hidehiro" last="Mizusawa">Hidehiro Mizusawa</name>
<affiliation wicri:level="1"><nlm:aff id="au10"><institution>Department of Neurology and Neurological Science, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
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</affiliation>
</author>
<author><name sortKey="Kanai, Kazuaki" sort="Kanai, Kazuaki" uniqKey="Kanai K" first="Kazuaki" last="Kanai">Kazuaki Kanai</name>
<affiliation wicri:level="1"><nlm:aff id="au11"><institution>Department of Neurology, Chiba University School of Medicine</institution>
<addr-line>Chiba, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Chiba</wicri:regionArea>
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</author>
<author><name sortKey="Hattori, Takamichi" sort="Hattori, Takamichi" uniqKey="Hattori T" first="Takamichi" last="Hattori">Takamichi Hattori</name>
<affiliation wicri:level="1"><nlm:aff id="au11"><institution>Department of Neurology, Chiba University School of Medicine</institution>
<addr-line>Chiba, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Chiba</wicri:regionArea>
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</author>
<author><name sortKey="Kuwabara, Satoshi" sort="Kuwabara, Satoshi" uniqKey="Kuwabara S" first="Satoshi" last="Kuwabara">Satoshi Kuwabara</name>
<affiliation wicri:level="1"><nlm:aff id="au11"><institution>Department of Neurology, Chiba University School of Medicine</institution>
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</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Chiba</wicri:regionArea>
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</author>
<author><name sortKey="Arai, Kimihito" sort="Arai, Kimihito" uniqKey="Arai K" first="Kimihito" last="Arai">Kimihito Arai</name>
<affiliation wicri:level="1"><nlm:aff id="au12"><institution>Division of Neurology, National Hospital Organization, Chiba East Hospital</institution>
<addr-line>Chiba, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Chiba</wicri:regionArea>
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</author>
<author><name sortKey="Koyano, Shigeru" sort="Koyano, Shigeru" uniqKey="Koyano S" first="Shigeru" last="Koyano">Shigeru Koyano</name>
<affiliation wicri:level="1"><nlm:aff id="au13"><institution>Department of Clinical Neurology and Stroke Medicine, Graduate School of Medicine, Yokohama City University</institution>
<addr-line>Yokohama, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Yokohama</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kuroiwa, Yoshiyuki" sort="Kuroiwa, Yoshiyuki" uniqKey="Kuroiwa Y" first="Yoshiyuki" last="Kuroiwa">Yoshiyuki Kuroiwa</name>
<affiliation wicri:level="1"><nlm:aff id="au14"><institution>Department of Neurology, Teikyo University School of Medicine University Hospital</institution>
<addr-line>Mizonokuchi, Kawasaki, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Mizonokuchi, Kawasaki</wicri:regionArea>
<wicri:noRegion>Kawasaki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hasegawa, Kazuko" sort="Hasegawa, Kazuko" uniqKey="Hasegawa K" first="Kazuko" last="Hasegawa">Kazuko Hasegawa</name>
<affiliation wicri:level="1"><nlm:aff id="au15"><institution>Division of Neurology, National Hospital Organization, Sagamihara National Hospital</institution>
<addr-line>Sagamihara, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Sagamihara</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yuasa, Tatsuhiko" sort="Yuasa, Tatsuhiko" uniqKey="Yuasa T" first="Tatsuhiko" last="Yuasa">Tatsuhiko Yuasa</name>
<affiliation wicri:level="1"><nlm:aff id="au16"><institution>Department of Neurology, Kamagaya-Chiba Medical Center for Intractable Neurological Disease, Kamagaya General Hospital</institution>
<addr-line>Chiba, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Chiba</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yasui, Kenichi" sort="Yasui, Kenichi" uniqKey="Yasui K" first="Kenichi" last="Yasui">Kenichi Yasui</name>
<affiliation wicri:level="1"><nlm:aff id="au17"><institution>Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University</institution>
<addr-line>Yonago, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Yonago</wicri:regionArea>
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<author><name sortKey="Nakashima, Kenji" sort="Nakashima, Kenji" uniqKey="Nakashima K" first="Kenji" last="Nakashima">Kenji Nakashima</name>
<affiliation wicri:level="1"><nlm:aff id="au17"><institution>Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University</institution>
<addr-line>Yonago, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Yonago</wicri:regionArea>
</affiliation>
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<author><name sortKey="Ito, Hijiri" sort="Ito, Hijiri" uniqKey="Ito H" first="Hijiri" last="Ito">Hijiri Ito</name>
<affiliation wicri:level="1"><nlm:aff id="au18"><institution>Department of Neurology, Mifukai Vihara Hananosato Hospital</institution>
<addr-line>Hiroshima, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Hiroshima</wicri:regionArea>
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</author>
<author><name sortKey="Izumi, Yuishin" sort="Izumi, Yuishin" uniqKey="Izumi Y" first="Yuishin" last="Izumi">Yuishin Izumi</name>
<affiliation wicri:level="1"><nlm:aff id="au19"><institution>Department of Clinical Neuroscience, Institute of Health Biosciences, University of Tokushima Graduate School</institution>
<addr-line>Tokushima, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokushima</wicri:regionArea>
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</author>
<author><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name>
<affiliation wicri:level="1"><nlm:aff id="au19"><institution>Department of Clinical Neuroscience, Institute of Health Biosciences, University of Tokushima Graduate School</institution>
<addr-line>Tokushima, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokushima</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kato, Takeo" sort="Kato, Takeo" uniqKey="Kato T" first="Takeo" last="Kato">Takeo Kato</name>
<affiliation wicri:level="1"><nlm:aff id="au20"><institution>Departments of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University</institution>
<addr-line>Yamagata, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Yamagata</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kusunoki, Susumu" sort="Kusunoki, Susumu" uniqKey="Kusunoki S" first="Susumu" last="Kusunoki">Susumu Kusunoki</name>
<affiliation wicri:level="1"><nlm:aff id="au21"><institution>Department of Neurology, Kinki University School of Medicine</institution>
<addr-line>Osaka, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Osaki, Yasushi" sort="Osaki, Yasushi" uniqKey="Osaki Y" first="Yasushi" last="Osaki">Yasushi Osaki</name>
<affiliation wicri:level="1"><nlm:aff id="au22"><institution>Department of Geriatrics, Cardiology and Neurology, Kochi Medical School</institution>
<addr-line>Nankoku, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Nankoku</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Horiuchi, Masahiro" sort="Horiuchi, Masahiro" uniqKey="Horiuchi M" first="Masahiro" last="Horiuchi">Masahiro Horiuchi</name>
<affiliation wicri:level="1"><nlm:aff id="au23"><institution>Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine</institution>
<addr-line>Kawasaki, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kawasaki</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kondo, Tomoyoshi" sort="Kondo, Tomoyoshi" uniqKey="Kondo T" first="Tomoyoshi" last="Kondo">Tomoyoshi Kondo</name>
<affiliation wicri:level="1"><nlm:aff id="au24"><institution>Department of Neurology, Wakayama Medical University</institution>
<addr-line>Wakayama, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Wakayama</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Murayama, Shigeo" sort="Murayama, Shigeo" uniqKey="Murayama S" first="Shigeo" last="Murayama">Shigeo Murayama</name>
<affiliation wicri:level="1"><nlm:aff id="au25"><institution>Department of Neuropathology and the Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name>
<affiliation wicri:level="1"><nlm:aff id="au26"><institution>Department of Neurology, Juntendo University School of Medicine</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yamamoto, Mitsutoshi" sort="Yamamoto, Mitsutoshi" uniqKey="Yamamoto M" first="Mitsutoshi" last="Yamamoto">Mitsutoshi Yamamoto</name>
<affiliation wicri:level="1"><nlm:aff id="au27"><institution>Department of Neurology, Kagawa Prefectural Central Hospital</institution>
<addr-line>Takamatsu, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Takamatsu</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Murata, Miho" sort="Murata, Miho" uniqKey="Murata M" first="Miho" last="Murata">Miho Murata</name>
<affiliation wicri:level="1"><nlm:aff id="au28"><institution>Department of Neurology, National Center Hospital of Neurology and Psychiatry</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Satake, Wataru" sort="Satake, Wataru" uniqKey="Satake W" first="Wataru" last="Satake">Wataru Satake</name>
<affiliation wicri:level="1"><nlm:aff id="au29"><institution>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine</institution>
<addr-line>Kobe, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kobe</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Toda, Tatsushi" sort="Toda, Tatsushi" uniqKey="Toda T" first="Tatsushi" last="Toda">Tatsushi Toda</name>
<affiliation wicri:level="1"><nlm:aff id="au29"><institution>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine</institution>
<addr-line>Kobe, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kobe</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name>
<affiliation wicri:level="1"><nlm:aff id="au30"><institution>Department of Neurological Sciences, University Federico II</institution>
<addr-line>Naples, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Naples</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name>
<affiliation wicri:level="1"><nlm:aff id="au31"><institution>Department of Neurology, University of Bonn and German Center for Neurodegenerative Diseases (DZNE)</institution>
<addr-line>Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Bonn</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wullner, Ullrich" sort="Wullner, Ullrich" uniqKey="Wullner U" first="Ullrich" last="Wüllner">Ullrich Wüllner</name>
<affiliation wicri:level="1"><nlm:aff id="au31"><institution>Department of Neurology, University of Bonn and German Center for Neurodegenerative Diseases (DZNE)</institution>
<addr-line>Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Bonn</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nicholson, Garth" sort="Nicholson, Garth" uniqKey="Nicholson G" first="Garth" last="Nicholson">Garth Nicholson</name>
<affiliation wicri:level="1"><nlm:aff id="au32"><institution>Concord Hospital, University of Sydney at the Australian and New Zealand Army Corps (ANZAC) Research Institute</institution>
<addr-line>Sydney, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sydney</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gilman, Sid" sort="Gilman, Sid" uniqKey="Gilman S" first="Sid" last="Gilman">Sid Gilman</name>
<affiliation wicri:level="2"><nlm:aff id="au33"><institution>Department of Neurology, University of Michigan</institution>
<addr-line>Ann Arbor, Michigan</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name>
<affiliation wicri:level="2"><nlm:aff id="au34"><institution>Parkinson's Disease Research Education and Clinical Center, San Francisco Veteran's Affairs Medical Center</institution>
<addr-line>San Francisco, California</addr-line>
</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A" last="Kukull">Walter A. Kukull</name>
<affiliation wicri:level="2"><nlm:aff id="au35"><institution>Department of Epidemiology, University of Washington School of Public Health</institution>
<addr-line>Seattle, Washington</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stern, Mathew B" sort="Stern, Mathew B" uniqKey="Stern M" first="Mathew B" last="Stern">Mathew B. Stern</name>
<affiliation wicri:level="2"><nlm:aff id="au36"><institution>Parkinson's Disease and Movement Disorders Center, Department of Neurology, Perelman School of Medicine at the University of Pennsylvania</institution>
<addr-line>Philadelphia, Pennsylvania</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lee, Virginia M Y" sort="Lee, Virginia M Y" uniqKey="Lee V" first="Virginia M-Y" last="Lee">Virginia M-Y Lee</name>
<affiliation wicri:level="2"><nlm:aff id="au37"><institution>Institute on Aging, Udall Parkinson's Research Center, Center for Neurodegenerative Disease Research and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania</institution>
<addr-line>Philadelphia, Pennsylvania</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q" last="Trojanowski">John Q. Trojanowski</name>
<affiliation wicri:level="2"><nlm:aff id="au37"><institution>Institute on Aging, Udall Parkinson's Research Center, Center for Neurodegenerative Disease Research and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania</institution>
<addr-line>Philadelphia, Pennsylvania</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Masliah, Eliezer" sort="Masliah, Eliezer" uniqKey="Masliah E" first="Eliezer" last="Masliah">Eliezer Masliah</name>
<affiliation wicri:level="2"><nlm:aff id="au38"><institution>Department of Neurosciences, University of California San Diego</institution>
<addr-line>San Diego, California</addr-line>
</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Low, Phillip A" sort="Low, Phillip A" uniqKey="Low P" first="Phillip A" last="Low">Phillip A. Low</name>
<affiliation wicri:level="2"><nlm:aff id="au39"><institution>Department of Neurology, Mayo Clinic</institution>
<addr-line>Rochester, Minnesota</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sandroni, Paola" sort="Sandroni, Paola" uniqKey="Sandroni P" first="Paola" last="Sandroni">Paola Sandroni</name>
<affiliation wicri:level="2"><nlm:aff id="au39"><institution>Department of Neurology, Mayo Clinic</institution>
<addr-line>Rochester, Minnesota</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ozelius, Laurie J" sort="Ozelius, Laurie J" uniqKey="Ozelius L" first="Laurie J" last="Ozelius">Laurie J. Ozelius</name>
<affiliation wicri:level="2"><nlm:aff id="au40"><institution>Departments of Genetics and Genomic Sciences and Neurology, Icahn School of Medicine at Mount Sinai</institution>
<addr-line>New York, New York</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
<affiliation wicri:level="2"><nlm:aff id="au41"><institution>Department of Medical and Molecular Genetics, Indiana University School of Medicine</institution>
<addr-line>Indianapolis, Indiana</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Indiana</region>
</placeName>
<wicri:cityArea>Indianapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Variants associated with Gaucher disease in multiple system atrophy</title>
<author><name sortKey="Mitsui, Jun" sort="Mitsui, Jun" uniqKey="Mitsui J" first="Jun" last="Mitsui">Jun Mitsui</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Matsukawa, Takashi" sort="Matsukawa, Takashi" uniqKey="Matsukawa T" first="Takashi" last="Matsukawa">Takashi Matsukawa</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sasaki, Hidenao" sort="Sasaki, Hidenao" uniqKey="Sasaki H" first="Hidenao" last="Sasaki">Hidenao Sasaki</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neurology, Hokkaido University Graduate School of Medicine</institution>
<addr-line>Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Sapporo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yabe, Ichiro" sort="Yabe, Ichiro" uniqKey="Yabe I" first="Ichiro" last="Yabe">Ichiro Yabe</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neurology, Hokkaido University Graduate School of Medicine</institution>
<addr-line>Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Sapporo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Matsushima, Masaaki" sort="Matsushima, Masaaki" uniqKey="Matsushima M" first="Masaaki" last="Matsushima">Masaaki Matsushima</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neurology, Hokkaido University Graduate School of Medicine</institution>
<addr-line>Sapporo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Sapporo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name>
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<addr-line>F-75013, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>F-75013, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
<affiliation wicri:level="3"><nlm:aff id="au3"><institution>AP-HP, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Inserm, U 1127, Cnrs, UMR 7225, 3- Sorbonne Université, UPMC Univ Paris 06, UM 75, ICM</institution>
<addr-line>F-75013, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>F-75013, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Takashima, Hiroshi" sort="Takashima, Hiroshi" uniqKey="Takashima H" first="Hiroshi" last="Takashima">Hiroshi Takashima</name>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences</institution>
<addr-line>Kagoshima, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kagoshima</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kikuchi, Akio" sort="Kikuchi, Akio" uniqKey="Kikuchi A" first="Akio" last="Kikuchi">Akio Kikuchi</name>
<affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Neurology, Tohoku University School of Medicine</institution>
<addr-line>Sendai, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Sendai</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aoki, Masashi" sort="Aoki, Masashi" uniqKey="Aoki M" first="Masashi" last="Aoki">Masashi Aoki</name>
<affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Neurology, Tohoku University School of Medicine</institution>
<addr-line>Sendai, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Sendai</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ishiura, Hiroyuki" sort="Ishiura, Hiroyuki" uniqKey="Ishiura H" first="Hiroyuki" last="Ishiura">Hiroyuki Ishiura</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yasuda, Tsutomu" sort="Yasuda, Tsutomu" uniqKey="Yasuda T" first="Tsutomu" last="Yasuda">Tsutomu Yasuda</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Date, Hidetoshi" sort="Date, Hidetoshi" uniqKey="Date H" first="Hidetoshi" last="Date">Hidetoshi Date</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ahsan, Budrul" sort="Ahsan, Budrul" uniqKey="Ahsan B" first="Budrul" last="Ahsan">Budrul Ahsan</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Iwata, Atsushi" sort="Iwata, Atsushi" uniqKey="Iwata A" first="Atsushi" last="Iwata">Atsushi Iwata</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goto, Jun" sort="Goto, Jun" uniqKey="Goto J" first="Jun" last="Goto">Jun Goto</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ichikawa, Yaeko" sort="Ichikawa, Yaeko" uniqKey="Ichikawa Y" first="Yaeko" last="Ichikawa">Yaeko Ichikawa</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nakahara, Yasuo" sort="Nakahara, Yasuo" uniqKey="Nakahara Y" first="Yasuo" last="Nakahara">Yasuo Nakahara</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Momose, Yoshio" sort="Momose, Yoshio" uniqKey="Momose Y" first="Yoshio" last="Momose">Yoshio Momose</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Takahashi, Yuji" sort="Takahashi, Yuji" uniqKey="Takahashi Y" first="Yuji" last="Takahashi">Yuji Takahashi</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hara, Kenju" sort="Hara, Kenju" uniqKey="Hara K" first="Kenju" last="Hara">Kenju Hara</name>
<affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, Brain Research Institute, Niigata University</institution>
<addr-line>Niigata, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Niigata</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kakita, Akiyoshi" sort="Kakita, Akiyoshi" uniqKey="Kakita A" first="Akiyoshi" last="Kakita">Akiyoshi Kakita</name>
<affiliation wicri:level="1"><nlm:aff id="au7"><institution>Department of Pathology, Brain Research Institute, Niigata University</institution>
<addr-line>Niigata, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Niigata</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yamada, Mitsunori" sort="Yamada, Mitsunori" uniqKey="Yamada M" first="Mitsunori" last="Yamada">Mitsunori Yamada</name>
<affiliation wicri:level="1"><nlm:aff id="au7"><institution>Department of Pathology, Brain Research Institute, Niigata University</institution>
<addr-line>Niigata, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Niigata</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au8"><institution>Department of Clinical Research, Saigata Medical Center, National Hospital Organization</institution>
<addr-line>Niigata, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Niigata</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name>
<affiliation wicri:level="1"><nlm:aff id="au7"><institution>Department of Pathology, Brain Research Institute, Niigata University</institution>
<addr-line>Niigata, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Niigata</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Onodera, Osamu" sort="Onodera, Osamu" uniqKey="Onodera O" first="Osamu" last="Onodera">Osamu Onodera</name>
<affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, Brain Research Institute, Niigata University</institution>
<addr-line>Niigata, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Niigata</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nishizawa, Masatoyo" sort="Nishizawa, Masatoyo" uniqKey="Nishizawa M" first="Masatoyo" last="Nishizawa">Masatoyo Nishizawa</name>
<affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, Brain Research Institute, Niigata University</institution>
<addr-line>Niigata, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Niigata</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Watanabe, Hirohisa" sort="Watanabe, Hirohisa" uniqKey="Watanabe H" first="Hirohisa" last="Watanabe">Hirohisa Watanabe</name>
<affiliation wicri:level="1"><nlm:aff id="au9"><institution>Department of Neurology, Nagoya University Graduate School of Medicine</institution>
<addr-line>Nagoya, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Nagoya</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ito, Mizuki" sort="Ito, Mizuki" uniqKey="Ito M" first="Mizuki" last="Ito">Mizuki Ito</name>
<affiliation wicri:level="1"><nlm:aff id="au9"><institution>Department of Neurology, Nagoya University Graduate School of Medicine</institution>
<addr-line>Nagoya, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Nagoya</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sobue, Gen" sort="Sobue, Gen" uniqKey="Sobue G" first="Gen" last="Sobue">Gen Sobue</name>
<affiliation wicri:level="1"><nlm:aff id="au9"><institution>Department of Neurology, Nagoya University Graduate School of Medicine</institution>
<addr-line>Nagoya, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Nagoya</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ishikawa, Kinya" sort="Ishikawa, Kinya" uniqKey="Ishikawa K" first="Kinya" last="Ishikawa">Kinya Ishikawa</name>
<affiliation wicri:level="1"><nlm:aff id="au10"><institution>Department of Neurology and Neurological Science, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mizusawa, Hidehiro" sort="Mizusawa, Hidehiro" uniqKey="Mizusawa H" first="Hidehiro" last="Mizusawa">Hidehiro Mizusawa</name>
<affiliation wicri:level="1"><nlm:aff id="au10"><institution>Department of Neurology and Neurological Science, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kanai, Kazuaki" sort="Kanai, Kazuaki" uniqKey="Kanai K" first="Kazuaki" last="Kanai">Kazuaki Kanai</name>
<affiliation wicri:level="1"><nlm:aff id="au11"><institution>Department of Neurology, Chiba University School of Medicine</institution>
<addr-line>Chiba, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Chiba</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hattori, Takamichi" sort="Hattori, Takamichi" uniqKey="Hattori T" first="Takamichi" last="Hattori">Takamichi Hattori</name>
<affiliation wicri:level="1"><nlm:aff id="au11"><institution>Department of Neurology, Chiba University School of Medicine</institution>
<addr-line>Chiba, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Chiba</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kuwabara, Satoshi" sort="Kuwabara, Satoshi" uniqKey="Kuwabara S" first="Satoshi" last="Kuwabara">Satoshi Kuwabara</name>
<affiliation wicri:level="1"><nlm:aff id="au11"><institution>Department of Neurology, Chiba University School of Medicine</institution>
<addr-line>Chiba, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Chiba</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arai, Kimihito" sort="Arai, Kimihito" uniqKey="Arai K" first="Kimihito" last="Arai">Kimihito Arai</name>
<affiliation wicri:level="1"><nlm:aff id="au12"><institution>Division of Neurology, National Hospital Organization, Chiba East Hospital</institution>
<addr-line>Chiba, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Chiba</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koyano, Shigeru" sort="Koyano, Shigeru" uniqKey="Koyano S" first="Shigeru" last="Koyano">Shigeru Koyano</name>
<affiliation wicri:level="1"><nlm:aff id="au13"><institution>Department of Clinical Neurology and Stroke Medicine, Graduate School of Medicine, Yokohama City University</institution>
<addr-line>Yokohama, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Yokohama</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kuroiwa, Yoshiyuki" sort="Kuroiwa, Yoshiyuki" uniqKey="Kuroiwa Y" first="Yoshiyuki" last="Kuroiwa">Yoshiyuki Kuroiwa</name>
<affiliation wicri:level="1"><nlm:aff id="au14"><institution>Department of Neurology, Teikyo University School of Medicine University Hospital</institution>
<addr-line>Mizonokuchi, Kawasaki, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Mizonokuchi, Kawasaki</wicri:regionArea>
<wicri:noRegion>Kawasaki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hasegawa, Kazuko" sort="Hasegawa, Kazuko" uniqKey="Hasegawa K" first="Kazuko" last="Hasegawa">Kazuko Hasegawa</name>
<affiliation wicri:level="1"><nlm:aff id="au15"><institution>Division of Neurology, National Hospital Organization, Sagamihara National Hospital</institution>
<addr-line>Sagamihara, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Sagamihara</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yuasa, Tatsuhiko" sort="Yuasa, Tatsuhiko" uniqKey="Yuasa T" first="Tatsuhiko" last="Yuasa">Tatsuhiko Yuasa</name>
<affiliation wicri:level="1"><nlm:aff id="au16"><institution>Department of Neurology, Kamagaya-Chiba Medical Center for Intractable Neurological Disease, Kamagaya General Hospital</institution>
<addr-line>Chiba, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Chiba</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yasui, Kenichi" sort="Yasui, Kenichi" uniqKey="Yasui K" first="Kenichi" last="Yasui">Kenichi Yasui</name>
<affiliation wicri:level="1"><nlm:aff id="au17"><institution>Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University</institution>
<addr-line>Yonago, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Yonago</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nakashima, Kenji" sort="Nakashima, Kenji" uniqKey="Nakashima K" first="Kenji" last="Nakashima">Kenji Nakashima</name>
<affiliation wicri:level="1"><nlm:aff id="au17"><institution>Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University</institution>
<addr-line>Yonago, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Yonago</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ito, Hijiri" sort="Ito, Hijiri" uniqKey="Ito H" first="Hijiri" last="Ito">Hijiri Ito</name>
<affiliation wicri:level="1"><nlm:aff id="au18"><institution>Department of Neurology, Mifukai Vihara Hananosato Hospital</institution>
<addr-line>Hiroshima, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Hiroshima</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Izumi, Yuishin" sort="Izumi, Yuishin" uniqKey="Izumi Y" first="Yuishin" last="Izumi">Yuishin Izumi</name>
<affiliation wicri:level="1"><nlm:aff id="au19"><institution>Department of Clinical Neuroscience, Institute of Health Biosciences, University of Tokushima Graduate School</institution>
<addr-line>Tokushima, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokushima</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name>
<affiliation wicri:level="1"><nlm:aff id="au19"><institution>Department of Clinical Neuroscience, Institute of Health Biosciences, University of Tokushima Graduate School</institution>
<addr-line>Tokushima, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokushima</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kato, Takeo" sort="Kato, Takeo" uniqKey="Kato T" first="Takeo" last="Kato">Takeo Kato</name>
<affiliation wicri:level="1"><nlm:aff id="au20"><institution>Departments of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University</institution>
<addr-line>Yamagata, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Yamagata</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kusunoki, Susumu" sort="Kusunoki, Susumu" uniqKey="Kusunoki S" first="Susumu" last="Kusunoki">Susumu Kusunoki</name>
<affiliation wicri:level="1"><nlm:aff id="au21"><institution>Department of Neurology, Kinki University School of Medicine</institution>
<addr-line>Osaka, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Osaka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Osaki, Yasushi" sort="Osaki, Yasushi" uniqKey="Osaki Y" first="Yasushi" last="Osaki">Yasushi Osaki</name>
<affiliation wicri:level="1"><nlm:aff id="au22"><institution>Department of Geriatrics, Cardiology and Neurology, Kochi Medical School</institution>
<addr-line>Nankoku, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Nankoku</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Horiuchi, Masahiro" sort="Horiuchi, Masahiro" uniqKey="Horiuchi M" first="Masahiro" last="Horiuchi">Masahiro Horiuchi</name>
<affiliation wicri:level="1"><nlm:aff id="au23"><institution>Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine</institution>
<addr-line>Kawasaki, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kawasaki</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kondo, Tomoyoshi" sort="Kondo, Tomoyoshi" uniqKey="Kondo T" first="Tomoyoshi" last="Kondo">Tomoyoshi Kondo</name>
<affiliation wicri:level="1"><nlm:aff id="au24"><institution>Department of Neurology, Wakayama Medical University</institution>
<addr-line>Wakayama, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Wakayama</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Murayama, Shigeo" sort="Murayama, Shigeo" uniqKey="Murayama S" first="Shigeo" last="Murayama">Shigeo Murayama</name>
<affiliation wicri:level="1"><nlm:aff id="au25"><institution>Department of Neuropathology and the Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name>
<affiliation wicri:level="1"><nlm:aff id="au26"><institution>Department of Neurology, Juntendo University School of Medicine</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yamamoto, Mitsutoshi" sort="Yamamoto, Mitsutoshi" uniqKey="Yamamoto M" first="Mitsutoshi" last="Yamamoto">Mitsutoshi Yamamoto</name>
<affiliation wicri:level="1"><nlm:aff id="au27"><institution>Department of Neurology, Kagawa Prefectural Central Hospital</institution>
<addr-line>Takamatsu, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Takamatsu</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Murata, Miho" sort="Murata, Miho" uniqKey="Murata M" first="Miho" last="Murata">Miho Murata</name>
<affiliation wicri:level="1"><nlm:aff id="au28"><institution>Department of Neurology, National Center Hospital of Neurology and Psychiatry</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Satake, Wataru" sort="Satake, Wataru" uniqKey="Satake W" first="Wataru" last="Satake">Wataru Satake</name>
<affiliation wicri:level="1"><nlm:aff id="au29"><institution>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine</institution>
<addr-line>Kobe, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kobe</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Toda, Tatsushi" sort="Toda, Tatsushi" uniqKey="Toda T" first="Tatsushi" last="Toda">Tatsushi Toda</name>
<affiliation wicri:level="1"><nlm:aff id="au29"><institution>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine</institution>
<addr-line>Kobe, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kobe</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name>
<affiliation wicri:level="1"><nlm:aff id="au30"><institution>Department of Neurological Sciences, University Federico II</institution>
<addr-line>Naples, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Naples</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name>
<affiliation wicri:level="1"><nlm:aff id="au31"><institution>Department of Neurology, University of Bonn and German Center for Neurodegenerative Diseases (DZNE)</institution>
<addr-line>Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Bonn</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wullner, Ullrich" sort="Wullner, Ullrich" uniqKey="Wullner U" first="Ullrich" last="Wüllner">Ullrich Wüllner</name>
<affiliation wicri:level="1"><nlm:aff id="au31"><institution>Department of Neurology, University of Bonn and German Center for Neurodegenerative Diseases (DZNE)</institution>
<addr-line>Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Bonn</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nicholson, Garth" sort="Nicholson, Garth" uniqKey="Nicholson G" first="Garth" last="Nicholson">Garth Nicholson</name>
<affiliation wicri:level="1"><nlm:aff id="au32"><institution>Concord Hospital, University of Sydney at the Australian and New Zealand Army Corps (ANZAC) Research Institute</institution>
<addr-line>Sydney, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sydney</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gilman, Sid" sort="Gilman, Sid" uniqKey="Gilman S" first="Sid" last="Gilman">Sid Gilman</name>
<affiliation wicri:level="2"><nlm:aff id="au33"><institution>Department of Neurology, University of Michigan</institution>
<addr-line>Ann Arbor, Michigan</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name>
<affiliation wicri:level="2"><nlm:aff id="au34"><institution>Parkinson's Disease Research Education and Clinical Center, San Francisco Veteran's Affairs Medical Center</institution>
<addr-line>San Francisco, California</addr-line>
</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A" last="Kukull">Walter A. Kukull</name>
<affiliation wicri:level="2"><nlm:aff id="au35"><institution>Department of Epidemiology, University of Washington School of Public Health</institution>
<addr-line>Seattle, Washington</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stern, Mathew B" sort="Stern, Mathew B" uniqKey="Stern M" first="Mathew B" last="Stern">Mathew B. Stern</name>
<affiliation wicri:level="2"><nlm:aff id="au36"><institution>Parkinson's Disease and Movement Disorders Center, Department of Neurology, Perelman School of Medicine at the University of Pennsylvania</institution>
<addr-line>Philadelphia, Pennsylvania</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lee, Virginia M Y" sort="Lee, Virginia M Y" uniqKey="Lee V" first="Virginia M-Y" last="Lee">Virginia M-Y Lee</name>
<affiliation wicri:level="2"><nlm:aff id="au37"><institution>Institute on Aging, Udall Parkinson's Research Center, Center for Neurodegenerative Disease Research and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania</institution>
<addr-line>Philadelphia, Pennsylvania</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q" last="Trojanowski">John Q. Trojanowski</name>
<affiliation wicri:level="2"><nlm:aff id="au37"><institution>Institute on Aging, Udall Parkinson's Research Center, Center for Neurodegenerative Disease Research and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania</institution>
<addr-line>Philadelphia, Pennsylvania</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Masliah, Eliezer" sort="Masliah, Eliezer" uniqKey="Masliah E" first="Eliezer" last="Masliah">Eliezer Masliah</name>
<affiliation wicri:level="2"><nlm:aff id="au38"><institution>Department of Neurosciences, University of California San Diego</institution>
<addr-line>San Diego, California</addr-line>
</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Low, Phillip A" sort="Low, Phillip A" uniqKey="Low P" first="Phillip A" last="Low">Phillip A. Low</name>
<affiliation wicri:level="2"><nlm:aff id="au39"><institution>Department of Neurology, Mayo Clinic</institution>
<addr-line>Rochester, Minnesota</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sandroni, Paola" sort="Sandroni, Paola" uniqKey="Sandroni P" first="Paola" last="Sandroni">Paola Sandroni</name>
<affiliation wicri:level="2"><nlm:aff id="au39"><institution>Department of Neurology, Mayo Clinic</institution>
<addr-line>Rochester, Minnesota</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ozelius, Laurie J" sort="Ozelius, Laurie J" uniqKey="Ozelius L" first="Laurie J" last="Ozelius">Laurie J. Ozelius</name>
<affiliation wicri:level="2"><nlm:aff id="au40"><institution>Departments of Genetics and Genomic Sciences and Neurology, Icahn School of Medicine at Mount Sinai</institution>
<addr-line>New York, New York</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
<affiliation wicri:level="2"><nlm:aff id="au41"><institution>Department of Medical and Molecular Genetics, Indiana University School of Medicine</institution>
<addr-line>Indianapolis, Indiana</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Indiana</region>
</placeName>
<wicri:cityArea>Indianapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Graduate School of Medicine, University of Tokyo</institution>
<addr-line>Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Annals of Clinical and Translational Neurology</title>
<idno type="ISSN">2328-9503</idno>
<idno type="eISSN">2328-9503</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Objective</title>
<p>Glucocerebrosidase gene (<italic>GBA</italic>
) variants that cause Gaucher disease are associated with Parkinson disease (PD) and dementia with Lewy bodies (DLB). To investigate the role of <italic>GBA</italic>
variants in multiple system atrophy (MSA), we analyzed <italic>GBA</italic>
variants in a large case–control series.</p>
</sec>
<sec><title>Methods</title>
<p>We sequenced coding regions and flanking splice sites of <italic>GBA</italic>
in 969 MSA patients (574 Japanese, 223 European, and 172 North American) and 1509 control subjects (900 Japanese, 315 European, and 294 North American). We focused solely on Gaucher-disease-causing <italic>GBA</italic>
variants.</p>
</sec>
<sec><title>Results</title>
<p>In the Japanese series, we found nine carriers among the MSA patients (1.65%) and eight carriers among the control subjects (0.89%). In the European series, we found three carriers among the MSA patients (1.35%) and two carriers among the control subjects (0.63%). In the North American series, we found five carriers among the MSA patients (2.91%) and one carrier among the control subjects (0.34%). Subjecting each series to a Mantel–Haenszel analysis yielded a pooled odds ratio (OR) of 2.44 (95% confidence interval [CI], 1.14–5.21) and a <italic>P</italic>
-value of 0.029 without evidence of significant heterogeneity. Logistic regression analysis yielded similar results, with an adjusted OR of 2.43 (95% CI 1.15–5.37) and a <italic>P</italic>
-value of 0.022. Subtype analysis showed that Gaucher-disease-causing <italic>GBA</italic>
variants are significantly associated with MSA cerebellar subtype (MSA-C) patients (<italic>P </italic>
=<italic> </italic>
7.3 × 10<sup>−3</sup>
).</p>
</sec>
<sec><title>Interpretation</title>
<p>The findings indicate that, as in PD and DLB, Gaucher-disease-causing <italic>GBA</italic>
variants are associated with MSA.</p>
</sec>
</div>
</front>
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</listBibl>
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</TEI>
</record>
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