Changes in quality of life and disease-related symptoms in patients with polycythemia vera receiving ruxolitinib or standard therapy.
Identifieur interne : 002244 ( Main/Merge ); précédent : 002243; suivant : 002245Changes in quality of life and disease-related symptoms in patients with polycythemia vera receiving ruxolitinib or standard therapy.
Auteurs : Ruben Mesa [États-Unis] ; Srdan Verstovsek [États-Unis] ; Jean-Jacques Kiladjian [France] ; Martin Griesshammer [Allemagne] ; Tamas Masszi [Hongrie] ; Simon Durrant [Australie] ; Francesco Passamonti [Italie] ; Claire N. Harrison [Royaume-Uni] ; Fabrizio Pane [Italie] ; Pierre Zachee [Belgique] ; Huiling Zhen [États-Unis] ; Mark M. Jones [États-Unis] ; Shreekant Parasuraman [États-Unis] ; Jingjin Li [États-Unis] ; Isabelle Côté [États-Unis] ; Dany Habr [États-Unis] ; Alessandro M. Vannucchi [Italie]Source :
- European journal of haematology [ 1600-0609 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Femelle, Humains, Inhibiteurs de protéines kinases (administration et posologie), Inhibiteurs de protéines kinases (effets indésirables), Inhibiteurs de protéines kinases (usage thérapeutique), Mesures des résultats rapportés par les patients, Mâle, Norme de soins, Polyglobulie primitive essentielle (), Polyglobulie primitive essentielle (diagnostic), Polyglobulie primitive essentielle (épidémiologie), Pyrazoles (administration et posologie), Pyrazoles (effets indésirables), Pyrazoles (usage thérapeutique), Qualité de vie, Résultat thérapeutique, Sujet âgé.
- MESH :
- administration et posologie : Inhibiteurs de protéines kinases, Pyrazoles.
- diagnostic : Polyglobulie primitive essentielle.
- effets indésirables : Inhibiteurs de protéines kinases, Pyrazoles.
- usage thérapeutique : Inhibiteurs de protéines kinases, Pyrazoles.
- épidémiologie : Polyglobulie primitive essentielle.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Mesures des résultats rapportés par les patients, Mâle, Norme de soins, Polyglobulie primitive essentielle, Qualité de vie, Résultat thérapeutique, Sujet âgé.
English descriptors
- KwdEn :
- Adult, Aged, Female, Humans, Male, Middle Aged, Patient Reported Outcome Measures, Polycythemia Vera (diagnosis), Polycythemia Vera (epidemiology), Polycythemia Vera (therapy), Protein Kinase Inhibitors (administration & dosage), Protein Kinase Inhibitors (adverse effects), Protein Kinase Inhibitors (therapeutic use), Pyrazoles (administration & dosage), Pyrazoles (adverse effects), Pyrazoles (therapeutic use), Quality of Life, Standard of Care, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Protein Kinase Inhibitors, Pyrazoles.
- chemical , adverse effects : Protein Kinase Inhibitors, Pyrazoles.
- diagnosis : Polycythemia Vera.
- epidemiology : Polycythemia Vera.
- chemical , therapeutic use : Protein Kinase Inhibitors, Pyrazoles.
- therapy : Polycythemia Vera.
- Adult, Aged, Female, Humans, Male, Middle Aged, Patient Reported Outcome Measures, Quality of Life, Standard of Care, Treatment Outcome.
Abstract
Polycythemia vera (PV)-related symptoms may not be adequately controlled with conventional therapy. This current analysis of the RESPONSE trial evaluated the effects of ruxolitinib compared with standard therapy on quality of life (QoL) and symptoms in patients with PV who were hydroxyurea resistant/intolerant.
DOI: 10.1111/ejh.12707
PubMed: 26608702
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pubmed:26608702Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Changes in quality of life and disease-related symptoms in patients with polycythemia vera receiving ruxolitinib or standard therapy.</title>
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<author><name sortKey="Kiladjian, Jean Jacques" sort="Kiladjian, Jean Jacques" uniqKey="Kiladjian J" first="Jean-Jacques" last="Kiladjian">Jean-Jacques Kiladjian</name>
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<author><name sortKey="Passamonti, Francesco" sort="Passamonti, Francesco" uniqKey="Passamonti F" first="Francesco" last="Passamonti">Francesco Passamonti</name>
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<author><name sortKey="Harrison, Claire N" sort="Harrison, Claire N" uniqKey="Harrison C" first="Claire N" last="Harrison">Claire N. Harrison</name>
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<author><name sortKey="Pane, Fabrizio" sort="Pane, Fabrizio" uniqKey="Pane F" first="Fabrizio" last="Pane">Fabrizio Pane</name>
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<author><name sortKey="Zachee, Pierre" sort="Zachee, Pierre" uniqKey="Zachee P" first="Pierre" last="Zachee">Pierre Zachee</name>
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<author><name sortKey="Zhen, Huiling" sort="Zhen, Huiling" uniqKey="Zhen H" first="Huiling" last="Zhen">Huiling Zhen</name>
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<author><name sortKey="Jones, Mark M" sort="Jones, Mark M" uniqKey="Jones M" first="Mark M" last="Jones">Mark M. Jones</name>
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<author><name sortKey="Parasuraman, Shreekant" sort="Parasuraman, Shreekant" uniqKey="Parasuraman S" first="Shreekant" last="Parasuraman">Shreekant Parasuraman</name>
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<author><name sortKey="Li, Jingjin" sort="Li, Jingjin" uniqKey="Li J" first="Jingjin" last="Li">Jingjin Li</name>
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<placeName><region type="state">New Jersey</region>
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<author><name sortKey="Cote, Isabelle" sort="Cote, Isabelle" uniqKey="Cote I" first="Isabelle" last="Côté">Isabelle Côté</name>
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<author><name sortKey="Habr, Dany" sort="Habr, Dany" uniqKey="Habr D" first="Dany" last="Habr">Dany Habr</name>
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<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
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<author><name sortKey="Vannucchi, Alessandro M" sort="Vannucchi, Alessandro M" uniqKey="Vannucchi A" first="Alessandro M" last="Vannucchi">Alessandro M. Vannucchi</name>
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<series><title level="j">European journal of haematology</title>
<idno type="eISSN">1600-0609</idno>
<imprint><date when="2016" type="published">2016</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Patient Reported Outcome Measures</term>
<term>Polycythemia Vera (diagnosis)</term>
<term>Polycythemia Vera (epidemiology)</term>
<term>Polycythemia Vera (therapy)</term>
<term>Protein Kinase Inhibitors (administration & dosage)</term>
<term>Protein Kinase Inhibitors (adverse effects)</term>
<term>Protein Kinase Inhibitors (therapeutic use)</term>
<term>Pyrazoles (administration & dosage)</term>
<term>Pyrazoles (adverse effects)</term>
<term>Pyrazoles (therapeutic use)</term>
<term>Quality of Life</term>
<term>Standard of Care</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Inhibiteurs de protéines kinases (administration et posologie)</term>
<term>Inhibiteurs de protéines kinases (effets indésirables)</term>
<term>Inhibiteurs de protéines kinases (usage thérapeutique)</term>
<term>Mesures des résultats rapportés par les patients</term>
<term>Mâle</term>
<term>Norme de soins</term>
<term>Polyglobulie primitive essentielle ()</term>
<term>Polyglobulie primitive essentielle (diagnostic)</term>
<term>Polyglobulie primitive essentielle (épidémiologie)</term>
<term>Pyrazoles (administration et posologie)</term>
<term>Pyrazoles (effets indésirables)</term>
<term>Pyrazoles (usage thérapeutique)</term>
<term>Qualité de vie</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Protein Kinase Inhibitors</term>
<term>Pyrazoles</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Protein Kinase Inhibitors</term>
<term>Pyrazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Inhibiteurs de protéines kinases</term>
<term>Pyrazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Polycythemia Vera</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Polyglobulie primitive essentielle</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Inhibiteurs de protéines kinases</term>
<term>Pyrazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Polycythemia Vera</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Protein Kinase Inhibitors</term>
<term>Pyrazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Polycythemia Vera</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Inhibiteurs de protéines kinases</term>
<term>Pyrazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Polyglobulie primitive essentielle</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Patient Reported Outcome Measures</term>
<term>Quality of Life</term>
<term>Standard of Care</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mesures des résultats rapportés par les patients</term>
<term>Mâle</term>
<term>Norme de soins</term>
<term>Polyglobulie primitive essentielle</term>
<term>Qualité de vie</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Polycythemia vera (PV)-related symptoms may not be adequately controlled with conventional therapy. This current analysis of the RESPONSE trial evaluated the effects of ruxolitinib compared with standard therapy on quality of life (QoL) and symptoms in patients with PV who were hydroxyurea resistant/intolerant.</div>
</front>
</TEI>
</record>
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